| comparison of anti-inflammatory activities of six curcuma rhizomes: a possible curcuminoid-independent pathway mediated by curcuma phaeocaulis extract. | we aimed to compare the anti-inflammatory activities of six species of curcuma drugs using adjuvant arthritis model mice. when orally administered 1 day before the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. also when orally administered 1 day after the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling. other curcuma ... | 2006 | 16786056 |
| anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 mapk activation. | beta-elemene, a natural plant drug extracted from curcuma wenyujin, has been used as an antitumor drug for different tumors, including glioblastoma. however, the mechanism of its anti-tumor effect is largely unknown. here we report that anti-proliferation of glioblastoma cells induced by beta-elemene was dependent on p38 mapk activation. treatment of glioblastoma cell lines with beta-elemene, led to phosphorylation of p38 mapk, cell-cycle arrest in g0/g1 phase and inhibition of proliferation of ... | 2008 | 18442668 |
| [professor ling changquan's experience in treating primary liver cancer: an analysis of herbal medication]. | on the basis of outpatients' medical records concerning primary liver cancer (plc), data of 552 patients (with 2020 effective prescriptions) from the outpatient department of changhai hospital treated by professor ling changquan were collected. the nature, flavor and meridian distribution of the herbs used in the prescriptions were summarized by frequency method, and the features of the herbs used according to syndrome differentiation were analyzed by logistic regression. the couple herbs used w ... | 2008 | 19063833 |
| furanodiene induces g2/m cell cycle arrest and apoptosis through mapk signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. | furanodiene (c15h20o), a pure compound isolated from traditional chinese medicine, curcuma wenyujin, named ezhu in chinese, which structure was determined on the basis of nmr, ms and uv spectrum. in this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in human hepatoma hepg2 cells. furanodiene inhibited hepg2 cell growth by causing cell cycle arrest at g2/m and inducing apoptosis as evidenced by dna fragmentation assay. we found th ... | 2007 | 17611410 |
| authentication of panax notoginseng by 5s-rrna spacer domain and random amplified polymorphic dna (rapd) analysis. | the great majority of panax species are well-known herbal medicines in the orient, and many of them share a close resemblance in appearance and chemical composition. among these panax species, the root of p. notoginseng (sanqi) is a unique herb that has distinct clinical usage. here, the 5s-rrna spacer domains were isolated from p. notoginseng, p. japonicus var. major, p. stipuleanatus, p. quinquefolius, p. ginseng, p. zingiberensis, and p. wangianus, and four common adulterants of p. notoginsen ... | 2003 | 12865989 |
| an insight into the curdione biotransformation pathway by aspergillus niger. | curdione (1), a sesquiterpene with a germacrane skeleton from rhizomes of curcuma wenyujin, has attracted attention due to its important pharmacological properties. herein, we investigated the chemo-biotransformation of curdione (1) systematically using aspergillus niger as 3.739. regio- and stereoselective hydroxylation of curdione with filamentous fungus a. niger as 3.739 led to seven metabolites including four new compounds 3α-hydroxycurcumalactone, 2β-hydroxycurcumalactone, (10s)-9,10-dihydr ... | 2014 | 24456521 |
| "mirror-image" manipulation of curdione stereoisomer scaffolds by chemical and biological approaches: development of a sesquiterpenoid library. | the sesquiterpenoid curdione is one of the main bioactive components in the essential oil of rhizoma curcumae (curcuma wenyujin, curcuma phaeocaulis, and curcuma kwangsiensis), which has been clinically used for the treatment of cancer in mainland china. recently it was reported that natural curdione could be hydroxylated by aspergillus niger and transferred to its corresponding curcumalactones under acidic conditions. based on this study, the development of a sesquiterpenoid library through the ... | 2015 | 25679443 |
| down-regulation of survivin and hypoxia-inducible factor-1α by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenograft. | abstract elemene (1-methyl-1-vinyl-2,4-diisopropenyl-cyclohexane) is a naturally occurring compound that can be isolated from the traditional chinese medicinal herb curcuma wenyujin. β-elemene, its active component, has recently been demonstrated to enhance the radiosensitivity of human cancer cell lines in vitro and of one animal tumor in vivo. the underlying mechanism, however, is still unclear. in this study, we demonstrated for the first time that β-elemene significantly improves the radio ... | 2012 | 22248028 |
| a sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. | furanodiene, a sesquiterpene component extracted from the essential oil of the rhizome of curcuma wenyujin y.h. chen et c. ling (wen ezhu), is widely used in traditional chinese medicine. a sensitive analytical method was established and validated for furanodiene in rat plasma, which was further applied to assess the pharmacokinetics of furanodiene in rats receiving a single dose of furanodiene. liquid chromatography tandem mass spectrometry (lc/ms/ms) in multiple reaction monitoring mode was us ... | 2011 | 22052715 |
| induction of caspase-3-dependent apoptosis in human leukemia hl-60 cells by δ-elemene. | δ-elemene, an antitumor component, is a chemical compound isolated from curcuma wenyujin, a chinese traditional herb. we examined whether δ-elemene could inhibit cell growth and cell cycle progression and induce apoptosis in human leukemia hl-60 cells. the results demonstrated that δ-elemene induces significant apoptosis of hl-60 cells, as shown by mtt assay, annexin v (anv) binding of externalized phosphatidylserine (ps), and the mitochondrial probe jc-1 using flow cytometry. hl-60 cells treate ... | 2011 | 21881314 |
