| use of sera from humans and dolphins with lacaziosis and sera from experimentally infected mice for western blot analyses of lacazia loboi antigens. | antibodies in the sera of patients with lacaziosis recognized an approximately 193-kda antigen and other lacazia loboi antigens. paracoccidioides brasiliensis gp43 antigen was detected by all evaluated sera, but they failed to detect a protein with the same molecular mass in l. loboi extracts. this study is the first to examine the humoral response to l. loboi antigens by using multiple host sera. | 2008 | 17959822 |
| modeling lacaziosis lesion progression in common bottlenose dolphins tursiops truncatus using long-term photographic records. | lacaziosis (lobomycosis) is a skin disease caused by lacazia loboi, occurring naturally only in humans and dolphins. attempts to culture the pathogen in vitro have been unsuccessful, and inoculation studies of lacaziosis development in mice have provided only limited, short-term data on the progression and propagation of l. loboi. the present study used photographic data from long-term photo-identification and health assessment projects to model and quantify the progression of lacaziosis lesions ... | 2010 | 20662366 |
| molecular study of archival fungal strains isolated from cases of lacaziosis (jorge lobo's disease). | lacazia loboi, the aetiological agent of lacaziosis (jorge lobo's disease), is an uncultivated anomalous fungal microbe closely related to paracoccidioides brasiliensis, both restricted latin american pathogens. early reports suggesting that l. loboi had been isolated in pure culture from cases of lacaziosis, only added more confusion to the already confusing aetiology of this disease. these strains were later identified as unusual contaminants and some of them as p. brasiliensis. recent phyloge ... | 2007 | 17944708 |
| in vitro and in situ activation of the complement system by the fungus lacazia loboi. | since there are no studies evaluating the participation of the complement system (cs) in jorge lobo's disease and its activity on the fungus lacazia loboi, we carried out the present investigation. fungal cells with a viability index of 48% were obtained from the footpads of balb/c mice and incubated with a pool of inactivated serum from patients with the mycosis or with sterile saline for 30 min at 37 masculinec. next, the tubes were incubated for 2 h with a pool of noninactivated ab+ serum, in ... | 2007 | 17505668 |
| lacazia loboi and rhinosporidium seeberi: a genomic perspective. | in the past five years, with the use of molecular strategies the phylogenetic affinities of the two more resilient pathogens studied in medical mycology, lacazia loboi and rhinosporidium seeberi were finally deciphered. these studies found that l. loboi was the sister taxon to paraccidioides brasiliensis, and r. seeberi was closely related to protistan spherical aquatic fish pathogens, located at the point were animals diverged from the fungi, in the class mesomycetozoea. these initial studies i ... | 2005 | 16499413 |
| experimental reproduction of the jorge lobo's disease in balb/c mice inoculated with lacazia loboi obtained from a previously infected mouse. | long-term maintenance of lacazia loboi in the laboratory has not been reported. we report here the use balb/c mice to maintain the lacazia loboi for extended period of time. eight to ten week-old mice were inoculated intradermally in both hind footpads with a fungal suspension from a macerated footpad obtained from an original mouse previously infected with the fungi and sacrificed 8 months after inoculation. the inoculated animals were sacrificed at different time intervals, footpads were excis ... | 2002 | 12650594 |
| cutaneous granulomas in dolphins caused by novel uncultivated paracoccidioides brasiliensis. | cutaneous granulomas in dolphins were believed to be caused by lacazia loboi, which also causes a similar disease in humans. this hypothesis was recently challenged by reports that fungal dna sequences from dolphins grouped this pathogen with paracoccidioides brasiliensis. we conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. kex gene sequences of p. brasiliensis from dolphins showed 10 ... | 2016 | 27869614 |
| the cytotoxic t cells may contribute to the in situ immune response in jorge lobo's disease human lesions. | jorge lobo's disease (jld) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus lacazia loboi. it is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. in order to contribute to the comprehension of immune mechanisms in jld human lesions, we studied the cytotoxic immune response, focusing on tcd8+ and nk cells, and granzyme b. forty skin biopsies of lower limbs were selected and an immunohistochemistry protocol was d ... | 2017 | 27562863 |
