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establishment of cell lines from the wild rodent millardia meltada and tests for endogenous virus.four cell lines were established from the wild rodent, millardia meltada; an untransformed cell line (mm-d), a non-producer (np) cell line transformed with murine sarcoma virus (mm-cl4), and sv40-transformed cell lines (mm-8 mm-663). mm-d is epithelioid and contact-inhibited, whereas mm-cl4, mm-8, and mm-663 are fibroblastic and grow piling up. no endogenous virus was induced in millardia cell lines by a long-term culture with various inducers. millardia cell dna has no nucleotide sequence homol ...1979223935
morphology and histochemistry of ovarian changes in the field rat, millardia meltada.a study has been made of the morphological and histochemical changes of the ovary of the field rat, millardia meltada during its oestrous cycle and pregnancy. the follicular growth and atresia, ovulation and formation of corpora lutea occur throughout the year except severe winter months (december and january). fluctuations in the follicular development occur on different days of the oestrous cycle and pregnancy. the granulosa cells show a progressive increase in their size in successive stages ...1979575689
morphological and histochemical observations on the prenatal and postnatal testes of the field rat (millardia meltada).the foetal testis of the field rat (millardia meltada) shows seminiferous tubules and interstitium consisting of mesenchymal cells and differentiated leydig cells associated with blood vessels. the tubules during the prenatal period show gonocytes and sertoli cells. after birth, their diameter decreases but again increases progressively after postnatal days 9 and 10. spermatogonia appear among the gonocytes on postnatal day 1 and primary spermatocytes on day 8. secondary spermatocytes and sperma ...1977596664
experimental breeding and cytogenetics of the soft-furred rat, millardia meltada.the soft-furred rat, millardia meltada, has bred successfully in the laboratory for 10 generations of brother x sister mating. it is half way in size between the rat and the mouse, and is gentle and easy to handle. thin body hair and incisor teeth are present in the newborn. some individuals have low blood pressure. chromosome number (2n) in 50. it differs in several characteristics from the rat and mouse, and could become a useful experimental animal in biomedical research.1978672179
morphological and histochemical studies on the foetal and postnatal ovaries of the field rat (millardia meltada).a morphological and histochemical study has been made of the development of the field rat (millaridia meltada) ovary with special reference to follicular and interstitial gland tissue development. on day 17 of foetal life, the developing ovary consists of surface epithelium, clusters of germ cells associated with pregranulosa cells, undifferentiated stromal cells and blood vessels. the primordial follicles first appear on foetal day 19. the primary follicles develop on postnatal days 1 and 3, sm ...1978742414
epididymal resorption of spermatozoa in the field rat (millardia meltada).a study has been made of epididymal resorption of spermatozoa in the field rat (millardia meltada). at the height of its reproductive activity, many spermatozoa penetrate the epididymal epithelium and intertubular tissue where they undergo fragmentation and resorption. sperm disposal is maximum in the cauda epididymidis.1977907212
millardia meltada, a new host for acanthocheilonema viteae and a simple technique for separation of microfilariae from peripheral blood.millardia meltada were infected with acanthocheilonema viteae and examined for their susceptibility. the morbidity of infected m. meltada was low compared with that of jirds. on day 47 post-infection (p.i.), 13 of 14 m. meltada developed microfilaremia. male m. meltada then showed gradually increasing microfilaremia with a peak level of 7000 per 30 microliters blood at week 20 p.i., which was much higher than that (3000) of male jirds. in contrast, microfilarial densities of female m. meltada we ...19921487376
metacentric sex-chromosomes in a rodent species, rattus (millardia) meltada pallidior (ryley).the diploid chromosome number in rattus (millardia) meltada pallidior (ryley) is 52 where all the autosomes are acrocentric, and the sex-chromosomes x and y are metacentric. the x chromosome is the largest in the complement being 13.25 microns and the y chromosome is 6.00 microns in length. the autosomes range in size from 9 microns to 2.57 microns.19883251677