| experimental study on anti-inflammatory activity of a tcm recipe consisting of the supercritical fluid co(2) extract of chrysanthemum indicum, patchouli oil and zedoary turmeric oil in vivo. | ethnopharmacological relevance: chrysanthemum indicum (compositae) linné, pogostemon cablin (blanco) benth and curcuma wenyujin (zingiberaceae) y. h. chen et c. ling are three of the extensively used herbal remedies among traditional chinese medicines for the purpose of anti-inflammation. a traditional chinese medicine (tcm) recipe named cpz consisting extracts of the above three herbs, has shown noteworthy anti-influenza activity, which is closely related to its anti-inflammatory feature. aim o ... | 2011 | 21920423 |
| Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells. | Multidrug resistance (MDR) continues to be a major obstacle for successful anticancer therapy. In this work, fractions from 17 clinically used antitumour traditional Chinese medicinal herbs were tested for their potential to restore the sensitivity of MCF-7/ADR and A549/Taxol cells to a known antineoplastic agent. The effects of these fractions were evaluated by MTT method and an assay of the cellular accumulation of doxorubicin. Fractions from the PB group (herbs with the ability to promote blo ... | 2011 | 21848372 |
| comparison of anti-inflammatory and anti-nociceptive activities of curcuma wenyujin y.h. chen et c. ling and scutellaria baicalensis georgi. | the study aimed to compare the anti-inflammatory and anti-nociceptive activities of curcuma wenyujin y.h. chen et c. ling (curcuma wenyujin) and scutellaria baicalensis georgi (scutellaria baicalensis). this study used three parts to compare the two herbs. firstly, animals were randomly divided into a scutellaria baicalensis group, a curcuma wenyujin group, an indomethacin group, and a model-control group to perform an ear edema test, a carrageenin-induced paw edema test, a cotton pellet-induced ... | 2010 | 21731166 |
| b-cell lymphoma-2 over-expression protects d-elemene-induced apoptosis in human lung carcinoma mucoepidermoid cells via a nuclear factor kappa b-related pathway. | d-elemene, an antitumor component, is a chemical compound isolated from curcuma wenyujin, a chinese traditional herb. we examined whether d-elemene could affect apoptosis in human lung carcinoma mucoepidermoid nci-h292 cells, and test whether and how the over-expression of b-cell lymphoma-2 (bcl-2) and b-cell lymphoma extra large (bcl-xl) could off-set the effect of d-elemene on cell growth. the result demonstrated that d-elemene significantly induced apoptosis of nci-h292, as shown by 3-(4,5-di ... | 2011 | 21804218 |
| sesquiterpenes from curcuma wenyujin with their inhibitory activities on nitric oxide production in raw 264.7 cells. | one new sesquiterpene, 7α,11-epoxy-6α-hydroxy-carabrane-4,8-dione, along with 10 known ones were isolated from the essential oil of curcuma wenyujin y.h. chen et c. ling. their structures were established based on extensive spectroscopic analysis. the absolute configuration of compound 1 was determined by the cd analysis of the insitu formed [rh2(ococf3)4] complex, and the cd data analysis based on the octane rule of cyclohexanone. the inhibitory effects of these sesquiterpenes on nitric oxide p ... | 2017 | 27436766 |
| β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin. | β-elemene, a natural drug extracted from curcuma wenyujin, strongly inhibits glioblastoma growth. however, the mechanism of β-elemene antitumor action remains unclear. glia maturation factor β (gmfβ) regulates cellular growth, fission, differentiation and apoptosis. it has been reported that overexpression of gmfβ inhibits the growth of glioblastoma cells and decreases tumor volume. to illustrate the role of gmfβ in the anti-proliferative effect of β-elemene in glioblastoma, u87 cells were treat ... | 2011 | 21519795 |
| reversal of multidrug resistance in human breast cancer cells by curcuma wenyujin and chrysanthemum indicum. | the emergence of multidrug resistance (mdr) is a big challenge to cancer chemotherapy. plant-derived agents have great potential to prevent onset or delay progression of the carcinogenic process, and enhance the efficacy of mainstream antitumor agents. in this study, fractionated extracts of curcuma wenyujin and chrysanthemum indicum were tested for their potential to modulate the mdr phenotype and function of p-gp in mcf-7/adr and a549/taxol cells in vitro. fractions c. wenyujin c10, e10 from c ... | 2011 | 21306883 |
| ß-elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-flip and generation of ros. | ß-elemene is an active component of the herb medicine curcuma wenyujin with reported antitumor activity. to improve its antitumor ability, five novel piperazine derivatives of ß-elemene, 13-(3-methyl-1-piperazinyl)-ß-elemene (dx1), 13-(cis-3,5-dimethyl-1-piperazinyl)-ß-elemene (dx2), 13-(4-ethyl-1-piperazinyl)-ß-elemene (dx3), 13-(4-isopropyl-1-piperazinyl)-ß-elemene (dx4) and 13-piperazinyl-ß-elemene (dx5), were synthesized. the antiproliferative and apoptotic effects of these derivatives were ... | 2011 | 21283566 |
| ß-elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle g0/g1 arrest via mutually compensatory activation of mkk3 and mkk6. | ß-elemene, a natural plant drug extracted from curcuma wenyujin, has shown a strong anti-glioblastoma effect. however, the antitumor mechanism of ß-elemene remains unclear. mitogen-activated protein kinase kinase-3 (mkk3) and -6 (mkk6) can regulate cellular growth, fission, differentiation and apoptosis. to illustrate the role of mkk3 and mkk6 in the anti-glioblastoma proliferation effect of ß-elemene, u87 cells were treated with ß-elemene at various doses or for different times, and then phosph ... | 2010 | 21132268 |
| reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules. | glioblastoma is the most common and lethal type of primary brain tumor. β-elemene, a natural plant drug extracted from curcuma wenyujin, has shown strong anti-tumor effects in various tumors with low toxicity. however, the effects of β-elemene on malignant phenotypes of human glioblastoma cells remain to be elucidated. here we evaluated the effects of β-elemene on cell proliferation, survival, stemness, differentiation and the epithelial-to-mesenchymal transition (emt) in vitro and in vivo, and ... | 2015 | 26563263 |
| isolation and identification of phase 1 metabolites of curcumol in rats. | curcumol is one of the major components of the essential oil of curcuma wenyujin with the structure of a guaiane-type sesquiterpenoid hemiketal. it exhibits clear antitumor, antihepatic fibrosis, antioxidant, and antimicrobial activities. in this article, the metabolism of curcumol in rats was investigated by characterizing metabolites excreted into urine. sixteen phase 1 metabolites of curcumol were isolated from the urine of rats after an oral dose of 40 mg/kg, and their structures were elucid ... | 2010 | 20682749 |
| curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. | an essential oil extract, derived from the rhizome of curcuma wenyujin (cwe), possesses antioxidative, antimicrobial, and anti-inflammatory properties. however, it remains unknown how exactly cwe inhibits tumor growth. in this study, using human cervical cancer hela cells, the authors postulated that cwe has the ability to inhibit tumor growth. the study shows that cwe dose-dependently suppressed colony formation and inhibited the proliferation of hela cells through blockade of cell cycle progre ... | 2010 | 20150221 |
| [curcuma wenyujin diterpenoid compound c fought against gastric cancer: an experimental study]. | to study the role of nuclear factor (nf)-kappab pathway with p38mapk in curcuma wenyujin diterpenoid compound c (cdcc) fighting against inflammation and inducing gastric cancer cell apoptosis by stimulating gastric cell sgc7901 with tumor necrosis factor-alpha (tnf-alpha). | 2015 | 25881469 |
| cell apoptosis induced by delta-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway. | the chemical compound delta-elemene, isolated from the chinese herbal medicine plant curcuma wenyujin, has been known to exert antitumor activity. in this study we demonstrated that apoptotic cell death induced by delta-elemene in dld-1 cells was concentration-and time-dependent, and had little inhibition of the normal human liver cell line wrl-68. apoptosis was further confirmed and quantified by dna fragmentation elisa, annexin v (anv) binding of externalized phosphatidylserine and the mitocho ... | 2009 | 19881213 |
| potential anti-cancer activities of furanodiene, a sesquiterpene from curcuma wenyujin. | furanodiene is a sesquiterpene extracted from the essential oil of the rhizome of curcuma wenyujin y.h. chen et c. ling (wen ezhu). furanodiene is the primary component in wen ezhu's essential oil, accounting for more than 20% by weight. in vitro, mtt assay was used to compare the inhibitory effects of furanodiene and wen ezhu's essential oil on 11 human cancer cell lines. compared to the essential oil, furanodiene showed stronger growth inhibitions on hela, hep-2, hl-60, pc3, sgc-7901 and ht-10 ... | 2009 | 19606517 |
| [comparison and correlative analysis of trace elements in five kinds of radix curcumae]. | traditional chinese medicine materials (tcm) contained abundant trace elements needed in human body. mixed acid (hno3:hclo4) was added into samples treated by microwave digestion, and a systematic study was carried out by selection of the most appropriate working conditions and optimization of the sample mass. some inorganic elements in 5 kinds of radix curcumae (curcuma wenyujin y. h. chen et c. ling, curcuma longa l., curcuma kwangsiensis s. g. lee et c. f. liang, curcuma phaeocaulis val. and ... | 2008 | 19093592 |
| downregulation of peroxiredoxin-1 by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts. | β-elemene, the active component of elemene (1-methyl-1-vinyl-2,4-diisopropenyl-cyclohexane), is a naturally occurring compound isolated from the traditional chinese medicinal herb curcuma wenyujin. studies have confirmed that β-elemene enhances the radiosensitivity of lung cancer cell lines such as a549, by multiple pathways; however, their underlying mechanisms and pathways are yet to be elucidated. in the present study, two-dimensional differential in-gel electrophoresis and matrix-assisted la ... | 2015 | 25607351 |
| [reversal effect of curcuma wenyujin extract on sgc-7901/vcr induced subcutaneous transplanted tumor in nude mice and its effect on the expression of p-glycoprotein]. | to explore the reversal effect of multidrug resistance of curcuma wenyujin (cw) and its possible mechanism by establishing vincristine-resistant gastric cancer sgc-7901 cells (sgc-7901/vcr) induced subcutaneous transplanted tumor in nude mice. | 2014 | 25566627 |
| induction of apoptosis by furanodiene in hl60 leukemia cells through activation of tnfr1 signaling pathway. | furanodiene, a natural product isolated from curcuma wenyujin, has been reported to produce cytotoxic effect. in this study, we investigated its effects on human leukemia hl60 cells. furanodiene induced apoptosis of hl60 cells, characterized by dna fragmentation, cleavage of poly (adp-ribose) polymerase (parp), caspase-3, caspase-8 and caspase-9. in the bcl-2 family proteins, bid protein (a substrate of caspase-8) was activated by furanodiene, but bcl-2, bax and bcl-xl proteins were not influenc ... | 2008 | 18667267 |
| essential oil of curcuma wenyujin induces apoptosis in human hepatoma cells. | to investigate the effects of the essential oil of curcuma wenyujin (cwo) on growth inhibition and on the induction of apoptosis in human hepg2 cancer cells. | 2008 | 18666318 |
| anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: a proteomic study. | gastric cancer is a common malignancy with a poor prognosis. β-elemene is a broad-spectrum anticancer drug extracted from the traditional chinese medicinal herb curcuma wenyujin. in the present study, we investigated the anticancer effects of β-elemene in gastric cancer cells and the potential proteins involved. human sgc7901 and mkn45 gastric cancer cells were treated with different concentrations of β-elemene. cell viability, clonogenic survival and apoptotic cell death were assessed. β-elemen ... | 2014 | 25333415 |
| n-(beta-elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. | beta-elemene is an active component of herb medicine curcuma wenyujin and n-(beta-elemene-13-yl)tryptophan methyl ester (etme) was synthesized for increasing its antitumor activity. etme induced apoptosis in human leukemia hl-60 and nb4 cells at concentrations less than 40 microm. the apoptosis induction ability of etme was associated with the production of hydrogen peroxide (h(2)o(2)), the decrease of mitochondrial membrane potential, and the activation of caspase-3 that was blocked by catalase ... | 2008 | 18538921 |
