| micrurus surinamensis peruvian snake venom: cytotoxic activity and purification of a c-type lectin protein (ms-ctl) highly toxic to cardiomyoblast-derived h9c2 cells. | micrurus surinamensis (cuvier, 1817), popularly known as aquatic coral snake, has a broad geographic distribution in the rainforest of south america. the purpose of this study was to investigate the cytotoxic effect caused by m. surinamensis venom in h9c2 cardiomyoblast cells and to identify protein components involved in cardiotoxic processes. venom cardiotoxic potential is evidenced by cell viability reduction in a concentration-dependent manner. we have purified one of venom components respon ... | 2020 | 32781119 |
| comparative venomics of brazilian coral snakes: micrurus frontalis, micrurus spixii spixii, and micrurus surinamensis. | a comparative venom proteomic analysis of the brazilian southern coral snake, m. frontalis, the amazon coral snake m. spixii spixii, and the aquatic coral snake m. surinamensis is reported. venoms from m. frontalis and m. s. spixii were composed mainly (>90% of the total venom proteome) by 3ftxs and pla2s in different proportions, and minor proteins from 2 to 5 protein families. conversely, the aquatic coral snake expressed a streamlined (95%) 3ftx venom with low abundance (4.2%) of pla2 molecul ... | 2019 | 31091423 |
| a combined strategy to improve the development of a coral antivenom against micrurus spp. | accidents involving micrurus snakes are not the most common ones but are noteworthy due to their severity. victims envenomed by micrurus snakes are at high risk of death and therefore must be treated with coral antivenom. in brazil, the immunization mixture used to fabricate coral antivenom contains micrurus frontalis and micrurus corallinus venoms, which are difficult to be obtained in adequate amounts. different approaches to solve the venom limitation problem have been attempted, including th ... | 2019 | 31695693 |
| assessing the binding of venoms from aquatic elapids to the nicotinic acetylcholine receptor orthosteric site of different prey models. | the evolution of an aquatic lifestyle from land dwelling venomous elapids is a radical ecological modification, bringing about many evolutionary changes from morphology to diet. diet is an important ecological facet which can play a key role in regulating functional traits such as venom composition and prey-specific targeting of venom. in addition to predating upon novel prey (e.g., fish, fish eggs and invertebrates), the venoms of aquatic elapids also face the challenge of increased prey-escape ... | 2020 | 33036249 |
| proteomic analysis of the venom from the fish eating coral snake micrurus surinamensis: novel toxins, their function and phylogeny. | the protein composition of the soluble venom from the south american fish-eating coral snake micrurus surinamensis surinamensis, here abbreviated m. surinamensis, was separated by rp-hplc and 2-de, and their components were analyzed by automatic edman degradation, maldi-tof and esi-ms/ms. approximately 100 different molecules were identified. sixty-two components possess molecular masses between 6 and 8 kda, are basically charged molecules, among which are cytotoxins and neurotoxins lethal to fi ... | 2008 | 18384102 |
| envenomation by micrurus coral snakes in the brazilian amazon region: report of two cases. | two cases of proven coral snake bites were reported in belém, pará state, brazil. the first case was a severe one caused by micrurus surinamensis. the patient required mechanical ventilation due to acute respiratory failure. the second case showed just mild signs of envenomation caused by micrurus filiformis. both patients received specific micrurus antivenom and were discharged without further complications. coral snake bites are scarcely reported in the amazon region and there is a broad spect ... | 2012 | 21225218 |
| biological and molecular properties of yellow venom of the amazonian coral snake micrurus surinamensis. | the coral snake micrurus surinamensis, which is widely distributed throughout amazonia, has a neurotoxic venom. it is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. | 2017 | 28700055 |
| predation of sternopygus macrurus (bloch & schneider, 1801) by micrurus surinamensis (cuvier, 1817) in one fragment forest in amazon, brazil. | | 2018 | 29319756 |
| [note on micrurus surinamensis nattereri schmidt and micrurus pyrrhocryptus cope]. | | 1959 | 13715150 |
| myotoxicity and nephrotoxicity by micrurus venoms in experimental envenomation. | micrurus venoms are essentially neurotoxic but other activities, such as myotoxicity, may be apparent under experimental conditions. although this myotoxicity has been occasionally reported, there are no studies addressing it systematically across the genus, particularly in its relationship to other systemic manifestations such as renal impairment. the lethal potency of micrurus fulvius, micrurus nigrocinctus, micrurus surinamensis, micrurus altirostris, micrurus balyocoriphus and micrurus pyrrh ... | 2012 | 22133570 |
| endoparasites infecting the semiaquatic coral snake micrurus surinamensis (squamata: elapidae) in the southern amazonian region, mato grosso state, brazil. | a parasitological survey was conducted in specimens of the semiaquatic coral snake micrurus surinamensis, a poorly known south american elapid. four specimens collected at the southern amazon region in the brazilian state of mato grosso were analyzed for endoparasites. three parasite species were recovered from the snake hosts: the pentastomid sebekia oxycephala, the nematode physaloptera sp. and the trematode opisthogonimus lecithonotus. this represents new locality and host record for s. oxyce ... | 2013 | 24212707 |
| micrurus snake species: venom immunogenicity, antiserum cross-reactivity and neutralization potential. | micrurus snakebites can cause death by muscle paralysis and respiratory arrest a few hours after envenomation. the specific treatment for these snake envenomations is the intravenous application of heterologous antivenom. in brazil, this antivenom is produced from horses that are immunized with a mixture of micrurus corallinus and micrurus frontalis venoms, which are snakes that inhabit the south and southeastern regions of the country. previously, we demonstrated that the coral antivenom, which ... | 2016 | 27045363 |
| biological and enzymatic activities of micrurus sp. (coral) snake venoms. | the venoms of micrurus lemniscatus carvalhoi, micrurus frontalis frontalis, micrurus surinamensis surinamensis and micrurus nigrocinctus nigrocinctus were assayed for biological activities. although showing similar liposome disrupting and myotoxic activities, m. frontalis frontalis and m. nigrocinctus nigrocinctus displayed higher anticoagulant and phospholipase a2 (pla2) activities. the latter induced a higher edema response within 30 min. both venoms were the most toxic as well. in the isolate ... | 2005 | 15664321 |