| sporostatic effect of some oils against fungi causing otomycosis. | in vitro animycotic effect of mustard, groundnut, soybean, coconut and amla oils on five fungi i.e., aspergillus niger, a. flavus, absidia corymbifera, penicillium nigricans and candida albicans isolated from otitic fungal infection of external ear (tympanic membrane) of human being was studied. spore germination was evaluated in the oil samples as such after heating for two minutes & after boiling the oil. data show that mustard and coconut oil seem to be effective as in these the spore germina ... | 1992 | 1452224 |
| [on the use of mycelial fat of penicillium nigricans as the source of carbon nutrition during biosynthesis of antibiotics]. | | 1968 | 5690869 |
| effect of deuterium oxide on the culturing of penicillium janczewskii. 3. antigungal activity of fully deuterated griseofulvin. | | 1968 | 5725936 |
| verruculogen produced by soil fungi in england and wales. | soil fungi, including aspergillus fischeri, penicillium piceum, penicillium nigricans, and penicillium raistrickii, produced a tremorgenic toxin previously described as toxin x. chemical analysis showed that this toxin was predominantly verruculogen. | 1981 | 7316507 |
| fungitoxic effect of some organic volatile substances against fungi causing otomycosis. | the fungitoxic effect of seven volatile substances (ammonia, carbon disulphide, petroleum benzene, carbon dioxide, methanol, glacial acetic acid and hydrogen peroxide) against five fungi, i.e. aspergillus niger, a. flavus, absidia corymbifera, penicillium nigricans and candida albicans, was determined on the basis of their dry mycelial weight and sporulation or budding activity. these organisms were isolated from patients suffering from fungal infections of the ear. all the volatile substances t ... | 1994 | 7739663 |
| cis-fumagillin, a new methionine aminopeptidase (type 2) inhibitor produced by penicillium sp. f2757. | selective inhibition against the yeast metap2 (methionine aminopeptidase type 2) was detected in the fermentation broth of a fungus f2757 that was later identified as penicillium janczewskii. a new compound cis-fumagillin methyl ester (1) was isolated from the diazomethane treated fermentation extracts together with the known compound fumagillin methyl ester (2). the cis-fumagillin methyl ester, a stereoisomer of fumagillin methyl ester at the c2'-c3' position of the aliphatic side chain, select ... | 2000 | 11079802 |
| fungistatic activity of some perfumes against otomycotic pathogens. | the sporostatic effect of five otomycotic pathogens, i.e. aspergillus niger, a. flavus, absidia corymbifera, penicillium nigricans and candida albicans to nine different perfumes was determined on the basis of their spore germination. these organisms were isolated from patients suffering from fungal infection of the external auditory canal. volatile vapours emanating from musk, phulwari, jasmine, nagchampa and bela caused approximately 100% inhibition in spore germination of all the test fungi. ... | 2002 | 12000507 |
| cycloaspeptide a and pseurotin a from the endophytic fungus penicillium janczewskii. | penicillium janczewskii k. m. zalessky was isolated as an endophytic fungus from the phloem of the chilean gymnosperm prumnopitys andina. when grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. the compounds were for the first time isolated from this species and identified by spectroscopic methods as pseurotin a and cycloaspeptide a. this is the first report on the production of cyclic peptides by endophytic fungi from chilean gymnosperm ... | 2008 | 18669024 |
| screening pentachlorophenol degradation ability by environmental fungal strains belonging to the phyla ascomycota and zygomycota. | pentachlorophenol (pcp) bioremediation by the fungal strains amongst the cork-colonising community has not yet been analysed. in this paper, the co- and direct metabolism of pcp by each of the 17 fungal species selected from this community were studied. using hierarchical data analysis, the isolates were ranked by their pcp bioremediation potential. fifteen isolates were able to degrade pcp under co-metabolic conditions, and surprisingly chrysonilia sitophila, trichoderma longibrachiatum, mucor ... | 2009 | 19543759 |
