| nocardia cyriacigeorgici sp. nov.. | chemotaxonomic and 16s rrna gene sequence analyses of an isolate from the bronchial secretions of a patient with chronic bronchitis demonstrated clearly that it belongs to the genus nocardia. the 16s rrna gene sequence data, as well as the biochemical characteristics of the isolate, indicated that it belongs to a new species that differs from previously described members of the genus nocardia. the name nocardia cyriacigeorgici sp. nov. is proposed for this isolate, and is represented by strain i ... | 2001 | 11491341 |
| [nocardia cyriacigeorgici: first report of invasive human infection]. | diagnostic laboratories increasingly offer bacterial identification to the species level. the 17 nocardia species known to date differ in their clinical presentation, antibiotic resistance patterns and geographic distribution. the discovery of a new species with pathogenicity for humans calls for the characterization of its clinical and epidemiological properties. | 2003 | 12736853 |
| nocardia puris sp. nov. | a bacterial isolate (immib r-145(t)) from a human abscess was subjected to a polyphasic taxonomic study. chemotaxonomic investigations revealed the isolate to have cell wall chemotype iv and mycolic acids consistent with characteristics of the genus nocardia: comparative 16s rrna gene sequencing showed that the isolate constituted a distinct subline within the genus nocardia, displaying greater than 1.7 % sequence divergence with established species. however, a dna-dna hybridization study demons ... | 2003 | 13130054 |
| pneumonia involving aspergillus and rhizopus spp. after a near-drowning incident with subsequent nocardia cyriacigeorgici and n. farcinica coinfection as a late complication. | reported here is the case of a 22-year-old man who developed pneumonia with unusual pathogens after a near-drowning incident. on day 7 following admission, rhizopus spp. and aspergillus fumigatus were cultured from the patient's bronchoalveolar lavage fluid. one week later, sputum cultures revealed n. cyriacigeorgici as well as n. farcinica. the patient recovered fully after prolonged therapy with liposomal amphotericin b, amikacin, meropenem and cotrimoxazole. | 2005 | 15599783 |
| brain abscess caused by nocardia cyriacigeorgica in a patient with human immunodeficiency virus infection. | nocardia cyriacigeorgica is a recently characterized species within the genus of nocardia. we report a brain abscess, following a primary pulmonary colonization, due to this species in a human immunodeficiency virus-infected patient. this case confirms that isolation of nocardia in sputum is associated with a high risk of disseminated infection in immunocompromised patients. | 2005 | 16145170 |
| nocardia cyriacigeorgica is a significant pathogen responsible for nocardiosis in japan and thailand. | nocardia cyriacigeorgica is a recently described species. during routine diagnostic testing of 121 clinical isolates, we found that about one fourth of the strains from japan (19 isolates) and thailand (8 isolates), which were identified in our laboratories as n. asteroides, in fact belong to n. cyriacigeorgica. to our knowledge, this is the first report of infection due to n. cyriacigeorgica in japan and thailand, and the third report of infection anywhere in the world. although n. cyriacigeorg ... | 2005 | 16160763 |
| nocardia cyriacigeorgica septicemia. | we report two cases of nocardia cyriacigeorgica septicemia and disseminated infection in the setting of profound immunodeficiency. in both instances, diagnosis was rapidly facilitated by 16s rrna gene sequencing of blood culture isolates. these constitute the first confirmed reports of nocardia cyriacigeorgica bloodstream infection in humans. | 2006 | 16390991 |
| disseminated nocardiosis due to unusual species: two case reports. | pulmonary nocardiosis is the major clinical manifestation of human nocardiosis and disseminated infection can be seen in immunocompromised patients. n. asteroides is the predominant pathogen associated with disseminated diseases. we report 2 cases of pulmonary nocardiosis admitted with disseminated infection, caused by rare species of nocardia: nocardia transvalensis and nocardia cyriacigeorgica. | 2006 | 16798710 |
| nocardia cyriacigeorgica pleural empyema in an immunocompromised patient. | a case of fatal nocardia cyriacigeorgica pleural empyema in a patient with chronic obstructive pulmonary disease and long-term corticosteroid therapy is described. the organism was isolated from the pleural fluid in pure culture and was identified by conventional and molecular methods. despite the early administration of the appropriate antibiotic treatment, the patient died 4 days after hospital admission. | 2006 | 16854553 |
| clinical and microbiological features of nocardiosis 1997-2003. | nocardiosis has been believed to be caused by the members of the nocardia asteroides complex and the nocardia brasiliensis species. however, recent advances in genotypic identification have shown that the genus exhibits considerable taxonomic complexity and the phenotypic markers used in the past for its identification can be ambiguous. the aim of this study was to assess the species distribution of nocardia isolates and to determine whether there are differences in pathogenicity or antimicrobia ... | 2007 | 17374898 |
