| inhibition of hiv-1 reverse transcriptase and protease by phlorotannins from the brown alga ecklonia cava. | the bioassay-directed isolation of a marine brown alga, ecklonia cava, afforded four phlorotannin derivatives, eckol (1), 8,8'-bieckol (2), 8,4"'-dieckol (3), and phlorofucofuroeckol a (4). among these compounds, 2 and 3 exhibited an inhibitory effect on human immunodeficiency virus type 1 (hiv-1) reverse transcriptase (rt) and protease. specifically, they inhibited the rt more potently than the protease. the inhibitory activity of compound 2 (ic(50), 0.51 microm) against hiv-1 rt was comparable ... | 2004 | 15056863 |
| triphlorethol-a from ecklonia cava protects v79-4 lung fibroblast against hydrogen peroxide induced cell damage. | in the present study, triphlorethol-a, a phlorotannin, was isolated from ecklonia cava and its antioxidant properties were investigated. triphlorethol-a was found to scavenge intracellular reactive oxygen species (ros) and 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, and thus prevented lipid peroxidation. the radical scavenging activity of triphlorethol-a protected the chinese hamster lung fibroblast (v79-4) cells exposed to hydrogen peroxide (h2o2) against cell death, via the activation of erk ... | 2005 | 16036369 |
| improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. | phlorotannins, the polyphonic compounds found in brown eisenia and ecklonia algae, have several pharmacologically beneficial effects such as anti-inflammation. in addition, our recent data show that these compounds may improve the cognitive functions of aged humans suggesting the potential ability to enhance memory in several neurodegenerative disorders. to examine the experimental hypothesis that two effective components of ecklonia cava, dieckol and phlorofucofuroeckol (pff), have memory-enhan ... | 2005 | 16042079 |
| an antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from ecklonia cava. | osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to over-production under undesirable physiological conditions. phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as ... | 2006 | 16526282 |
| phlorotannins in ecklonia cava extract inhibit matrix metalloproteinase activity. | matrix metalloproteinase (mmp) inhibitors have been identified as potential therapeutic candidates for metastasis, arthritis, chronic inflammation and wrinkle formation. for the first time here we report a detailed study on the inhibitory effects of phlorotannins in brown algae, ecklonia cava (ec) on mmp activities in cultured human cell lines. a novel gelatin digestion assay could visualize complete inhibition of bacterial collagenase-1 activity at 20 microg/ml of ec extract during preliminary ... | 2006 | 16737716 |
| the inhibitory effects of eckol and dieckol from ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. | in order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of nf-kappab and ap-1, and mmp-1 expression. the extracts from 3 species of alariaceae, eisenia bicyclis, ecklonia cava and ecklonia stolonifera, have showed strong inhibition of both nf-kappab and ap-1 reporter activity, which were well correlated with their abilities to inhibit mmp-1 expression. in addition, mmp-1 expression was dramatically attenuated by trea ... | 2006 | 16880634 |
| antioxidant and antiinflammatory activities of ventol, a phlorotannin-rich natural agent derived from ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture. | osteoarthritis is thought to be induced by the aging-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as ec ... | 2004 | 17564307 |
| effects of ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: role of suppressor of cytokine signaling. | ecklonia cava (ec) is a brown alga that evidences radical scavenging activity, bactericidal activity, tyrosinase inhibitory activity, and protease inhibitory activity. however, its anti-allergic effects remain poorly understood. in the current study, we attempted to determine whether pretreatment with ec induces a significant inhibition of asthmatic reactions in a mouse asthma model. mice sensitized and challenged with ovalbumin (ova) evidenced typical asthmatic reactions, as follows: an increas ... | 2008 | 17804193 |
| immunomodulatory effects of an enzymatic extract from ecklonia cava on murine splenocytes. | we investigated whether the brown seaweed alariaceae ecklonia cava (e. cava) has immunological effects on splenocytes in vitro. for that purpose, we prepared an enzymatic extract from e. cava (eck) by using the protease, kojizyme. here, eck administered to icr mice dramatically enhanced the proliferation of their splenocytes and increased the number of their lymphocytes, monocytes and granulocytes. in flow cytometry assays performed to identify in detail the specific phenotypes of these prolifer ... | 2008 | 18172723 |
| radioprotective properties of eckol against ionizing radiation in mice. | we have investigated the radioprotective efficacy of eckol, a component of brown seaweed ecklonia cava, against the gamma ray-induced damage in vivo. our results showed that eckol significantly decreased the mortality of lethally irradiated mice. the mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged dna in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. thus, we ... | 2008 | 18294966 |
