| [investigation on the various species of bulb of fritillary and its application]. | through studies on ancient herbological works, it is claimed that the fritillary recorded in the classic of poet, shennong's herbology is not identical with the fritillary applied today. it belongs to balbostemma paiculatum (maxim). frang of cucurbitacea. ming yi bie lu is the earliest book that includes the fritillary of lilliae as a remedy, with its species fritillaria thunbergii mig. it can be sure that this should include the latter species. the fritillaria of sichuan makes its appearance in ... | 1995 | 11639635 |
| a new potyvirus from thunberg fritillary (fritillaria thunbergii miq.) in zhejiang, china. | a potyvirus causing mosaic symptoms in thunberg fritillary (fritillaria thunbergii) was found at two sites in zhejiang province, china. the virus was readily mechanically transmitted to its original host but not to any of 17 other widely used plant virus indicators. a polyclonal antiserum raised to purified virus particles reacted with its homologous virus but not with a range of other viruses (including 16 potyvirus species). in electron microscopy, virus particles and inclusion bodies typical ... | 2005 | 15789262 |
| in vitro anti-helicobacter pylori action of 30 chinese herbal medicines used to treat ulcer diseases. | infection by helicobacter pylori has been ascertained to be an important etiologic impetus leading usually to chronic active gastritis and gastric ulcer with growing incidences worldwide. utilizing as the test pathogen a standard and five clinic strains of helicobacter pylori, the antibacterial action was assessed in vitro with ethanol extracts of 30 chinese herbal medicines which have been frequently prescribed since ancient times for treating gastritis-like disorders. among the 30 tested mater ... | 2005 | 15814268 |
| detection and characterisation of a second potyvirus from thunberg fritillary in china. | plants of thunberg fritillary (fritillaria thunbergii miq.) from zhejiang province, were found to be co-infected with two distinct potyviruses. one was an isolate of the recently reported thunberg fritillary mosaic virus (tfmv; wei et al., (2005) arch virol 150: 1271-1280), while the other was a distinct virus that did not react with tfmv antiserum nor with antisera to 17 other potyviruses, except for a weak reaction with antibodies produced to soybean mosaic virus (smv) pinellia strain. both vi ... | 2006 | 16328133 |
| [simultaneous determination of peimine, peiminine and zhebeinine in fritillaria thunbergii from different habitat by hplc-elsd]. | to determine peimine, peiminine and zhebeinine in fritillaria thunbergii simultaneously by rp-hplc-elsd. | 2007 | 18027652 |
| turbulent-flow chromatography coupled on-line to fast high-performance liquid chromatography and mass spectrometry for simultaneous determination of verticine, verticinone and isoverticine in rat plasma. | a method based on the on-line turbulent-flow chromatography and fast high-performance liquid chromatography/mass spectrometry (tfc-lc/ms) was developed for sensitive and high throughput pharmacokinetic study of traditional chinese medicines (tcms). in this method, an on-line extraction column (waters oasis hlb) and a fast hplc column with sub-2 microm particle size (agilent zorbax stablebond-c(18), 4.6 mm x 50 mm, 1.8 microm) in a column-switching set-up were utilized. hlb is a reversed-phase ex ... | 2010 | 20060789 |
| establishment of element fingerprint and multielement analysis of fritillaria thunbergii by inductively coupled plasma optical emission spectrometry. | element fingerprints were deciphered for fritillaria thunbergii from chinese ten major fritillaria-producing regions for the purpose of examining differences in element composition with region of origin and identifying elements' importance to f. thunbergii. analysis by inductively coupled plasma optical emission spectrometry allowed simultaneous determination of 18 elements in f. thunbergii (al, b, ca, cd, co, cr, cu, fe, k, mg, na, mn, mo, s, ni, p, pb, and zn), and patterns in element concentr ... | 2010 | 20174977 |
| [study on the compound fritilaria thunbergii miq particles to the subcellular accumulation ability and inducing apoptoais of k562/a02 cells]. | to investigate the effects of the compound fritillaria thunbergii miq particles (cfmp) to the sub-cellular accumulation ability and inducing the apoptosis of k562/a02 cells, explore the mechanism of the cfmp reserve the multi-drug resistance of k562/a02 cells. | 2010 | 20462045 |
| [simultaneous determination of peimine and peiminine in rat plasma by lc-ms/ms and its application in the pharmacokinetic study]. | to establish an lc-ms/ms method for simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of fritillaria thunbergii miq. extract, the pharmacokinetic parameters were calculated as well. peimine, peiminine and internal standard carbamazepine were extracted from plasma with liquid-liquid extraction by ethyl acetate, then separated on a luna c18 column by using acetonitrile-water containing 10 mmol x l(-1) ammonium formate (35:65), as mobile pha ... | 2010 | 20931788 |
| fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and mapks in mast cells. | fritillaria ussuriensis (fu, derived from the bulbs of various species of the genus fritillaria, including fritillaria thunbergii miq.) is used in herbal medicine to treat conditions such as eczema, skin burns, and frostbite. in this study, we investigated the mechanism of the anti-allergy effect of fu. fu extract (80 mg/kg), orally administered to sprague-dawley (sd) rats, significantly inhibited the passive cutaneous anaphylaxis (pca) reaction. it inhibited the compound 48/80-induced release o ... | 2011 | 21821956 |
| Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract. | A sensitive LC-MS-MS method has been successfully applied to pharmacokinetic study of peimine and peiminine in rat plasma after oral administration of Fritillaria thunbergii Miq. exact and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract. The results indicated that plasma profiles of peimine and peiminine confirmed to two-compartment open model with weighting function of 1/C2 for data fitting and parameter estimation and the utilization with Glycyrrhiza uralensis Fisch. ... | 2011 | 22026124 |
| [effect of compound zhajin granule on toll-like receptor 4 signaling pathway in nonalcoholic steatohepatitis mice]. | to observe the effect of compound zhajin granule (czg) on toll-like re-ceptor 4 (tlr4) signaling pathway in high-fructose corn syrup induced nash mice. | 2016 | 27323620 |
| mechanistic studies of the transport of peimine in the caco-2 cell model. | fritillaria thunbergii miq. has been widely used in traditional chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. moreover, modern pharmacological studies have demonstrated that f. thunbergii miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. the aim of this study was to investigate the intesti ... | 2016 | 27006896 |
| a non-derivative method for the quantitative analysis of isosteroidal alkaloids from fritillaria by high performance liquid chromatography combined with charged aerosol detection. | a non-derivative method was developed for the qualitative and quantitative analysis of isosteroidal alkaloids from fritillaria thunbergii. during method development the performance of two universal detectors, the charged aerosol detector (cad) and evaporative light scattering detector (elsd), were evaluated. the cad was found to be 30 to 55 times more sensitive than elsd enabling the measurement of low levels of reference compound impurities that could not be detected by elsd. the peak area perc ... | 2016 | 26946033 |
| verticine, ebeiedine and suchengbeisine isolated from the bulbs of fritillaria thunbergii miq. inhibited the gene expression and production of muc5ac mucin from human airway epithelial cells. | the bulb of fritillaria thunbergii has been utilised as mucoregulators and expectorants for controlling the airway inflammatory diseases in folk medicine. | 2016 | 26926170 |
| [study on accumulation law of peimine in different fritillaria thunbergii cultivar]. | in order to study the accumulation of fritillaria thunbergii cultivar, peimine content in xiaye, kuanye, duozi and xiaosanzi bulbs of different sizes and parts was determined by hplc-else. the results indicated that the peimine content varied significantly with the cultivar type, the size and part of bulb. the distribution laws of peimine were as follow: xiaosanzi > duozi > xiaye > kuanye, small-size bulb > big-size bulb, core bud > scale. the peimine yield per plant in duozi was the highest. | 2015 | 26084163 |
| [rapid identification of fresh-cut and sulphur fumigation processed fritillaria thunbergii bulb slices based on near-infrared spectroscopy]. | a rapid identification model of the fresh-cut and sulphur fumigation processed fritillaria thunbergii bulb slices was developed by near-infrared spectroscopy (nir) with chemometrics method. | 2014 | 26080499 |
| [differences of fungal diversity and structure in rhizosphere of fritillaria thunbergii from different provenances]. | to explore the mechanism of soil microbial ecology, the differences of fungal diversities in rhizosphere of different provenances of fritillaria thunbergii were analyzed. the diversities and compositions of rhizo-fungi of the samples were analyzed by using dgge and 454 pyrosequencing. dgge results showed the shannon index of ninbo provenance planted in ninbo was the highest one. and its dominant fungi were ascomycota, deuteromycota and zygomycota. except the same fungi, every provenance planted ... | 2014 | 25850257 |
| element analysis and characteristic identification of non-fumigated and sulfur-fumigated fritillaria thunbergii miq. using microwave digestion-inductively coupled plasma atomic emission spectrometry combined with fourier transform infrared spectrometry. | sulfur-fumigation may induce chemical transformation of traditional chinese medicines leading to harmful effects following patient ingestion. for quality control, it is urgently needed to develop a reliable and efficient method for sulfur-fumigation identification. | 2014 | 24914306 |
