| immunomodulating chinese herbal medicines. | traditional chinese medicine always pays close attention to the strengthening of the patient's general resistance against illness, there are many chinese herbs used for thousands of years are considered as tonics. animal experiments and modern clinical trails have shown that quite a number herbs are immunologically active, and most of the tonics are excellent immunomodulating agents, such as polysaccharides or saponins isolated from astragalus mongholicus, acanthopanax senticosus and panax notog ... | 1991 | 1841992 |
| a study on the mutagenicity of 102 raw pharmaceuticals used in chinese traditional medicine. | the mutagenic potential of traditional chinese drugs was studied. after extraction with boiling water and frozen vacuum drying, preparations from 102 raw drugs were tested with the ames test, and the micronucleus and chromosomal aberration assays in mice in vivo. astragalus mongholicus bunge (+s9), sophora japonica l. (+/- s9) and eucommia ulmoides oliv. (+/- s9) were found to significantly induce his+ revertants in salmonella typhimurium ta98 and/or ta100. besides these 3, 10 other extracts wer ... | 1991 | 2027343 |
| [in vitro effect of astragalus mongholicus on activity of cyclic nucleotide phosphodiesterases (camp-pde) in liver and spleen cells of mice]. | | 1982 | 6295649 |
| astragalus mongholicus and angelica sinensis compound alleviates nephrotic hyperlipidemia in rats. | to investigate the mechanism of lipid-lowering effect of the astragalus mongholicus and angelica sinensis compound (a&a) on nephrotic hyperlipidemia in rats. | 2000 | 11775225 |
| chemical analysis of radix astragali (huangqi) in china: a comparison with its adulterants and seasonal variations. | radix astragali (root of astragalus; huangqi) is a popular traditional chinese medicine, and astragalus membranaceus and a. membranaceus var. mongolicus are two commonly used species; however, there are many astragalus species that could act as adulterants of radix astragali. to find the chemical composition of radix astragali, the main constituents including flavonoids, saponins, polysaccharides, amino acids, and trace elements were determined in two radices astragali, a. membranaceus and a. me ... | 2002 | 12166972 |
| antifibrotic effect of the chinese herbs, astragalus mongholicus and angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis. | nephrotic syndrome has long been treated in china with two herbs, astragalus mongholicus and angelica sinensis, which may have antifibrotic effects. methods: rats with chronic puromycin-induced nephrosis were treated with astragalus and angelica 3 ml/d (n = 7) or enalapril 10 mg/kg/d (n = 7). normal control rats (n = 7) received saline rather than puromycin, and an untreated control group (n = 7) received puromycin but no treatment. after 12 weeks, stained sections of the glomerulus and tubuloin ... | 2004 | 14738908 |
| astragalus mongholicus and polygonum multiflorum's protective function against cyclophosphamide inhibitory effect on thymus. | the protective effects of two chinese herbs, astragalus mongholicus, polygonum multiflorum and astragalus mongholicus-polygonum multiflorum in combination against thymus injury induced by cyclophosphamide were evaluated by transmission electron microscopy, image analysis, dna gel electrophoresis as well as flow cytometry. results showed that mice pretreated with cyclophosphamide had degenerated thymus with less normal thymocytes; when those mice were treated with the herbs, thymus morphology imp ... | 2004 | 15633803 |
| isoflavonoids from astragalus mongholicus protect pc12 cells from toxicity induced by l-glutamate. | lsoflavonoids, formononetin, 9,10-dimethoxypterocarpan 3-o-beta-d-glucoside, ononin, calycosin 7-o-glc and calycosin, were isolated from the roots of astragalus mongholicus bunge (leguminosae). the neuroprotective roles and direct antioxidant effects of these isoflavonoids were investigated by using pc12 cell model and dpph (1,1-diphenyl-2-picrylhydrazyl) assay. formononetin, ononin and calycosin were found inhibiting glutamate-induced cell injury, with an estimated 50% effective concentration ( ... | 2005 | 15763368 |
| a novel homodimeric lectin from astragalus mongholicus with antifungal activity. | a novel lectin (amml) was isolated from a chinese herb, i.e., the roots of astragalus mongholicus, using a combination of ammonium sulfate fraction and ion exchange chromatographies. the molecular mass of intact amml was determined to be 66,396 da by maldi-tof mass spectrometry and 61.8 kda by gel filtration, respectively. amml was a dimeric protein composed of two identical subunits each with a molecular mass of 29.6 kda. the lectin was a glycoprotein with a neutral carbohydrate content of 19.6 ... | 2005 | 16140255 |