| modulation of apoptosis of eckol against ionizing radiation in mice. | to investigate the radioprotective potential of eckol, a component of the seaweed ecklonia cava, against radiation in vivo, we evaluated the effect of eckol on cyto- and histo-protective capability of the lymphocytes and intestine against damage induced by a single whole body irradiation (wbi) in vivo. here, we ascertained that eckol protected the lymphocytes' viability and rescued intestinal cells from radiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and bax and increas ... | 2008 | 18522802 |
| inhibitory effects of triphlorethol-a on mmp-1 induced by oxidative stress in human keratinocytes via erk and ap-1 inhibition. | oxidative stress is known to generate reactive oxygen species (ros) in cells, which subsequently induce the synthesis of matrix metalloproteinases (mmp) and an aging phenomenon. the protective effects of triphlorethol-a, derived from ecklonia cava, were investigated against hydrogen peroxide (h(2)o(2))-induced damage using human skin keratinocytes. data showed that triphlorethol-a inhibited ros formation, induced catalase expression, inhibited dna damage, and increased cell viability in keratino ... | 2008 | 18569608 |
| anti-hiv-1 activity of phloroglucinol derivative, 6,6'-bieckol, from ecklonia cava. | ecklonia cava (ec), which is an edible marine brown alga with a broad range of bioactivities, belongs to the family of laminariaceae. the bioactive 6,6'-bieckol, one of the main phloroglucinol derivatives naturally occurred from this genus, was isolated and characterized by nmr techniques. for the first time, human immunodeficiency virus type-1 (hiv-1) inhibitory activity of 6,6'-bieckol showed wild inhibition against hiv-1 induced syncytia formation (ec(50) 1.72 microm), lytic effects (ec(50) 1 ... | 2008 | 18693022 |
| ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in bv2 microglia via the map kinase and nf-kappab pathways. | ecklonia cava (ec) is a brown alga that has demonstrated radical scavenging, bactericidal, tyrosinase inhibitory, and protease inhibitory activities. however, the molecular mechanisms underlying its anti-inflammatory action remain unclear. in the current study, we attempted to determine whether pretreatment with ec induces a significant inhibition of anti-inflammatory activity in lipopolysaccharide (lps)-stimulated murine bv2 microglia. our results indicate that ec inhibits lps-induced nitric ox ... | 2009 | 19111593 |
| ecklonia cava extract suppresses the high-affinity ige receptor, fcepsilonri expression. | basophils and mast cells express fcepsilonri, a high-affinity receptor for ige, on the cell surface and act as effector cells in allergic reactions. in this study, we investigated the inhibitory effect of ecklonia cava (ec) methanolic extract on the expression of fcepsilonri in human basophilic ku812f cells. flow cytometric analysis revealed that ec extract caused a concentration-dependent reduction in the cell surface expression of fcepsilonri. the extract was also capable of reducing the bindi ... | 2009 | 19138721 |
| differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to cox-2, inos, mmps, and mapk signaling: implication for chronic articular disease. | arthritis is one of the most prevalent chronic inflammatory diseases, and it is characterized by structural and biochemical changes in major tissues of the joint, including degradation of the cartilage matrix, insufficient synthesis of extracellular matrix (ecm). ecklonia cava (ec) is a member of the family of laminariaceae, which is an edible marine brown alga with various bioactivities. in this study of the methanol extract of brown alga ec, the dieckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2' ... | 2009 | 19330880 |
| inhibitory effect of phlorotannins isolated from ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse b16f10 melanoma cells. | in this study, to assess the feasibility of phlorotannins isolated from ecklonia cava as an inhibitor of melanin formation, we evaluated its inhibitory effects on mushroom tyrosinase and 3-isobutyl-1-methylxanthine (ibmx)-induced melanin formation inhibitory effects in b16f10 melanoma cell. the ethanolic (etoh) extract and ethyl acetate (etoac) soluble fraction obtained from e. cava evidenced a marked inhibitory effect on mushroom tyrosinase at a concentration of 50 μg/ml. repeated column chroma ... | 2009 | 19361156 |
| induction of apoptosis by phloroglucinol derivative from ecklonia cava in mcf-7 human breast cancer cells. | phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from ecklonia cava. their ability to inhibit the proliferation of human breast cancer cells were evaluated by measuring cell death via induction of apoptosis. compound 1 exerted a higher anti-proliferative activity in human breast cancer cells compared with compound 2. furthermore, compound 1 induced a significant proliferative i ... | 2009 | 19393283 |
| protective effects of dieckol isolated from ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. | the effect of dieckol, one of phlorotannin polyphenol compound purified from ecklonia cava (e. cava) against high glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (huvecs), which is susceptible to oxidative stress. high glucose (30mm) treatment induced huvecs cell death, but dieckol, at concentration 10 or 50microg/ml, significantly inhibited the high glucose-induced cytotoxicity. furthermore, treatment with dieckol dose-dependently decreased thiobar ... | 2010 | 19896528 |