| [karyotype and pollen morphology of main fritillaria thunbergii cultivars]. | to study the differences in pollen morphology and karyotype among main fritillari thunbergii cultivars. | 2013 | 24422389 |
| [fingerprint analysis of fritillaria thunbergii using rapid resolution liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry]. | a fingerprint method for quality assessment of fritillaria thunbergii was developed by rapid resolution liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (rrlc-q-tof-ms). the separation was performed using agilent eclipse plus c18 column (2.1 mm x 100 mm, 1.8 microm) by gradient elution with acetonitrile and 0.1% formic acid aqueous solution (containing 10 mmol x l(-1) ammonium formate) as the mobile phase. q-tof-ms was used to obtain t ... | 2013 | 24380306 |
| [valuation on analgesic, expectorant and antitussive effects of compatible use of aconiti radix cocta and fritillaria cirrhosa or fritillaria thunbergii]. | to study the analgesic, expectorant and antitussive effects of the compatible use of aconiti radix cocta and fritillaria cirrhosa or f. thunbergii with different matching ratio or dose in mice. | 2013 | 24228591 |
| sex dependent pharmacokinetics, tissue distribution and excretion of peimine and peiminine in rats assessed by liquid chromatography-tandem mass spectrometry. | fritillaria thunbergii miq. has been traditionally used in china as antitussive and expectorant herbs, and newly used in the clinical treatment of leukemia in recent years. | 2013 | 23123795 |
| study on the destructive effect to inherent quality of fritillaria thunbergii miq. (zhebeimu) by sulfur-fumigated process using chromatographic fingerprinting analysis. | the after-harvesting sun-dried processing of fritillariae thunbergii bulbus (zhebeimu) was the traditional treatment for commodity. over recent decades the natural drying process for bulbus of fritillariae has been replaced by sulfur-fumigation for reducing the drying duration and pest control. we used ultra-performance liquid chromatography coupled with evaporative light scattering detection (uplc-elsd) fingerprinting analysis and major alkaloids determination to investigate the potential damag ... | 2012 | 22326548 |
| [analysis of volatile components of flowers of fritillaria thunbergii by gc-tof-ms]. | to determine the structures and contents of the volatile components of flowers of fritillaria thunbergii, and investigate the effects of operation modes on its volatile components. | 2011 | 22242431 |
| differences in soil properties and bacterial communities between the rhizosphere and bulk soil and among different production areas of the medicinal plant fritillaria thunbergii. | to explore rhizosphere effects, geographical differences and their effects on the bacterial community associated with the geoherb fritillaria thunbergii, some physicochemical properties of soil samples (3 sampling sites × 2 habitats (rhizosphere and bulk soil)) were measured and the soil bacterial community detected by pcr-denaturing gradient gel electrophoresis (dgge). among the three regions, soil ph varied between 4.48 and 7.73 indicating that f. thunbergii could grow both in acid and slightl ... | 2011 | 21747705 |
| [determination and comparison of trace elements in four sorts of bulbus fritillariae by microwave digestion-atomic absorption spectrometry]. | the contents of elements such as zn, fe, mn, cu, na, mg, k, ca, as, pb, cd, co, cr, sr, and al in four sorts of bulbus fritillariae, namaly from fritillaria thunbergii miq. (panan and ningbo), fritillaria thunbergii miq. var. chekiangensis hsiao et k. c. hsia and fritillaria cirrhosa d. don, were determined by flame atomic absorption spectrometry (faas) and graphite furnace atomic absorption spectrometry (gfaas) respectively. the effect of different microwave digestion conditions on the analysis ... | 2007 | 18330318 |
| [determination of peimine and peiminine in fritillaria thunbergii by hplc-elsd]. | to determine peimine and peiminine in fritillaria drug simultaneously by rp-hplc-elsd. | 2005 | 16144323 |
| new diterpene isopimara-7,15-dien-19-oic acid and its prolyl endopeptidase inhibitory activity. | the ethanolic extract of the bulbs of fritillaria imperialis was subjected to fractionation by solvent-solvent extraction. the nonpolar fraction showed inhibitory activity against prolyl endopeptidase (pep) (ec.3.4.21.26), a large intracellular enzyme that preferentially hydrolyze proline-containing oligopeptidase at the carboxylic side of a prolyl residue. we have isolated a diterpenoid isopimara-7,15-dien-19-oic acid (1) from the nonpolar fraction of f. imperialis, and on methylation of compou ... | 2005 | 15700640 |