| [comparison of the effect of eight kinds of volatile oil of chinese material medica on percutaneous absorption of ibuprofen in vitro]. | to compare the permeation-enhancing effect of the volatile oil of eight kinds of chinese material medica including fructus evodia, radix saposhnikoviae, rhizoma atractylodes lancea radix aucklandiae, radix curcuma wenyujin, rhizoma et radix notopterygii, lignum aquilariae resinatum, herba schizonepetae on the model drug of ibuprofen in order to provide theoretic foundation for the selection and application of natural penetration enhancer. | 2007 | 17727065 |
| down regulation of mammalian target of rapamycin decreases hif-1α and survivin expression in anoxic lung adenocarcinoma a549 cell to elemene and/or irradiation. | mammalian target of rapamycin (mtor) is associated with gene transcription, protein translation and initiation, the synthesis of ribosomes, and apoptosis. the down regulation of mtor induces apoptosis in malignant tumor cells. elemene, a sesquiterpene from the traditional chinese medicinal herb curcuma wenyujin, is active against a wide range of tumor types. in the present study, decreasing the expression of mtor with mtor small interfering rna (sirna) increased the toxicity of elemene and irrad ... | 2014 | 24972968 |
| bioactive metabolites from chaetomium globosum l18, an endophytic fungus in the medicinal plant curcuma wenyujin. | an endophytic fungus, strain l18, isolated from the medicinal plant curcuma wenyujin y.h. chen et c. ling was identified as chaetomium globosum kunze based on morphological characteristics and sequence data for the internal transcribed spacer (its-5.8s-its2) of the nuclear ribosomal dna. a new metabolite named chaetoglobosin x (1), together with three known compounds erogosterol (2), ergosterol 5α,8-peroside (3) and 2-methyl-3-hydroxy indole (4), were isolated from c. globosum l18. their structu ... | 2011 | 22112725 |
| combined effects of furanodiene and doxorubicin on the migration and invasion of mda-mb-231 breast cancer cells in vitro. | furanodiene is one of the major bioactive components isolated from the natural product of the plant, curcuma wenyujin y.h. chen et c. ling. furanodiene has been found to exert anticancer effects in various types of cancer cell lines, as well as exhibit antimetastatic activities. however, the antimetastatic capacity of furanodiene in combination with the common chemotherapy drug doxorubicin has not been investigated. we found that doxorubicin at a non-toxic concentration induced cell migration an ... | 2017 | 28184941 |
| β-elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the egfr signaling pathway. | glioblastoma multiforme (gbm) is the most common and severe form of primary tumor in the central nervous system of adults which has poor prognosis and limited therapeutic options. epidermal growth factor receptor (egfr) inhibitor, such as gefitinib (brand name iressa, zd1839), has been approved as a targeted medicine for several types of tumor including glioblastoma multiforme. however, gefitinib exerted very limited effects on some glioblastoma multiforme patients after a period of treatment du ... | 2016 | 27498706 |
| optimization and in vitro antiproliferation of curcuma wenyujin's active extracts by ultrasonication and response surface methodology. | curcuma wenyujin, a member of the genus curcuma, has been widely prescribed for anti-cancer therapy. multiple response surface optimization has attracted a great attention, while, the research about optimizing three or more responses employing response surface methodology (rsm) was very few. | 2016 | 27186236 |
| p21 (waf1/cip1) is required for non-small cell lung cancer sensitive to gefitinib treatment. | lung cancer is the leading cause of death from cancer in the world. gefitinib is known to its inhibition of egfr tyrosine kinase and worldwide used for antitumor in non-small cell lung cancer (nsclc). here, we show that gefitinib reduces p-akt levels, concomitant with elevation of p21 levels and suppression of cdk2/4 and cycline/d1 activities which result in impaired cell cycle progression through g1 arrest only in nsclc cells in which it inhibits growth. we find that gefitinib-induced p21 prote ... | 2011 | 21616632 |
| furanodiene alters mitochondrial function in doxorubicin-resistant mcf-7 human breast cancer cells in an ampk-dependent manner. | furanodiene is a bioactive sesquiterpene isolated from the spice-producing curcuma wenyujin plant (y. h. chen and c. ling) (c. wenyujin), which is a commonly prescribed herb used in clinical cancer therapy by modern practitioners of traditional chinese medicine. previously, we have shown that furanodiene inhibits breast cancer cell growth both in vitro and in vivo, however, the mechanism for this effect is not yet known. in this study, therefore, we asked (1) whether cultured breast cancer cells ... | 2016 | 26987443 |
| β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1. | β-elemene, a curcuma wenyujin plant extract, has been used widely as a tumor adjuvant therapeutic agent. however, how to obtain optimum therapeutic effects by combining this compound with other agents remain unclear. in this study, we found that β-elemene, which alone had little effect on hepatocellular carcinoma (hcc) cell proliferation, exerted a synergistic anti-proliferative effect in hcc cells when dosed in combination with oxaliplatin, which increased the amounts of platinum accumulation a ... | 2016 | 26867799 |
| β-elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase. | β-elemene is a natural anticancer compound extracted from the chinese medicinal herb curcuma wenyujin. this study was done to determine the effect of β-elemene on the apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (ra-fls) and associated molecular mechanisms. | 2016 | 26721344 |
| conservation and population genetic diversity of curcuma wenyujin (zingiberaceae), a multifunctional medicinal herb. | curcuma wenyujin is an important multifunctional medicinal herb in china. currently, populations of c. wenyujin are decreasing, and wild individuals have almost disappeared from their natural habitats. moreover, little is known regarding the molecular characteristics of this plant. in this study, we investigated the genetic diversity and variation of five populations of c. wenyujin, using ran-dom amplified polymorphic dna (rapd) and inter-simple sequence repeat (issr) markers. we found that the ... | 2015 | 26400273 |
