a lycium chinense miller component inducing ovulation in adult female rabbits. 19725038587
determination of trace selenium by solid substrate-room temperature phosphorescence enhancing method based on potassium chlorate oxidizing phenyl hydrazine-1,2-dihydroxynaphthalene-3,6-disulfonic acid system.a new method for the determination of trace selenium based on solid substrate-room temperature phosphorimetry (ss-rtp) has been established. this method was based on the fact that in hcl-kcl buffer solution, potassium chlorate could oxidize phenyl hydrazine to form chloridize diazo-ion after being heated at 100 degrees c for 20 min, and then the diazo-ion reacted with 1,2-dihydroxynaphthalene-3,6-disulfonic acid to form red azo-compound which could emit strong room temperature phosphorescence (r ...200716959532
cytoprotective effect of the fruits of lycium chinense miller against oxidative stress-induced hepatotoxicity.fruits of lycium chinense miller (solanaceae), distributed in northeast asia, have gained attraction for their hepatoprotective role in traditional oriental medicine. the excessive production of reactive oxygen species (ros) is hazardous for living organisms and damage major cellular constituents such as dna, lipid, and protein. the cytoprotective effect of lycium chinense fruits (lycium extract) was assessed against h(2)o(2)-induced chang liver cell damage.201020546868
Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils.Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa var. purpurae, Panax ginseng, Poria cocos, Lycium chinense, Aquillaria agallocha and honey, has been used to treat age-related symptoms, such as amnesia or dementia, and has been shown to ameliorate scopolamine-induced memory impairment in mice. However, the effects of KOK on transient cerebral global ischemia-induced brain damage are unclear.201122020275
the diterpenoid 7-keto-sempervirol, derived from lycium chinense, displays anthelmintic activity against both schistosoma mansoni and fasciola hepatica.two platyhelminths of biomedical and commercial significance are schistosoma mansoni (blood fluke) and fasciola hepatica (liver fluke). these related trematodes are responsible for the chronic neglected tropical diseases schistosomiasis and fascioliasis, respectively. as no vaccine is currently available for anti-flukicidal immunoprophylaxis, current treatment is mediated by mono-chemical chemotherapy in the form of mass drug administration (mda) (praziquantel for schistosomiasis) or drenching ( ...201525768432
cloning of a cytosolic ascorbate peroxidase gene from lycium chinense mill. and enhanced salt tolerance by overexpressing in evaluate the physiological importance of cytosolic ascorbate peroxidase (apx) in the reactive oxygen species (ros)-scavenging system, a full-length cdna clone, named lmapx, encoding a cytosolic ascorbate peroxidase was isolated from lycium chinense mill. using homologous cloning, then the expression of lmapx under salt stress was investigated. after sequencing and related analysis, the lmapx cdna sequence was 965 bp in length and had an open reading frame (orf) of 750 bp coding for 250 amino ...201424704025
antioxidant activity in extracts of 27 indigenous taiwanese vegetables.the objectives of this study were to identify the antioxidants and antioxidant axtivity in 27 of taiwan's indigenous vegetables. lycium chinense (lc), lactuca indica (li), and perilla ocymoides (po) contained abundant quercetin (que), while artemisia lactiflora (al) and gynura bicolor (gb) were rich in morin and kaempferol, respectively. additionally, nymphoides cristata (nc) and sechium edule (se)-yellow had significantly higher levels of myricetin (myr) than other tested samples. cyanidin (cya ...201424858497
in silico investigation of potential traf6 inhibitor from traditional chinese medicine against has been indicated that tumor necrosis factor receptor-associated factor-6 (traf6) will upregulate the expression of hypoxia-inducible factor-1α (hif-1α) and promote tumor angiogenesis. traf6 proteins can be treated as drug target proteins for a differentiation therapy against cancers. as structural disordered disposition in the protein may induce the side-effect and reduce the occupancy for ligand to bind with target protein, pondr-fit protocol was performed to predict the disordered disposi ...201425089269
neuroprotective effect of lucium chinense fruit on trimethyltin-induced learning and memory deficits in the order to the neuroprotective effect of lycium chinense fruit (lcf), the present study examined the effects of lycium chinense fruit on learning and memory in morris water maze task and the choline acetyltransferase (chat) and cyclic adenosine monophosphate (camp) of rats with trimethyltin (tmt)-induced neuronal and cognitive impairments. the rats were randomly divided into the following groups: naïve rat (normal), tmt injection+saline administered rat (control) and tmt injection+lcf administe ...201122110372