| toward the identification, characterization and experimental culture of lacazia loboi from atlantic bottlenose dolphin (tursiops truncatus). | lobomycosis (lacaziosis) is a chronic, granulomatous, fungal infection of the skin and subcutaneous tissues of humans and dolphins. to date, the causative agent, the yeast-like organism lacazia loboi, has not been grown in the laboratory, and there have been no recent reports describing attempts to culture the organism. as a result, studies on the efficacy of therapeutics and potential environmental reservoirs have not been conducted. therefore, the objective of the current study was to utilize ... | 2016 | 27118803 |
| detection of multiple budding yeast cells and a partial sequence of 43-kda glycoprotein coding gene of paracoccidioides brasiliensis from a case of lacaziosis in a female pacific white-sided dolphin (lagenorhynchus obliquidens). | lacaziosis, formerly called as lobomycosis, is a zoonotic mycosis, caused by lacazia loboi, found in humans and dolphins, and is endemic in the countries on the atlantic ocean, indian ocean and pacific ocean of japanese coast. susceptible cetacean species include the bottlenose dolphin (tursiops truncatus), the indian ocean bottlenose dolphin (t. aduncus), and the estuarine dolphin (sotalia guianensis); however, no cases have been recorded in other cetacean species. we diagnosed a case of lacazi ... | 2016 | 26883513 |
| lacaziosis-like disease in tursiops truncatus from brazil: a histopathological and immunohistochemical approach. | cetacean lacaziosis-like disease or lobomycosis-like disease (lld) is a chronic skin condition caused by a non-cultivable yeast of the order onygenales, which also includes lacazia loboi, as well as paracoccidioides brasiliensis and p. lutzii, respectively responsible for lacaziosis and paracoccidioidomycosis in humans. complete identification and phylogenetic classification of the lld etiological agent still needs to be elucidated, but preliminary phylogenetic analyses have shown a closer relat ... | 2016 | 26758656 |
| report of the first human case of lobomycosis in the united states. | we describe the first human case of lobomycosis caused by lacazia loboi in a 42-year-old white male resident of georgia. the patient had traveled to venezuela 7 years earlier, where he had planned to rappel down angel falls in canaima. although he never actually rappelled the falls, he did walk under the falls at least three times, exposing himself to the high water pressures of the falls. he noticed a small pustule with surrounding erythema developing on the skin of his right chest wall. the le ... | 2000 | 10699043 |
| lacazia loboi gen. nov., comb. nov., the etiologic agent of lobomycosis. | the new genus lacazia p. taborda, v. taborda, et mcginnis is proposed to accommodate lacazia loboi (o. m. fonseca et lacaz) p. taborda, v. taborda, et mcginnis, the obligate pathogen that causes lobomycosis in mammals. the continued placement of that fungus in the genus paracoccidioides almeida as paracoccidioides loboi is taxonomically inappropriate. loboa loboi ciferri et al. is a synonym of paracoccidioides brasiliensis. | 1999 | 10325371 |
| molecular diagnosis of lobomycosis-like disease in a bottlenose dolphin in captivity. | we report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. the clinical picture and the absence of growth in conventional media resembled the features associated with lacazia loboi. however sequencing of ribosomal dna and further phylogenetic analyses showed a novel sequence more related to paracoccidioides brasilensis than to l. loboi. moreover, the morphology of the yeast cells differed from those l. loboi causing infections humans. thes ... | 2011 | 21838615 |
| jorge lobo's disease with restricted labial presentation. | jorge lobo's disease (jld) is a chronic granulomatous cutaneous mycosis caused by lacazia loboi. the most typical lesions are keloid-like growths preferentially located on limbs and ears. to the best of the authors' knowledge, only one labial case has previously been reported. we describe the case of a man who presented with a left-sided papulonodular lesion of 10 years' duration on the vermillion border of the upper lip. a successful surgical resection of the lesion was performed and there was ... | 2011 | 21603828 |
