Publications

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detection of antimicrobial compounds by bioautography of different extracts of leaves of selected south african tree species.the hexane, acetone, dichloromethane and methanol extracts of combretum vendae a.e. van wyk (combretaceae), commiphora harveyi (engl.) engl. (burseraceae), khaya anthotheca (welm.) c.dc (meliaceae), kirkia wilmsii engl. (kirkiaceae), loxostylis alata a. spreng. ex rchb. (anacardiaceae), ochna natalitia (meisn.) walp. (ochnaceae) and protorhus longifolia (bernh. ex c. krauss) engl. (anacardiaceae) were screened for their antimicrobial activity. the test organisms included bacteria (enterococcus f ...200921304615
chaenothecopsis khayensis, a new resinicolous calicioid fungus on african mahogany.the new species chaenothecopsis khayensis (ascomycota, mycocaliciaceae) is described from ghana, western africa, on the resin of khaya anthotheca and k. ivorensis. the species is distinctive in forming asci without crosiers and in possessing ascospores that are faintly longitudinally striate. analysis of large subunit rdna gene sequences positioned this species within a clade corresponding to the mycocaliciales and identified its closest relative as sphinctrina leucopoda. chaenothecopsis khayens ...201121471291
antimalarial activity of anthothecol derived from khaya anthotheca (meliaceae).antimalarial activity of anthothecol, a limonoid of khaya anthotheca (meliaceae) against plasmodium falciparum was tested using a [(3)h]-hypoxanthine and 48h culture assay in vitro. anthotechol showed potent antimalarial activity against malaria parasites with ic(50) values of 1.4 and 0.17microm using two different assays. also, gedunin had antimalarial activity with ic(50) values of 3.1 and 0.14microm. however, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. ...200817913482
acylperoxylated and seco-mexicanolides from stems of khaya anthotheca.the stems of khaya anthotheca yielded two new limonoids, which were identified on the basis of spectroscopic analysis as 1alpha,8alpha-oxido-3beta-acetoxy-2alpha-acylperoxy-1alpha,14alpha-dihydroxy-[3.3.1(10,2)]-bicyclomeliac-7,19-olide (3) and 3-acetoxy-8,14-dien-8,30-seco-khayalactone (4). methyl 1alpha,2beta,3alpha,6,8alpha,14beta-hexahydroxy-[4.2.1(10,30).1(1,4)]-tricyclomeliac-7-oate, scopoletin, and 3-o-beta-d-glucopyranosylsitosterol were also isolated. the limonoids were of little value ...200515787447
antiprotozoal activity of khaya anthotheca, (welv.) c.d.c. a plant used by chimpanzees for self-medication.khaya species, endemic to africa and madagascar, continues to be valuable in indigenous traditional medicine. their bitter tasting barks are decocted to treat fevers, several febrile conditions, microbial infections and worm infestations. in the budongo rain forest of western uganda, non-human primates, especially chimpanzees and baboons, have been observed to eat the bitter non-nutritious bark and occasionally the seed.201323501156
in vitro inhibition of plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used south african plant species.extracts of plant species, used traditionally to treat malaria, have been extensively investigated for their activity against plasmodium intraerythrocytic asexual parasites in search of new antimalarial drugs. however, less effort has been directed towards examining their efficacy in blocking transmission. here, we report the results of the in vitro screening of extracts from eight selected plant species used traditionally to treat malaria in south africa for activity against plasmodium falcipar ...201626994818
root-shoot allometry of tropical forest trees determined in a large-scale aeroponic system.this study is a first step in a multi-stage project aimed at determining allometric relationships among the tropical tree organs, and carbon fluxes between the various tree parts and their environment. information on canopy-root interrelationships is needed to improve understanding of above- and below-ground processes and for modelling of the regional and global carbon cycle. allometric relationships between the sizes of different plant parts will be determined.201323250916
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