| brown alga ecklonia cava attenuates type 1 diabetes by activating ampk and akt signaling pathways. | the antidiabetic therapeutic effect of ecklonia cava, a brown alga, was investigated using streptozotocin-induced type 1 diabetes mellitus rats and c2c12 myoblasts. the methanol extract of e. cava (ecm), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats. moreover, the elevation of plasma alt in diabetic rats was dramatically restored near to normal range by the treatment of ecm, whereas ast ... | 2010 | 19913068 |
| antibacterial activity of ecklonia cava against methicillin-resistant staphylococcus aureus and salmonella spp. | ecklonia cava is a brown alga (laminariales, phaeophyta) growing on the subtidal rocky shores of korea. it has antioxidant, antidiarrhea, and anticoagulant effects. in this study, the antimicrobial activity of e. cava etoh extract and its fractions (n-hexane, ch2cl2, etoac, n-buoh, and h2o) were investigated against methicillin-resistant staphylococcus aureus and salmonella spp. the e. cava etoac fraction showed good antibacterial activity against all bacteria. eckol isolated from e. cava etoac ... | 2010 | 20001325 |
| inhibition of the expression on mmp-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga ecklonia cava. | matrix metalloproteinases (mmps) are a family of zinc-endopeptidases which can degrade extracellular matrix (ecm) components and play important roles in a variety of biological and pathological processes. 6,6'-bieckol isolated and characterized from an edible marine brown alga ecklonia cava (ec), according to the comprehensive spectral analysis of ms and nmr data. here the influence of 6,6'-bieckol on expressions of mmps was examined by zymography and western blot analysis via human fibrosarcoma ... | 2010 | 20132738 |
| phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo. | exposure of cells to gamma-rays induces the production of reactive oxygen species (ros) that play a main role in ionizing radiation damage. we have investigated the radioprotective effect of phloroglucinol (1,3,5-trihydroxybenzene), phlorotannin compound isolated from ecklonia cava, against gamma-ray radiation-induced oxidative damage in vitro and in vivo. phloroglucinol significantly decreased the level of radiation-induced intracellular ros and damage to cellular components such as the lipid, ... | 2010 | 20188716 |
| protective effects of enzymatic digest from ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. | antioxidants can prevent pathological damage caused by hyperglycaemia-induced oxidative stress associated with diabetes. in the present study, we investigated whether the brown alga ecklonia cava has protective effects against high glucose-induced oxidative stress in human umbilical vein endothelial cells (huvecs). for that purpose, we prepared an enzymatic digest from e. cava (ecc) by using the carbohydrate, celluclast. | 2010 | 20355053 |
| ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells. | ecklonia cava (ec) is a brown alga that evidences radical scavenging, bactericidal, tyrosinase inhibitory and protease inhibitory activities. however, the antiinflammatory effects in human endothelial cells and its molecular mechanism remain poorly understood. in this study, we attempted to determine whether pretreatment with ec extracts induce a significant inhibition of antiinflammatory activities in lipopolysaccharide (lps) induced human endothelial cells. we found that each ec extract inhibi ... | 2010 | 20363280 |
| enzymatic extract from ecklonia cava induces the activation of lymphocytes by il-2 production through the classical nf-κb pathway. | activated nuclear factor-kappa b (nf-κb), a well-known transcription factor, leads to the development, differentiation, and proliferation of t and b lymphocytes and the secretion of cytokines by the classical pathway. we have examined here whether an enzymatic extract (eck) from the brown seaweed, alariaceae laminariales ecklonia cava may contribute to activating lymphocytes through the nf-κb pathway for participation in immune responses. in our study, eck dose-dependently enhanced the prolifera ... | 2011 | 20480199 |
| dieckol isolated from ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. | this study was designed to investigate whether dieckol may inhibit α-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. dieckol isolated from ecklonia cava, brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase. the ic(50) values of dieckol against alpha-glucosidase and alpha-amylase were 0.24 and 0.66 mm, respectively, which evidenced the higher activities than that of acarbose. die ... | 2010 | 20600532 |
| phlorotannins from ecklonia cava (phaeophyceae): biological activities and potential health benefits. | the importance of bioactive derivatives as functional ingredients has been well recognized due to their valuable health beneficial effects. therefore, isolation and characterization of novel functional ingredients with biological activities from seaweeds have gained much attention. ecklonia cava kjellman is an edible seaweed, which has been recognized as a rich source of bioactive derivatives mainly, phlorotannins. these phlorotannins exhibit various beneficial biological activities such as anti ... | 2010 | 20803523 |
| dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. | to evaluate the radioprotective effect of dieckol, a component of the brown algae ecklonia cava. | 2010 | 20883140 |
| influenza virus neuraminidase inhibitory activity of phlorotannins from the edible brown alga ecklonia cava. | influenza a virus infections continue to pose a major threat to humans and several animal species. neuraminidase (na) is one of the most promising targets for the development of drugs against influenza viruses because of its critical role in the viral life cycle. during the course of a search for na inhibitors from edible natural sources, we found that the ethyl acetate layer of ethanol extracts of ecklonia cava showed extremely high na-inhibitory activity (72.1% inhibition at 30 μg/ml). bioacti ... | 2011 | 21585204 |
| dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates mmp-2 and mmp-9 expression via nf-+¦b pathway. | the matrix metalloproteinase (mmp) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. in the present study, dieckol was obtained with high yield from marine brown alga ecklonia cava (ec), and its effect was assessed on the expression of mmp-2 and -9 and morphological changes in human fibrosarcoma cell line (ht1080). dieckol inhibited the expression of mmp-2 and -9 in a dose-de ... | 2011 | 21826183 |
| phloroglucinol (pg) purified from ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes. | phloroglucinol (pg), a polyphenol compound of eckloniacava known as brown algae abundant in jeju island, has been proposed to exert the antioxidative and cytoprotective effects against oxidative stress. in this study, we confirmed that pg protected mice from damages caused by ionizing radiation and investigated its protection mechanism in detail. the result showed that pg increased the viability of splenocytes without cytotoxicity. also, pg significantly enhanced the proliferation of splenocytes ... | 2011 | 21693160 |
| Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity. | In this study, the phlorotannin dieckol, which was isolated from the brown alga Ecklonia cava, was examined for its inhibitory effects on melanin synthesis. Tyrosinase inhibitors are important agents for cosmetic products. We therefore examined the inhibitory effects of dieckol on mushroom tyrosinase and melanin synthesis, and analyzed its binding modes using the crystal structure of Bacillus megaterium tyrosinase (PDB ID: 3NM8). Dieckol inhibited mushroom tyrosinase with an IC(50) of 20µM and w ... | 2012 | 22112542 |
| a polysaccharide isolated from ecklonia cava fermented by lactobacillus brevis inhibits the inflammatory response by suppressing the activation of nuclear factor-κb in lipopolysaccharide-induced raw 264.7 macrophages. | we previously reported that the increment of carbohydrate content in the viscozyme(®) l (novozyme corp., oklahoma city, ok, usa) extract of lactobacillus brevis-fermented ecklonia cava affected the inhibition of nitric oxide (no) production and that it might be related to the polysaccharide compound. however, there is no report of anti-inflammatory effects of the polysaccharide or its biological mechanism. here, we investigated the anti-inflammatory effects of the polysaccharide and its biologic ... | 2011 | 22145773 |
| in vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, propionibacterium acnes. | this study was conducted to evaluate the antimicrobial activities of common seaweeds from the coast of south korea against the etiologic agents of acne vulgaris. fifty-seven species of seaweed were screened for potential antimicrobial activity. methanol extracts of 13 species (22.8%) showed inhibitory effects against propionibacterium acnes. the aqueous extracts of only two species (3.5%) showed antimicrobial activity. when tested with the agar disk diffusion method, ecklonia cava, e. kurome, is ... | 2011 | 22167943 |
| effects of brown alga, ecklonia cava on glucose and lipid metabolism in c57bl/ksj-db/db mice, a model of type 2 diabetes mellitus. | recently, there has been a growing interest in alternative therapies of marine algae for diabetes. therefore, the anti-diabetic effects of brown alga, ecklonia cava was investigated in type 2 diabetic animal. male c57bl/ksj-db/db (db/db) mice were divided into control, dieckol rich extract of e. cava (ag-dieckol), or rosiglitazone (rg) groups. the blood glucose, blood glycosylated hemoglobin levels, and plasma insulin levels were significantly lower in the ag-dieckol and rg groups than in the co ... | 2011 | 22227338 |
| studies on technology for seaweed forest construction and transplanted ecklonia cava growth for an artificial seaweed reef. | we installed seaweed reef for restoration of barron ground coast. we hollowed out a u-shaped groove in a cross-shaped artificial seaweed reef and covered it with a zinc sheet (u-bar) to transplant ecklonia cava growing on dellenia wood by hand, installing the u-bar on the artificial seaweed reef, fixing it with concrete. thus seaweed can be attached easily, with pre-installed stainless bolts and nuts. the length of ecklonia cava leaf transplanted to the cross-shaped reef was 7.2 cm in february 2 ... | 2012 | 23734467 |