| detection of cytokines and nitric oxide synthase in skin lesions of jorge lobo's disease patients. | studies investigating the immunopathological aspects of jorge lobo's disease have shown that the inflammatory infiltrate consists mainly of histiocytes and multinucleated giant cells involving numerous yeast-like cells of lacazia loboi, with the t lymphocytes more common than b lymphocytes and plasma cells. the quantification of cytokines in peripheral blood mononuclear cells culture supernatant has revealed alterations in the cytokines profile, characterized by predominance of a th2 profile. in ... | 2011 | 21208026 |
| lobomycosis. | a case of lobomycosis in a patient from the brazilian amazon region is presented. lobomycosis is a subcutaneous mycosis caused by the yeast lacazia loboi. it often affects adult males and has been reported in dolphins. therapeutical options for localized lesions, such as the ones shown by the patient in this report, are eletrocoagulation, surgical exeresis, and cryotherapy. disseminated lesions may be treated with itraconazole or combination therapy with clofazimine. there is still no curative t ... | 2010 | 20520944 |
| lobomycosis in man and lobomycosis-like disease in bottlenose dolphin, venezuela. | we report 1 case of lobomycosis caused by lacazia loboi in a fisherman and 1 case of lobomycosis-like disease in a bottlenose dolphin (tursiops truncatus) along the coast of venezuela. these findings suggest that the marine environment is a likely habitat for l. loboi and a reservoir for infection. | 2009 | 19751598 |
| lobomycosis-like disease and other skin conditions in indo-pacific bottlenose dolphins tursiops aduncus from the indian ocean. | lobomycosis is a chronic mycotic disease of the skin and subdermal tissues caused by the yeast-like organism lacazia loboi, which affects humans and delphinidae. cases of lobomycosis and lobomycosis-like disease (lld), a disease very similar to lobomycosis but for which a histological diagnostic is missing, have been reported in small cetaceans from the americas and europe. here we report on lld in indo-pacific bottlenose dolphins tursiops aduncus from the tropical lagoon of mayotte, between moz ... | 2009 | 19476285 |
| molecular phylogeny of animal pathogen lacazia loboi inferred from rdna and dna coding sequences. | lacazia loboi is a geographically restricted, uncultivated fungal pathogen of humans and dolphins. previous investigations using 18s small unit rdna, chitin synthase 2 and gp43 dna sequences positioned l. loboi as a close relative of paracoccidioides brasiliensis. however, given the few individuals of l. loboi studied and the high degree of genetic variation observed in p. brasiliensis, the existence of l. loboi as an independent species has been questioned. to investigate the phylogenetic posit ... | 2009 | 19439181 |
| fungal foes: lacazia loboi. | | 2009 | 19326689 |
| analysis of microvasculature phenotype and endothelial activation markers in skin lesions of lacaziosis (lobomycosis). | jorge lobo's disease is a rare mycosis characterized by chronic inflammation, which causes skin lesions in the absence of visceral dissemination. the disease occurs mainly in hot and humid climates and most cases have been registered in the brazilian amazon region. this study investigated possible microvascular alterations in skin lesions caused by infection with lacazia loboi which may interfere with the clinical progression of the disease. immunohistochemistry was used to evaluate the density ... | 2015 | 25450888 |
| lobomycosis: epidemiology, clinical presentation, and management options. | lobomycosis is a subcutaneous mycosis of chronic evolution caused by the lacazia loboi fungus. its distribution is almost exclusive in the americas, and it has a particularly high prevalence in the amazon basin. cases of lobomycosis have been reported only in dolphins and humans. its prevalence is higher among men who are active in the forest, such as rubber tappers, bushmen, miners, and indian men. it is recognized that the traumatic implantation of the fungus on the skin is the route by which ... | 2014 | 25328400 |
| lacaziosis-like disease among bottlenose dolphins tursiops truncatus photographed in golfo dulce, costa rica. | lacaziosis (also known as lobomycosis) is a chronic dermal disease caused by the fungal agent lacazia loboi, which affects both humans and dolphins. photographic data have been used to identify lacaziosis-like disease (lld) among dolphins in the waters of north and south america, and here we report lld in bottlenose dolphins tursiops truncatus off the coast of costa rica, the first reporting in central american waters. during the periods of 1991 to 1992 and 2010 to 2011, 3 research teams conduct ... | 2014 | 24429468 |
| accidental jorge lobo's disease in a worker dealing with lacazia loboi infected mice: a case report. | abstract: | 2009 | 19220901 |