| [sequences of 5s-rrna gene spacer region and comparison of alkaloid content in fritillaria thunbergii from different habitats]. | to study the genetic basis of the formation of indigenous chinese medicine materials. | 2001 | 12587167 |
| [herbological study for the beimu categorical chinese medicine on the original plants]. | this article reports the herbological study of "beimu" categorical chinese medicine on the original plants. the result showed that the medicinal "beimu" before "weijin" period is "jia beimu" (bolbostemma paniculatum); "nenbei" daynasty began to used "zhe beimu" (fritillaria thunbergii), but "jia beimu" and "hubei beimu" (f. hupehensis) occupied an important position continuously; last phase of "ming" dynasty began to used the "zhe beimu" and "chuan beimu" (f. cirrhosa, f. unibracteato, f. przewa ... | 2000 | 12575173 |
| [studies on variations of alkaloids in zhebeimu (fritillaria thunbergii miq.) by improved colormetric determination]. | to find out the seasonal variation of active alkaloids in zhebeimu(f. thunbergii) collected from zhejiang ninbo and jiangsu nantong, and confirm the suitable harvesting time for the crude drug. | 1999 | 12205955 |
| [preliminary analysis and isolation of genomic total dna in fritillaria thunbergii miq]. | genomic total dna of leaf, fresh scale and dry scale in fritillaria thumbergii were isolated by two different methods and analysed by agarose gel electrophoresis. the results show that the dna contents are different under these two isolating methods. two bands besides the band of genomic total dna have been found by electrophoresis, these two bands deserve further study. | 1998 | 11596265 |
| [peroxidase assay over the course of dormancy relieving with low temperature in fritillaria thunbergii miq. by electrophoresis]. | in order to study the physiological basis of dormancy relieving with low temperature in fritillaria thunbergii, isoperoxidase changes of bud, adaxial epiderm and inner tissues in scale were assayed by means of electrophoresis over the course of dormancy relieving. all the patterns in bud and different parts of scale change at different stages, and the peroxidase activity in bud and adaxial epiderm is higher than that in the inner tissue of scale. these results indicate both bud and scale join in ... | 1997 | 11038940 |
| [diastase and reducing sugar in fritillaria thunbergii miq. during the process of dormancy relieving with low temperature]. | the changes of diastase's activity and reducing sugar's content in fritillaria thunbergii were studied during the process of relieving dormancy with low temperature. the results showed that the metabolism in bud and scale was changed, the diastase's activity and reducing sugar's content of the adaxial epiderm were higher than those of the inner store tissue in the scale, but were approximate to those of the bud. | 1997 | 11038911 |
| [changes of soluble protein contents in fritillaria thunbergii miq. over the course of dormancy relieving with low temperature]. | the changes of soluble protein contents in bud, adaxial cortex and inner tissue in the scale of fritillaria thunbergii were assayed over the course of dormancy relieving with low temperature. there was a peak in each of the three diagrams at 25 days or 35 days treated with low temperature. all of the soluble protein contents of bud, adaxial cortex and inner tissue in scale tended to increased in the stage before dormancy relieving. | 1997 | 11038896 |
| [isoesterase assay over the course of dormancy relieving with low temperature in the seed of fritillaria thunbergii miq. by electrophoresis]. | in order to study the physiological basis of dormancy relieving with low temperature in the seed of frit-illaria thunbergii isoesterase patterns were assaved by means of electrophoresis over the courses of dormancy relieving at 8-10 degrees c and 3-5 degrees c. the changes of isoesterase patterns are similar at the two different temperatures. over the courses of dormancy relieving, some new bands are detected and some original bands are enhanced. these results show that the physiological basis m ... | 1997 | 11038883 |
| [electrophoresis assay on isoperoxidase in the course of seed dormancy relieving for fritillaria thunbergii miq. at two different low temperatures]. | the relieving of seed dormancy for fritillaria thunbergii required 50 days at 8-10 degrees c and 80 days at 3-5 degrees c. during the relieving process, isoperoxidase pattern changes were studied by means of electrophoresis. the results showed that some new bands were detected, some original bands enhanced as the seeds were treated with a low temperature, and the changes of lsoperoxidase patterns were similar at two different low temperatures. | 1997 | 11038958 |
| [changes of inorganic elements in senescent scales of fritillaria thumbergii miq. at the late stage]. | by means of inductively coupled plasma-atomic emission spectroscopy (icp-aes), the changes of inorganic elements in the senescent scales of fritillaria thunbergii at the late stage were determined. the results showed that the main trends of the changes of p, s and k were continuously removing, while those of most elements such as al were less removing. the inorganic elements for the growth of new organs were absorbed mainly from soil by the root. | 1996 | 9812690 |
