| thrombin-like activity in snake venoms from peruvian bothrops and lachesis genera. | venoms from lachesis muta muta, bothrops pictus, b. barnetti, b. atrox and b. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. b. barnetti and l. muta muta venoms have greater activity on canine fibrinogen and b. atrox and b. hyoprorus venoms, a greater activity on bovine fibrinogen. gel filtration showed one peak of coagulant activity in all venoms except b. atrox venom which possessed two peaks. the apparent mol. wt of these enzymes ranged from 45,0 ... | 1991 | 1796478 |
| preliminary studies of the effects of a peruvian snake bothrops pictus (jergon of the coast) venom upon fibrinogen. | bothrops pictus (jergon of the coast) venom has a coagulant effect in vitro on both canine fibrinogen and on human and canine plasma, with a greater affinity for canine plasma. in vivo a single dose of venom produced partial defibrinogenation in conscious dogs, plasma fibrinogen being reduced to about 60% of control values after 6 hr. | 1988 | 3188056 |
| [toxicity and neutralization of venoms from peruvian snakes of the genera bothrops and lachesis (serpentes: viperidae)]. | the lethal potencies (median lethal dose) of the venoms of peruvian snakes (bothrops atrox, bothrops barnetti, bothrops pictus and lachesis muta muta) were determined in mice by using intravenous and intraperitoneal routes of injection. in addition, the neutralizing ability of three antivenoms (bothropic polyvalent, bothropic bivalent and lachetic) was studied by preincubation-type experiments. b. pictus venom had the highest lethality by the intraperitoneal route whereas b. atrox venom had the ... | 1993 | 7701074 |
| partial in vitro analysis of toxic and antigenic activities of eleven peruvian pitviper snake venoms. | this work used eleven peruvian snake venoms (bothrops andianus, bothrops atrox, bothrops barnetti, bothrops castelnaudi, bothriopsis chloromelas, bothrocophias microphthalmus, bothrops neuwiedi, bothriopsis oligolepis, bothriopsis peruviana, bothrops pictus and bothriopsis taeniata) to perform in vitro experimentation and determine its main characteristics. hyaluronidase (hyal), phospholipase a2 (pla2), snake venom metalloproteinase (svmp), snake venom serine protease (svsp) and l-amino acid oxi ... | 2015 | 26365916 |
| biochemical, biological and molecular characterization of an l-amino acid oxidase (laao) purified from bothrops pictus peruvian snake venom. | an l-amino acid oxidase from peruvian bothrops pictus (bpic-laao) snake venom was purified using a combination of size-exclusion and ion-exchange chromatography. bpic-laao is a homodimeric glycosylated flavoprotein with molecular mass of ∼65 kda under reducing conditions and ∼132 kda in its native form as analyzed by sds-page and gel filtration chromatography, respectively. n-terminal amino acid sequencing showed highly conserved residues in a glutamine-rich motif related to binding substrate. t ... | 2017 | 29024770 |
| fibrinogen-clotting enzyme, pictobin, from bothrops pictus snake venom. structural and functional characterization. | a thrombin-like enzyme, pictobin, was purified from bothrops pictus snake venom. it is a 41-kda monomeric glycoprotein as showed by mass spectrometry and contains approx. 45% carbohydrate by mass which could be removed with n-glycosidase. pictobin coagulates plasma and fibrinogen, releasing fibrinopeptide a and induces the formation of a friable/porous fibrin network as visualized by sem. the enzyme promoted platelet aggregation in human prp and defibrination in mouse model and showed catalytic ... | 2020 | 32169454 |
| [characterization of thrombin like enzyme from bothrops pictus venom]. | to perform a biochemical and molecular characterization of the coagulant principle from bothrops pictus venom. | 2015 | 26732911 |