| studies of chemical constituents and their antioxidant activities from astragalus mongholicus bunge. | to evaluate the antioxidant activities of different chemical constituents from astragalus mongholicus bunge and their protection against xanthine (xa)/xanthine oxidase (xo)-induced toxicity in pc12 cells. | 2005 | 16370311 |
| [effects of components isolated from astragalus mongholicus on expression of p-selectin in shock wave induced kidney injury in rabbit model]. | to investigate the effective components of astragalus mongholicus and their mechanisms in alleviating extracorporeal shock wave lithotripsy (eswl) induced kidney injury. | 2005 | 16422544 |
| promotion of axonal maturation and prevention of memory loss in mice by extracts of astragalus mongholicus. | neurons with atrophic neurites may remain alive and therefore may have the potential to regenerate even when neuronal death has occurred in some parts of the brain. this study aimed to explore effects of drugs that can facilitate the regeneration of neurites and the reconstruction of synapses even in severely damaged neurons. | 2006 | 16981006 |
| [effect of astragalus mongholicus on inducing differentiations of rat bone marrow-derived mesenchymal stem cells into neurocyte-like cells]. | to investigate the differentiations of rat bone marrow-derived mesenchymal stem cells (mscs) into neurocyte-like cells induced by astragalus mongholicus. | 2007 | 17593820 |
| simultaneous quantification of three isoflavonoid glycosides in rabbit plasma after oral administration of astragalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | a selective and sensitive liquid chromatography coupled with triple stage quadruple tandem mass spectrometry (hplc/tsq-ms/ms) was developed and validated for simultaneous quantification of calycosin-7-o-beta-d-glycoside (ccsg), formononetin-7-o-beta-d-glycoside (ononin) and (6r,10r)-9,10-dimethoxypterocarpan-3-o-beta-d-glycoside (dpg) in rabbit plasma. plasma samples were extracted with solid-phase extraction (spe), separated on an inertsil ods-3 column and detected by tandem mass spectrometry w ... | 2007 | 17933611 |
| [effect of astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy]. | to study the effect of astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy by cdna microarray. | 2008 | 18590199 |
| [regulative effect of astragalus mongholicus on hepatocyte growth factor and transforming growth factor-beta1 in rats with unilateral ureteral obstruction]. | to study the effect of astragalus mongholicus (am) on renal interstitial fibrosis caused by unilateral ureteral obstruction (uuo) in rats in order to elucidate the mechanisms underlying the renoprotective effects of am. | 2008 | 19069655 |
| [effect of astragalus mongholicus on expression of connective tissue growth factor in kidney of sd rats with unilateral ureteral obstruction]. | to study the effect of astrangalus mongholicus (am) on the expression of connective tissue growth factor (ctgf) in sd rats with unilateral ureteral obstruction (uuo) and elucidate the mechanism underlying the renorotective effects of am. | 2008 | 19112898 |
| [effect of astragalus mongholicus on expression of hepatocyte growth factor in sd rats with unilateral ureteral obstruction]. | to study the effect of astragalus mongholicus (am) on the expression of hepatocyte growth factor (hgf) in sd rats with unilateral ureteral obstruction (uuo) and to elucidate the mechanisms underlying the renoprotective effects of am. | 2009 | 19292056 |
| [effect of astragalus mongholicus on expression of transforming growth factor- beta1 in sd rats with unilateral ureteral occlusion]. | to study the effect of astragalus mongholicus (am) on the expression of transforming growth factor-beta1 (tgf-beta1) in sd rats with unilateral ureteral occlusion (uuo) and to elucidate the mechanisms underlying the renoprotective effects of am. | 2009 | 19385185 |
| antiproliferation and apoptosis of human tumor cell lines by a lectin (amml) of astragalus mongholicus. | a lectin (amml) from the roots of astragalus mongholicus was extracted and purified by affinity chromatographic technique. human cervical carcinoma cell line (hela), human osteoblast-like cell line (mg63) and human leukemia cell line (k562) were used to check the effects of amml on cell proliferation, apoptosis and cell cycle. maximum growth inhibition (92%) was observed with hela cells, followed by k562 cells (84%) and mg63 (48%) cells. morphological observation showed that amml-treated hela ce ... | 2009 | 19403285 |
| astragalus mongholicus ameliorates renal fibrosis by modulating hgf and tgf-beta in rats with unilateral ureteral obstruction. | astragalus mongholicus (am) derived from the dry root of astragalus membranaceus bge. var. mongolicus (bge.) hsiao is a widely used traditional chinese medicine. the present study investigated the potential role of am on renal fibrosis on a rat model of unilateral ureteral obstruction (uuo). we divided 48 sprague-dawley rats randomly into 4 groups: sham-operated group (sham), untreated uuo group, am-treated (10 g/(kg x d)) uuo group, and losartan-treated (20 mg/(kg x d)) uuo group as positive co ... | 2009 | 19434765 |