| [a summary of the study on fritillaria thunbergii mig]. | | 1996 | 9388917 |
| [changes of enzymes and proteins in fritillaria thunbergii miq. during the process of exchange between new and old organs]. | | 1996 | 9388930 |
| [preliminary study on physiology and biochemistry in fritillaria thunbergii miq. in the alternate process of new and old organs]. | the changes of weights, various sugars and diastase of the old scale and bud in fritillaria thunbergii were studied in the alternate process of the new and old organs. the results showed that starch was finally disintegrated and inverted to sucrose before being transported to the new organ. | 1995 | 8703333 |
| [collection, evaluation and utilization of local varieties of fritillaria thunbergii miq]. | nine local varieties of fritillaria thunbergii were collected and their plant morphology, phenology, disease resistance yield characters and breeding rate were studied. a new and better variety (duozhi) was found and put to use. | 1993 | 8267852 |
| [chemical constituents of fresh bulbs of fritillaria thunbergii miq]. | | 1993 | 8274214 |
| [studies of several factors bearing on tissue culture of fritillaria thunbergii miq]. | | 1992 | 1301750 |
| [determination of total alkaloid in seedling bulbs of fritillaria thunbergii miq]. | this paper reports the determination of total alkaloid in the seedling bulbs and cultivars of the traditional chinese medicine fritillaria thunbergii. the result shows that the content of total alkaloid reaches the standard value specified in chinese pharmacopeia, and thus is useful for further production of sexual propagation. | 1992 | 1418560 |
| [effect of moisture and temperature on seed viability of fritillaria thunbergii miq]. | this paper deals with the effect of two moisture levels (9.2%, 16.7%) and three temperature levels (15, 25, 35 degrees c) on seed viability of fritillaria thunbergii. the results show that moisture and temperature have significant effects on seed viability. | 1992 | 1418530 |
| [studies on the chemical constituents of fritillaria thunbergii miq. iii. isolation and identification of zhebeinone]. | a new c- nor d-homo steroidal alkaloid named zhebeinone was isolated from the bulbs of fritillaria thunbergii miq. its structure was determined by spectral analyses and chemical conversion as 5 alpha, 14 alpha-cevanine-3 beta, 20 beta-dihydroxy-6-one or c-27 epimer of peiminine. | 1992 | 1442077 |
| [methods of cryopreservation of pollen in fritillaria thunbergii miq]. | the effects of cryomethods, cryoprotectants, pollen age and pollen water content on the viability of pollen in fritillaria thunbergii after cryopreservation were studied. the viability came highest (56.4%) when pollen of the flowering day (20% pollen water content) was treated by step-cooling. hybridization in the fields showed that cryopreserved pollen could go to seed as well. | 1991 | 1910502 |
| [preliminary studies on intervarietal and interspecific hybridization breeding methods of fritillaria thunbergii miq. and its kindred species]. | intervarietal f1 hybrids of fritiliaria thunbergii and interspecific f1 hybrids between f. thunbergii and its kindred species were successfully obtained. the methods of breaking the dormancy of f1 seeds and f1 bulbs were investigated. moreover, the temperature off-season generational advance was preliminarily grouped. | 1991 | 1786092 |
| [determination of seed activity of fritillaria thunbergii miq]. | this paper presents a quantitative determination of the seed activity of fritillaria thunbergii. the result shows that the optical density (o. d.) of highly active seeds is 0.241-0.247, of lowly active seeds is 0.171-0.192 and of inactive seeds is 0.005-0.006. | 1991 | 2069696 |
| [studies on chemical constituents of fritillaria thunbergii miq]. | a new c-nor-d-homosteroidal alkaloid was isolated from the bulbs of fritillaria thunbergii miq. with peimine (i) and peiminine (ii), named zhebeinine (iii), c27h45o3n, mp. 240-242 degrees c. on the basis of the ir, 1hnmr, 13cnmr and ms of zhebeinine (iii), the structure of zhebeinine (iii) has been established as 5 alpha, 14 alpha-cevanine-3 beta, 6 alpha, 20 beta-triol. | 1991 | 1957666 |
| [role of auxin in increasing the output of fritillaria thunbergii miq]. | | 1988 | 3255524 |
| [technic of culturing fritillaria thunbergii]. | | 1987 | 2954697 |
| [biological characteristics of fritillaria thunbergii grown in hubei province]. | | 1986 | 2952358 |
| [study on the sulphur fume processing of bulbus fritillaria thunbergii]. | | 1985 | 2934153 |
| [utilization and culture of fritillaria thunbergii]. | | 1985 | 2931192 |
| [cultivation of medicinal plants. iii. the trial cultivation of fritillaria thunbergii miq]. | | 1974 | 4477500 |