| suppressive effects of mycoviral proteins encoded by magnaporthe oryzae chrysovirus 1 strain a on conidial germination of the rice blast fungus. | magnaporthe oryzae chrysovirus 1 strain a (mocv1-a) is the causal agent of growth repression and attenuated virulence (hypovirulence) of the rice blast fungus, magnaporthe oryzae. we previously revealed that heterologous expression of the mocv1-a orf4 protein resulted in cytological damage to the yeasts saccharomyces cerevisiae and cryptococcus neoformans. since the orf4 protein is one of the components of viral particles, we evaluated the inhibitory effects of the purified virus particle agains ... | 2016 | 27329666 |
| immobilization and stabilization of beta-xylosidases from penicillium janczewskii. | β-xylosidases are critical for complete degradation of xylan, the second main constituent of plant cell walls. a minor β-xylosidase (bxyl ii) from penicillium janczewskii was purified by ammonium sulfate precipitation (30% saturation) followed by deae-sephadex chromatography in ph 6.5 and elution with kcl. the enzyme presented molecular weight (mw) of 301 kda estimated by size exclusion chromatography. optimal activity was observed in ph 3.0 and 70-75 °c, with higher stability in ph 3.0-4.5 and ... | 2016 | 27882482 |
| fructose affecting morphology and inducing β-fructofuranosidases in penicillium janczewskii. | fructose, glucose, and an equimolar mixture of both sugars affected differently hyphae thickness, biomass production and secretion of β-fructofuranosidase in penicillium janczewskii. reduced growth, thinner hyphae and visible injuries were early observed during fungal cultivation in fructose-containing medium, reaching the maximum between 12 and 15 days of culture. total sugar content from the cell wall was lower when fructose was supplied and polysaccharides lower than 10 kda predominated, rega ... | 2015 | 26380163 |
| production of xylanolytic enzymes by penicillium janczewskii. | the production of extracellular xylanase, beta-xylosidase and alpha-l-arabinofuranosidase by the mesophilic fungus penicillium janczewskii under submerged cultivation was investigated with different carbon sources. optimization steps included studies of carbon source concentration, temperature of cultivation and initial ph of culture medium. the production of these enzymes was increased two times when cultures were supplemented with brewer's spent grain at 2% concentration, ph 6.0 and carried ou ... | 2010 | 20122825 |
| cell-wall structure and composition of penicillium janczewskii as affected by inulin. | penicillium janczewskii, a filamentous fungus isolated from the rhizosphere of vernonia herbacea (asteraceae), grows rapidly on media containing either sucrose or inulin as carbon sources. maintenance of p. janczewskii on inulin medium induces secretion of proteins with high inulinase activity but results in a mycelium that easily collapses and breaks. we evaluated the influence of inulin on fungal growth and colony morphology and on cell-wall structure and composition in comparison with growth ... | 2006 | 16396337 |
| directed evolution of penicillium janczewskii zalesk α-galactosidase toward enhanced activity and expression in pichia pastoris. | in this study, the activity of an α-galactosidase obtained from penicillium janczewskii zalesk was improved via modifying its gene by error-prone pcr and dna shuffling. the mutated dna was ligated to pbgp1, an autonomous-replicating vector, which was subsequently transformed into pichia pastoris x-33. the expressed enzyme activities were measured after single colonies were cultured in yeast-peptone-dextrose medium in deep-well plates. after two rounds of screening, two mutants with higher activi ... | 2012 | 22833403 |
| effect of deuterium oxide on the culturing of penicillium janczewskii. ii. isolation of fully deuterated griseofulvin. | | 2014 | 4299548 |
| toxicological potential of mycotoxin mt81 and its benzoylated derivative on testicular spermatogenesis and steroidogenesis in mature male wistar albino rats. | mycotoxin mt81 was isolated, purified, and identified from a fungal strain of penicillium nigricans. it is a cns depressant, hyperglycemic agent and produces massive bone marrow depression, hepatotoxicity, and nephrotoxicity. its benzolylated analog (benzoylated-mt81) was synthesized in our laboratory having a ld50 value of 87.1 mg/kg body weight in mice. this study was designed to assess the toxicological effects of mycotoxin mt81 and its analog on testicular spermatogenesis and steroidogenesis ... | 2011 | 21417635 |
