| [pharmacological studies of extracts of tussilago farfara l. (ii) effects on the cardio-vascular system (author's transl)]. | | 1979 | 506726 |
| carcinogenic activity of coltsfoot, tussilago farfara l. | the carcinogenicity of young, pre-blooming flowers of coltsfoot, tussilago farfara l., which is a herb of the tribe senecioneae, family compositae, and widely used as a herbal remedy, was studied in inbred strain aci rats. rats were divided into 4 groups: group i received 32% coltsfoot diet for 4 days, and subsequently 16% diet until the termination of experiment. groups ii and iii respectively received 8% and 4% coltsfoot diet for 600 days. group iv was fed a normal diet as a control group. the ... | 1976 | 1269853 |
| l-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from tussilago farfara l. | l-652,469, 14-acetoxy-7 beta-(3'-ethylcrotonoyloxy)-notonipetranone, isolated from the methylene chloride extracts of the buds of tussilago farfara l, was found to inhibit both platelet activating factor (paf) and ca2+ entry blocker binding to membrane vesicles. it inhibits the [3h]paf specific binding to rabbit platelet membranes with equilibrium inhibition constants (ki) of 3.2 and 4.0 microm in the presence of 150 mm nacl and 10 mm mgcl2 respectively. it is a competitive paf receptor antagoni ... | 1987 | 2824219 |
| evaluation of tussilagone: a cardiovascular-respiratory stimulant isolated from chinese herbal medicine. | 1. traditional chinese herbal medicine has long used kuandong hua (tussilago farfara l.) in the treatment of various respiratory conditions. 2. recently, it has been found that an extract of this plant (7r,14r)-14-acetoxy-7-[(2'e)-3'-methylpent-2'-enoyloxy ]-oplopanone, is a potent cardiovascular and respiratory stimulant. 3. this compound has been named tussilagone (tus) and when administered intravenously, has been shown to produce an instant and dose dependent pressor effect in anesthetized d ... | 1988 | 3350333 |
| [components and activity of tussilago farfara (author's transl)]. | | 1982 | 7103364 |
| screening of some siberian medicinal plants for antimicrobial activity. | the antimicrobial activity of crude ethanolic extracts of 16 siberian medicinal plants was tested against five species of microorganisms: bacillus cereus, escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, and candida albicans. of the 16 plants tested, 12 showed antimicrobial activity against one or more species of microorganisms. the most active antimicrobial plants were bergenia crassifolia, chelidonium majus, rhaponticum carthamoides, sanguisorba officinalis, and tussilago farfa ... | 2002 | 12169406 |
| traditional medicine in sakarya province (turkey) and antimicrobial activities of selected species. | traditional medicine in north-west of turkey (sakarya province) were studied during a 2 months field study by interviewing local informants from several villages. plant species used to treat infections were tested for antimicrobial activity. information was collected for 46 plant species from 30 families and for 5 animal species. twenty four of the plant species were cultivated. most used families were asteraceae, cucurbitaceae, lamiaceae and rosaceae and the most used plants were artemisia absi ... | 2004 | 15507351 |
| neuroprotective and antioxidant effects of the ethyl acetate fraction prepared from tussilago farfara l. | the flower buds of tussilago farfara l. (compositae) have been traditionally used in oriental medicine for the treatment of bronchitis and asthma. the extract of t. farfara was reported to exhibit antiinflammatory actions by inhibiting arachidonic acid metabolism and nitric oxide (no) production in lipopolysaccharide-activated macrophages. in the present study, we investigated the effects of the ethyl acetate (ea) fraction on various types of neuronal cell damage induced in primary cultured rat ... | 2005 | 15744068 |
| antioxidative effects of quercetin-glycosides isolated from the flower buds of tussilago farfara l. | a bioassay-guided fractionation of the ethylacetate soluble fraction from the flower buds of tussilago farfara l. (compositae) yielded two flavonoids, quercetin 3-o-beta-l-arabinopyranoside and quercetin 3-o-beta-d-glucopyranoside. these two sugar conjugates of quercetin exhibited higher antioxidative activity than their aglycone, quercetin by nbt superoxide scavenging assay. moreover, treatment with quercetin 3-o-beta-l-arabinopyranoside significantly increased the total glutathione (gsh) conte ... | 2006 | 16574296 |
| [herbs on the internet: risky information]. | we analyzed internet information about herbal products and dietary supplements regulated by ministry of public health. we screened 522 italian web sites and we found information about toxic risks on germander (teucrium chamaedrys), red yeast fermented rice (monascus ruber), borage (borago officinalis) and coltsfoot (tussilago farfara) respectively in: 63%, 47%, 3% and 22% of the web sites. it is also possible the on-line purchase. results show that in internet there are not correct instructions ... | 2006 | 16729486 |