| exfoliative cytology as a rapid diagnostic tool for lobomycosis. | lobomycosis is a common subcutaneous mycosis in south america. it is caused by lacazia loboi. we report two cases of lobomycosis which were diagnosed by exfoliative cytology without any special staining. we highlight this diagnostic tool as a simple, low-cost, painless, non-invasive and fast method for the diagnosis of lobomycosis. | 2009 | 18705665 |
| enzymatic isolation of lacazia loboi cells from skin lesions of lobomycosis. | lacazia loboi is the etiologic agent of jorge lobo's disease, a cutaneous and subcutaneous mycosis endemic to latin america tropical regions and characterized by chronic nodular or keloidal lesions which develop after traumatic events. a new method for the extraction of l. loboi yeast cells from biopsies of lobomycosis skin lesions is presented. the method is based on the proteolytic action of the enzyme dispase which is known for its action against fibronectin and collagen type iv. fungal ident ... | 2009 | 18651310 |
| lobomycosis: an emerging disease in humans and delphinidae. | lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. it was first described in the 1930s by brazilian dermatologist jorge lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. soil and vegetat ... | 2012 | 22429689 |
| lacaziosis and lacaziosis-like prevalence among wild, common bottlenose dolphins tursiops truncatus from the west coast of florida, usa. | lacaziosis (lobomycosis; lacazia loboi) is a fungal skin disease that naturally occurs only in humans and dolphins. the first reported case of lacaziosis in a bottlenose dolphin tursiops truncatus occurred in 1970 in sarasota bay, florida, usa, and subsequent photo-id monitoring of the sarasota bay dolphin population has revealed persistence of the disease. the objectives of this study were to estimate lacaziosis prevalence (p) in 2 bottlenose dolphin populations on the west coast of florida (sa ... | 2011 | 21797035 |
| lacaziosis in bottlenose dolphins tursiops truncatus along the coastal atlantic ocean, florida, usa. | this study represents the first systematic study of lacaziosis (lobomycosis) in bottlenose dolphins tursiops truncatus in the atlantic ocean along the east-central coast of florida, usa. lacaziosis is a chronic infection of the skin caused by the fungus lacazia loboi, which affects only dolphins and humans. previous studies have shown a high prevalence (6.8 to 12.0%) of lacaziosis in resident dolphins from the adjacent indian river lagoon estuary (irl), where the disease is endemic. we examined ... | 2010 | 21166316 |
| lobomycosis. literature review and future perspectives. | lobomycosis is a cutaneous infection of tropical and subtropical regions caused by the fungus lacazia loboi, which still has a controversial taxonomical position. the first description of the disease and fungus was made in 1930 by jorge lobo. it is a chronic disease with predominance of lesions similar to keloids, in exposed areas, limited to skin and semimucosa. there is no systemic involvement and patients maintain a good general health. diagnosis is confirmed by direct or histopathologic exam ... | 2009 | 20096202 |
| immunohistochemical study of langerhans cells in cutaneous lesions of the jorge lobo's disease. | jorge lobo's disease is a chronic infection caused by the fungus lacazia loboi endemic in south america. the infection is characterized by the appearance of parakeloidal, ulcerated or verrucous nodular or plaque-like cutaneous lesions. the histopathological aspect is characterized by poorly organized granulomas with histiocytes and multinucleated giant cells. little is known about local immune response in lobomycosis skin lesions. thirty-three skin biopsies from patients with jorge lobo's diseas ... | 2010 | 20044969 |
| lacaziosis in bottlenose dolphins (tursiops truncatus) in the indian river lagoon, florida, usa. | the objective of this study was to document the presence of the fungal granulomatous skin disease lacaziosis in stranded indian river lagoon (irl) bottlenose dolphins (tursiops truncatus). from 1 january 2007 through 31 december 2007, stranded dolphins from the northern part of the irl were thoroughly examined, and appropriate tissue samples were collected. the intralesional fungal agent (lacazia loboi) was identified histologically in three bottlenose dolphins. histologically, lacaziosis has be ... | 2009 | 19617500 |