| β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the atm signaling pathway. | glioblastoma multiforme (gbm), a tumor associated with poor prognosis, is known to be resistant to radiotherapy and alkylating agents such as temozolomide (tmz). β-elemene, a monomer found in chinese traditional herbs extracted from curcuma wenyujin, is currently being used as an antitumor drug for different types of tumors including gbm. in the present study, we investigated the roles of β-elemene in the radiosensitivity and chemosensitivity of gbm cells. human gbm cell lines u87-mg, t98g, u251 ... | 2015 | 26062577 |
| [the molecular mechanisms of curcuma wenyujin extract-mediated inhibitory effects on human esophageal carcinoma cells in vitro]. | to study the molecular mechanisms of curcuma wenyujin extract-mediated inhibitory effects on human esophageal carcinoma cells. | 2012 | 23185763 |
| sesquiterpenoids from curcuma wenyujin with anti-influenza viral activities. | five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αh-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βh-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βh-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αh-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of curcuma wenyujin. their structures and relative configurations were determined on the basis of spectroscopic methods including ... | 2013 | 23098899 |
| sesquiterpenes from the essential oil of curcuma wenyujin and their inhibitory effects on nitric oxide production. | three new sesquiterpenes including a new elemane-type sesquiterpene, 5βh-elem-1,3,7,8-tetraen-8,12-olide (1), and two new carabrane-type sesquiterpenes, 7α,11-epoxy-6α-methoxy-carabrane-4,8-dione (2) and 8,11-epidioxy-8-hydroxy-4-oxo-6-carabren (3), together with eight known sesquiterpenes (4-11) were isolated from curcuma wenyujin y. h. chen et c. ling. their structures were elucidated based on extensive spectroscopic analyses. a possible biogenetic scheme for the related compounds was postulat ... | 2015 | 25819782 |
| elemene, the essential oil of curcuma wenyujin, inhibits osteogenic differentiation in ankylosing spondylitis. | to explore the effects of elemene, the essential oil of curcuma wenyujin, on bone morphogenetic protein/drosophila mothers against decapentaplegic proteins (bmp/smads) signal pathway in ankylosing spondylitis (as) fibroblasts. | 2015 | 25636898 |
| inhibition of platelet aggregation by curdione from curcuma wenyujin essential oil. | curdione, one of the major sesquiterpene compounds from rhizoma curcumae, has been shown to exhibit multiple bioactive properties. in this study, we investigated the anti-platelet aggregation and antithrombotic activities of curdione with different methods both in vitro and in vivo. the purpose of the study was to explore an inhibitor of platelet aggregation, which promised to be a preventive or therapeutic agent for various vascular diseases. | 2012 | 22560337 |
| [study on the mechanism of reversal effect of curcuma wenyujin on mdr of sgc7901/vcr]. | to study the mechanism of reversal effect of curcuma wenyujin n-butyl alcohol extract (cwnae) on multiple drugs resistance (mdr) of sgc7901/vcr cells. | 2014 | 25632754 |
| β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of bax and fas/ fasl and downregulation of bcl-2. | β-elemene, extracted from herb medicine curcuma wenyujin has potent anti-tumor effects in various cancer cell lines. however, the activity of β-elemene against glioma cells remains unclear. in the present study, we assessed effects of β-elemene on human glioma cells and explored the underlying mechanism. | 2014 | 25556484 |
| curcumolide, a unique sesquiterpenoid with anti-inflammatory properties from curcuma wenyujin. | curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from curcuma wenyujin. the structure and absolute configuration were elucidated by extensive nmr, ecd data analysis, and a single-crystal x-ray study. this molecule exhibited significant anti-inflammatory effects in lps-induced raw 264.7 macrophages. it suppressed lps-induced nf-κb activation, including the nuclear translocation and dna binding activity of nf-κb, and decreased tumor necrosis factor-α (tnf-α ... | 2015 | 25515561 |
| [fingerprints of curcuma wenyujin by rp-hplc]. | to establish a mutual mode fingerprint of curcuma wenyujin for quality control of c. wenyujin. | 2010 | 21548361 |
| [comparison of content of curdione, curcumol, germacrone and beta-elemene in different varieties of vinegar backed rhizoma curcuma]. | to establish a hplc method for determination of 4 components in different varieties of vinegar backed rhizoma curcuma. | 2010 | 21322942 |
| [essential oil composition of three herbal medicines from curcuma wenyujin by gc-ms]. | to compare the contents and composition of volatile oil of wenyujin (steamed root of curcuma wenyujin) wenezhu (steamed rhieome of curcuma wenyujin) and pianjianghuang (rhizome of curcuma wenyujin). | 2010 | 21174771 |
| [study on geo-herbalism of curcuma wenyujin based on ecological factors]. | to reveal the effects of ecological factors on geo-herbalism,by researching the correlation between yields or qualities of curcuma wenyujin and ecological factors. | 2010 | 21049606 |
| [analysis on adaptive area of curcuma wenyujin based on gis]. | this stdudy was to determine the suitable area for curcuma wenyujin in wenzhou, and expand its growing region, based the growth characteristic of curcuma wenyujin. | 2010 | 20845776 |
| microbial transformation of curcumol by aspergillus niger. | curcumol is a representative index component for the quality control of the essential oil of curcuma wenyujin y.h. chen et c. ling, an antivirus and anticancer drug in china. microbial transformation of curcumol (1) by aspergillus niger as 3.739 yielded two products. their structures were elucidated as 3alpha-hydroxycurcumol (2) and 3alpha-(4'-methoxy-succinyloxy)-curcumol (3) by extensive spectroscopic methods including 2d-nmr and hresi-ms. among them, 3 is a new compound. esterification of the ... | 2013 | 23513713 |
| four new sesquiterpenes from curcuma wenyujin and their inhibitory effects on nitric-oxide production. | four new sesquiterpenes including the novel sesquiterpene lactone (6r)-dehydroxysipanolinolide (1), two new eudesmane-type sesquiterpenes, curcolide (2) and curcodione (3), and a new xanthane-type sesquiterpene, curcumadionol (4), were isolated from curcuma wenyujin y. h. chen et c. ling, together with five known ones, 5-9. the structures of the new compounds were elucidated by spectroscopic methods. the inhibitory effects of compounds 1-9 on nitric-oxide production in lipopolysaccaride-activate ... | 2010 | 20491080 |