| targeting of mannosylated liposome incorporated benzyl derivative of penicillium nigricans derived compound mt81 to reticuloendothelial systems for the treatment of visceral leishmaniasis. | the antileishmanial property of a benzyl derivative of a new antibiotic mt81 (bz2mt81), isolated and purified from a fungal strain of penicillium nigricans nrrl 917 was tested in free, liposome intercalated and mannose coated liposome intercalated forms in vivo against visceral leishmaniasis in hamsters. mannose grafted liposome intercalated bz2mt81 eliminated intracellular amastigotes of leishmania donovani within splenic macrophages more efficiently than the liposome intercalated bz2mt81 or fr ... | 2005 | 16199372 |
| studies in the biochemistry of micro-organisms. 111. the production of l-phenylalanine anhydride (cis-l-3, 6-dibenzyl-2, 5-dioxopiperazine) by penicillium nigricans (bainier) thom. | | 1962 | 13971138 |
| [peculiarities of growth and development of penicillium nigricans under conditions of submerged griseofulvin biosynthesis]. | | 1963 | 14124724 |
| [the variability of penicillium nigricans bain., the producer of griseofulfin, under the action of ultraviolet and x-rays and ethylenimine]. | | 2013 | 14238135 |
| [coenzyme a content in the development cycle of penicillium nigricans bain--the producent of griseofulvin]. | | 1966 | 5993085 |
| effect of deuterium oxide on culturing of penicillium janczewskii. i. growth, nutritional factors, and antibiotic production. | | 1967 | 6049688 |
| [differentiation of nuclei in penicillium nigricans thom]. | | 2000 | 5732077 |
| [variation of producer of griseofulvin penicillium nigricans thom. induced by s35]. | | 1970 | 5447125 |
| [use of uv rays in the selection of the griseofulvin-producing penicillium nigricans thom]. | | 1971 | 5138881 |
| [action of n-nitroso-n-methylbiuret on penicillium nigricans thom and the protective effect in uv irradiation]. | n-nitrozo-n-methylbiuret (nmb) in a concentration of 0.2% and exposition for 2,3,4 and 6 hours with the survival rate of the conidia of 4-25% induced slight morphological variation of the griseofulvin-producing organism and increased the variation rate with respect to the antibiotic production by 40-140%. preliminary treatment of the conidia with nmb decreased the lethal effect of uv-rays approximately by 15-25 times. the protective range with respect to morphological variation was 10 times lowe ... | 1976 | 1275460 |
| effect of ph on the tolerance of penicillium nigricans to copper and other heavy metals. | | 2013 | 19699 |
| [adenylate level in the mycelium of penicillium nigricans thom. grown on various carbon sources]. | concentrations of atp and adp and their dynamics during cultivation (2, 5, 9 and 13 days) of a highly productive strains of p. nigricans on a mineral medium in the presence of various carbon sources, such as glucose, succinate or acetate were studied. it was shown that the levels of atp and adp in the mycelium depended on the carbon source: the maximum and minimum atp concentrations were found on the glucose and acetate media respectively, the maximum and minimum adp concentrations showed invers ... | 1979 | 426491 |
| n-tetracosanoic (lignoceric) acid from penicillium nigricans mycelium. | | 1979 | 500147 |
| [effect of supplementary carbohydrate and nitrogen sources on metabolite concentration in the mycelium of penicillium nigricans thom]. | the effect of additional sources of carbon (glucose) and nitrogen (nano3) on the dynamics of the levels of glucose-6-phosphate (g-6-p), phosphoenolpyruvate (pep) and pyruvate in the mycelium of the productive strain of p. nigricans synthesizing griseofulvin was studied. it was found that the pep level was characterized by stability, while the levels of g-6-p and pyruvate depended on the mycelium age at the time of the source addition, the addition type, i.e. addition of a source alone or a mixtu ... | 1980 | 7362218 |
| a novel process for the production of penitrem mycotoxins by submerged fermentation of penicillium nigricans. | a strain of penicillium nigricans, which produces both the antifungal antibiotic griseofulvin and tremorgenic penitrem mycotoxins concurrently in static liquid culture, also elaborated both metabolites in submerged culture when stimulated by calcium chloride to sporulate. maximum yield of penitrems (60 mg l-1) occurred within 5 d in a 60 l stirred fermenter, thus constituting the first significant process for penitrem production in submerged culture. | 1984 | 6470667 |