agglutination of african primate and rodent erythrocytes by adenoviruses, reoviruses, and enteroviruses.african nonhuman primate and rodent erythrocytes were tested for agglutination by adenoviruses, reoviruses, and enteroviruses. squirrel erythrocytes were agglutinated by reovirus serotypes and adenovirus types 3, 11, 16, and 21. adenoviruses also agglutinated brazza monkey erythrocytes to the same titers as those obtained with either rhesus or grey monkey cells. prototype reovirus types 1 and 2 agglutinated grey monkey erythrocytes to much lower titers than either squirrel or human group o red c ...19724631106
effect of pmhi, an antifertility compound, on reproductive biology of the soft-furred field rat millardia meltada (gray). 19873440576
unique male mammary tumors developing in the inbred soft-furred field rats millardia meltada.inbred lines of the soft-furred rat, millardia meltada, were studied with special reference to spontaneous male mammary tumors. adult males had the hyperplastic, pigmented inguinal mammary tissues and frequently developed bilateral mammary tumors. the tumors, no longer pigmented, were histologically well-differentiated adenocarcinomas associated with the myoepithelial cells and showed a variety of growth patterns depending on the stage of progression. they were transplantable to male, but not to ...19892551171
[the host-opportunistic protozoa system. the dissemination of leishmania infantum infection in naturally susceptible laboratory animals subjected to drug-induced immunosuppression].the possibility to awake the disseminated infection of leishmania infantum in golden hamsters mesocricetus auratus, hispid cotton rats sigmodon hispidus, soft furred rats mastomys natalensis by means of different immunodepressants has been examined. on the background of the immunosuppression caused by corticosteroids of short time activity (metipred, hydrocortison) leishmaniae were revealed both in the target organs (spleen, liver, marrow) and in lungs, in cases of using the corticosteroid of pr ...19947816511
changes with age of mammary glands in male and female soft-furred rat, millardia meltada, in relation to prolactin and testosterone.the soft-furred rat, millardia (millardia meltada), is characterized by the development of androgen-dependent mammary tumours only in males. the age-related changes of the activities of thymidylate synthetase (ts) and thymidine kinase (tk), which contribute to dna synthesis through de novo and salvage pathways, respectively, and structure in the mammary glands were studied in both males and females of this species between 5-28 months of age. while tk activity had no relation to age, ts activity ...19948158967
isolation and identification of mycoplasma strains from various species of wild rodents.attempts were made to isolate mycoplasmas from respiratory and urogenital tracts of 35 apparently healthy wild rodents comprising 7 species under 4 genera. mycoplasmas were isolated from nasal and oral cavities, tracheas, vaginas and penises of the wild rats: ricefield rats (rattus argentiventer), roof rats (r. rattus) and polynesian rats (r. exulans), but none was isolated from brown rats (r. norvegicus), house mice (mus musculus), smithi's voles (eothenomys smithi) and soft-furred field rats ( ...19938513017
studies of angiostrongylus cantonensis in two experimental hosts.lung infection with angiostrongylus cantonensis was established in experimentally infected indian soft-furred rats (millardia meltada) and indian spiny mice (mus platythrix). pulmonary arterial migration occurred earlier (at day 20 after infection) in m. meltada than in wistar rats. m. meltada and m. platythrix could serve as useful animal models for comparative studies of mechanisms determining host specificity of a. cantonensis.19846501859
meta-phosphoric acid-its use in the selective extraction of rna from fixed tissue sections.this communication presents a new quick method for selective extraction of rna from formalin-fixed tissues, such as kidney, intestine, ovary and testis of white rat and liver of rodents, tatera indica and millardia meltada and of the frog, rana tigrina as well as of human wart. sections of pancreas and kidney fixed in acetic acid-alcohol were also tried. the method is to treat deparaffinised sections in 20% and 15% meta-phosphoric acid at 5 degrees c for 10-20 and 20-30 min, respectively, and th ...19816171707