| lobomycosis in offshore bottlenose dolphins (tursiops truncatus), north carolina. | lacazia loboi, a cutaneous fungus, is found in humans and dolphins from transitional tropical (florida) and tropical (south america) regions. we report 2 cases of lobomycosis in stranded bottlenose dolphins (tursiops truncatus) and 1 case of lobomycosis-like disease in 1 free-swimming, pelagic, offshore bottlenose dolphin from north carolina, where no cases have previously been observed. | 2009 | 19331739 |
| macrophage and tgf-beta immunohistochemical expression in jorge lobo's disease. | jorge lobo's disease, or lacaziosis, is a chronic deep mycosis that clinically manifests as solid, variable-sized nodular parakeloidal lesions. few studies have characterized the in situ cellular and humoral immune response, especially the involvement of cytokines with immunosuppressive effects such as tgf-beta. the objective this paper was to analyze the expression of tgf-beta in cutaneous lesions in lacaziosis and investigate its importance in the etiopathogy of the disease. the results indica ... | 2008 | 17959227 |
| evaluation of the detection of melanin by the fontana-masson silver stain in tissue with a wide range of organisms including cryptococcus. | it is not uncommon for surgical pathologists to encounter yeast and yeast-like organisms in tissue sections, and correct identification is imperative for guiding therapy. the fontana-masson silver stain for detecting melanin has been accepted as a relatively specific stain for diagnosing cryptococcosis in tissue based on few studies with limited numbers of organisms. this study was designed to test the value of the fontana-masson silver by investigating a large collection of tissues with infecti ... | 2011 | 22154051 |
| a case of stranded indo-pacific bottlenose dolphin (tursiops aduncus) with lobomycosis-like skin lesions in kinko-wan, kagoshima, japan. | lobomycosis is a chronic fungal disease caused by the etiologic agent, lacazia loboi, in the skin and subcutaneous tissues in humans and dolphins in tropical and transitional tropical climates. an indo-pacific bottlenose dolphin (tursiops aduncus) stranded in kagoshima, japan, had severe skin lesions characterized by granulomatous reactions and hyperkeratosis that were similar to those of the lobomycosis, but no fungal organism was observed in the skin lesion. in this paper, we report a stranded ... | 2015 | 25866402 |
| lobomycosis in venezuela. | lobomycosis is a chronic dermal infection that presents a wide spectrum of clinical- dermatological manifestations, mainly characterized by the development of keloid lesions as well as nodular, verrucoid and sometimes ulcerous forms. the etiological agent at an international level, according to the consensus nomenclature, has been called loboa loboi, even though recently it has been accommodated as lacazia loboi. the present review extensively covers the clinical-epidemiological aspects as well ... | 2007 | 17269972 |
| comparative morphology of lacazia loboi (syn. loboa loboi) in dolphins and humans. | lacazia loboi (syn. loboa loboi), the etiological agent of lobomycosis, was compared in human and dolphin tissue using light and electron microscopy, and computer-assisted morphometrics. the histological features of the lesions were similar; however, preliminary electron microscopy data indicates that cell wall destruction may vary in the two hosts. calcofluor stained tissue sections of human and dolphin tissue were examined with uv light microscopy and the images digitized. measurements of area ... | 2000 | 10746221 |
| fine-needle aspiration may replace skin biopsy for the collection of material for experimental infection of mice with mycobacterium leprae and lacazia loboi. | procedures involving the use of mycobacterium leprae and lacazia loboi, uncultivated organisms, depend on the collection of material from the lesions of patients or experimental animals. this study compared fine-needle aspiration (fna) and skin biopsy methods for obtaining bacilli and fungal cells to experimentally infect animals. | 2010 | 20149978 |
| neglected fungal zoonoses: hidden threats to man and animals. | zoonotic fungi can be naturally transmitted between animals and humans, and in some cases cause significant public health problems. a number of mycoses associated with zoonotic transmission are among the group of the most common fungal diseases, worldwide. it is, however, notable that some fungal diseases with zoonotic potential have lacked adequate attention in international public health efforts, leading to insufficient attention on their preventive strategies. this review aims to highlight so ... | 2015 | 25769429 |