| protection of pc12 cells against superoxide-induced damage by isoflavonoids from astragalus mongholicus. | to further investigate the neuroprotective effects of five isoflavonoids from astragalus mongholicus on xanthine (xa)/ xanthine oxidase (xo)-induced injury to pc12 cells. | 2009 | 19462688 |
| formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. | we evaluated the vasorelaxation effects of formononetin, an isoflavone/phytoestrogen found abundantly in astragalus mongholicus bunge, on rat isolated aorta and the underlying mechanisms involved. cumulative administration of formononetin, genistein, daidzein and biochanin a relaxed phenylephrine-preconstricted aorta. formononetin and biochanin a caused a similar magnitude of relaxation whereas daidzein was least potent. mechanical removal of endothelium, l-name (100 microm) and methylene blue ( ... | 2010 | 19570671 |
| anti-convulsant effect and mechanism of astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. | astragalus mongholicus (am) is a traditional medicinal herb used as a neuroprotective agent for its anxiolytic, antidepressant, antiamnestic, and antiaggresive effects. however, the mechanisms underlying its anti-convulsant properties are not well studied. in the present study, we examined the anticonvulsant effects on pentylenetetrazol (ptz)-induced seizures in mice and the possible mechanisms of protection against oxidative damage and mitochondrial dysfunction in vitro. the behavioral studies ... | 2010 | 19578991 |
| astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of tnf-alpha and interleukin-8. | to explore the effect of astragalus mongholicus polysaccharide (aps) on gene expression and mitogen-activated protein kinase (mapk) transcriptional activity in intestinal epithelial cells (iec). | 2009 | 19653348 |
| cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}b activation. | β-defensin 2 (bd-2), an antimicrobial peptide, participates in airway defence. cigarette smoke (cs) is a major risk factor for the development of chronic obstructive pulmonary disease. this study mainly aims to investigate the effect of cs on rat bd-2 (rbd-2) expression in rat airways. rats were exposed to cs and treated with caffeic acid phenethyl ester (cape), a nuclear factor (nf)-κb inhibitor, or astragaloside iv (as-iv), an active ingredient of astragalus mongholicus. besides the analysis o ... | 2010 | 20150208 |
| evaluation of the effects of astragalus mongholicus bunge saponin extract on central nervous system functions. | in traditional medicine, astragalus mongholicus (am) has been used for the treatment of general weakness, chronic illness, and to increase overall vitality. | 2010 | 20655376 |
| [ecological environment of cultivated astragali radix and market specification of prepared slices]. | astragali radix is derived from roots of astragalus membranaceus var. mongholicus and a. membranaceus. the exhaustion of wild astragali radix has made cultivated astragali radix possess the commercial market of astragali radix. so the ecological environment of cultivated astragali radix should be investigated through field survey. through investigation, we found that a. membranaceus var. mongholicus are cultivated in hengshan mountain of shanxi province, longnan of gansu province, south of inner ... | 2010 | 20707062 |
| extraction and purification of a lectin from red kidney bean and preliminary immune function studies of the lectin and four chinese herbal polysaccharides. | reversed micelles were used to extract lectin from red kidney beans and factors affecting reverse micellar systems (ph value, ionic strength and extraction time) were studied. the optimal conditions were extraction at ph 4-6, back extraction at ph 9-11, ion strength at 0.15 m nacl, extraction for 4-6 minutes and back extraction for 8 minutes. the reverse micellar system was compared with traditional extraction methods and demonstrated to be a time-saving method for the extraction of red kidney b ... | 2010 | 20976304 |
| astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of cd4+ cd25(high) t cells. | backgroud: astragalus polysaccharides (aps) isolated from one of the chinese herbs, astragalus mongholicus, are known to have a variety of immunomodulatory activities. however, it is not yet clear whether aps can exert an effect on the immune functions of regulatory t cells (tregs). this study was carried out to investigate the effect of aps on the immune function of peripheral blood tregs in postburn sepsis. methodology/principal findings: balb/c mice were randomly divided into six groups as fo ... | 2011 | 21698274 |
| [chemical constituents and activities of total flavonoids from yushen tang]. | to study the chemical constituents and activity of total flavonoids contained in yushen tang,in order to lay a foundation for defining active consituents of the prescription and their mechanism. | 2012 | 23477145 |