| biological screening of some turkish medicinal plant extracts for antimicrobial and toxicity activities. | screening of antibacterial activity and toxicity of 22 aqueous plant extracts from 17 turkish plants was conducted. antibacterial activity was performed with six bacteria including escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, streptococcus pyogenes, staphylococcus aureus and staphylococcus epidermidis. extracts of tussilago farfara leaves, helichyrsum plicatum flowers, solanum dulcamara aerial parts and urtica dioica leaves gave the best inhibitory activity against s. pyogene ... | 2008 | 18075897 |
| safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of n-oxide determination. | two recent mass spectrometry-based reports concerning senecio scandens yielded remarkably dissimilar pyrrolizidine alkaloid constituents. in both studies, and in a related analysis of senecio scandens and tussilago farfara using micellar electrokinetic chromatography, the presence of hazardous n-oxides of the alkaloids was either not considered or was inadequately considered. this raises concerns about the effectiveness of the methodologies used in these, and similar, studies in assessing the py ... | 2008 | 18618436 |
| determination and pharmacokinetic study of tussilagone in rat plasma by rp-hplc method. | a simple and rapid high-performance liquid chromatographic method was used to study the pharmacokinetics of tussilagone, one of the main bioactive constituents in the flower buds of tussilago farfara l. of traditional chinese medicines, in rat plasma. plasma was deproteinized by ethyl acetate for sample clean-up. the drugs were separated on a dikma diamonsil c18 column (4.6 x 250 mm, 5.0 microm), and detected by uv absorption at 220 nm. methanol-water (75:25, v/v) was used as the mobile phase. i ... | 2008 | 18651585 |
| sesquiterpenoids isolated from the flower buds of tussilago farfara l. inhibit diacylglycerol acyltransferase. | inhibition of acyl coa:diacylglycerol acyltransferase (dgat), which is a key enzyme in triglyceride synthesis in eukaryotic organisms, has been proposed as one of the drug targets for treating obesity, type ii diabetes mellitus, and metabolic syndrome. bioassay-guided fractionation of etoh extract of the flower buds of tussilago farfara , using an in vitro dgat enzyme assay, resulted in the isolation of four known sesquiterpenoids, tussilagonone (1), tussilagone (2), 7beta-(3-ethyl-cis-crotonoyl ... | 2008 | 18937486 |
| [effect of plant polysaccharides on th1-dependent immune response: screening investigation]. | we have studied the influence of water-soluble polysaccharides isolated from tussilago farfara l. leaves, betula verrucosa ehrh. leaves, calendula officinalis l. flowers, acorus calamus rhizomes, inula helenium l. rhizomes, overground part of trifolium pretense l., and overground part ofartemisia absinthium l., on thl immune response induced by sheep red blood cells and on no production by murine peritoneal macrophages in vitro. all the investigated polysaccharides have stimulated a th1 response ... | 2010 | 20726346 |
| metabolomic profiling of the flower bud and rachis of tussilago farfara with antitussive and expectorant effects on mice. | ethnopharmacological relevance: flower bud of tussilago farfara l. is widely used for the treatment of cough, bronchitis and asthmatic disorders in the traditional chinese medicine. however, due to the increasing demands, adulteration with rachis is frequently encountered in the marketplace. no report demonstrated the chemical and pharmacological differences between flower bud and rachis before. materials and methods: the water extracts were orally administrated to mice. ammonia induced mice cou ... | 2011 | 22210102 |
| yakammaoto inhibited human coxsackievirus b4 (cvb4)-induced airway and renal tubular injuries by preventing viral attachment, internalization, and replication. | yakammaoto is a prescription of traditional chinese medicine (tcm) containing nine ingredients, including ephedra sinica, pinellia ternate, zingiber officinale, tussilago farfara, aster tataricus, ziziphus jujube, belamcanda chinensis, asarum sieboldii, and schisandra chinensis. yakammaoto has been used against flu-like symptoms for more than two thousand years in china and japan. coxsackievirus b4 (cvb4) causes not only flu-like symptoms but life-threatening diseases, such as pneumonia, acute k ... | 2014 | 24361333 |
| flos farfarae inhibits enterovirus 71-induced cell injury by preventing viral replication and structural protein expression. | enterovirus 71 (ev71) infection can cause airway symptoms, brainstem encephalitis, neurogenic shock, and neurogenic pulmonary edema with high morbidity and mortality. there is no proven therapeutic modality. flos farfarae is the dried flower bud of tussilago farfara l. that has been used to manage airway illnesses for thousands of years. it has neuro-protective activity and has been used to manage neuro-inflammatory diseases. however, it is unknown whether flos farfarae has activity against ev71 ... | 2017 | 28231741 |