| preparative isolation and purification of six volatile compounds from essential oil of curcuma wenyujin using high-performance centrifugal partition chromatography. | six volatile compounds, curdione (1), curcumol (2), germacrone (3), curzerene (4), 1,8-cineole (5) and beta-elemene (6), were successfully isolated from the essential oil of curcuma wenyujin by high-performance centrifugal partition chromatography using a nonaqueous two-phase solvent system consisting of petroleum ether-acetonitrile-acetone (4:3:1 v/v/v). a total of 8 mg of curdione (1), 4 mg of curcumol (2), 10 mg of germacrone (3), 18 mg of curzerene (4), 9 mg of 1,8-cineole (5) and 17 mg of b ... | 2010 | 20405479 |
| guaiane-type sesquiterpenes from curcuma wenyujin and their inhibitory effects on nitric oxide production. | four new guaiane-type sesquiterpenes (1s,4s,5s,10r)-zedoarondiol, zedoalactones d, e, and f (1-4), along with 10 known ones (5-14), were isolated from curcuma wenyujin y.h. chen et c. ling. the structures of these new compounds were elucidated by spectroscopic methods. the inhibitory effects of compounds 1-14 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated. | 2009 | 20183317 |
| [study on genetic diversity of curcuma wenyujin from various habitats by srap]. | the dna fingerprints of curcuma wenyujin from various habitats were generated by using srap markers to find the feasibility in analyzing their relationship. | 2009 | 20112709 |
| chemical constituents from the radix of curcuma wenyujin. | phytochemical study on the ethanol extract of the radixes of curcuma wenyujin y. h. chen et c. ling led to the isolation of three new compounds curcuminol f (1) curcuminol g (2) and wenyujinoside (3) and a known compound aurantiamide (4). their structures were elucidated on the basis of extensive spectroscopic analysis. | 2009 | 19446613 |
| [analysis of growth dynamics of curcuma wenyujin]. | to study the accumulation of matter and dynamic of chemical compositions in rhizoma of curcuma wenyujin for its cultivation. | 2009 | 19445112 |
| [sesquiterpenes from stems and leaves of curcuma wenyujin]. | to study the chemical constituents of the stem and leaves from curcuma wenyujin. | 2008 | 18589781 |
| chemical constituents from aerial part of curcuma wenyujin. | to investigate the chemical constituents from aerial part of curcuma wenyujin. | 2007 | 18338597 |
| [study on effects of seed stock, cultivating density on the yields and volatile oil of curcuma wenyujin]. | according to the study on effects of cultivating density and seed stock on the yield and volatile oil, to provide a scientific basis for standardized cultivating measures. | 2007 | 18323198 |
| combination efficacy of astragalus membranaceus and curcuma wenyujin at different stages of tumor progression in an imageable orthotopic nude mouse model of metastatic human ovarian cancer expressing red fluorescent protein. | the present study determined the efficacy of extracts of astragalus membranaceus (am) and curcuma wenyujin (cw), a traditional chinese medicine herbal mixture, at different tumor stages of an orthotopic nude mouse model of human ovarian cancer expressing red fluorescent protein. | 2015 | 26026079 |
| β-elemene inhibits proliferation through crosstalk between glia maturation factor β and extracellular signal‑regulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells. | β-elemene, a plant-derived drug extracted from curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. however, the underlying molecular mechanisms of the antitumor activity of β-elemene remain to be elucidated. previously, it was identified that the glia maturation factor β (gmfβ)/mitogen-activated protein kinase kinase (mapk) 3/6/p38 pathway participates in the antiproliferative activity of β-elemene on glioblastoma. in the present study ... | 2014 | 24866280 |
| [study on ingredients of essential oils of curcuma wenyujin extracted by supercritical-co2 fluid extraction and steam distillation]. | to compare the ingredients of essential oils of curcuma wenyujin extracted by supercritical-co2 fluid extraction and by steam distillation. | 2006 | 17087087 |
| fast determination of curcumol, curdione and germacrone in three species of curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. | curcumol, germacrone and curdione are the main active ingredients in a common traditional chinese medicine (tcm) of rhizoma curcuma, and commonly used as the tcm quality control markers. in the present work, microwave-assisted extraction (mae) followed by headspace solid-phase microextraction (hs-spme) and gas chromatography-mass spectrometry (gc-ms) was developed for the quantitative analysis of curcumol, curdione and germacrone in rhizoma curcuma. the mae and hs-spme parameters were studied, a ... | 2006 | 16678191 |
| [the fingerprint of ezhu by gc-ms]. | to study the fingerprint of ezhu by gc-ms. | 2005 | 16499086 |
| assessing the quality of rcts on the effect of beta-elemene, one ingredient of a chinese herb, against malignant tumors. | to evaluate the quality of randomized controlled trials (rcts) for elemene injections, one ingredient of chinese herb curcuma wenyujin, for malignant tumors widely used in clinical practice in china. | 2006 | 16243588 |
| [study on names of wenyujin rhizoma curcumae and rhizoma curcumae longae concisa and their origins]. | to study the name of wenyujin rhizoma concisum and film turmeric by literature research methods provide the basis for correct application of cuba in modern clinical application. wenyujin rhizoma concisum and film turmeric often called each other mutual generation and used as the same kind of medicine in the ancient prescriptions books. they were often recorded and stated as the same species of curcumae longae rhizoma. wenyujin rhizoma concisum and curcumae longae rhizoma also often called each o ... | 2015 | 26084188 |
| molecular genetic and chemical assessment of rhizoma curcumae in china. | rhizoma curcumae (ezhu) is a traditional chinese medicine that has been used in removing blood stasis and alleviating pain for over a thousand years. three species of curcuma rhizomes are being used, which include curcuma wenyujin, curcuma phaeocaulis, and curcuma kwangsiensis. in china, the production of rhizoma curcumae largely depends on agricultural farming. the essential oils are considered as active constituents in rhizoma curcumae, which include curdione, curcumol, and germacrone. on the ... | 2005 | 16028990 |
