| characterization and manipulation of the human adenovirus 4 genome. | human adenovirus 4 (hadv-4), the only serotype of the species hadv-e to be isolated from man, was first identified by its association with outbreaks of acute respiratory disease in military recruits. to combat such outbreaks, a live, oral hadv-4 vaccine that is delivered via an enteric-coated capsule was developed. this vaccine has been used for nearly 40 years and has been shown to be safe and efficacious. in this study, the complete dna sequence (35 994 bp) of the vaccine strain is described a ... | 2004 | 15483252 |
| generation of an adenoviral vaccine vector based on simian adenovirus 21. | adenoviral vectors can be used to generate potent humoral and cellular immune responses to transgene products. use of adenoviral vectors based on non-human isolates may allow for their utilization in populations harbouring neutralizing antibodies to common human serotypes. a vector chimera was constructed using simian adenovirus 22 (a serotype belonging to the species human adenovirus e) and simian adenovirus 21 (a serotype belonging to the species human adenovirus b) expressing the ebola (zaire ... | 2006 | 16894185 |
| in silico structure analysis and epitope prediction of e3 cr1-beta protein of human adenovirus e for vaccine design. | human adenoviruses are divided into 7 species of human adenovirus a to g based on dna genome homology. the human adenovirus e (hadvs-e) genome is a linear, double-stranded dna containing 38 protein-coding genes. wild-type adenoviruses type e, are linked to a number of slight illnesses. the most important part of hadvs-e is e3 cr1-beta protein which controls the host immune response and viral attachment. | 2016 | 28043417 |
| molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around moukalaba-doudou national park (gabon). | adenoviruses are widespread in human population as well as in great apes, although the data about the naturally occurring adenovirus infections remain rare. we conducted the surveillance of adenovirus infection in wild western lowland gorillas in moukalaba-doudou national park (gabon), in order to investigate naturally occurring adenovirus in target gorillas and tested specifically a possible zoonotic transmission with local people inhabiting the vicinity of the park. fecal samples were collecte ... | 2016 | 27290717 |
| differential immunogenicity between hadv-5 and chimpanzee adenovirus vector chadox1 is independent of fiber and penton rgd loop sequences in mice. | replication defective adenoviruses are promising vectors for the delivery of vaccine antigens. however, the potential of a vector to elicit transgene-specific adaptive immune responses is largely dependent on the viral serotype used. hadv-5 (human adenovirus c) vectors are more immunogenic than chimpanzee adenovirus vectors from species human adenovirus e (chadox1 and adc68) in mice, though the mechanisms responsible for these differences in immunogenicity remain poorly understood. in this study ... | 2015 | 26576856 |
| the relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species. | adenovirus vaccine vectors generated from new viral serotypes are routinely screened in pre-clinical laboratory animal models to identify the most immunogenic and efficacious candidates for further evaluation in clinical human and veterinary settings. here, we show that studies in a laboratory species do not necessarily predict the hierarchy of vector performance in other mammals. in mice, after intramuscular immunization, hadv-5 (human adenovirus c) based vectors elicited cellular and humoral a ... | 2015 | 25629523 |
| adenovirus infection in savanna chimpanzees (pan troglodytes schweinfurthii) in the issa valley, tanzania. | adenoviruses are a widespread cause of diverse human infections with recently confirmed zoonotic roots in african great apes. we focused on savanna-dwelling chimpanzees in the issa valley (tanzania), which differ from those from forested sites in many aspects of behavior and ecology. pcr targeting the dna polymerase gene detected adv in 36.7% (69/188) of fecal samples. we detected five groups of strains belonging to the species human mastadenovirus e and two distinct groups within the species hu ... | 2018 | 28980083 |
| adenovirus infections in african humans and wild non-human primates: great diversity and cross-species transmission. | non-human primates (nhps) are known hosts for adenoviruses (advs), so there is the possibility of the zoonotic or cross-species transmission of advs. as with humans, adv infections in animals can cause diseases that range from asymptomatic to fatal. the aim of this study was to investigate the occurrence and diversity of advs in: (i) fecal samples of apes and monkeys from different african countries (republic of congo, senegal, djibouti and algeria), (ii) stool of humans living near gorillas in ... | 2020 | 32570742 |