| mutagenicity and antibacterial activity of mycotoxins produced by penicillium islandicum sopp and penicillium rugulosum. | twelve mycotoxins produced by penicillium islandicum sopp and penicillium rugulosum in solid-state fermentation on grains were purified and tested for mutagenicity and antibacterial activity in salmonella/mammalian microsome assays. the mutations studied were reversions of histidine auxotrophs to prototrophy in strains ta98 and ta100 and forward mutations to 8-azaguanine resistance (8agr) in strain tm677. rubroskyrin, (+)rugulosin, lumiluteoskyrin [a photoproduct of (-)luteoskyrin], and simatoxi ... | 1978 | 368283 |
| 2,2'-dimethoxy-4a,4a'-dehydrorugulosin (rugulin), a minor metabolite from penicillium rugulosum. | a new metabolite was isolated from the culture of penicillium rugulosum and its structure was determined from physico-chemical data. accompanying metabolites skyrin and rugulosin were characterized by uv, ir, cd, mass and nmr spectra. | 1978 | 564320 |
| isolation and characterization of luteoskyrin and rugulosin, two hepatotoxic anthraquinonoids from penicillium islandicum sopp. and penicillium rugulosum thom. | | 1976 | 987085 |
| cephalosporin c acylase in the autolysis of filamentous fungi. | cephalosporin c acylase activity was studied using fluorescamine determination of free--nh2 groups produced in the deacylation of cephalosporin c by the enzyme. fourteen fungi from different genera were studied and low extracellular cephalosporin c acylase activity was found in the genera aspergillus, fusarium and penicillium. forty one fungi of these genera were checked but not all presented acylase activity. the enzyme was generally found to be an extracellular enzyme and during the process of ... | 1990 | 1972399 |
| of4949, new inhibitors of aminopeptidase b. i. taxonomy, fermentation, isolation and characterization. | new aminopeptidase b inhibitors that we named of4949-i, ii, iii and iv were isolated from the culture broth of a fungus, penicillium rugulosum of4949. the molecular formula of i was c23h26n4o8 and that of ii, c22h24o8, judging from elemental analysis and secondary ion mass spectrometry. the concentrations of i, ii, iii and iv required for 50% inhibition of aminopeptidase, using ehrlich ascites carcinoma cells as the source of the enzyme, were 0.0054, 0.0048, 3.4 and 1.7 micrograms/ml, respective ... | 1986 | 3818441 |
| of4949, new inhibitors of aminopeptidase b. iii. biosynthesis. | to elevate production of of4949 by penicillium rugulosum of4949 and to elucidate the pathway of its biosynthesis, mutants were selected on the basis of their resistance to growth inhibition by phenylalanine analogs. a mutant resistant to m-fluorophenylalanine, strain no. m414, had 3-fold the production of the parent. in a study of the biosynthesis of of4949-i and ii, several 14c-labeled compounds were examined as possible precursors of of4949. l-[14c]tyrosine and l-[14c]asparagine were incorpora ... | 1986 | 3818443 |
| toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of penicillium rugulosum thom. | | 1971 | 5314585 |
| chronic toxicity and hepatocarcinogenicity of (+) rugulosin, an anthraquinoid mycotoxin from penicillium species: preliminary surveys in mice. | (+) rugulosin (rug) is bis-anthraquinoid pigment produced by fungi such as penicillium rugulosum thom, p. tardum and others, and its chemical structure is very close to (-) luteoskyrin, one of bis-anthraquinoid pigments of penicillium islandicum sopp and hepatocarcinogenic to mice and rats. this investigation was concerned with the subacute and chronic effects of rug on hepatic injury and hepatocellular tumor induction in male mice fed purified diets for 22 days containing 1.5 mg/5 g diet/animal ... | 1980 | 7218376 |