| organisms designated as nocardia asteroides drug pattern type vi are members of the species nocardia cyriacigeorgica. | nocardia cyriacigeorgica has recently been described as an "emerging" pathogen. however, dna-dna hybridization results confirm that nocardia asteroides drug pattern type vi, which has long been recognized as a common and significant pathogen in the united states, belongs to the species n. cyriacigeorgica. | 2007 | 17475753 |
| pleuropulmonary and soft tissue nocardia cyriacigeorgici infection in a patient with behcet's disease. | infections with nocardia species are generally seen in immunocompromised subjects. in this report, we present a case of pleuropulmonary and skin nocardia cyriacigeorgici infection in a male patient with behcet's disease who used corticosteroids and immunosupressives for a long period of time. he died before the diagnosis of nocardia infection was made. | 2007 | 17768476 |
| in vitro activity of fluoroquinolones against clinical isolates of nocardia identified by partial 16s rrna sequencing. | fluoroquinolones have several properties that make them potentially attractive candidates for the treatment of nocardia infections, but information regarding their in vitro activity is limited. minimum inhibitory concentrations (mic) of five fluoroquinolones and other antimicrobials were determined by the reference broth dilution and e-test methods for 33 consecutive clinical isolates of nocardia speciated by 16s rrna gene sequences. the isolates included: nocardia cyriacigeorgica (n = 6), n. no ... | 2008 | 17992548 |
| nocardia cyriacigeorgica, an emerging pathogen in the united states. | nocardia cyriacigeorgica is recognized as an emerging pathogen in many parts of the world. we present the first case description of invasive n. cyriacigeorgica pulmonary infection in the united states identified to the species level by 16s rrna and hsp65 sequence analysis. a subsequent retrospective molecular screening of recent nocardia clinical isolates at our new york city medical center yielded an additional six n. cyriacigeorgica isolates. because routine laboratory algorithms for the pheno ... | 2008 | 18003809 |
| nocardia cyriacigeorgica: pulmonary infection in a patient with basedow-graves disease and a short review of reported cases. | | 2008 | 18023385 |
| an unusual murine behavior following infection with log-phase nocardia asteroides type 6 strain guh-2 (nocardia cyriacigeorgica guh-2). | nocardia asteroides (nocardia cyriacigeorgica) strain guh-2 infects the brains of mice following intravenous injection. non-lethal infections resulted in a transitory increase of bacterial numbers in the brain followed by the development of permanent impaired movements at a time when bacteria appeared to be eliminated from the brain. these signs included headshake, rigidity, stooped posture, dyskinesia, retropulsion, and abnormal tail positioning in approximately 20% of infected animals. the att ... | 2008 | 18538618 |
| nocardia cyriacigeorgica--an established rather than an emerging pathogen. | | 2008 | 18614666 |
| [pulmonary nocardiosis with a large solitary cavitary nodule caused by nocardia cyriacigeorgica in a patient receiving corticosteroid therapy]. | nocardiosis is a rare disease generally caused by members of nocardia asteroides complex, particularly in immunosupressed patients. nocardia cyriacigeorgica is a newly described member of this complex. in this article, a case of pulmonary nocardiosis with a large solitary cavitary nodule caused by n. cyriacigeorgica, in a patient receiving corticosteroid therapy was presented. a 29 years old male patient receiving prednisolone for 5 months was admitted to our hospital with fever, cough, right th ... | 2008 | 18822894 |
| [epidemiology and clinical manifestations of infection due to nocardia species in tarragona, 1997-2008: nocardia cyriacigeorgica is an emerging pathogen]. | nocardia infections are uncommon, and the clinical experience with this pathogen is limited. | 2009 | 19477044 |
| assignment of reference 5'-end 16s rdna sequences and species-specific sequence polymorphisms improves species identification of nocardia. | 16s rdna sequence analysis is the most accurate method for definitive species identification of nocardiae. however, conflicting results can be found due to sequence errors in gene databases. this study tested the feasibility of species identification of nocardia by partial (5'-end 606-bp) 16s rdna sequencing, based on sequence comparison with "reference" sequences of well-annotated strains. this new approach was evaluated using 96 american type culture collection (n=6), and clinical (n=90) nocar ... | 2009 | 19639036 |
| nocardia cyriacigeorgica: a case of endocarditis with disseminated soft-tissue infection. | nocardia cyriacigeorgica is a common environmental organism. it has been isolated from clinical samples in europe, asia and north america, predominantly from respiratory samples but also from samples from several other sites. we present a case report of an 85-year-old female patient in the uk who was found to have a multi-focal soft-tissue infection from which n. cyriacigeorgica was isolated. she had a background history of chronic obstructive pulmonary disease and corticosteroid use for polymya ... | 2010 | 19797466 |