| genetic diversity and distribution of rhizobia associated with the medicinal legumes astragalus spp. and hedysarum polybotrys in agricultural soils. | with the increasing cultivation of medicinal legumes in agricultural fields, the rhizobia associated with these plants are facing new stresses, mainly from fertilization and irrigation. in this study, investigations on the nodulation of three cultivated medicinal legumes, astragalus mongholicus, astragalus membranaceus and hedysarum polybotrys were performed. bacterial isolates from root nodules of these legumes were subjected to genetic diversity and multilocus sequence analyses. in addition, t ... | 2016 | 26915496 |
| ensifer glycinis sp. nov., a rhizobial species associated with species of the genus glycine. | rhizobial strains from root nodules of astragalus mongholicus and soybean (glycine max) were characterized phylogenetically as members of the genus ensifer (formerly named sinorhizobium), based on 16s rrna gene sequence comparisons. results based upon concatenated sequence analysis of three housekeeping genes (reca, atpd and glnii, ≤ 93.8 % similarities to known species) and average nucleotide identity (ani) values of whole genome sequence comparisons (ranging from 89.6 % to 83.4 % to ensifer fr ... | 2016 | 27125987 |
| simultaneous determination of six active metabolites in astragalus mongholicus (fisch.) bge. under salt stress by ultra-pressure liquid chromatography with tandem mass spectrometry. | astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus, family leguminosae) is one of the most important traditional chinese herbs because it contains lots of bioactive metabolites, which have beneficial and pharmacological effects on health. simultaneously, it has been proved to be a salt-tolerant plant-one of the potential species to control the soil salinization. therefore, a sensitive and specific ultra-pressure liquid chromatography coupled with tandem mass spectrometric ... | 2016 | 27386371 |
| [comparison between astragalus membranaceus var. mongholicus and hedysarum polybotrys based on its sequences and metabolomics]. | astragalus membranaceus var. mongholicus and hedysarum polybotrys belong to different genera, but have similar drug efficacy in traditional chinese medicine theory, and h. polybotrys was used as the legal a. membranaceus var. mongholicus previously. in this study, similarities and differences between them were analyzed via their its/its2 fragments information. the its (internal transcribed spacer) regions were amplified using polymerase chain reaction and then sequenced in two-way. the alignment ... | 2015 | 27169287 |
| distinguishing astragalus mongholicus and its planting soil samples from different regions by icp-aes. | "daodi herb" enjoys a good reputation for its quality and clinical effects. as one of the most popular daodi herbs, astragalus membranaceus (fisch.) bge var. mongholicus (bge.) hsiao (a. membranaceus) is popularly used for its anti-oxidant, anti-inflammatory and immune-enhancing properties. in this study, we used inductively coupled plasma atomic emission spectrometry (icp-aes) technique to investigate the inorganic elements contents in a. mongholicu and its soil samples from daodi area (shanxi) ... | 2016 | 27077837 |
| [correlation between chemical constituents and ecological factors of astragalus membranaceus var. mongholicus]. | principal component analysis (pca) and correlation analysis (ca) were applied to analyze the correlation of the main chemical components in astragalus membranaceus var. mongholicus and ecological factors. the results showed that the contents of astragaloside, campanulin, ononin, kaempferol and astragalus polysaccharides (aps) of a. membranaceus var. mongholicus produced. in shanxi were significantly higher than in inner mongolia and gansu. the main climatic factors for affecting the contents of ... | 2015 | 26211053 |
| optimization of enzyme assisted extraction of polysaccharides from astragalus membranaceus. | astragalus polysaccharide (aps) is known to have a variety of pharmacological activities. in the present study, enzyme assisted extraction of aps from astragalus mongholicus using various enzymes were examined. research found that glucose oxidase offered a better performance in enhancement of extraction yields of aps than other ones. glucose oxidase assisted extraction process was further optimized by using response surface method (rsm) to obtain maximum yield of crude aps. the optimized extract ... | 2014 | 25037388 |
| microscopic research on a multi-source traditional chinese medicine, astragali radix. | astragali radix is a widely and commonly used chinese herbal medicine, which is derived from roots of astragalus membranaceus var. mongholicus and astragalus membranaceus. to find a quick and reliable method of distinguishing these two species of astragali radix and of determining the age of a sample, microscopic characteristics of the two species were compared using light microscopy. the results showed that the microscopic characteristics, such as number of layers of phellem, continuing lignifi ... | 2014 | 24085529 |