| a prebiotic role of ecklonia cava improves the mortality of edwardsiella tarda-infected zebrafish models via regulating the growth of lactic acid bacteria and pathogen bacteria. | in this study, the beneficial prebiotic roles of ecklonia cava (e. cava, ec) were evaluated on the growth of lactic acid bacteria (lab) and pathogen bacteria and the mortality of pathogen-bacteria infected zebrafish model. the result showed that the original e. cava (ec) led to the highest growth effects on three labs (lactobacillus brevis, l. brevis; lactobacillus pentosus, l. pentosus; lactobacillus plantarum; l. plantarum) and it was dose-dependent manners. also, ec, its celluclast enzymatic ... | 2016 | 27192145 |
| a prebiotic effect of ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria. | olive flounder (paralichthys olivaceus), also known as the japanese flounder in japan, is one of the most important commercial marine finfish species cultured in korea and japan. the purpose of this study was to evaluate how a species of brown algae (ecklonia cava, e. cava) affects the growth rate of olive flounder and its immune response to pathogenic bacteria. first, the experimental fish were divided into four groups: the control group was fed the diet containing only 1.0% lactobacillus plant ... | 2016 | 26921543 |
| effects of ecklonia cava as fucoidan-rich algae on growth performance, nutrient digestibility, intestinal morphology and caecal microflora in weanling pigs. | in the present study, role of increasing levels of ecklonia cava (seaweed) supplementation in diets was investigated on growth performance, coefficient of total tract apparent digestibility (cttad) of nutrients, serum immunoglobulins, cecal microflora and intestinal morphology of weanling pigs. | 2017 | 27165019 |
| antimicrobial, antioxidant, and anticancer activities of biosynthesized silver nanoparticles using marine algae ecklonia cava. | green synthesis of silver nanoparticles (agnps) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. in this study, agnps were synthesized by using extracts of marine algae ecklonia cava as reducing and capping agents. the formation of agnps using aqueous extract of ecklonia cava was confirmed visually by color change and their surface plasmon resonance peak at 418 nm, measured by uv-visible spectroscopy. the size, shape, and morphology of the bios ... | 2016 | 28335363 |
| anti-hiv-1 activity of phlorotannin derivative 8,4‴-dieckol from korean brown alga ecklonia cava. | 8,4‴-dieckol is a natural product which has been isolated from brown alga, ecklonia cava. this polyphenolic compound is a phlorotannin derivative with a broad range of bioactivities. its inhibitory activity on human immunodeficiency virus type-1 (hiv-1) was tested and the results indicated that 8,4‴-dieckol inhibited hiv-1 induced syncytia formation, lytic effects, and viral p24 antigen production at noncytotoxic concentrations. furthermore, it was found that 8,4‴-dieckol selectively inhibited t ... | 2014 | 25229850 |
| radio-protective effect of polysaccharides isolated from lactobacillus brevis-fermented ecklonia cava. | we investigated the radioprotective effects of a polysaccharide isolated from enzymatic extracts of ecklonia cava (e. cava) fermented by fungi and bacteria. we identified that the aqueous extract of the lactobacillus brevis-fermented e. cava especially showed the highest proliferation effect. in addition, the enzymatic extract prepared by enzyme-assisted extraction using viscozyme (vlfe) significantly increased cell proliferation. further study indicated that the polysaccharides isolated from th ... | 2013 | 23068138 |
| inhibitory effects of brown algae extracts on histamine production in mackerel muscle via inhibition of growth and histidine decarboxylase activity of morganella morganii. | this study was performed to investigate the inhibitory effects of brown algae extracts on histamine production in mackerel muscle. first, antimicrobial activities of brown algae extracts against morganella morganii were investigated using a disk diffusion method. an ethanol extract of ecklonia cava (ecee) exhibited strong antimicrobial activity. the minimum inhibitory concentration (mic) of ecee was 2 mg/ml. furthermore, the brown algae extracts were examined for their ability to inhibit crude h ... | 2014 | 24394193 |
| in vitro antiviral activity of phlorotannins isolated from ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination. | despite the prepdominat agent causing severe entero-pathogenic diarrhea in swine, there are no effective therapeutical treatment of porcine epidemic diarrhea virus (pedv). in this study, we evaluated the antiviral activity of five phlorotannins isolated from ecklonia cava (e. cava) against pedv. in vitro antiviral activity was tested using two different assay strategies: (1) blockage of the binding of virus to cells (simultaneous-treatment assay) and (2) inhibition of viral replication (post-tre ... | 2013 | 23746631 |
| enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich ecklonia cava extract seanol(®) to endow antibacterial properties and promote mineralization. | hydrogels offer several advantages as biomaterials for bone regeneration, including ease of incorporation of soluble substances such as mineralization-promoting enzymes and antibacterial agents. mineralization with calcium phosphate (cap) increases bioactivity, while antibacterial activity reduces the risk of infection. here, gellan gum (gg) hydrogels were enriched with alkaline phosphatase (alp) and/or seanol(®), a seaweed extract rich in phlorotannins (brown algae-derived polyphenols), to indu ... | 2016 | 27509486 |