| identification of pathogenic nocardia species by reverse line blot hybridization targeting the 16s rrna and 16s-23s rrna gene spacer regions. | although 16s rrna gene sequence analysis is employed most often for the definitive identification of nocardia species, alternate molecular methods and polymorphisms in other gene targets have also enabled species determinations. we evaluated a combined nocardia pcr-based reverse line blot (rlb) hybridization assay based on 16s and 16s-23s rrna gene spacer region polymorphisms to identify 12 american type culture collection and 123 clinical nocardia isolates representing 14 species; results were ... | 2010 | 19955277 |
| oxidation of aliphatic, branched chain, and aromatic hydrocarbons by nocardia cyriacigeorgica isolated from oil-polluted sand samples collected in the saudi arabian desert. | a soil bacterium isolated from oil-polluted sand samples collected in the saudi arabian desert has been determined as nocardia cyriacigeorgica, which has a high capacity of degrading and utilizing a broad range of hydrocarbons. the metabolic pathways of three classes of hydrocarbons were elucidated by identifying metabolites in cell-free extracts analyzed by gc/ms and hplc/uv-vis in comparison with standard compounds. during tetradecane oxidation, tetradecanol; tetradecanoic acid; dodecanoic aci ... | 2010 | 20143352 |
| acute spinal cord compression caused by disseminated nocardia infection involving the conus medullaris. | distinguishing between an infective and malignant process provides a diagnostic challenge for clinicians. this case highlights an example of an acute spinal cord compression that could fall into either of these two categories. the diagnosis in this case of disseminated nocardiosis is an extremely rare cause of acute spinal cord compression and to our knowledge intrinsic conus medullaris infection from nocardia has not previously been reported in the literature. nocardia cyriacigeorgica is an eme ... | 2010 | 20646828 |
| nocardia cyriacigeorgica abscess of the conus medullaris in an immunocompetent host. | conus medullaris abscesses are a distinct and rare subset of spinal intramedullary infections. we report a patient with a pyogenic abscess of the conus from which we cultured nocardia cyriacigeorgica following operative evacuation. this is the first report identifying this species as a pathogen in conus abscess formation. | 2010 | 20700949 |
| seca1 gene sequence polymorphisms for species identification of nocardia species and recognition of intraspecies genetic diversity. | sequence analysis of the nocardia essential secretory protein seca1 gene (seca1) for species identification of 120 american type culture collection (atcc) and clinical isolates of nocardia (16 species) was studied in comparison with 5'-end 606-bp 16s rrna gene sequencing. species determination by both methods was concordant for all 10 atcc strains. seca1 gene sequencing provided the same species identification as 16s rrna gene analysis for 94/110 (85.5%) clinical isolates. however, 40 (42.6%) is ... | 2010 | 20810768 |
| phylogeny and identification of nocardia species on the basis of multilocus sequence analysis. | nocardia species identification is difficult due to a complex and rapidly changing taxonomy, the failure of 16s rrna and cellular fatty acid analysis to discriminate many species, and the unreliability of biochemical testing. here, nocardia species identification was achieved through multilocus sequence analysis (mlsa) of gyrase b of the β subunit of dna topoisomerase (gyrb), 16s rrna (16s), subunit a of seca preprotein translocase (seca1), the 65-kda heat shock protein (hsp65), and rna polymera ... | 2010 | 20844218 |
| nocardia cyriacigeorgica abscess of the conus medullaris in an immunocompetent host. | conus medullaris abscesses are a distinct and rare subset of spinal intramedullary infections. we report a patient with a pyogenic abscess of the conus from which we cultured nocardia cyriacigeorgica following operative evacuation. this is the first report identifying this species as a pathogen in conus abscess formation. | 2010 | 20965127 |
| antimicrobial susceptibility testing and profiling of nocardia species and other aerobic actinomycetes from south africa: comparative evaluation of broth microdilution versus the etest. | nocardiosis is an underrecognized clinical entity in south africa, for which interspecies epidemiological and clinical differences are poorly understood. the taxonomical state of flux and the lack of a simple antimicrobial susceptibility testing method are partly responsible. definitive identification is molecularly based, which further complicates the study of this ubiquitous organism, as this methodology is beyond the scope of most routine diagnostic laboratories. the etest methodology has bee ... | 2010 | 20980572 |
| pneumonia due to nocardia cyriacigeorgica in a patient with crohn's disease treated with infliximab. | infliximab, an anti-tumor necrosis factor α (tnf-α) antibody, is useful in the treatment of rheumatoid arthritis, crohn's disease etc. it has been related to increases in the rate of several infections. we present the case of a 53-year-old woman diagnosed with community-acquired pneumonia due to nocardia cyriacigeorgica who was taking infliximab, azathioprine and prednisone for crohn's disease. | 2008 | 21172233 |