| inhibition of experimental murine tumors by mt81, a new mycotoxin from penicillium nigricans. | effects of a new mycotoxin mt81 obtained from the fungal strain penicillium nigricans on the growth of two transplantable murine tumors and the life span of the hosts were studied. remarkable decrease in tumor volume and viable tumor cell count was found in both the tumors. antitumor effect of the compound was more pronounced in sarcoma 180 (s180) than in ehrlich ascites carcinoma (eac). the tumor-inhibitory effect was also manifested by the reduction in mitotic activity and appearance of membra ... | 1997 | 9473795 |
| effect of mycotoxins isolated from penicillium nigricans on glucose-6-phosphate dehydrogenase. | a new mycotoxin product (nmp) was isolated from the culture of mutated wild strain of p. nigricans which is less toxic and has sterol derivative. nmp (ld50 > 1 g/kg) showed antimicrobial and antineoplastic activities and does not affect the hematological parameters like rbc count and hemoglobin. it maintained normal blood glucose level by increasing the enzyme activity of glucose-6-phosphate dehydrogenase (ec-1.1.1.49; g-6-pdh) by 30%. it also maintained the normal ion balance in the blood of mi ... | 1997 | 9567755 |
| extracellular inulinases from penicillium janczewskii, a fungus isolated from the rhizosphere of vernonia herbacea (asteraceae). | extracellular inulinases from penicillium janczewskii were obtained from the filtrate of 12 day-old cultures supplemented with inulin from vernonia herbacea. crude filtrates and partially-purified enzyme preparations (peaks i and ii) were active on inulin, sucrose and raffinose. the apparent m(r) of the enzymes from peaks i and ii were 48 and 66 kda, respectively. the apparent k(m) (mmol l-1) values of peak i were 0.43 for inulin and 18.7 for sucrose; for peak ii they were 0.87 and 18.5 for inul ... | 1999 | 10432595 |
| diastereomeric quinolinone alkaloids from the marine-derived fungus penicillium janczewskii. | from penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3s,4r-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1h)-quinolinone (1) and 3r,4r-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1h)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1h)-quinolinone (4). cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on skov-3 cells. | 2005 | 16180822 |
| proteomic insights on the metabolism ofpenicillium janczewskiiduring the biotransformation of the plant terpenoid labdanolic acid. | plant terpenoids compose a natural source of chemodiversity of exceptional value. many of these compounds own biological/pharmacological activity, others are regarded as unique chemical skeletons for the synthesis of derivatives with improved properties. functional chemical modification of terpenoids through biotransformation frequently relies on the use of ascomycota strains, but information on major cellular responses is still largely lacking.penicillium janczewskiimediates a stereo-selective ... | 2017 | 28824907 |
| transmission of penicillium aurantiogriseum partiti-like virus 1 to a new fungal host (cryphonectria parasitica) confers higher resistance to salinity and reveals adaptive genomic changes. | we attempted to transfect six recently characterized virus species to protoplasts of penicillium janczewskii and chryphonectria parasitica. none of the recovered p. janczewskii colonies was positive for the transfected viruses, but penicillium aurantiogriseum partiti-like virus 1 (paplv1) was detected in three distinct regenerated c. parasitica colonies. we screened the phenotype of the infected strains in up to 45 different conditions combining different media, salinity and temperatures: our re ... | 2017 | 28836717 |
| purification and properties of exo-inulinases from penicillium janczewskii growing on distinct carbon sources. | penicillium janczewskii, isolated from the rhizosphere of vernonia herbacea, grows rapidly on media containing either sucrose or inulin, although inulin more than sucrose induced the production of inulinases. three different extracellular beta-fructofuranosidases (two inulinases and one invertase) were purified from fungal cultures grown on sucrose or inulin, through precipitation with ammonium sulfate, and anion-exchange, hydrophobic interaction and gel filtration chromatographies. the optimum ... | 2007 | 18065000 |
| a fungistatic and bacteriostatic red pigment produced by a strain of the penicillium nigricans-janczewskii series. | | 1947 | 20340768 |