| [study of the association between human leukocyte antigens and jorge lobo's disease]. | jorge lobo's disease is a cutaneous/subcutaneous mycosis with a chronic course, caused by the fungus lacazia loboi. considering its epidemiology and the few studies on immunological aspects of this disease, the objective of the present study was to investigate a possible association between hla class ii specificities in 21 jorge lobo's disease patients, by comparing them with healthy individual of the same ethnic group. hla typing was performed using pcr-ssp method. the result did not show any a ... | 2005 | 16172755 |
| molecular model for studying the uncultivated fungal pathogen lacazia loboi. | lacazia loboi is an uncultivated fungal pathogen of humans and dolphins that causes cutaneous and subcutaneous infections only in the tropical areas of the americas. it was recently found by phylogenetic analysis that this unusual pathogen is closely related to paracoccidioides brasiliensis and to the other fungal dimorphic members of the order onygenales. that original phylogenetic study used universal primers to amplify well-known genes. however, this approach cannot be applied to the study of ... | 2005 | 16081893 |
| immunohistochemical characterization of the cellular infiltrate in jorge lobo's disease. | few studies have been conducted to evaluate the cellular composition of the granulomatous lesions induced by lacazia loboi. thus, the objective of the present study was to characterize the mononuclear cell population present in cutaneous lesions obtained from 15 patients with jorge lobo's disease. histological sections were stained with hematoxylin-eosin and methenamine silver and the following mononuclear cells were identified by immunohistochemistry: t lymphocytes (cd3+), helper t lymphocytes ... | 2005 | 15813683 |
| the taxonomic status of lacazia loboi and rhinosporidium seeberi has been finally resolved with the use of molecular tools. | | 2001 | 15487915 |
| [cancer and mycoses and literature review]. | various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. there is less evidence concerning the implication of fungal infection in carcinogenesis. the role of chronic candida infection in the development of squamous cell carcinoma has been suspected for years. candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. other epidemiological evidence of a link between candida infection and cancer is what is observ ... | 2017 | 28188605 |
| phylogenetic analysis of lacazia loboi places this previously uncharacterized pathogen within the dimorphic onygenales. | lacazia loboi is the last of the classical fungal pathogens to remain a taxonomic enigma, primarily because it has resisted cultivation and only causes cutaneous and subcutaneous infections in humans and dolphins in the new world tropics. to place it in the evolutionary tree of life, as has been done for the other enigmatic human pathogens pneumocystis carinii and rhinosporidium seeberi, we amplified its 18s small-subunit ribosomal dna (ssu rdna) and 600 bp of its chitin synthase-2 gene. our phy ... | 2001 | 11136789 |
| inoculation of lacazia loboi into the subcutaneous tissue of the hamster cheek pouch. | the subcutaneous tissue of the hamster cheek pouch, a site of immunologic privilege, has been used to investigate the potential infectivity of different types of parasites. it has been demonstrated that the implantation of fragments of lesions induced by the fungus lacazia loboi, the etiologic agent of jorge lobo's disease, into the subcutaneous tissue of the hamster cheek pouch resulted in parasite multiplication and dissemination to satellite lymph nodes16. here we describe the evolution of le ... | 2000 | 10887368 |
| jorge lobo's disease. | jorge lobo's disease is a rare, chronic granulomatous cutaneous mycosis, which is typical of tropical and subtropical regions. it is caused by the traumatic implantation of the fungus lacazia loboi into the skin and subcutaneous tissue. the disease was first described in 1931 by jorge lobo, in recife (pe), brazil. it is common in central and south america, and predominates in the amazon region. we report a case of jorge lobo's disease, which had been initially referred as being paracoccidioidomy ... | 2017 | 26375233 |
| nutritional status and immune response in murine experimental jorge lobo's disease. | there are no studies investigating the role of nutritional status and immunity associated with jorge lobo's disease. the objective of this study was to evaluate the effects of protein-calorie malnutrition on the immune response of balb/c mice inoculated with lacazia loboi. in this study,the animals were divided into four groups: g1: inoculated with restricted diet, g2: not inoculated with restricted diet, g3: inoculated with regular diet, g4: not inoculated with regular diet. the animals of grou ... | 2015 | 26156007 |