identification of novel pregnane x receptor activators from traditional chinese investigate the ability of traditional chinese medicines (tcms) and their bioactive compounds to activate pregnane x receptor (pxr) signalling pathway.201121524698
isolation of 5-(hydroxymethyl)furfural from lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells.the effect of hot water extracts of lycium chinense fruits (lcf) on the β-hexosaminidase (β-hexo) release by ige sensitized bsa stimulated rat basophilic leukemia (rbl-2h3) cells was investigated. the ethylacetate (etoac) layer of the extract has shown an inhibitory effect on β-hexo release from rbl-2h3 cells at the antigen antibody binding stage. the water (h₂o) fraction (efw) of the chloroform (chcl₃) extract from the etoac layer also inhibited β-hexo release at the same stage in a dose-depend ...201021031336
anti-obesity and hypolipidemic effects of lycium chinense leaf powder in obese rats.this study aimed to elucidate the obesity control, hypolipidemic, and antioxidant effects of lycium chinense leaf powder intake by obese rats. obesity was induced in rats through 13 weeks of high-fat diet. the obese rats were then divided into four different groups, which were fed for 8 weeks with general diet (g), high-fat diet (f), 5% l. chinense leaf powder with a high-fat diet (flp5), or 10% l. chinense leaf powder with a high-fat diet (flp10). the body weight gain of the flp5 group was sign ...201020673056
antimetastatic and immunomodulating effect of water extracts from various mushrooms.this experiment was conducted to evaluate inhibitory effects against lung metastasis and promotion of splenocytes by water extracts from various mushrooms including armillaria mellea, grifola frondosa, garnoderma frondosa, codyceps militaris, hericium erinaceus, coriolus versicolor, agaricus blazei with lycium chinense miller (known as m8). analysis of carbohydrate using hptlc showed that beta-glucan and pachyman were some of the major components of m8. oral administration of m8 resulted in a do ...200920633495
elevation of intracavernous pressure and no-cgmp activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats.we created a new herbal formulation that mainly consists of the seeds of lycium chinense, cornus officinalis, rubus coreanus, cuscuta chinensis and schizandra chinensis. these materials have been long used by korean people as they are known to be good for health and sexual function; hence we could say that their safety have been proven in a certain sense. we investigated the effects of this herbal formulation on the penile erection and corpus cavernosum of spontaneous hypertensive male rats (shr ...200818762238
effects of chinese wolfberry (lycium chinense p. mill.) leaf hydrolysates on the growth of pediococcus acidilactici.growth stimulating effects of lych leaf hydrolysates on pediococcus acidilactici imt101 cells were observed when mrs broth was supplemented with 20% (v/v) h1+h2, the mixture of hydrolysates prepared by a traditional tea-making process. cells grown on mrs containing h1+h2 showed a shortened lag phase while yielding a cell concentration (x(s)) significantly higher than other conditions investigated entering stationary phase. the maximal specific growth rate (mu(max)) was also the highest among all ...200817383176
fermentation of a milk-soymilk and lycium chinense miller mixture using a new isolate of lactobacillus paracasei subsp. paracasei ntu101 and bifidobacterium longum.a milk-soymilk mixture was fermented using lactobacillus paracasei subsp. paracasei ntu101 and bifidobacterium longum bcrc11847 at different inoculum ratios (1:1, 1:2, 1:5, 2:1, and 5:1). when the inoculum ratio was 1:2, the cell numbers of both strains were balanced after 12 h of cultivation. the ph and titratable acidity were very similar at the various inoculum ratios of cultivation. the milk-soymilk mixture was supplemented with 5, 10, 15, and 20% lycium chinense miller juice and fermented w ...200415662546
protective effect of lycium chinense fruit on carbon tetrachloride-induced the present study, we investigated the protective effect of lycium chinense miller (solanaceae) fruit (lfe) against ccl(4)-induced hepatotoxicity and the mechanism underlying these protective effects in rats. the pretreatment of lfe has shown to possess a significant protective effect by lowering the serum aspartate and alanine aminotransferase (ast and alt) and alkaline phosphatase (alp). this hepatoprotective action was confirmed by histological observation. in addition, pretreatment of lfe ...200415619574