| antitubercular activity of arctium lappa and tussilago farfara extracts and constituents. | arctium lappa and tussilago farfara (asteraceae) are two plant species used traditionally as antitubercular remedies. the aim of this study was (i) to screen arctium lappa and tussilago farfara extracts for activity against mycobacterium tuberculosis and (ii) to isolate and identify the compound(s) responsible for this reputed anti-tb effect. | 2014 | 24955560 |
| antioxidant and anti-inflammatory activities of selected chinese medicinal plants and their relation with antioxidant content. | the main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional chinese medicinal herbal extracts and to examine these activities in relation to their antioxidant content. | 2012 | 23038995 |
| seed germination strategies of five perennial weeds. | the germination responses of seeds of achillea millefolium l., artemisia vulgaris l., cirsium arvense (l.) scop., taraxacum officinale weber, sensu lato, and tussilago farfara l. to light, nitrate, alternating temperatures, chilling, light quality, and water availability were studied in laboratory tests, using fresh seed and seed stored for 6 months at 27°c and buried in the soil. a factorial experiment with light, nitrate, alternating temperatures, and seed age as factors found that all four af ... | 1978 | 28309232 |
| short-term variability of plant populations within a regularly disturbed habitat. | the changing populations of weeds during 13 years of the broadbalk continuous wheat experiment were analysed to investigate the extent of differences in shortterm variability of cover between species. the data were from two sections of the experiment where winter wheat was grown continuously under herbicide treatment for 13 and 6 years respectively. logistic regressions were fitted to the data. equisetum arvense showed significant long-term increases on both sections; long-term trends were also ... | 1993 | 28313670 |
| medicinal plants of the russian pharmacopoeia; their history and applications. | due to the location of russia between west and east, russian phytotherapy has accumulated and adopted approaches that originated in european and asian traditional medicine. phytotherapy is an official and separate branch of medicine in russia; thus, herbal medicinal preparations are considered official medicaments. the aim of the present review is to summarize and critically appraise data concerning plants used in russian medicine. this review describes the history of herbal medicine in russia, ... | 2014 | 24742754 |
| [macroscopic differentiation of tussilago farfara l. from arctium lappa l. and petasites officinalis moench]. | | 1955 | 14391351 |
| of the importance of a leaf: the ethnobotany of sarma in turkey and the balkans. | sarma - cooked leaves rolled around a filling made from rice and/or minced meat, possibly vegetables and seasoning plants - represents one of the most widespread feasting dishes of the middle eastern and south-eastern european cuisines. although cabbage and grape vine sarma is well-known worldwide, the use of alternative plant leaves remains largely unexplored. the aim of this research was to document all of the botanical taxa whose leaves are used for preparing sarma in the folk cuisines of tur ... | 2015 | 25890379 |
| plants with topical uses in the ripollès district (pyrenees, catalonia, iberian peninsula): ethnobotanical survey and pharmacological validation in the literature. | the skin is the main structure that protects the human body from environmental factors and has, in addition, a relevant relationship to people׳s appearance and beauty. official medicine and cosmetics have shown interest on elaborating products to protect the dermal system, yet the role of folk medicine is highly unknown in this field. taking this into account, we performed an ethnobotanical study in a catalan district of the eastern pyrenees (northeast iberian peninsula), with the purpose of ass ... | 2015 | 25666424 |
| biological screening of 100 plant extracts for cosmetic use (i): inhibitory activities of tyrosinase and dopa auto-oxidation. | the aim of this study was to evaluate several plant extracts with a view to developing melanogenesis inhibitors. in this study, 100 plant extracts were screened to elucidate their whitening effects using in vitro inhibition of tyrosinase and dopa auto-oxidation activity. several plant extracts such as chaenomeles speciosa, dryopteris crassirhizoma, gastrodia ellata, glycyrrhiza glabra, morus alba, myristica fragrans, rheum palmatum and sophora japonica showed inhibition of mushroom tyrosinase ac ... | 1997 | 18505483 |
| total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | antioxidant capacities of 56 selected chinese medicinal plants were evaluated using the trolox equivalent antioxidant capacity (teac) and ferric reducing antioxidant power (frap) assays, and their total phenolic content was measured by the folin-ciocalteu method. the strong correlation between teac value and frap value suggested that the antioxidants in these plants possess free radical scavenging activity and oxidant reducing power, and the high positive correlation between antioxidant capaciti ... | 2010 | 20640157 |