| imipenem-resistant nocardia cyriacigeorgica infection in a child with chronic granulomatous disease. | nocardia spp. can lead to local or disseminated infections, especially in immunocompromised patients. combination therapy of amikacin and imipenem is commonly used to treat severe nocardial infections. we describe a patient with imipenem-resistant nocardia cyriacigeorgica, which, to our knowledge, has not been previously reported among isolates of this species. | 2010 | 21177900 |
| clinical isolation of nocardia cyriacigeorgica from patients with various clinical manifestations, the first report from iran. | we herein describe five various cases of human infections by nocardia cyriacigeorgica. the identification included conventional and molecular sequencing tests. the current study provides further evidences that n. cyriacigeorgica species is a ubiquitous organism capable of establishing long-term infection in healthy and immunocompromised patients. | 2011 | 21441712 |
| [microbiological and clinical features of nine cases with nocardial infections]. | following recent advance in medical technology, the increase of immunocompromised patients results in an increase of opportunistic infections such as nocardiosis. however, little is known about relationships between clinical features of nocardial infections and each nocardia species, especially newly identified ones. therefore, we identified clinical isolates of nocardia species by genetic methods and analyzed clinical features of nocardiosis. nine clinical isolates were obtained in kyushu unive ... | 2011 | 21560401 |
| persistent neutrophilic meningitis in an immunocompetent patient after basilar skull fracture: case report. | abstract: background: persistent neutrophilic meningitis is an unusual form of chronic meningitis that is defined as clinical meningitis with a neutrophilic pleocytosis that persists for greater than 7 days despite empiric antimicrobial therapy. although numerous disease processes can cause this syndrome, the majority of cases are due to opportunistic pathogens infecting immunocompromised hosts. case presentation: a 47 year-old female presented after basilar skull fracture with persistent neutro ... | 2011 | 21595944 |
| disseminated nocardia cyriacigeorgica presenting as right lung abscess and skin nodule. | nocardia species are ubiquitous in the environment and can be found worldwide. direct inhalation remains the most commonly attributed route of infection with nocardia asteroides complex, causing 50% of invasive infections. improved molecular methods have identified a significant proportion of n. asteroides complex isolates to be nocardia cyriacigeorgica. we report a case of a 58-year-old male working as a contractor in bagram air force base, afghanistan, with disseminated n. cyriacigeorgica invo ... | 2011 | 21634308 |
| nocardia cyriacigeorgica bacteraemia presenting with cytomegalovirus disease and rapidly fatal pneumonia in a renal transplant patient: a case report. | abstract: | 2011 | 21699674 |
| susceptibility of rapidly growing mycobacteria and nocardia isolates from cats and dogs to pradofloxacin. | rapidly growing mycobacteria (rgm) and nocardiae can cause severe or refractory infections in cats and dogs. prolonged antibacterial therapy is required to cure these infections. as fluoroquinolones have been used in combination therapy for treating rgm infections, isolates from the mycobacterium smegmatis cluster (n=64), mycobacterium fortuitum cluster (n=17), and m. mageritense cluster (n=2), collected from feline and canine patients, underwent susceptibility testing to pradofloxacin. the mic( ... | 2011 | 21726965 |
| [a case of pulmonary nocardiosis due to nocardia cyriacigeorgica with prompt diagnosis by gram stain]. | an 82-year-old woman with a past history of a colectomy for colon cancer was admitted to our hospital because of fever and cough. her chest radiologic images on admission showed bilateral pulmonary infiltration, which suggested community-acquired pneumonia. however, the results of gram and acid-fast staining demonstrated branching acid-bacilli, which suggested pulmonary nocardiosis. we administered sulfamethoxazole-trimethoprim, and her condition and radiology findings promptly improved. nocardi ... | 2011 | 21894775 |
| successful use of extracorporeal membrane oxygenation for acute respiratory failure in a patient with chronic granulomatous disease. | a 9-year-old boy presented with pneumonia, bilateral pulmonary lesions, and fulminant respiratory failure requiring support with extracorporeal membrane oxygenation (ecmo). open lung biopsy and subsequent bronchoscopy identified nocardia cyriacigeorgica and burkholderia cepacia pneumonia. chronic granulomatous disease (cgd) was diagnosed by an abnormal neutrophil oxidative burst assay. an aggressive diagnostic and therapeutic strategy, which included ecmo, allowed for patient survival and return ... | 2012 | 22595605 |
| necrotizing pneumonia and empyema in an immunocompetent patient caused by nocardia cyriacigeorgica and identified by 16s rrna and seca1 sequencing. | | 2013 | 24422202 |