| protective effect of the edible brown alga ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | as part of our efforts to isolate anti-hepatotoxic agents from marine natural products, we screened the ability of 14 edible varieties of korean seaweed to protect against doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | 2014 | 24628384 |
| seaweed extracts as a potential tool for the attenuation of oxidative damage in obesity-related pathologies(1). | recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. the exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity-related pathologies. the objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ros) production during the adipogenesis ... | 2011 | 27021984 |
| triphlorethol-a from ecklonia cava up-regulates the oxidant sensitive 8-oxoguanine dna glycosylase 1. | this study investigated the protective mechanisms of triphlorethol-a, isolated from ecklonia cava, against oxidative stress-induced dna base damage, especially 8-oxoguanine (8-oxog), in chinese hamster lung fibroblast v79-4 cells. 8-oxoguanine dna glycosylase-1 (ogg1) plays an important role in the removal of 8-oxog during the cellular response to dna base damage. triphlorethol-a significantly decreased the levels of 8-oxog induced by h2o2, and this correlated with increases in ogg1 mrna and ogg ... | 2014 | 25353254 |
| cytoprotective effects of triphlorethol-a against formaldehyde-induced oxidative damage and apoptosis: role of mitochondria-mediated caspase-dependent pathway. | the toxicity of formaldehyde (hcho) has been attributed to its ability to form adducts with dna and proteins. triphlorethol-a, derived from ecklonia cava, was reported to exert a cytoprotective effect against oxidative stress damage via an antioxidant mechanism. the aim of this study was to examine the mechanisms underlying the triphlorethol-a ability to protect chinese hamster lung fibroblast (v79-4) cells against hcho-induced damage. triphlorethol-a significantly decreased the hcho-induced int ... | 2010 | 20954074 |
| up-regulation of nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of erk and pi3k/akt. | the aim of the present study was to examine the cytoprotective effect of eckol, a phlorotannin found in ecklonia cava and to elucidate underlying mechanisms. heme oxygenase-1 (ho-1) is an important antioxidant enzyme that plays a role in cytoprotection against oxidative stress. eckol-induced ho-1 expression both at the level of mrna and protein in chinese hamster lung fibroblast (v79-4) cells, resulting in increased ho-1 activity. the transcription factor nf-e2-related factor 2 (nrf2) is a criti ... | 2010 | 19931411 |
| eckol isolated from ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. | we have investigated the cytoprotective effect of eckol, which was isolated from ecklonia cava, against oxidative stress induced cell damage in chinese hamster lung fibroblast (v79-4) cells. eckol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, hydrogen peroxide (h(2)o(2)), hydroxy radical, intracellular reactive oxygen species (ros), and thus prevented lipid peroxidation. as a result, eckol reduced h(2)o(2) induced cell death in v79-4 cells. in addition, eckol inhibited cell damage ... | 2005 | 16253238 |
| cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. | we investigated the cytoprotective effect of phloroglucinol, which was isolated from ecklonia cava (brown alga), against oxidative stress induced cell damage in chinese hamster lung fibroblast (v79-4) cells. phloroglucinol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, hydrogen peroxide (h(2)o(2)), hydroxy radical, intracellular reactive oxygen species (ros), and thus prevented lipid peroxidation. as a result, phloroglucinol reduced h(2)o(2) induced apoptotic cells formation ... | 2006 | 16215988 |
| protective effects of phlorotannins against ultraviolet b radiation in zebrafish (danio rerio). | exposure to ultraviolet b (uv-b) radiation has been associated with a variety of adverse effects in all forms of life, including micro-organisms, plants, animals and humans. ultraviolet b induces cell damage at the molecular level and consequently organisms must employ strategies to protect themselves from sunlight and to repair uv-b-induced cellular damage. in this study, the uv-b protective effects of four different phlorotannins isolated from a brown alga (ecklonia cava) were determined using ... | 2012 | 22040269 |
| modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during ndea-induced rat hepatocarcinogenesis. | dieckol (dek) is a major polyphenol of marine brown seaweed ecklonia cava which is a potential candidate for cancer therapy. however, the underlying mechanism of dek as an anticancer drug remains to be elucidated. in this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of dek in n-nitrosodiethylamine (ndea)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (xmes), apoptosis, invasion, and angiogenesis. rats administere ... | 2017 | 28397013 |
| the effect of phloroglucinol, a component of ecklonia cava extract, on hepatic glucose production. | phloroglucinol is a phenolic compound that is one of the major compounds in ecklonia cava (brown alga). it has many pharmacological activities, but its anti-diabetic effect is not yet fully explored. in this study, we investigated the effect of phloroglucinol on the control of blood glucose levels and the regulation of hepatic glucose production. phloroglucinol significantly improved glucose tolerance in male c57bl/6j mice fed a high fat diet (hfd) and inhibited glucose production in mouse prima ... | 2017 | 28379184 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28350055 |