cytological similarity between the heterochromatin of the large x and y chromosomes of the soft-furred field rat, millardia meltada (family: muridae).patterns of dna replication, fluorescence, and meiotic pairing have been studied in the composite x and y chromosomes of a rodent, the soft-furred field rat, millardia meltada. the heterochromatin of both the chromosomes replicated during late s and fluoresces brightly with netropsin-olivomycin. the fluorescence with actinomycin d-hoechst is dull, suggesting that the heterochromatin of both the x and the y is relatively gc-rich. when surface-spread testis cells are analyzed after silver staining ...19817273859
chromosome homology between mouse and three muridae species, millardia meltada, acomys dimidiatus and micromys minutus, and conserved chromosome segments in murid karyotypes.comparative chromosome painting with mouse (mus musculus, mmu) chromosome-specific dna probes was performed for three muridae species, the indian soft-furred field rat (millardia meltada), the spiny mouse (acomys dimidiatus) and the harvest mouse (micromys minutus). all probes except for the y probe were successfully hybridized to the chromosomes of all species, and homologous chromosome segments between mouse and the three species were identified at the molecular level. comparison of our data w ...200718095177
sensitive enzyme-linked immunosorbent assay (elisa) to measure parasite-specific antibodies of indian soft-furred rats, millardia meltada.immunoglobulin g (igg) of indian soft-furred rat, millardia meltada, was purified by an immunoaffinity chromatography and antibodies against it was raised in rabbit. using this rabbit anti-m. meltada igg antibody, sensitivity of enzyme-linked immunosorbent assay (elisa) to measure parasite-specific antibodies in the sera of m. meltada was markedly enhanced than the previous method using rabbit anti-mouse igg and rabbit anti-rat igg antibodies, which could cross-react to m. meltada igg. since m. ...19979234230
resistance of cotton rats, sigmodon hispidus, to primary infection by nippostrongylus brasiliensis.the resistance of cotton rats, sigmodon hispidus to nippostrongylus brasiliensis infection was examined and compared the response to that of the susceptible indian soft-furred rat, millardia meltada. after a primary infection with infective third-stage n. brasiliensis larvae (l3), the number of eggs in feces and adult worm recovery rates from the small intestine of cotton rats were significantly lower than in the controls. to determine whether cotton rat resistance was observed during the migrat ...200212069075
long-term survival of 'damaged' nippostrongylus brasiliensis adult worms in the testosterone-treated indian soft-furred rat, millardia meltada.when testosterone-treated female millardia meltada were infected with nippostrongylus brasiliensis, adult worms persisted for over seven weeks. the kinetics of faecal egg counts showed a biphasic pattern having a transient decline at around two weeks post infection (p.i.). thus the status of n. brasiliensis adult worms surviving in the small intestines of testosterone-treated m. meltada was examined. the fecundity and maturity of eggs in the uteri of female adult worms were examined at one, two, ...19979372513
effect of testosterone on the mucosal defence against intestinal helminths in indian soft-furred rats, millardia meltada with reference to goblet and mast cell responses.effects of testosterone on the mucosal defence mechanisms against intestinal helminths were examined in millardia meltada. when female m. meltada were treated with testosterone at the pharmacological dose, nippostrongylus brasiliensis infection persisted for over seven weeks with prominent biphasic pattern of faecal egg production, whereas almost complete expulsion was observed by two weeks in untreated controls. in spite of a biphasic pattern of faecal egg production, the worm burden of testost ...19958552417
the indian soft-furred rat, millardia meltada, a new host for nippostrongylus brasiliensis, showing androgen-dependent sex difference in intestinal mucosal defence.susceptibility of the indian soft-furred rat, millardia meltada, to infection with the intestinal helminth, nippostrongylus brasiliensis, was examined. after subcutaneous infection with 1500 infective larvae (l3), daily faecal egg output (epg) of both male and female animals reached a peak at 1 week post-infection (p.i.) with the same magnitude (about 20,000 epg faeces) and then rapidly decreased below detection level at around 2 weeks p.i. in male animals, however, after a transient cessation a ...19947883438
[experimental animal information file: millardia meltada]. 19853966809
[experimental animal information file: millardia meltada]. 19853970561
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