anti-fungal effects of phenolic amides isolated from the root bark of lycium chinense.four phenolic amides, dihydro-n-caffeoyltyramine (1), trans-n-feruloyloctopamine (2), trans-n -caffeoyltyramine (3), and cis-n-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of lycium chinense miller. all had an anti-fungal effect; compounds 1-3 were potent at 5-10 microg ml(-1) and were without hemolytic activity against human erythrocyte cells. compound 4 was active at 40 microg ml(-1). all four compounds impeded the dimorphic transition of pathogen, candida ...200415266117
antiosteoporotic activity of the water extract of dioscorea spongiosa.after 60 meoh and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four meoh extracts (cynomorium songaricum, drynaria fortunei, lycium chinense, rehmannia glutinosa) and seven water extracts (cornus officinalis, dendrobium nobile, dioscorea spongiosa, drynaria fortunei, eucommia ulmoides, lycium chinensis, viscum coloratum) showed that potent activities were evaluated for inhibition of osteoclast formation. the results indicated that t ...200415056872
inhibition of monoamine oxidase b (mao-b) by chinese herbal medicines.monoamine oxidase (mao) catalyzes the oxidative deamination of biogenic amines accompaned by the release of h2o2. two subtypes, mao-a and mao-b, exist on the basis of their specificities to substrates and inhibitors. the regulation of mao-b activity is important in the treatment of neurodegenerative diseases. twenty-seven species of plants used in traditional chinese medicines, selected from an enthnobotanical survey, were used in an investigation of their inhibitory effect on mao-b in rat brain ...200314692725
hepatoprotective pyrrole derivatives of lycium chinense a part of our search for hepatoprotective compounds from lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. these compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microm (64.4 and 65.8%, respectively).200312467621
zeaxanthin dipalmitate from lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats.we previously reported that zeaxanthin dipalmitate (zd), a carotenoid from lycium chinense fruit, reduces myofibroblast-like cell proliferation and collagen synthesis in vitro. to determine whether zd might reduce the severity of hepatic fibrosis in an animal model, hepatic fibrosis was induced in rats by bile duct ligation/scission (bdl) for a period of 6 weeks. treatment of bdl rats with zd at a dose of 25 mg/kg body weight significantly reduced the activities of aspartate transaminase (p<0.05 ...200211913541
lcc, a cerebroside from lycium chinense, protects primary cultured rat hepatocytes exposed to galactosamine.primary cultures of rat hepatocytes exposed to galactosamine (galn) were used as a screening system to assess whether a new cerebroside, lcc, isolated from the fruits of lycium chinense, exhibits hepatoprotective activity. cultured rat hepatocytes injured with galn routinely release glutamic pyruvic transaminase (gpt) and sorbitol dehydrogenase (sdh) into the culture medium. treatment of these galn-injured primary cultures with lcc markedly blocked the release of both gpt and sdh in a dose-depen ...200010960900
new antihepatotoxic cerebroside from lycium chinense fruits.two cerebrosides isolated from lycium chinense fruits have been characterized as 1-o-beta-d-glucopyranosyl-(2s, 3r,4e,8z)-2-n-palmitoyloctadecasphinga-4,8-dienine+ ++ (1) and 1-o-beta-d-glucopyranosyl -(2s,3r,4e,8z)-2-n-(2'-hydroxypalmitoyl)octadecasph inga-4,8-dienine (2). while 2 is already known, the structure of 1 was determined by spectral and chemical studies. incubation of ccl4-intoxicated hepatocytes with 1 and 2, respectively, significantly reduced the levels of glutamic pyruvic transam ...19979090870
first report of anthracnose caused by colletotrichum fioriniae on chinese matrimony vine in korea.a fungus, colletotrichum fioriniae, was isolated for the first time from fruits of chinese matrimony vine (lycium chinense mill.) in korea. it was classified as c. fioriniae based on the morphological characteristics and nucleotide sequence of glyceraldehyde-3-phosphate-dehydrogenase and β-tubulin. to the best of our knowledge, this is the first report of c. fioriniae causing anthracnose of chinese matrimony vine in korea.201628154492
zeaxanthin dipalmitate from lycium chinense has hepatoprotective activity.we previously reported the isolation of zeaxanthin and zeaxanthin dipalmitate using bioactivity-guided fractionation to discover hepatoprotective components of lycium chinense against carbon tetrachloride induced hepatotoxicity. the present study was designed to uncover the effects of zeaxanthin dipalmitate on hepatic parenchymal and nonparenchymal cells in vitro. uptake of [3h]thymidine by cultured rat ito cells in response to zeaxanthin dipalmitate was measured. collagen synthesis was assessed ...19979387190