| [pulmonary co-infection due to nocardia cyriacigeorgica and aspergillus fumigatus]. | pulmonary nocardiosis is an uncommon pulmonary infection caused by aerobic gram-positive bacteria of the genus nocardia. nocardia sp. are environmental organisms spread worldwide. approximately 50 nocardia species have been described to date, about 30 of which are known to cause human disease. nocardia cyriacigeorgica was first reported in 2001. | 2017 | 28176520 |
| pulmonary nocardiosis in chronic obstructive pulmonary disease: a new clinical challenge. | pulmonary nocardiosis (pn) is a rare but severe disease caused by nocardia spp. despite the traditional description as opportunistic infection, case reports and case series of pulmonary nocardiosis have recently been reported in immunocompetent patients too, in particular among people with chronic pulmonary diseases such as advanced chronic obstructive pulmonary disease (copd). pn is characterized by non-specific symptoms and radiological findings; bacteriological culture can be difficult. for t ... | 2016 | 27144111 |
| pulmonary nocardiosis caused by nocardia cyriacigeorgica in patients with mycobacterium avium complex lung disease: two case reports. | pulmonary nocardiosis frequently occurs in immunocompromised hosts and in some immunocompetent hosts with chronic lung disease; however, few reports have described pulmonary nocardiosis with nontuberculous mycobacterial lung infection. here we report for the first time two cases of pulmonary nocardiosis caused by nocardia cyriacigeorgica associated with mycobacterium avium complex (mac) lung disease caused by m. avium. | 2014 | 25491030 |
| biotransformation of 4-sec-butylphenol by gram-positive bacteria of the genera mycobacterium and nocardia including modifications on the alkyl chain and the hydroxyl group. | the environmental pollutant 4-sec-butylphenol (4-sec-bp) which possesses estrogenic properties was transformed by the aerobic gram-positive bacteria mycobacterium neoaurum and nocardia cyriacigeorgica into three main products (p1-p3) which were isolated and structurally characterized in detail. two of them were products of a process resembling anaerobic metabolism of alkylphenols based on modifications of the alkyl side chain of 4-sec-bp. the first product (p1) was identified as 4-(2-hydroxy-1-m ... | 2013 | 23912120 |
| two different primary oxidation mechanisms during biotransformation of thymol by gram-positive bacteria of the genera nocardia and mycobacterium. | thymol has antibacterial, antifungal, insecticidal, and antioxidative properties which are the basis for the wide use of this compound in the cosmetic, food, and pharmaceutical industries. although thymol is a ubiquitously occurring substance in the environment, data about its degradation and detoxification by bacteria are sparse. here, we show the existence of two different pathways for the biotransformation of thymol by nocardia cyriacigeorgica and mycobacterium neoaurum which were described f ... | 2013 | 22828982 |
| epidemiology and susceptibility to antimicrobial agents of the main nocardia species in spain. | the aims of this study were to explore the clinical distribution, by species, of the genus nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in spain. | 2017 | 27999029 |
| nocardiosis in 132 patients with cancer: microbiological and clinical analyses. | to correlate the microbiological and clinical features of infections caused by nocardia species. | 2014 | 25239419 |
| nocardiosis in the tropical northern territory of australia, 1997-2014. | nocardia is an opportunistic pathogen that can cause life-threatening disease. we aimed to characterize the epidemiological, microbiological, and clinical features of nocardiosis in the tropical north of australia. | 2016 | 27942539 |
| comparison of restriction enzyme pattern analysis and full gene sequencing of 16s rrna gene for nocardia species identification, the first report of nocardia transvalensis isolated of sputum from iran, and review of the literature. | nocardial infections occur in different organs of the body and are common in immune disorder diseases of individuals. the aim of this study was to assess nocardia species identification by phenotypic tests and molecular techniques applied to nocardiosis in iranian patients. in the current study, various clinical samples were collected and cultured on conventional media and using the paraffin baiting method. various phenotypic tests were performed. for accurate identification at the species level ... | 2016 | 27613736 |
| genome based analysis of type-i polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative nocardia species. | actinobacteria of the genus nocardia usually live in soil or water and play saprophytic roles, but they also opportunistically infect the respiratory system, skin, and other organs of humans and animals. primarily because of the clinical importance of the strains, some nocardia genomes have been sequenced, and genome sequences have accumulated. genome sizes of nocardia strains are similar to those of streptomyces strains, the producers of most antibiotics. in the present work, we compared second ... | 2014 | 24884595 |