| lacaziosis - unusual clinical presentation. | lacaziosis or jorge lobo's disease is a fungal, granulomatous, chronic infectious disease caused by lacazia loboi, which usually affects the skin and subcutaneous tissue. it is characterized by slow evolution and a variety of cutaneous manifestations with the most common clinical expression being nodular keloid lesions that predominate in exposed areas. we report the case of a patient who had an unusual clinical presentation, with a single-plated lesion on the back. histopathological examination ... | 2015 | 25831004 |
| dna damage in balb/c mice infected with lacazia loboi and its relation to nutritional status. | jorge lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. it is caused by the fungus lacazia loboi. herein we report a study that relates the genotoxicity caused by l. loboi in isogenic mice with nutritional status, through a normal or restricted diet. | 2015 | 25821459 |
| disseminated infection with lacazia loboi and immunopathology of the lesional spectrum. | the pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followed by cd45ro(+), cd4(+), and cd8(+) t cells; cd57(+) natural killer cells; s-100(+) cells; and cd20(+) b lymphocytes. a 54-year-old man and living in the state of para, amazon region ... | 2015 | 25532940 |
| jorge lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions. | jorge lobo's disease (jld) is a cutaneous chronic mycosis caused by lacazia loboi. we studied factor xiiia + dermal dendrocytes (fxiiia + dd), langerhans cells (lc) through the expression of langerin and the expression of s100 protein. | 2015 | 25487975 |
| jorge lobo's disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area. | lobomycosis or lacaziosis is a chronic subcutaneous fungal infection, caused by the fungus lacazia loboi, which is phylogenetically related to coccidioides, blastomyces, histoplasma, and paracoccidioides. the disease was first recognized in 1931 by jorge lobo, who found the disease to be a keloidal blastomycosis and named it jorge lobo's disease. this case was perplexing initially as this fungal infection is very uncommon in the usa. however, with the ever-increasing frequency of international t ... | 2014 | 25469235 |
| lobomycosis: risk of zoonotic transmission from dolphins to humans. | lobomycosis, a fungal disease of the skin and subcutaneous tissues caused by lacazia loboi, is sometimes referred to as a zoonotic disease because it affects only specific delphinidae and humans; however, the evidence that it can be transferred directly to humans from dolphins is weak. dolphins have also been postulated to be responsible for an apparent geographic expansion of the disease in humans. morphological and molecular differences between the human and dolphin organisms, differences in g ... | 2013 | 23919604 |
| lobomycosis: a case from southeastern europe and review of the literature. | lobomycosis, also known as jorge lobo's disease, represents a rare chronic subcutaneous mycosis caused by the fungus lacazia loboi, an organism that is found within lesions but has not been cultured to date. the natural reservoir of l. loboi is unknown but it is believed to be aquatic, or associated with soil and vegetation. more than 550 human cases have been reported, especially in patients with a history of travel or residence in endemic areas (central and south america, particularly brazil) ... | 2012 | 23091581 |
| lobomycosis. | lobomycosis is a rare chronic fungal infection of the subcutaneous tissue found in south america, mainly in brazil. it is caused by lacazia loboi. its clinical manifestations are dermal nodules, either lenticular or in plaques, and keloidlike lesions that can resemble nodular leprosy or leishmaniasis, other subcutaneous mycoses (sporotrychosis, chromomycosis, paracoccidioidomycosis), keloids, and malignant tumors. diagnosis is made by the histopathological findings of the fungus. for treatment, ... | 2013 | 22682191 |
| lobomycosis in atlantic bottlenose dolphins from the indian river lagoon, florida. | to determine the prevalence of lobomycosis, a mycotic infection of dolphins and humans caused by a yeastlike organism (lacazia loboi), among dolphins in the indian river lagoon in florida. | 2006 | 16426180 |
| comparative experimental infection of lacazia loboi in balb/c and b10.a mice. | both hind foot pads of balb/c and b10.a mice strains, were inoculated with a fungal suspension of lacazia loboi obtained from a jorge lobo's disease patient. the suspension had 9 x 105 cells/ml and its viability index was 45%. the animals were sacrificed at different time periods varying from 24 h to 18 months after inoculation. the balb/c mice developed an extensive granulomatous infiltrate, similar to the disease in humans, that progressively evolved. the number of fungal elements also increas ... | 2003 | 15456372 |
