Publications

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formation of aflatoxins by aspergillus ostianus wehmer. 19676049312
three new chlorine containing antibiotics from a marine-derived fungus aspergillus ostianus collected in pohnpei.a marine bacterium ruegeria atlantica (designated as strain tuf-d) was isolated from a glass plate submerged in the coastal water. three new chlorine containing compounds (1 to approximately 3), together with penicillic acid (4) were obtained from a marine-derived fungus aspergillus ostianus strain tuf 01f313 isolated from a marine sponge at pohnpei as antibacterial components against r. atlantica. the structures of three new antibiotics were determined based on their spectral data as 8-chloro-9 ...200314632284
pentaketides relating to aspinonene and dihydroaspyrone from a marine-derived fungus, aspergillus ostianus.three new pentaketides, aspinotriols a ( 1) and b ( 3) and aspinonediol ( 5), were isolated together with two known compounds, aspinonene ( 7) and dihydroaspyrone ( 9), from the marine fungus aspergillus ostianus strain 01f313, which was collected in pohnpei and cultured with bromine-modified artificial seawater. the structures of the new compounds were determined by spectroscopic analyses including 1d and 2d nmr. although 1 and 3 are diastereomers, they show nearly superimposable (1)h and (13)c ...200717994702
new cytotoxic 14-membered macrolides from marine-derived fungus aspergillus ostianus.three new 14-membered macrolides, named aspergillides a, b, and c (1, 5, and 7), were isolated from marine-derived fungus aspergillus ostianus strain 01f313, cultured in a medium composed of bromine-modified artificial seawater. the structures of the new compounds were determined by analyses of 1d and 2d nmr spectra. their absolute configurations were elucidated by the modified mosher's method and chemical conversions. the new compounds showed cytotoxic activity against mouse lymphocytic leukemi ...200818078344
structure revision of circumdatins a and b, benzodiazepine alkaloids produced by marine fungus aspergillus ostianus, by x-ray crystallography.the structures of circumdatins a and b, pentacyclic alkaloids produced by aspergillus ostianus, were revised from the previously reported betaine structures to unique oxepin ones by x-ray crystallography. the co-occurring known alkaloids, circumdatins d, e, and h, and a new compound reported here, circumdatin j, have a common framework.200818459812
enantioselective total synthesis of aspergillide c.the first enantioselective total synthesis of aspergillide c, a cytotoxic 14-membered macrolide isolated from the marine-derived fungus aspergillus ostianus, has been accomplished from a commercially available chiral glycidol derivative by a 12-step sequence involving an expeditious preparation of a cyclic acetal intermediate and a trans-selective ferrier-type two-carbon homologation reaction.200919128025
metagenomic analysis of medicinal cannabis samples; pathogenic bacteria, toxigenic fungi, and beneficial microbes grow in culture-based yeast and mold tests.background: the presence of bacteria and fungi in medicinal or recreational cannabis poses a potential threat to consumers if those microbes include pathogenic or toxigenic species. this study evaluated two widely used culture-based platforms for total yeast and mold (tym) testing marketed by 3m corporation and biomérieux, in comparison with a quantitative pcr (qpcr) approach marketed by medicinal genomics corporation. methods: a set of 15 medicinal cannabis samples were analyzed using 3m and bi ...201627853518
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