| a phlorotannin constituent of ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | 2,7″-phloroglucinol-6,6'-bieckol is a type of phlorotannin isolated from brown algae, ecklonia cava kjellman (phaeophyceae; laminareaceae). 2,7″-phloroglucinol-6,6'-bieckol mediates antioxidant activities. however, there has been no research on improving postprandial hyperglycaemia using 2,7″-phloroglucinol-6,6'-bieckol. | 2017 | 28219252 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28204815 |
| protective effects of dieckol on n-nitrosodiethylamine induced hepatocarcinogenesis in rats. | dieckol (dek) is a naturally occuring phlorotannins found in marine brown algae ecklonia cava which is attributed with various pharmacological properties. this study was aimed to investigate the protective role of dek on n-nitrosdiethylamine (ndea) induced rat hepatocarcinogenesis. in this investigation 0.01% ndea in drinking water for 15 weeks to induce hepatocellular carcinoma (hcc). dek was administered orally (10, 20 and 40mg/kg body weight) for 15 weeks with 0.01% ndea through drinking wate ... | 2016 | 27825803 |
| dioxinodehydroeckol enhances the differentiation of osteoblasts by regulating the expression of phospho-smad1/5/8. | lack of bone formation-related health problems are a major problem for the aging population in the modern world. as a part of the ongoing trend of developing natural substances that attenuate osteoporotic bone loss conditions, dioxinodehydroeckol (dhe) from edible brown alga ecklonia cava was tested for its effects on osteoblastogenic differentiation in mc3t3-e1 pre-osteoblasts. dhe was observed to successfully enhance osteoblast differentiation, as indicated by elevated cell proliferation, alka ... | 2016 | 27649211 |
| protective effect of a purified polyphenolic extract from ecklonia cava against noise-induced hearing loss: prevention of temporary threshold shift. | noise is one of the most common causes of hearing loss. approximately 16% of american teenagers (12-19 years) have hearing loss caused by loud noise. the implication of noise-induced hearing loss (nihl) in teenagers has received increasing attention. although temporary threshold shift (tts), a type of nihl, is a transient hearing loss, it can accelerate age-related hearing loss. reactive oxygen species are a primary cause of tts. as the polyphenols from ecklonia cava are known to have potent ant ... | 2016 | 27368468 |
| microrna134 mediated upregulation of jnk and downregulation of nfkb signalings are critically involved in dieckol induced antihepatic fibrosis. | though dieckol, a phlorotannin of ecklonia cava, was known to have antioxidant, anticancer, antidiabetic, and anti-inflammatory effects, the underlying antifibrotic mechanism of dieckol still remains unclear until now. thus, in the current study, the inhibitory mechanism of dieckol on liver fibrosis was elucidated mainly in hepatic stellate cells (hscs). dieckol exerted cytotoxicity in lx-2, hsc-t6, and hepg2 cells with the reduced fibrosis features of large, spread out, and flattened polygonal ... | 2016 | 27321552 |
| a molecular investigation of the genus ecklonia (phaeophyceae, laminariales) with special focus on the southern hemisphere. | brown algae of the order laminariales, commonly referred to as kelps, are the largest and most productive primary producers in the coastal inshore environment. the genus ecklonia (lessoniaceae, phaeophyceae) consists of seven species with four species in the northern hemisphere and three in the southern hemisphere. it was recently transferred to the family lessoniaceae based on phylogenetic analyses of nuclear and chloroplastic markers, though the type of the genus was not included and its relat ... | 2015 | 26986519 |
| enhancement of human hair growth using ecklonia cava polyphenols. | ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. e. cava polyphenols (ecps) are known to increase fibroblast survival. the human dermal papilla cell (hdpc) has the properties of mesenchymal-origin fibroblasts. | 2016 | 26848214 |
| protective effect of brown alga phlorotannins against hyper-inflammatory responses in lipopolysaccharide-induced sepsis models. | brown algae have been recognized as a food ingredient and health food supplement in japan and korea, and phlorotannins are unique marine phenol compounds produced exclusively by brown algae. sepsis is a whole-body inflammatory condition with a mortality rate of 30-40%. here, we investigated the effects of a phlorotannin-rich extract of the edible brown alga ecklonia cava against hyper-inflammatory response in lps-induced septic shock mouse model. e. cava extract significantly increased the survi ... | 2016 | 26730445 |
| seapolynol extracted from ecklonia cava inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. | seapolynol (sn) is a polyphenol mixture derived from ecklonia cava. we evaluated the effects of sn on lipid accumulation in adipocytes, zebrafish, and mice. sn effectively inhibited lipid accumulation in three experimental models by suppressing adipogenic factors. triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (dgat1) and gpat3 were also downregulated by sn. this sn-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of sn on early adipo ... | 2015 | 26690099 |