| [isoflavonoids from roots of astragalus membranaceus var. mongholicus]. | to study the isoflavonoid constituents of the roots of astragalus membranaceus var. mongholicus. | 2012 | 23397722 |
| [effect of astragalus membranaceus var. mongholicus seed extracts on seed germination and seedling growth of different codonopsis pilosula caltiver]. | to reveal the allelopathy effect of astragalus membranaceus var. mongholicus seeds and provide information for the intercrop production. | 2012 | 23373205 |
| study of the relationship between genetics and geography in determining the quality of astragali radix. | astragali radix (ar), prepared from the roots of astragalus membranaceus (fisch. ex link) bunge or its variey, a. membranaceus (fisch. ex link) bunge var. mongholicus (bunge) hsiao., is one of the most used and valuable traditional chinese medicines (tcms). historically, hunyuan, shanxi province in china is the geo-authentic producing area of ar and crude ar from here called "geo-authentic." according to tradition, geo-authentic tcms define both authenticity and quality. however, no scientific i ... | 2011 | 21881225 |
| comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysari. | radix astragali (ra), known as "huangqi" in china, is one of the most popular herbal medicines known worldwide to reinforce "qi". ra is traditionally prepared from the dried roots of astragalus membranaceus (mjhq) and a. membranaceus var. mongholicus (mghq). radix hedysari is named "hongqi" (hq), which is similar to ra. we assessed and compared the chemical constituents and bioactivity of ra and hq. different constituents were extracted into five major parts and were analyzed using different met ... | 2010 | 20224658 |
| [study on genetic relationship of astragalus membranaceus var mongholicus in different producing area using srap]. | to study the genetic relationship of astragalus membranaceus var. mongholicus in different producing area and provide theoretical basis for the evaluation of astragalus germplasm resources. | 2009 | 19459294 |
| [study on difference of biological characteristics and resistance to powdery mildew of different astragalus populations]. | to study difference among populations which belong to astragalus membranaceus and a. membranaceus var. mongholicus on morphology, habit, characteristics of physiology and resistance to powdery mildew, and classify them in order to provide theoretical basis for breeding and improving varieties. | 2008 | 18652339 |
| simultaneous characterization of isoflavonoids and astragalosides in two astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry. | a method was developed for the simultaneous identification of astragalosides (ags) and isoflavonoids (ifs) in the roots of astragalus membranaceus and astragalus mongholicus by hplc coupled with atmospheric pressure chemical ionization ms/ms (hplc-apci-ms/ms). diagnostic fragment ions of ags and different group of ifs were obtained with one ag and eight if standards analyzed by cid-ms, which were adopted as characteristic ms/ms fingerprints for further identification of these compounds in the tw ... | 2007 | 17657828 |
| accumulation of calycosin and its 7-o-beta-d-glucoside and related gene expression in seedlings of astragalus membranaceus bge. var. mongholicus (bge.) hsiao induced by low temperature stress. | the changes in calycosin and calycosin-7-o-beta-d-glucoside content as well as the expression of genes involved in their biosynthesis were monitored in roots, stems and leaves of astragalus membranaceus bge. var. mongholicus (bge.) hsiao seedlings during 10 days of low temperature treatment. the concentrations of calycosin and its 7-o-beta-d-glucoside in the different tissues were analyzed using high-performance liquid chromatography. higher glycoside contents were observed at 2 degrees c than t ... | 2007 | 17253088 |
| phylogeny of astragalus in china: molecular evidence from the dna sequences of 5s rrna spacer, its, and 18s rrna. | radix astragali (root of astragalus; huangqi) is a traditional chinese medicine commonly used as an immunostimulant, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, and sedative drug. although the species of radix astragali have been defined as astragalus membranaceus and a. membranaceus var. mongholicus in pharmacopoeia of china, their taxonomy remains controversial. the phylogenetic relationships among 10 astragalus taxa, which are commonly found in china including a. membran ... | 2003 | 14582964 |