| uncommon mandibular osteomyelitis in a cat caused by nocardia africana. | nocardiosis is an unusual infection in companion animals characterized by suppurative to pyogranulomatous lesions, localized or disseminated. cutaneous-subcutaneous, pulmonary and systemic signs are observed in feline nocardiosis. however, osteomyelitis is a rare clinical manifestation in cats. nocardia cyriacigeorgica (formerly n. asteroides sensu stricto), nocardia brasiliensis, nocardia otitidiscaviarum, and nocardia nova are the most common pathogenic species identified in cats, based on rec ... | 2012 | 23216681 |
| multisite reproducibility of the broth microdilution method for susceptibility testing of nocardia species. | antimicrobial susceptibility testing (ast) of clinical isolates of nocardia is recommended to detect resistance to commonly used antimicrobial agents; such testing is complicated by difficulties in inoculum preparation and test interpretation. in this study, six laboratories performed repetitive broth microdilution testing on single strains of nocardia brasiliensis, nocardia cyriacigeorgica, nocardia farcinica, nocardia nova, and nocardia wallacei. for each isolate, a total of 30 microdilution p ... | 2012 | 22219309 |
| molecular identification and susceptibility pattern of clinical nocardia species: emergence of nocardia crassostreae as an agent of invasive nocardiosis. | nocardia species are rare, opportunistic organisms that cause disease in both immunocompetent and immunocompromised individuals. | 2013 | 24421815 |
| endogenous nocardia endophthalmitis presenting as a mass lesion in a patient with metatstatic nonsmall cell carcinoma of the lung. | to report a case of nocardia cyriacigeorgica endophthalmitis. | 2017 | 28129236 |
| systemic nocardiosis in a dog caused by nocardia cyriacigeorgica. | systemic nocardiosis due to nocardia cyriacigeorgica has not been reported in dogs. | 2017 | 28109291 |
| chronic granulomatous disease due to neutrophil cytosolic factor (ncf2) gene mutations in three unrelated families. | chronic granulomatous disease (cgd) is an inheritable and genetically heterogeneous disease resulting from mutations in different subcomponents of the nadph oxidase system. mutations in the ncf2 gene account for <5% of all cases of cgd. we analyzed the clinical and laboratory findings of cgd with mutations in the ncf2 gene from amongst our cohort of cgd patients. a homozygous mutation (c.835_836delac, p.t279fsx294), a deletion in ncf2 gene was found in two cases. in the third case, two heterozyg ... | 2017 | 28035544 |
| disseminated nocardiosis masquerading as metastatic malignancy. | nocardiosis is an uncommon gram-positive bacterial infection caused by aerobic actinomycetes of the genus nocardia. it can be localized or systemic and is regarded as an opportunistic infection that is commonly seen in immunocompromised hosts. we report a case of disseminated nocardiosis caused by nocardia cyriacigeorgica in a patient with underlying malignancy in whom the clinical presentation was highly suggestive of a metastatic disease. | 2017 | 27578940 |
| accurate identification of common pathogenic nocardia species: evaluation of a multilocus sequence analysis platform and matrix-assisted laser desorption ionization-time of flight mass spectrometry. | species identification of nocardia is not straightforward due to rapidly evolving taxonomy, insufficient discriminatory power of conventional phenotypic methods and also of single gene locus analysis including 16s rrna gene sequencing. here we evaluated the ability of a 5-locus (16s rrna, gyrb, seca1, hsp65 and rpob) multilocus sequence analysis (mlsa) approach as well as that of matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) in comparison with sequen ... | 2016 | 26808813 |
| a mimic's imitator: a cavitary pneumonia in a myasthenic patient with history of tuberculosis. | a 77-year-old man with myasthenia gravis receiving prednisone and plasmapheresis was found to have right upper lobe cavitary pneumonia on radiological imaging studies after thymectomy. he had a remote history of treated pulmonary tuberculosis (tb) at the age of 19. on the basis of history of tb and current prednisone therapy, reactivation of pulmonary tb was highly suspected. branching gram-positive bacilli were identified on bronchoalveolar lavage (bal). bal ziehl-neelsen acid-fast bacilli stai ... | 2015 | 26150643 |
| nocardia cyriacigeorgica in an immunocompetent patient. | | 2015 | 25583961 |
| fatal nocardia cyriacigeorgica spontaneous bacterial peritonitis. | we report the first case of fatal spontaneous bacterial peritonitis and fulminant hepatitis caused by nocardia cyriacigeorgica in a patient with hepatitis c-related liver cirrhosis. | 2013 | 25356325 |
| a french multicentric study and review of pulmonary nocardia spp. in cystic fibrosis patients. | some bacterial species recovered from the airways of cystic fibrosis (cf) patients are indisputably associated with lung infections, whereas the clinical relevance of others, such as nocardia spp., remains unclear. sixteen french cf cases of colonization/infection with nocardia spp. were reviewed in order to evaluate the epidemiology, the clinical impact and the potential treatment of these bacteria, and results were compared to those of the literature. five nocardia species were identified, noc ... | 2015 | 25344657 |
