| use of pavo cristatus feather extract for the better management of snakebites: neutralization of inflammatory reactions. | in indian traditional medicine, peacock feather in the form of ash (bhasma) or water extract are used against snakebite and to treat various problems associated with lungs. this study was aimed to evaluate the water extract of peacock feather (pcf) against the local tissue damage caused due to snakebite. pcf water extract showed inhibition towards phospholipase a2 enzyme activity from snake venom (naja naja and vipera russelii), inflammatory fluids (synovial, pleural, ascites) and normal serum i ... | 2005 | 15894132 |
| strong myotoxic activity of trimeresurus malabaricus venom: role of metalloproteases. | trimeresurus malabaricus is an endemic snake found in the southern region of western ghats section of india along with the more widely distributed species like naja naja and daboia russelii. t. malabaricus venom is not lethal when injected (i.p.) up to 20 mg/kg body weight in mice, but causes extensive local tissue degeneration. n. naja and d. russelii are highly toxic (i.p.) with minimum local tissue damage in experimental mice. in this study a comparative analysis of local tissue damage of t. ... | 2006 | 16317522 |
| differential action of proteases from trimeresurus malabaricus, naja naja and daboia russellii venoms on hemostasis. | the action of venom proteases and their role in hemostasis has been compared in the venoms of trimeresurus malabaricus, daboia russellii and naja naja from the southern region of western ghats, india. these venoms exhibit varying amounts of proteolytic activity and also influence hemostasis differently. casein hydrolyzing activity of t. malabaricus venoms was 16 and 24 fold higher than those of n. naja and d. russellii venoms, respectively. with the synthetic substrate tame, the highest activity ... | 2006 | 16627005 |
| purification and characterization of 'trimarin' a hemorrhagic metalloprotease with factor xa-like activity, from trimeresurus malabaricus snake venom. | in the present study, we describe the purification and characterization of a metalloprotease 'trimarin' from trimeresurus malabaricus snake venom. trimarin is a single-chain basic protein, with a molecular mass of 29.6kda. trimarin showed proteolytic activity towards casein and fibrinogen, which was irreversibly inhibited by edta and 1,10-phenanthroline. the metal ion associated with trimarin was found to be zn(2+). trimarin exhibited pharmacological activities including hemorrhage, myotoxicity, ... | 2010 | 20850171 |
| vanillic acid as a novel specific inhibitor of snake venom 5'-nucleotidase: a pharmacological tool in evaluating the role of the enzyme in snake envenomation. | vanillic acid has been investigated for its inhibitory effect on naja naja, daboia russellii, and trimeresurus malabaricus venom 5'-nucleotidase activity. trimeresurus malabaricus venom 5'-nucleotidase activity was 1.3- and 8.0-fold higher than that of n. naja and d. russellii venoms, respectively. substrate specificity studies showed that for all the venoms tested, 5'-amp was the preferred substrate for 5'-nucleotidase. this indicates the central role of adenosine in snake envenomation. vanilli ... | 2009 | 19961411 |
| factors influencing habitat selection by arboreal pit vipers. | we studied factors influencing habitat selection by two arboreal species of pit viper, namely trimeresurus malabaricus (malabar pit viper) and t. gramineus (bamboo pit viper). the macrohabitat of these species was classified as forest, forest edge, or open habitat. to determine microhabitat selection, a variety of features at every other snake location were measured. whether or not the animal was found in a tree, the tree species, its height of perch, position on the branch (distal/ apical/middl ... | 2013 | 23317362 |
| malabarase, a serine protease with anticoagulant activity from trimeresurus malabaricus venom. | in the present study we describe the purification and characterization of malabarase, a serine protease from trimeresurus malabaricus venom. purification was achieved by gel-permeation chromatography on sephadex g-75 followed by ion-exchange chromatography on cm sephadex c-25. homogeneity of malabarase was confirmed by rp-hplc. malabarase is a monomer that migrated as a single protein band on sds-page under both reducing and non-reducing conditions. the molecular mass of malabarase was determine ... | 2013 | 23182950 |
| characterization of major zinc containing myonecrotic and procoagulant metalloprotease 'malabarin' from non lethal trimeresurus malabaricus snake venom with thrombin like activity: its neutralization by chelating agents. | a major myonecrotic zinc containing metalloprotease 'malabarin' with thrombin like activity was purified by the combination of gel permeation and anion exchange chromatography from t. malabaricus snake venom. maldi-tof analysis of malabarin indicated a molecular mass of 45.76 kda and its n-terminal sequence was found to be ile-ile-leu- pro(leu)-ile-gly-val-ile-leu(glu)-thr-thr. atomic absorption spectral analysis of malabarin raveled the association of zinc metal ion. malabarin is not lethal whe ... | 2011 | 21682679 |
| delineating the venom toxin arsenal of malabar pit viper (trimeresurus malabaricus) from the western ghats of india and evaluating its immunological cross-reactivity and in vitro cytotoxicity. | the venom protein components of malabar pit viper (trimeresurus malabaricus) were identified by combining sds-page and ion-exchange chromatography pre-fractionation techniques with lc-ms/ms incorporating novor and peaks-assisted de novo sequencing strategies. total 97 proteins that belong to 16 protein families such as l-amino acid oxidase, metalloprotease, serine protease, phospholipase a2, 5'-nucleotidase, c-type lectins/snaclecs and disintegrin were recognized from the venom of a single exemp ... | 2020 | 31982532 |
| trimeresurus malabaricus bites: need of species-specific management for snakebites. | | 2020 | 33013098 |
| biochemical and pharmacological characterization of trimersurus malabaricus snake venom. | trimeresurus malabaricus is a venomous pit viper species endemic to southwestern part of india. in earlier reports, we have shown that envenomation by t. malabaricus venom leading to strong local tissue damage but the mechanism of action is not clearly revealed. local tissue damage affected by t. malabaricus venom is of great importance since the poison has serious systemic effects including death in the case of multiple attacks. the present study details the major manifestations of t. malabaric ... | 2018 | 29528146 |