| [research on the technology of soaking under pressure and cutting process of radix curcumae]. | to determine the best processing technology parameters. | 2005 | 16011090 |
| identification and quantitation of eleven sesquiterpenes in three species of curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. | in this paper, gc-ms and pressurized liquid extraction (ple) was developed for identification and quantitative determination/estimation 11 sesquiterpenes including germacrene d, curzerene, gamma-elemene, furanodienone, curcumol, isocurcumenol, furanodiene, germacrone, curdione, curcumenol and neocurdione in ezhu which are derived from three species of curcuma, i.e., curcuma phaeocaulis, curcuma wenyujin and curcuma kwangsiensis by using an analogue as standard. the results showed the methodology ... | 2005 | 15946818 |
| [breeding of new curcuma wenyujin variety "wenyujin no. 1"]. | in order to breed and spread a new cultivar of curcuma wenyujin, the c. wenyujin germplasm resources were investigated in authentic regions. better varieties were chosen by comparing the yield, economic characters and quality differences between different cultivars. the results showed that the character of new selected cultivar was stable, the yield of zedoary, turmeric and curcuma was reached 313.7, 177.9, 91.2 kg per 667 m2, respectively, it increased 11.6%, 10.2%, 14.2% comparing with farmer ... | 2014 | 25751938 |
| furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro. | furanodiene is a bioactive compound isolated from curcuma wenyujin y. h. chen et c. ling (c. wenyujin). it is one of the major components of volatile oil extracted from c. wenyujin. furanodiene has anti-tumor activities in various cancer cell lines, as well as anti-metastatic activities. however, the underlying mechanisms of anti-metastatic activities of furanodiene have not been well investigated. in this study, we demonstrated that at low concentrations (5-25μm), furanodiene inhibited adhesion ... | 2014 | 24824922 |
| [the volatile oil of zedoaria iv: tlc densitometric determination of germacrone in the essential oils from curcuma wenyujin and c. kwangsinensis]. | | 1985 | 2938786 |
| the absolute stereostructure of curcumol isolated from curcuma wenyujin. | | 1984 | 6525666 |
| [isolation and identification of elemene from the essential oil of curcuma wenyujin]. | | 1983 | 6224579 |
| qualitative and quantitative analysis of four species of curcuma rhizomes using twice development thin layer chromatography. | the rhizomes of curcuma phaeocaulis, curcuma kwangsiensis, curcuma wenyujin and curcuma longa are used as ezhu or jianghuang in traditional chinese medicine for a long time. due to their similar morphological characters, it is difficult to distinguish their origins of raw materials used in clinic. in this study, a simple, rapid and reliable twice development tlc method was developed for qualitative and quantitative analysis of the four species of curcuma rhizomes. the chromatography was performe ... | 2008 | 18722068 |
| interplay of dna methyltransferase 1 and ezh2 through inactivation of stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells. | β-elemene, a compound extracted from curcuma wenyujin plant, exhibits anticancer activity in many cancer types. however, the detailed mechanism by which β-elemene inhibits growth of nasopharyngeal carcinoma (npc) cells remains unknown. we showed that β-elemene reduced phosphorylation of signal transducer and activator of transcription 3 (stat3), and protein expressions of dna methyltransferase 1 (dnmt1) and enhancer of zeste homolog 2 (ezh2). exogenously expressed stat3 antagonized the effect of ... | 2017 | 28360411 |
| curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38mapk/nf-κ b signaling. | retinal inflammation in a hyperglycemic condition is believed to play a crucial role in the development of diabetic retinopathy, and targeting inflammatory mediators is a promising strategy for the control of diabetic retinopathy. curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from curcuma wenyujin. in this study, we demonstrate that treatment with curcumolide alleviated retinal inflammatory activities both in vitro and in vivo in a stz-induced diabetic ... | 2017 | 28274631 |
| quantitative analysis and discrimination of steamed and non-steamed rhizomes of curcuma wenyujin by gc-ms and hplc. | simple gas chromatography-mass spectrometry (gc-ms) and high-performance liquid chromatography (hplc) methods were developed for quantifying eight volatile compounds and 10 sesquiterpenoids, respectively. gc-ms analysis was performed on an hp-5ms capillary column (30 m×0.25 mm i.d.) coated with 0.25 μm film 5% phenyl-95% methylpolysiloxane and selected ion monitoring was used for quantification. four volatile and previously unquantified monoterpenoids were determined. hplc analysis was performed ... | 2014 | 24105919 |
| two new sesquiterpenoids including a sesquiterpenoid lactam from curcuma wenyujin. | two new sesquiterpenoids, namely elema-1,3,7(11),8-tetraen-8,12-lactam (1) and 7β,8α-dihydroxy-1α,4αh-guai-9,11-dien-5β,8β-endoxide (2), together with five known analogs were isolated from the etoac extract of the rhizomes of curcuma wenyujin. their structures and relative configurations were determined on the basis of spectroscopic methods including 2d-nmr techniques. all compounds were tested for the inhibition of lipopolysaccharide (lps)-induced nitric oxide (no) production. compound 1 showed ... | 2013 | 23995362 |
| chemical composition and antimicrobial activity of three essential oils from curcuma wenyujin. | curcuma wenyujin is a traditional medicinal plant in china. the non-steamed rhizomes, steamed rhizomes and steamed roots of this plant are used as herbal medicines in three clinics, namely pian-jiang-huang (pjh), wen-e-zhu (wez), and wen-yu-jin (wyj), and are officially listed in the chinese pharmacopoeia. the purpose of this study was to conduct a comparative analysis of the three essential oils extracted from the c. wenyujin rhizomes and roots using gc-ms, and in doing so thirty compounds were ... | 2013 | 23738470 |
