| pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus pochonia suchlasporia var. suchlasporia tama 87 as a potent beta-n-acetylglucosaminidase inhibitor. | a new polyhydroxylated pyrrolizidine alkaloid designated as pochonicine (1) was isolated from a solid fermentation culture of the fungal strain pochonia suchlasporia var. suchlasporia tama 87. the structure of 1 was determined using nmr and ms techniques as (1r*, 3s*, 5s*, 6s*, 7r*, 7a s*)-5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine. pochonicine (1) showed potent inhibition against beta-n-acetylglucosaminidases (glcnacases) of various organisms including insects, fungi, mamma ... | 2009 | 19775896 |