| species identification of radix astragali (huangqi) by dna sequence of its 5s-rrna spacer domain. | about 300 species and varieties of astragalus are identified in china, making the identification of the origin of a particular astragalus species on the consumer market difficult. a molecular genetic approach was developed to identify various species of astragalus. although the 5s-rrna coding sequence is conserved in higher eukaryotes, the spacer domain of the 5s-rrna gene has great diversity among different species. the 5s-rrna spacer domain was amplified by polymerase chain reaction (pcr) from ... | 2000 | 10897476 |
| global protein expression analysis of molecular markers of ds-1-47, a component of implantation-promoting traditional chinese medicine. | this study investigated the molecular markers of ds-1-47, a component of an implantation- promoting traditional chinese medicine consisting of astragalus mongholicus, atractylodes macrocephala, scutellaria baicalensis and dipsacales, in an attempt to clarify the molecular mechanism and action targets of ds-1-47. controlled ovarian stimulation (cos) method was used to establish the implantation dysfunction models of mice. animals were divided into normal pregnant group, cos model group and ds-1-4 ... | 2016 | 27924510 |
| [enhanced radiosensitivity of h22 ascitic tumor to 12c6+ ions radiation in ultra-filtration extract mixture from astragalus mongholicus-treated mice]. | this study was designed to investigate the impact of ultra-filtration extract mixture from astragals mongholicus (uemam) o radiosensitivity of h22 ascitic tumor in mice to 12c6+ ions radiation. the h22 ascitic tumor model was established in mice by intraperitoneal injection of 0.2 ml h22 ascitic cells. the animals were subsequently divided into 4 groups randomly, treated with normal saline, uemam, heavy ion beam radiotherapy and uemam plus heavy ion beam radiotherapy, respectively. the body weig ... | 2015 | 27169282 |
| [effect of astragalus mongholicus polysaccharides on gene expression profiles of dendritic cells isolated from healthy donors]. | to investigate the anti-atherosclerosis mechanism of astragalus mongholicus polysaccharides (aps) by examining its effect on gene expression profiles of the dendritic cells (dcs) from healthy donors. | 2015 | 26714920 |
| complete plastid genome of astragalus mongholicus var. nakaianus (fabaceae). | the first complete plastid genome (plastome) of the largest angiosperm genus, astragalus, was sequenced for the korean endangered endemic species a. mongholicus var. nakaianus. its genome is relatively short (123,633 bp) because it lacks an inverted repeat (ir) region. it comprises 110 genes, including four unique rrnas, 30 trnas, and 76 protein-coding genes. similar to other closely related plastomes, rpl22 and rps16 are absent. the putative pseudogene with abnormal stop codons is atpe. this pl ... | 2016 | 26119117 |
| astragalus polysaccharide suppresses excessive collagen accumulation in a murine model of bleomycin-induced scleroderma. | systemic scleroderma is an autoimmune disease characterized by fibrotic changes in skin and other organs involving excessive collagen deposition. the transforming growth factor-β (tgf-β) signaling pathway plays a key role in the fibrotic process in systemic scleroderma (ssc). astragalus polysaccharides (aps) isolated from one of the chinese herbs, astragalus mongholicus, are known to have a variety of immunomodulatory activities. the present study aimed to investigate the effect of aps on tgf-β ... | 2015 | 26064283 |
| [therapeutic effects of ethanol extracts of angelica sinensis and astragalus mongholicus in diabetic gastroparesis rats]. | to observe therapeutic effects of the ethanol extract of angelica sinensis and astragalus mongholicus (1:2) in diabetic gastroparesis (dg) rats. | 2014 | 25726651 |
| astragalus mongholicus regulate the toll-like-receptor 4 meditated signal transduction of dendritic cells to restrain stomach cancer cells. | according to the traditional view, we depend on three methods to treat tumors; surgery, chemotherapy and radiotherapy. however, these methods have its own limitations in application. traditional chinese medicine (tcm) is one of the oldest healing systems. astragalus mongholicus (ams) that is the common herbal medicine, the biggest part of tcm, have been proved to be effective in treating cancers from lots of clinical cases. however, we have not fully understood the anti-tumor mechanism of ams, a ... | 2014 | 25371568 |
| protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of tlr4/nf-κb p65 signal pathway. | tea polyphenols (tp) was investigated in rats for its protective effect on renal ischemia/reperfusion injury (riri). rats were randomized into groups as follows: (i) sham group (n=10); (ii) riri group (n=10); (iii) riri+tp (100mg/kg) group (n=5); (iv) riri+tp (200mg/kg) group (n=5); (v) riri+tp+ astragalus mongholicus aqueous extract (amae) (300 mg/kg+100mg/kg) group (n=5). for the iri+tp groups, rats were orally given with tea polyphenols (100, 200 and 300 mg/kg body weight) once daily 10 days ... | 2014 | 24630969 |