in silico investigation of potential pyruvate kinase m2 regulators from traditional chinese medicine against cancers.a recent research in cancer research demonstrates that tumor-specific pyruvate kinase m2 (pkm2) plays an important role in chromosome segregation and mitosis progression of tumor cells. to improve the drug development of tcm compounds, we aim to identify potent tcm compounds as lead compounds of pkm2 regulators. pondr-fit protocol was utilized to predict the disordered disposition in the binding domain of pkm2 protein before virtual screening as the disordered structure in the protein may cause ...201425089263
a novel cerebroside from lycii fructus preserves the hepatic glutathione redox system in primary cultures of rat hepatocytes.we previously reported the isolation of a novel cerebroside (1-o-(beta-d-glucopyranosyl)-(2s,3r,4e,8z)-2-n-palmityloc tadecasphinga-4,8-diene; lcc) from the fruits of lycium chinense mill. (solanaceae) which protected primary cultured rat hepatocytes from the toxicity induced by carbon tetrachloride (ccl4). the present study was conducted to determine the mechanism(s) by which lcc might exert its hepatoprotective activity. to determine the effect of lcc on the glutathione (gsh) redox system, we ...199910480330
alpha-tocopherol content in 62 edible tropical plants.vitamin e was determined by the high-performance liquid chromatography (hplc) method. all the plants tested showed differences in their alpha-tocopherol content and the differences were significant (p < 0.05). the highest alpha-tocopherol content was in sauropus androgynus leaves (426.8 mg/kg edible portion), followed by citrus hystrix leaves (398.3 mg/kg), calamus scipronum (193.8 mg/kg), starfruit leaves averrhoa belimbi (168.3 mg/kg), red pepper capsicum annum (155.4 mg/kg), local celery apiu ...200111410015
antimicrobial property of (+)-lyoniresinol-3alpha-o-beta-d-glucopyranoside isolated from the root bark of lycium chinense miller against human pathogenic microorganisms.(+)-lyoniresinol-3alpha-o-beta-d-glucopyranoside (1) was isolated from an ethyl acetate extract of the root bark from lycium chinense miller, and its structure was determined using 1d and 2d nmr spectroscopy including dept, hmqc, and hmbc. (+)-lyoniresinol-3alpha-o-beta-d-glucopyranoside exhibited potent antimicrobial activity against antibiotic-resistant bacterial strains, methicillin-resistant staphylococcus aureus (mrsa) isolated from patients, and human pathogenic fungi without having any he ...200516212233
reduction of blood lead levels in lead-exposed mice by dietary supplements and natural antioxidants.lead exposure is a global environmental problem that induces lifelong adverse health effects. our aim was to investigate the effect of dietary supplements and natural antioxidants on blood lead levels (bll) in lead-exposed mice, and observe their impact on the absorption of calcium, iron and zinc in vivo.201021218482
overexpression of lycopene ε-cyclase gene from lycium chinense confers tolerance to chilling stress in arabidopsis thaliana.lutein plays an important role in protecting the photosynthetic apparatus from photodamage and eliminating ros to render normal physiological function of cells. as a rate-limiting step for lutein synthesis in plants, lycopene ε-cyclase catalyzes lycopene to δ-carotene. we cloned a lycopene ε-cyclase gene (lcε-lyc) from lycium chinense (l. chinense), a deciduous woody perennial halophyte growing in various environmental conditions. the lcε-lyc gene has an orf of 1569bp encoding a protein of 522 a ...201626526130
specific alpha-galactosidase inhibitors, n-methylcalystegines--structure/activity relationships of calystegines from lycium examination of the roots of lycium chinense (solanaceae) has resulted in the discovery of 14 calystegines, a cycloheptane bearing an amino group and three hydroxyl groups, and two polyhydroxylated piperidine alkaloids. calystegines a7 and b5, in addition to the previously known calystegines a3, a5, a6, b1, b2, b3, b4, c1, c2 and n1, were isolated and determined as 1alpha,2beta,4alpha-trihydroxy-nortropane and 1alpha,2alpha,4alpha,7alpha-tetrahydroxy-nort ropane, respectively. l. chinense also ...19979346281