| evaluation of the phagocytic activity of peripheral blood monocytes of patients with jorge lobo's disease. | studies on host-parasite interaction in jorge lobo's disease are scarce, with no report in the literature on the phagocytosis of lacazia loboi by phagocytic mononuclear cells. thus, the objective of the present study was to assess the phagocytic activity of blood monocytes in the presence of l. loboi in patients with the disease and in healthy subjects (controls) over 3 and 24 hours of incubation. statistical analyses of the results showed no significant difference in percent phagocytosis of the ... | 2008 | 15094903 |
| analysis of immune response markers in jorge lobo's disease lesions suggests the occurrence of mixed t helper responses with the dominance of regulatory t cell activity. | jorge lobo's disease (jld) is a chronic infection that affects the skin and subcutaneous tissues. its etiologic agent is the fungus lacazia loboi. lesions are classified as localized, multifocal, or disseminated, depending on their location. early diagnosis and the surgical removal of lesions are the best therapeutic options currently available for jld. the few studies that evaluate the immunological response of jld patients show a predominance of th2 response, as well as a high frequency of tgf ... | 2015 | 26700881 |
| the relevance of nutritional status and histopathological findings on the infectious process of balb/c mice inoculated with lacazia loboi. | the aim of this study was to evaluate the effects of the protein-calorie malnutrition in balb/c isogenic mice infected with lacazia loboi, employing nutritional and histopathological parameters. four groups were composed: g1: inoculated with restricted diet, g2: not inoculated with restricted diet, g3: inoculated with regular diet, g4: not inoculated with regular diet. once malnutrition had been imposed, the animals were inoculated intradermally in the footpad and after four months, were sacrifi ... | 2017 | 26603230 |
| leprosy and lobomycosis: first report from the amazon region. | leprosy is still a relevant health problem in brazil with 31 044 new cases diagnosed in 2013, of which 781 new cases diagnosed in the state of amazonas. lobomycosis is a cutaneous-subcutaneous mycosis caused by lacazia loboi, an in vitro uncultivable fungus. lobomycosis has been mainly reported in the amazon region of brazil and colombia affecting mainly male farmers and workers in extraction of rubber. lobomycosis is clinically characterised by keloid-like lesions and chronic evolution. even if ... | 2015 | 26502693 |
| evaluation of the vital staining method for lacazia loboi through the experimental inoculation of balb/c mice. | the viability of the currently unculturable fungal pathogen lacazia loboi can be determined by means of fluorescein diacetate-ethidium bromide (fd-eb) staining. this technique can be used in experimental study of the mycosis, in attempts to cultivate the fungus and in attempts to gauge the success of therapies. in the present study, the potential applications of fd-eb vital staining were studied using a proposed murine experimental model of lobomycosis. balb/c mice were inoculated in the footpad ... | 2003 | 12964712 |
| [sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32 years duration of disease]. | lobomycosis, caused by the fungal pathogen lacazia loboi, is a chronic deep mycosis and is only found in central and south america. clinically the disease is characterized by shiny keloidal nodules appearing mainly on the exposed parts such as face and the upper and lower extremities. therapeutically the surgical removal of the lesions is considered as the only successful treatment. we describe the therapeutic response of a patient with lobo's disease treated for one year with a combination of c ... | 2002 | 12297950 |
| inoculation of balb/c mice with lacazia loboi. | in a previous study, the authors inoculated swiss mice with lacazia loboi (l. loboi) and succeeded in maintaining a granulomatous infiltrate and viable fungal cells up to one year and six months after inoculation. considering the experimental work on paracoccidioidomycosis, 0.03 ml of a fungal suspension obtained from a biopsy of a jorge lobo's disease patient were inoculated into both hind foot pads of 32 six week-old balb/c mice of both sexes. the animals were sacrificed 1, 4, 7 and 10 months ... | 2003 | 11058932 |