| accelerated sample preparation and formation of astragaloside iv in astragali radix. | abstract context: astragali radix (huangqi; astragalus mongholicus bunge, fabaceae) is used in herbal medicinal products as well as in many food supplements. in traditional chinese medicine, the roots are used for its qi tonifying, immunostimulant, cardioprotective, hepatoprotective and hypoglycemic effects. objective: astragaloside iv (ags-iv), a cycloartane-type triterpene glycoside is used as a marker compound for the quality control of astragali radix in various pharmacopoeias. materials and ... | 2013 | 24171819 |
| [simultaneous determination of formononetin, calycosin and isorhamnetin from astragalus mongholicus in rat plasma by lc-ms/ms and application to pharmacokinetic study]. | to establish a method to determine the concentration of formononetin, calycosin and isorhamnetin from astragalus mongholicus in rats' plasma using lc-ms/ms and calculate their pharmacokinetic parameters. | 2013 | 24134007 |
| isolation and characterization of ten microsatellite loci from korean astragalus mongholicus (fabaceae). | | 2013 | 23981935 |
| neuroprotective effects of formononetin against nmda-induced apoptosis in cortical neurons. | formononetin (fmnt) is an isoflavone found in many herbs including trifolium pratense l., spatholobus suberectus dunn., and astragalus mongholicus bunge. the purpose of this study is to investigate pharmacological properties of fmnt on neurotoxicity induced by n-methyl-d-asparate (nmda) in primary-cultured cortical neurons. the cell viability was significantly decreased after exposure to nmda (200 μm) for 40 min. pretreatment of fmnt (10 μm) for 12 h significantly attenuated the cell loss induce ... | 2013 | 23362211 |
| [regularity of drug use of patents in force of traditional chinese medicine compounds in preventing and treating cardiovascular diseases on basis of frequency analysis]. | to study the regularity of drug use of patents in force of traditional chinese medicine compounds in treating cardiovascular diseases and provide reference for new drug r&d and patent protection. | 2012 | 23236773 |
| study of astragalus mongholicus polysaccharides on endothelial cells permeability induced by hmgb1. | astragalus mongholicus polysaccharide (aps) shows various biological activities. here, we explored the effect of aps on high mobility group protein 1 (hmgb1) -induced endothelial cell permeability. the results indicated aps pretreatment effectively inhibited hmgb1-induced increased permeability in endothelial cells (ecs). signal transduction studies showed aps inhibited not only the activation of small guanylate rho and its downstream effector rho kinase (rock), but also the subsequent phosphory ... | 2013 | 23218386 |
| the effect of astragaloside iv on immune function of regulatory t cell mediated by high mobility group box 1 protein in vitro. | high mobility group box 1 protein (hmgb1), a potent pro-inflammatory cytokine, contributes to the pathogenesis of diverse inflammatory and infectious disorders. some studies have illustrated the potential effect of hmgb1 on regulatory t cells (tregs). astragaloside iv (ast iv) isolated from a chinese herb, astragalus mongholicus, is known to have a variety of immunomodulatory activities. however, it is not yet clear whether ast iv possesses potential regulatory effect on the pro-inflammatory abi ... | 2012 | 22981502 |
| study of the effects of total flavonoids of astragalus on atherosclerosis formation and potential mechanisms. | astragalus mongholicus bunge has long been used to treat cardiovascular disease in chinese traditional medicine. however, its mechanisms are not fully understood. in this study, we explored potential mechanisms and protective effects of total flavonoids of astragalus (tfa) on cardiovascular disease using in vitro experiments and diet-induced atherosclerotic rabbits. we identified six components and their proportion in tfa. the animal experiments showed that tfa significantly reduced plasma level ... | 2012 | 22496932 |
| astragalus polysaccharides regulate t cell-mediated immunity via cd11c(high)cd45rb(low) dcs in vitro. | astragalus polysaccharides (aps) isolated from one of the chinese herbs, astragalus mongholicus, are known to have a variety of immunomodulatory activities. however, it is not yet clear whether aps can induce the activation and differentiation of dendritic cells (dcs) and subsequently activate t cells. | 2011 | 20620204 |
| [antioxidant activity of different extracts from astragalus mongholicus]. | to study the antioxidant activities of different extracts from astragalus mongholicus. | 2009 | 20209962 |
| [effect of astragalus mongholicus injection on proliferation and apoptosis of hormone sensitive (mcf-7) breast cancer cell lines with physiological dose e2]. | to investigate the effect of astragalus mongholicus injection on proliferation and apoptosis in hormone sensitive breast cancer cell lines (mcf-7) with physiological dose e2. | 2009 | 19771851 |