| three new guaiane sesquiterpene lactones from rhizomes of curcuma wenyujin. | three new guaiane sesquiterpene lactones (4s)-4-hydroxy-gweicurculactone (1), zedoalactone g (2), and (1r, 4r, 5s, 10s)-zedoalactone b (3), and three known guaiane sesquiterpene lactones, including zedoarolide b (4), zedoalactone b (5), and a new natural product (+)-zedoalactone a (6), were isolated from the rhizomes of curcuma wenyujin y.h. chen et c. ling. the structures were elucidated by spectroscopic methods including 1d and 2d nmr and hr-esi-ms. the absolute configuration of 2 was determin ... | 2013 | 23679107 |
| the role of e3 ubiquitin ligase cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells. | recent studies indicate that β-elemene, a compound isolated from the chinese herbal medicine curcuma wenyujin, is capable of reversing tumor mdr, although the mechanism remains elusive. in this study, β-elemene treatment markedly increased the intracellular accumulation of doxorubicin (dox) and rhodamine 123 in both k562/dnr and sgc7901/adr cells and significantly inhibited the expression of p-gp. treatment of sgc7901/adr cells with β-elemene led to downregulation of akt phosphorylation and sign ... | 2013 | 23665906 |
| simultaneous determination of three curcuminoids in curcuma wenyujin y.h.chen et c.ling. by liquid chromatography-tandem mass spectrometry combined with pressurized liquid extraction. | a sensitive and efficient method based on pressurized liquid extraction (ple) followed by liquid chromatography-tandem mass spectrometry (lc-ms/ms) was developed for simultaneous identification and quantification of three curcuminoids in curcuma wenyujin y.h.chen et c.ling., a well known traditional chinese medicinal herb. ple was performed using methanol as the extractant, and with the temperature set at 100 °c and the pressure at 1500 psi. shorter extraction time and less solvent consumption w ... | 2016 | 23648558 |
| simultaneous determination of multiple sesquiterpenes in curcuma wenyujin herbal medicines and related products with one single reference standard. | some curcuma species are widely used as herbal medicines. sesquiterpenes are their important bioactive compounds and their quantitative analysis is generally accomplished by gas chromatography (gc) or high performance liquid chromatography (hplc), but the instability and high cost of some sesquiterpene reference standards have limited their application. it is necessary to find a practicable means to control the quality of herbal medicines. using one stable component contained in curcuma species ... | 2013 | 23389255 |
| [advance in chemical constituents and pharmacological activity of curcuma wenyujin]. | on the basis of a sysmatic survey on literatures, this essay summarized the studies on chemical constituents and pharmacological activity of curcuma wenyujin. according to statistics, the reports for chemical constituents of the plant were mainly concentrated between 2007 and 2010. so far, totally 82 compounds were reported, including 57 sesquiterpenoids, 6 diterpenoids, 6 monoterpenes and 10 other components. particularly, 23 compounds were new. studies on its pharmacological activity covered a ... | 2012 | 23373201 |
| identification of insecticidal constituents of the essential oil of curcuma wenyujin rhizomes active against liposcelis bostrychophila badonnel. | the aim of this research was to determine the chemical composition and insecticidal activity of the essential oil of curcuma wenyujin y.h. chen et c. ling rhizomes against the booklouse liposcelis bostrychophila badonnel and to isolate any insecticidal constituents from the essential oil. the essential oil of c. wenyujin rhizomes was obtained by hydrodistillation and analyzed by gc-ms. a total of 43 components of the essential oil were identified and the principal compounds in the essential oil ... | 2012 | 23085655 |
| furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. | previous studies have reported that the curcuma wenyujin y.h. chen et c. ling extract, which has a high furanodiene content, showed anti-cancer effects in breast cancer cells in vitro. the present study was designed to evaluate the in vitro and in vivo anti-cancer activity of furanodiene. | 2012 | 22854281 |
| potential role of β-elemene on histone h1 in the h22 ascites hepatoma cell line. | β-elemene is extracted from the chinese medicinal herb curcuma wenyujin. it has a broad-spectrum antitumor effect on many types of cancer. however, the exact mechanism of action of β-elemene in hepatocellular carcinoma (hcc) remains unknown. histone h1 is thought to act as a repressor of transcription by promoting the compaction of chromatin into higher order structures. we found that histone h1 plays an important role in the antitumor function of β-elemene. in this study, histone h1 expression ... | 2012 | 22552783 |
| β-elemene inhibits hsp90/raf-1 molecular complex inducing apoptosis of glioblastoma cells. | β-elemene, an active component of herb medicine curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. however, how β-elemene induces apoptosis of these cells remains unclear. in this study, we report that β-elemene disrupted the formation of the hsp90/raf-1 complex, a key step in maintaining the conformation stability of raf-1, and caused deactivation of raf-1 and inhibition of the erk pathway, thereby leading to apoptosis of glioblastoma cells. specifically, t ... | 2012 | 22160627 |
| [studies on identification and secondary metabolites of endophytic fungi strain e8 from curcuma wenyujin]. | to identify the endophyte strain e8 with high activity from curcuma wenyujin and study its secondary metabolites. | 2011 | 21710748 |
| [mechanism study of beta-elemene derivative (et) in nb4 cell on apoptosis induction]. | beta-elemene is an active component of herb medicine curcuma wenyujin, n-(beta-elemene-13-yl)tryptophan (et) was synthesized to increase the activity. the antiproliferative and apoptotic effects of et were investigated with nb4 cell. | 2010 | 20707207 |
| inos inhibitory activity of sesquiterpenoids and a monoterpenoid from the rhizomes of curcuma wenyujin. | eleven new sesquiterpenoids, wenyujinins a-k (1-11), and a new monoterpenoid, wenyujinin l (12), were isolated from the rhizomes of curcuma wenyujin. their structures and relative configurations were elucidated using 1d and 2d nmr, x-ray crystallographic analysis, and hresims data. the absolute configurations of 1, 2, 3, 4, 6, 8, 9, and 10 were determined by comparison of the experimental and calculated ecd spectra. the absolute configuration of 5 was determined from the ecd data of the [rh2(oco ... | 2014 | 25275213 |