| [lung cavities caused by nocardia cyriacigeorgica in an immunosuppressed boy]. | the identification of nodules and/or cavitations in the chest x-ray of a chronically or acute ill patient will rise the suspicion of tuberculosis. however, it is important to be aware of pulmonary nocardiosis as a rare but important differential diagnosis, especially in case of no hilar adenitis. in this case report, we describe a six-year-old boy receiving prednisolone due to nephrotic syndrome, who developed pneumothorax because of pulmonal nocardiosis. the prognosis is good in case of early d ... | 2014 | 25294520 |
| long-term treatment of persistent disseminated nocardia cyriacigeorgica infection. | in this paper a disseminated persistent nocardia cyriacigeorgica infection in an immunocompetent patient is described. the patient's long-term treatment, as well as its implications for managing similar cases in the future, is emphasized. presenting with high fever, multiple nodules, and ulcerative cutaneous lesions of body sites, the patient was treated with various antimicrobials. under combined therapy, empyema and arthritis, leading to disseminated nocardiosis, were seen. the overall treatme ... | 2014 | 24833199 |
| nocardia cyriacigeorgica as the causative agent of mandibular osteomyelitis (lumpy jaw) in a cat. | an unusual case of osteomyelitis caused by nocardia cyriacigeorgica infection and resulting in mandibular osteomyelitis and cellulitis (lumpy jaw) is described in a young cat. a 1-cm hard nodular mass was an incidental finding in the right mandible of a 14-month-old cat during routine physical examination. the lesion was fast growing, reaching up to 6 cm in its largest dimension over a 5-week period. a core biopsy of the affected mandible revealed foci of osteolysis, woven bone formation, and a ... | 2014 | 24821693 |
| pulmonary nocardiosis associated with cerebral abscess successfully treated by co-trimoxazole: a case report. | nocardiosis is an acute or chronic infectious disease caused by the soil-borne filamentous bacteria belonging to the genus nocardia. the organisms opportunistically infect both immunocompromised and immunocompetent individuals. the lungs are the primary site of infection and brain abscess is, by far, the most common complication following nocardial metastasis from pulmonary lesions. although surgical intervention must always be considered in the treatment of nocardial brain abscess, it can obvio ... | 2014 | 24385294 |
| molecular identification of nocardia isolates from clinical samples and an overview of human nocardiosis in brazil. | nocardia sp. causes a variety of clinical presentations. the incidence of nocardiosis varies geographically according to several factors, such as the prevalence of hiv infections, transplants, neoplastic and rheumatic diseases, as well as climate, socio-economic conditions and laboratory procedures for nocardia detection and identification. in brazil the paucity of clinical reports of nocardia infections suggests that this genus may be underestimated as a cause of human diseases and/or either ne ... | 2013 | 24340116 |
| molecular identification and antimicrobial susceptibility of nocardia spp. isolated from bovine mastitis in brazil. | nocardia spp. infections can cause severe damage to the mammary gland due to suppurative pyogranulomatous lesions and lack of clinical cure in response to conventional antimicrobial therapy. although nocardia infections are considered relatively uncommon in cows, there has been an apparent worldwide increase in the incidence of bovine mastitis caused by nocardia spp, perhaps due to environmental transmission of this ubiquitous pathogen. the objectives of present study were to determine: (i) spec ... | 2013 | 24060098 |
| brain abscess caused by nocardia cyriacigeorgica in two patients with multiple myeloma: novel agents, new spectrum of infections. | introduction of high-dose chemotherapy and the novel agents including bortezomib, lenalidomide, and thalidomide has provided a significant progress in the treatment of multiple myeloma (mm) with an increase in median overall survival up to 6-8 years. however, the advances in myeloma treatment comes at a price with new spectrum of treatment-related infectious complications which should be taken into consideration while treating these patients. | 2014 | 23906027 |
| [brain abscess due to nocardia cyriacigeorgica simulating an ischemic stroke]. | nocardia spp. are bacteria often implicated in pulmonary diseases and central nervous system infections, especially in immunocompromised patients. we report here the case of an immunocompromised woman presenting an insidious brain abcess initially treated as a cerebral stroke. despite a cotrimoxazole and rifampicin treatment she did not improve. she died 3 month later after she stopped her treatment. | 2013 | 23747674 |
| nocardia cyriacigeorgica intracavitary lung colonization: first report of an actinomycetic rather than fungal ball in bronchiectasis. | we report the first case of an isolated endobronchial mass caused by nocardia cyriacigeorgica in an immunocompetent patient with a history of lung surgery; this is a rare presentation of an emerging opportunistic pathogen. the infection was successfully eradicated by surgery. microbiologists and clinicians should pay more attention to this group of filamentous bacteria, which in the past have often been neglected by medical personnel. | 2013 | 23661649 |