| characterization of a pathogenesis-related class 10 protein (pr-10) from astragalus mongholicus with ribonuclease activity. | a pathogenesis-related (pr) class 10 protein (designated ampr-10) was first isolated from the chinese medicinal material astragalus mongholicus using a combination of affinity chromatography on zn-chelate agarose 4b, ion exchange chromatography on qae sephadex a-25 and gel filtration on sephadex g50. the purified ampr-10 showed a single band with a molecular mass of 17.2kda in sds-page. the molecular mass of intact ampr-10 was determined to be 32.8kda by gel filtration. thus, ampr-10 is a dimeri ... | 2008 | 18024144 |
| [simultaneous determination of five isoflavonoids in commercial radix astragali by high performance liquid chromatography]. | a reversed-phase high performance liquid chromatographic method (rp-hplc) was developed for the simultaneous analysis of five isoflavonoids of huangqi, the roots of astragalus mongholicus. hplc determination was performed on a diamonsil c18 column (200 mm x 4.6 mm i.d., 5 microm) and detected at 230 nm. the mobile phase consisted of (a) acetonitrile and (b) water. gradient program was adopted as follows: 0-25 min from 17% a to 31% a, 25 -45 min 35% a. the flow rate was maintained at 1.0 ml/min. ... | 2006 | 17165544 |
| regulation on maturation and function of dendritic cells by astragalus mongholicus polysaccharides. | astragalus mongholicus polysaccharides(asp) isolated from one of the chinese herbs-a. mongholicus which are known to have a variety of immunomodulatory activity. however, little is known about their immunomodulatory effects on murine bone marrow (bm)-derived dendritic cells (dc). dc are professional antigen presenting cells, which are pivotal for initiation of primary immune response. in this study, the regulatory effects of asp on maturation and function of cultured murine bm-derived dc were in ... | 2006 | 16714220 |
| [influence of leaf-picking on effective constituents of the astragalus mongholicus roots]. | after the application of the orthogonal design, experiments show that the proportion and time of leaf-picking have a great influence not only on the total content of 17 kinds of amino acids but also on that of astragaloside. if the proportion is large and the time is delated, both contents of 17 kinds of amino acids and astragaloside will be reduced accordingly compared to the control group. there is less influence on the contents if the time of leaf-picking is set on june 15 each year and the p ... | 1997 | 12572517 |
| liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of astragalus mongholicus and a. membranaceus. | high-performance liquid chromatography-electrospray ionization mass spectrometry has been applied to analyze the flavonoids of huangqi, the roots of astragalus mongholicus and a. membranaceus. eight flavonoids were identified as calycosin-7-o-beta-d-glucoside, calycosin-7-o-beta-d-glucoside-6"-o-malonate (2), ononin, (6ar,11ar)-3-hydroxy-9,10-dimethoxypterocarpan-3-o-bet a-d-glucoside, calycosin, (3r)-7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-o-beta-d-glucoside, formononetin-7-o-beta-d-glucoside ... | 2000 | 10823504 |
| immunomodulating components from chinese medicines. | modern scientific studies have shown that several components from chinese herbal medicines are immunologically active. astragalus mongholicus polysaccharide aps, a polymer of glucose and arabinose, increases specific antibody formation as well as synthesis of rna, dna and protein in mouse spleen. the polysaccharide pes isolated from acanthopanax senticosus used as a tonic and sedative agent also induces interferon production. an oligosaccharide abps isolated from achyranthes bidentata with a mw ... | 2000 | 23531136 |
| [the effect of honey-frying on anti-oxidation activity of astragalus mongholicus bunge]. | the anti-free radical effects of water extracts of crude astragalus mongholicus (cawe) and honey-fried astragalus mongholicus (hawe) have been studied. both extracts have similar effects in scavenging 0.2 in xan/xo system. the effect of cawe is stronger than that of hawe in scavenging reactive oxygen species (ros) produced by pma and stimulated by pmn and also in scavenging oh engendered by fentons reaction. this suggests that frying process may decrease the ros scavenging activities of astragal ... | 1994 | 7945838 |
| new constituents of astragalus mongholicus. | | 1991 | 17226215 |
| an acidic polysaccharide having activity on the reticuloendothelial system from the root of astragalus mongholicus. | an acidic polysaccharide, designated as amon-s, was isolated from the roots of astragalus mongholicus bunge. it was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 10(4). it showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. it is composed of l-arabinose: d-galactose: d-galacturonic acid: d-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of o-acetyl groups and peptid ... | 1991 | 1799943 |