| comparison of methods for estimating the biomass of three food-borne fungi with different growth patterns. | to evaluate the effectiveness of steps taken to reduce the growth of molds in food and feed, methods that can accurately quantify the degree of fungal contamination of solid substrates are needed. in this study, the ergosterol assay has been evaluated by comparing the results of this assay with spore counts and hyphal length measurements made with a microscope and with cfu counts. three fungi with different growth patterns during cultivation on a synthetic agar substrate were used in these exper ... | 1993 | 8434921 |
| fungal colonization of the paranasal sinuses. | fungal infection of the paranasal sinuses occur in four primary types: acute invasive (1), chronic invasive (2), chronic fungus ball (3) and allergic fungal sinusitis (4). the first and second form can be fatal and is often found in immunosuppressed patients. the present paper concerns a group of immunocompetent patients with non-invasive chronic sinusitis caused by moulds. over the period from 1994 to 1998, 132 tissue samples from the paranasal sinuses obtained by endoscopic operation from 117 ... | 1999 | 10865901 |
| a beta-rutinosidase from penicillium rugulosum ifo 7242 that is a peculiar flavonoid glycosidase. | a beta-rutinosidase, which was specific for releasing the disaccharide rutinose from the flavonoid glycoside rutin, was purified from penicillium rugulosum ifo 7242. this enzyme had the molecular weight of 245,000, a very low optimum ph of 2.2, and the remarkable specificity that the glycosidase did not hydrolyze any other substrates like 4-nitrophenyl beta-glucoside and cellobiose, but only rutin and isoquercitrin. | 2000 | 10923813 |
| [rugulosuvines a and b--diketopiperazine alkaloids from penicillium rugulosum and penicillium piscarium fungi]. | two diketopiperazine alkaloids, rugulosuvines a and b (tryptophan and phenylalanine are precursors), were isolated and purified from the culture liquid of penicillium rugulosum vkm f-352 and penicillium piscarium vkm f-325 fungi. physical and physicochemical studies showed the absolute structure of rugulosuvine a. the absolute structure of rugulosuvine b was demonstrated to be similar to that of rugulosuvine a. | 2001 | 11443897 |
| rock phosphate solubilization and colonization of maize rhizosphere by wild and genetically modified strains of penicillium rugulosum. | maize root colonization and phosphate solubilizing activity of the fungus penicillium rugulosum were assessed in a greenhouse trial using soil-plant microcosms. the bacterial gene hph conferring resistance to hygromicin b was introduced by electroporation in the wild-type strain ir-94mf1 of p. rugulosum and one transformant, w-t3, was selected. maize plants were grown for 5 weeks in a p-poor soil and fertilized with a florida apatite mineral, with navay, an apatite rock deposit from venezuela, o ... | 2002 | 12019460 |
| studies in the biochemistry of micro-organisms. 95. rugulosin, a crystalline colouring matter of penicillium rugulosum thom. | | 1955 | 13249956 |
| pcr-rflp of its rdna for the rapid identification of penicillium subgenus biverticillium species. | rflp of its rdna is proposed as a useful tool for molecular identification of the most common species of biverticillate penicillia. 60 isolates were analysed representing 13 species and 21 unique sequences were produced. the combination of five restriction enzymes was successful in separating 12 species. however, the variety penicillium purpurogenum var. rubrisclerotium remained indistinguishable from penicillium funiculosum. p. funiculosum appeared as the most confused species, being mis-identi ... | 2006 | 17196020 |
| tritirachium egenum, a thiamine- and siderophore-auxotrophic fungal species isolated from a penicillium rugulosum. | tritirachium egenum sp. nov., a biotrophic mycosymbiont, was found growing in association with a penicillium rugulosum. this new species was unable to grow in axenic culture on traditional semi-synthetic culture media unless the growth medium was supplemented with a fraction of the culture filtrate of its host. the hot water extract of alternaria alternata, containing the 'growth factor' of several contact mycosymbionts (biotrophic contact mycoparasites) also supported the growth of t. egenum. s ... | 2010 | 20618858 |