| the nocardia cyriacigeorgica guh-2 genome shows ongoing adaptation of an environmental actinobacteria to a pathogen's lifestyle. | nocardia cyriacigeorgica is recognized as one of the most prevalent etiological agents of human nocardiosis. human exposure to these actinobacteria stems from direct contact with contaminated environmental matrices. the full genome sequence of n. cyriacigeorgica strain guh-2 was studied to infer major trends in its evolution, including the acquisition of novel genetic elements that could explain its ability to thrive in multiple habitats. | 2013 | 23622346 |
| pulmonary nocardiosis in southern taiwan. | nocardiosis mainly affects immunocompromised patients. the objectives of this study were to better understand the epidemiologic, demographic, clinical, and laboratory information in patients with pulmonary nocardiosis in southern taiwan. | 2013 | 23017691 |
| a pcr-based intergenic spacer region-capillary gel electrophoresis typing method for identification and subtyping of nocardia species. | while 16s rrna sequence-based identification of nocardia species has become the gold standard, it is not without its limitations. we evaluated a novel approach encompassing the amplification of the nocardia 16s-23s rrna intergenic spacer (igs) region followed by fragment analysis by capillary gel electrophoresis (cge) of the amplified product for species identification of nocardia. one hundred forty-five nocardia isolates (19 species) and four non-nocardia aerobic actinomycetes were studied. rep ... | 2012 | 22875897 |
| molecular identification and thermoresistance to boiling of nocardia farcinica and nocardia cyriacigeorgica from bovine bulk tank milk. | two strains of nocardia spp. were isolated from bovine milk of two individual bulk tank. molecular identification classified the strains as nocardia farcinica and nocardia cyriacigeorgica. the thermorresistance to boiling of the isolates was carried out and was observed bacterial growth after boiling. our findings indicate the potential risk of pathogen transmission to humans through contaminated milk with nocardia spp. | 2012 | 24031926 |
| mixed nocardia cyriacigeorgica and staphylococcus aureus infection in the periocular skin and orbit in an immunocompetent adult. | a 32-year-old non-alcoholic, immunocompetent male with history of prior trauma presented with pain and protrusion of the left eye of 8 months' duration. a firm nontender mass could be palpated in the superomedial orbit and the periocular skin had multiple discharging nodules. computed tomography of the orbit showed an ill-defined lesion in the left orbit with preseptal soft tissue thickening, lacrimal gland infiltration and a moth eaten appearance of the left orbital roof. tissue sampling from d ... | 2012 | 22715939 |
| nocardia cyriacigeorgica infections attributable to unlicensed cosmetic procedures--an emerging public health problem? | we describe an outbreak of nocardia cyriacigeorgica soft-tissue infections attributable to unlicensed cosmetic injections and the first report using multilocus sequence typing sequence data for determining nocardia strain relatedness in an outbreak. all 8 cases identified had a common source exposure and required hospitalization, surgical debridement, and prolonged antimicrobial therapy. | 2012 | 22491504 |
| genome sequence of the human- and animal-pathogenic strain nocardia cyriacigeorgica guh-2. | the pathogenic strain nocardia cyriacigeorgica guh-2 was isolated from a fatal human nocardiosis case, and its genome was sequenced. the complete genomic sequence of this strain contains 6,194,645 bp, an average g+c content of 68.37%, and no plasmids. we also identified several protein-coding genes to which n. cyriacigeorgica's virulence can potentially be attributed. | 2012 | 22461543 |
| short communication: molecular characteristics, antimicrobial susceptibility, and pathogenicity of clinical nocardia cyriacigeorgica isolates from an outbreak of bovine mastitis. | the occurrence of nocardial mastitis, mostly in the context of outbreaks, has been reported in many countries. however, there is a paucity of reports regarding detailed characterization of nocardia cyriacigeorgica from bovine mastitis. thus, herein we report characteristics, antimicrobial susceptibility patterns, molecular identification, and pathogenicity of n. cyriacigeorgica isolated from an outbreak of clinical mastitis in a dairy herd in northern china. a total of 182 (80.2%) lactating cows ... | 2017 | 28803018 |
| nocardia cyriacigeogica from bovine mastitis induced in vitro apoptosis of bovine mammary epithelial cells via activation of mitochondrial-caspase pathway. | nocardia is one of the causing agents of bovine mastitis and increasing prevalence of nocardial mastitis in shape of serious outbreaks has been reported from many countries. however, the mechanisms by which this pathogen damages the bovine mammary epithelial cells (bmecs) is not yet studied. therefore, this study was designed with the aim to evaluate the apoptotic effects elicited by nocardia and to investigate the pathway by which the nocardia induce apoptosis in bmecs. clinical nocardia cyriac ... | 2017 | 28573110 |