| plant polysaccharides attenuate fluorouracil toxicity for the small intestinal epithelium. | polysaccharides from tussilago farfara l., acorus calamus l., and echinacea purpurea (l.) moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with lewis lung carcinoma. addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. no stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed. | 2016 | 27383155 |
| determination of elements by atomic absorption spectrometry in medicinal plants employed to alleviate common cold symptoms. | eleven important medicinal plants generally used by the people of turkey for the treatment of common cold have been studied for their mineral contents. eleven minor and major elements (essential, non-essential and toxic) were identified in the asplenium adiantum-nigrum l. , althaea officinalis l. , verbascum phlomoides l., euphorbia chamaesyce l., zizyphus jujube miller, peganum harmala l., arum dioscoridis sm., sambucus nigra l., piperlongum l., tussilago farfara l. and elettaria cardamomum mat ... | 2014 | 25532362 |
| [new sesquiterpenoids from the rhizomes of petasites japonicus maxim. and the roots of ligularia dentata hara]. | over the past twenty years, our research group has been involved in the phytochemical study of terpenoids from compositae plants. from seven species, namely, erigeron annuus (l.) pers., erigeron philadelphicus l., erigeron sumatrensis retz., ligularia dentata hara, ligularia stenocephala matsum. et koidz., petasites japonicus maxim., and tussilago farfara l., we isolated 83 new compounds. in this review, structural features of 19 eremophilane-type sesquiterpenoids from rhizomes of p. japonicus a ... | 2012 | 22864346 |
| terpenoids and related compounds from plants of the family compositae (asteraceae). | this review will summarize the authors' studies on the structures of terpenoids and related compounds from plants of the family compositae (asteraceae). eighty three new compounds have been obtained and characterized from seven species of the plants, namely, erigeron annuus (l.) pers., erigeron philadelphicus l., erigeron sumatrensis retz, ligularia dentata hara, ligularia stenocephala matsum. et koidz., petasites japonicus maxim. and tussilago farfara l. | 2012 | 22574461 |
| [measurement of mefv in 66 cases of asthma in the convalescent stage and after treatment with chinese herbs]. | this paper reported the measurement of maximal expiratory flow-volume curve (mefv) for 66 cases of asthmatics in the convalescent stage. among which the data of fev, pef, v75, v50, v25 in 35 cases (53.03% of the total) gave different abnormal as compared with healthy persons. it showed that in the convalescent stage, most of the asthmatics still possessed obstruction of airways and chiefly of small airways. 35 cases of asthmatics in the convalescent stage was given the chinese herbal decoction o ... | 1989 | 2611953 |
| [ft-ir spectroscopic analysis in monitoring of hydroxyl stretching vibrations in plant hydrogels]. | in recent years, some bioactive hydrogels isolated from natural sources have attracted much attention in the field of biochemistry and pharmacology. this article attempts to review the current structural and conformational characterization of some importantly bioactive hydrogels isolated from following plant: symphytum officinale, thymus pulegioides, trigonella foenum-graecum l., tussilago farfara l., hyssopus officinalis, althaea officinalis l., equisetum arvense l. linum usitatissimum l. and f ... | 2011 | 22332324 |
| inhibition of cytosolic phospholipase a2α (cpla2α) by medicinal plants in relation to their phenolic content. | the cytosolic phospholipase a2α(cpla2α) is one of the potential targets for anti-inflammatory drugs, since this enzyme plays a key role in the inflammation processes seen in health disorders, like asthma, allergic reactions, arthritis and neuronal diseases. in this study, cpla2α inhibition by 43 methanol extracts from medicinal plants rich in polyphenols was determined. the eight most active extracts were derived from ribes nigrum (ic50 of 27.7 μg/ml), ononis spinosa (ic50 of 39.4 μg/ml), urtica ... | 2015 | 26287155 |
| simultaneous determination of n-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. | cation-exchange solid-phase extraction using lichrolut scx (merck, darmstadt) cartridges filled with polymeric strong cation-exchanger enabled efficient isolation of both n-oxides and free bases of pyrrolizidine alkaloids (pas). the recoveries were about 80% for retrorsine-n-oxide, 90% for retrorsine and 100% for senkirkine and were assessed both by tlc-densitometry and ion-pair high-performance liquid chromatography (hpipc) on hypersil bds c8 stationary phase and hexane-l-sulfonic acid as ion-p ... | 2002 | 11999741 |