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snakebites notified to the poison control center of morocco between 2009 and 2013.snakebites cause considerable death and injury throughout the globe, particularly in tropical regions, and pose an important yet neglected threat to public health. in 2008, the centre anti poison et de parmacovigilance du maroc (capm) started to set up a specific strategy for the control of snakebites that was formalized in 2012. the aim of the present study is to describe and update the epidemiological characteristics of snakebites notified to capm between 2009 and 2013.201626985186
haemostasis disorders caused by envenomation by cerastes cerastes and macrovipera mauritanica vipers.viper venoms are a real source of proteolytic enzymes causing clotting, bleeding, edema, necrosis, hemorrhage, pain at the bite site and systemic changes. this study was conducted to evaluate the changes induced in hematological and haemostatic parameters in rabbits after 1, 3, 6 and 24 h post-venom of subcutaneously administration of a sublethal dose of cerastes cerastes and macrovipera mauritanica venoms. our results indicated that most hematological and haemostatic parameters showed significa ...201626724273
purification and biochemical characterization of a fibrin(ogen)olytic metalloprotease from macrovipera mauritanica snake venom which induces vascular permeability.in the present study, a novel fibrin(ogen)olytic metalloprotease from macrovipera mauritanica snake venom was purified and characterized in terms of enzyme kinetics and substrate specificity. the purified enzyme [termed snake venom metalloprotease-macrovipera mauritanica (svmp‑mm)] was composed of a single polypeptide with an apparent molecular weight of 27 kda, as shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. the n-terminus of the enzyme was composed of nh(2)-qrfapryiel-co ...201425069477
snake venomics of macrovipera mauritanica from morocco, and assessment of the para-specific immunoreactivity of an experimental monospecific and a commercial antivenoms.proteomic analysis of the venom of the medically relevant snake macrovipera mauritanica from morocco revealed a complex proteome composed of at least 45 toxins from 9 protein families targeting the hemostatic system of the prey or victim. the toxin profile of moroccan m. mauritanica displays great similarity, but also worth noting departures, with the previously reported venom proteome of m. lebetina from tunisia. despite fine compositional differences between these macrovipera taxa, their overa ...201222387317
molecular phylogeny of vipera laurenti, 1768 and the related genera macrovipera (reuss, 1927) and daboia (gray, 1842), with comments about neurotoxic vipera aspis aspis populations.we used mtdna sequences (cytochrome b and nadh dehydrogenase subunit 2) to reconstruct molecular phylogenies of vipera sensu lato, vipera sensu stricto, and vipera aspis. three major clades were identified within the vipera s.l. group: (1) the european vipers, (2) the oriental vipers, consisting of montivipera (vipera 2) plus macrovipera lebetina, and (3) a group of asian and north african vipers consisting of daboia russelii, v. palaestinae, and macrovipera mauritanica. we also distinguished th ...200515737580
isolation of an anti-tumour disintegrin: dabmaurin-1, a peptide lebein-1-like, from daboia mauritanica venom.in the soft treatment of cancer tumours, consequent downregulation of the malignant tissue angiogenesis constitutes an efficient way to stifle tumour development and metastasis spreading. as angiogenesis requires integrin-promoting endothelial cell adhesion, migration, and vessel tube formation, integrins represent potential targets of new therapeutic anti-angiogenic agents. our work is a contribution to the research of such therapeutic disintegrins in animal venoms. we report isolation of one p ...202032033352
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