endophytic fungi from lycium chinense mill and characterization of two new korean records of colletotrichum.chinese boxthorn or matrimony vine (lycium chinense mill) is found primarily in southeastern europe and asia, including korea. the dried ripe fruits are commonly used as oriental medicinal purposes. endophytic fungi were isolated from surface sterilized tissues and fruits of the medicinal plant in 2013 to identify the new or unreported species in korea. among 14 isolates, 10 morphospecies were selected for molecular identification with the internal transcribed spacer (its) gene. phylogenetic ana ...201425170812
antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced dna damage in human lymphocytes.herbaceous plants containing antioxidants can protect against dna damage. the purpose of this study was to evaluate the antioxidant substances, antioxidant activity, and protection of dna from oxidative damage in human lymphocytes induced by hydrogen peroxide (h2o2). our methods used acidic methanol and water extractions from six herbaceous plants, including bidens alba (ba), lycium chinense (lc), mentha arvensis (ma), plantago asiatica (pa), houttuynia cordata (hc), and centella asiatica (ca).201324279749
antidiabetic effects of carassius auratus complex formula in high fat diet combined streptozotocin-induced diabetic mice.carassius auratus complex formula, including carassius auratus, rhizoma dioscoreae, lycium chinense, and rehmannia glutinosa libosch, is a combination prescription of traditional chinese medicine, which has always been used to treat diabetes mellitus in ancient china. in this study, we provided experimental evidence for the use of carassius auratus complex formula in the treatment of high fat diet combined streptozotocin- (stz-) induced type 2 diabetes. carassius auratus complex formula aqueous ...201424511320
[measurement of mefv in 66 cases of asthma in the convalescent stage and after treatment with chinese herbs].this paper reported the measurement of maximal expiratory flow-volume curve (mefv) for 66 cases of asthmatics in the convalescent stage. among which the data of fev, pef, v75, v50, v25 in 35 cases (53.03% of the total) gave different abnormal as compared with healthy persons. it showed that in the convalescent stage, most of the asthmatics still possessed obstruction of airways and chiefly of small airways. 35 cases of asthmatics in the convalescent stage was given the chinese herbal decoction o ...19892611953
micromonospora lycii sp. nov., a novel endophytic actinomycete isolated from wolfberry root (lycium chinense mill).a novel actinomycete, designated strain neau-gq11(t), was isolated from wolfberry root (lycium chinense mill) and characterized using a polyphasic approach. strain neau-gq11(t) was observed to form rough-surfaced spores that borne singly on the substrate hyphae but aerial mycelia were not developed. the organism showed closest 16s rrna gene sequence similarity to micromonospora saelicesensis lupac 09(t) (99.4%), and phylogenetically clustered with m. chokoriensis 2-19/6(t) (99.3%), 'm. zeae' nea ...201626506858
dihydrocaffeoyl polyamines (kukoamine and allies) in potato (solanum tuberosum) tubers detected during metabolite profiling.four related phenolic amides previously undescribed from the species were revealed during metabolic profiling of potato (solanum tuberosum) tubers. n(1),n(12)-bis(dihydrocaffeoyl)spermine (kukoamine a) and n(1),n(8)-bis(dihydrocaffeoyl)spermidine were positively identified by comparison with authentic standards, while the structures n(1),n(4),n(12)-tris(dihydrocaffeoyl)spermine and n(1),n(4),n(8)-tris(dihydrocaffeoyl)spermidine are proposed for the other two metabolites. each amide was present a ...200515969534
natural products of relevance in the prevention and supportive treatment of depression.the use of herbs or their parts: leaves, roots, rhizomes, flowers, seeds, natural strains, as well as extracts or isolated metabolites is becoming more and more popular. natural remedies not only act prophylactically, but also help to alleviate symptoms of many diseases and enhance the overall functioning of the internal organs. many raw materials of natural origin plays a role in treatment of health problems, and also in case of serious diseases such as depression. depression (affective disorde ...201626276913
effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells.betaine, coumarin, hesperidin and kaempferol are the components derived from lycium chinense, angelicae decursiva, poncirus trifoliata and polygonatum odoratum, respectively. these plants have been used for the treatment of respiratory diseases in oriental medicine and their respective components were reported to have various biological effects. in this study, we investigated whether these natural products affect mucin release from cultured hamster tracheal surface epithelial cells and compared ...200415162365
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