| hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha. | blind subterranean mole rats (spalax, spalacidae) evolved adaptive strategies to cope with hypoxia that climaxes during winter floods in their burrows. by using real-time pcr, we compared gene expression of erythropoietin (epo), a key regulator of circulating erythrocytes, and hypoxia-inducible factor 1 alpha (hif-1 alpha), epo expression inducer, in the kidneys of spalax and white rats, rattus norvegicus. our results show significantly higher, quicker, and longer responses to different o(2) lev ... | 2004 | 15210955 |
| methionine sulfoxide reductases and methionine sulfoxide in the subterranean mole rat (spalax): characterization of expression under various oxygen conditions. | the blind subterranean mole rat (spalax ehrenbergi) exhibits a relatively long life span, which is attributed to an efficient antioxidant defense affording protection against accumulation of oxidative modifications of proteins. methionine residues can be oxidized to methionine sulfoxide (meto) and then enzymatically reduced by the methionine sulfoxide reductase (msr) system. in the current study we have isolated the cdna sequences of the spalax msr genes as well as 23 additional selenoproteins a ... | 2011 | 22230185 |
| cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. | blind mole rats spalax (bmr) are small subterranean rodents common in the middle east. bmr is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer. spontaneous tumors have never been observed in spalacids. to understand the mechanisms responsible for this resistance, we examined the growth of bmr fibroblasts in vitro of the species spalax judaei and spalax golani. bmr cells proliferated actively for 7-20 ... | 2012 | 23129611 |
| congruent mammalian trees from mitochondrial and nuclear genes using bayesian methods. | analyses of mitochondrial and nuclear gene sequences have often produced different mammalian tree topologies, undermining confidence in the merit of molecular approaches with respect to "traditional" morphological classification. the recent sequencing of the complete mitochondrial genomes of two additional rodents (spalax judaei and jaculus jaculus) and one lagomorph (ochotona princeps) has prompted us to reinvestigate the issue. using bayesian phylogenetics, we found phylogenetic relationships ... | 2004 | 14660685 |
| adaptation of pelage color and pigment variations in israeli subterranean blind mole rats, spalax ehrenbergi [corrected]. | concealing coloration in rodents is well established. however, only a few studies examined how soil color, pelage color, hair-melanin content, and genetics (i.e., the causal chain) synergize to configure it. this study investigates the causal chain of dorsal coloration in israeli subterranean blind mole rats, spalax ehrenbergi. | 2013 | 23935991 |
| cross talk between s-nitrosylation and s-glutathionylation in control of the na,k-atpase regulation in hypoxic heart. | oxygen-induced regulation of na,k-atpase was studied in rat myocardium. in rat heart, na,k-atpase responded to hypoxia with a dose-dependent inhibition in hydrolytic activity. inhibition of na,k-atpase in hypoxic rat heart was associated with decrease in nitric oxide (no) production and progressive oxidative stress. accumulation of oxidized glutathione (gssg) and decrease in no availability in hypoxic rat heart were followed by a decrease in s-nitrosylation and upregulation of s-glutathionylatio ... | 2012 | 22982781 |