| polyphenol-rich fraction of ecklonia cava improves nonalcoholic fatty liver disease in high fat diet-fed mice. | ecklonia cava (e. cava; ca) is an edible brown alga with beneficial effects in diabetes via regulation of various metabolic processes such as lipogenesis, lipolysis, inflammation, and the antioxidant defense system in liver and adipose tissue. we investigated the effect of the polyphenol-rich fraction of e. cava produced from gijang (g-ca) on nonalcoholic fatty liver disease (nafld) in high-fat diet (hfd)-fed mice. c57bl6 mice were fed a hfd for six weeks and then the hfd group was administered ... | 2015 | 26569269 |
| dioxinodehydroeckol protects human keratinocyte cells from uvb-induced apoptosis modulated by related genes bax/bcl-2 and caspase pathway. | although ultraviolet b (uvb) has a low level of skin penetration, it readily results in epidermal sunburn of keratinocytes that are destined to apoptosis after sun expose, and leads to dna damage. dioxinodehydroeckol (dhe), a phlorotannin from ecklonia cava has been explored for its preventive activity against uvb-induced apoptosis in human keratinocyte (hacat) cells; however, the protective effects of treatment with low doses of dhe on uvb-damaged cells post-uvb exposure and their underlying me ... | 2015 | 26529485 |
| flavobacterium jejuensis sp. nov., isolated from marine brown alga ecklonia cava. | a bacterial strain, designated ec11(t) was isolated from brown alga ecklonia cava collected from jeju island, korea. ec11(t) was identified as a gram-negative, rod-shaped and yellow-pigmented bacterial strain. the strain ec11(t) grew over a temperature range of 10 °c to 30 °c (optimally at 25 °c), and a ph range of 6.0-10.5 (optimally at ph 7.5). phylogenetic analysis based on 16s rrna gene sequences showed that strain ec11(t) belongs to the genus flavobacterium. strain ec11(t) shared close simi ... | 2015 | 26502959 |
| the cytoprotective effects of ethanol extract of ecklonia cava against oxidative stress are associated with upregulation of nrf2-mediated ho-1 and nqo-1 expression through activation of the mapk pathway. | the aim of the present study was to examine the cytoprotective effect of ecklonia cava against oxidative stress in c2c12 myoblasts. the ethanol extract of e. cava (eeec) prevented hydrogen peroxide (h₂o₂)-induced inhibition of the growth of c2c12 myoblasts and exhibited scavenging activity against intracellular reactive oxygen species (ros) induced by h₂o₂. eeec treatment attenuated h2o2-induced comet tail formation and phospho-histone γh2a.x expression. furthermore, eeec treatment enhanced the ... | 2016 | 26492067 |
| evaluation of effective mmp inhibitors from eight different brown algae in human fibrosarcoma ht1080 cells. | matrix metalloproteinases (mmps) are crucial extracellular matrices degrading enzymes that have important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. marine plants are on the rise for their potential to provide natural products that exhibit remarkable health benefits. in this context, brown algae species have been of much interest in the pharmaceutical field with reported instances of isolation of bioactive comp ... | 2015 | 26451351 |
| the anti-aging properties of a human placental hydrolysate combined with dieckol isolated from ecklonia cava. | in the present study, we aimed to examine the anti-aging properties of human placental hydrolysate (hpe) and dieckol (de) from ecklonia cava against free radical scavenging, muscle hypertrophy-related follistatin mrna expression, amelioration of cognition-related genes and proteins, inhibition of collagenase-regulating genes, and elastinase activity. | 2015 | 26438076 |
| a sulfated polysaccharide of ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. | we investigated anticancer effects of the crude polysaccharides (cps) isolated from ecklonia cava enzymatic extracts using amg, viscozyme, protamex, and alcalase enzyme against a colon cancer cell line, ct26 cells. among them, the cp of protamex extract (pcp) contained the highest fucose and sulfated group contents and showed the highest growth inhibitory effect against ct-26 cells. in addition, pcp dose-dependently increased the formation of apoptotic body and the percentage of sub-g1 dna conte ... | 2015 | 26417363 |
| 6,6'-bieckol protects insulinoma cells against high glucose-induced glucotoxicity by reducing oxidative stress and apoptosis. | pancreatic β cells are highly sensitive to oxidative stress, which might play an important role in β cell death in diabetes. the protective effect of 6,6'-bieckol, a phlorotannin polyphenol compound purified from ecklonia cava, against high glucose-induced glucotoxicity was investigated in rat insulinoma cells. high glucose (30 mm) treatment induced the death of rat insulinoma cells, but treatment with 10 or 50 μg/ml 6,6'-bieckol significantly inhibited the high glucose-induced glucotoxicity. fu ... | 2015 | 26343533 |
| phloroglucinol attenuates the cognitive deficits of the 5xfad mouse model of alzheimer's disease. | alzheimer's disease (ad) is the most common form of dementia among the elderly. neuritic plaques whose primary component is amyloid beta peptide (aβ) and neurofibrillary tangles which are composed of hyperphosphorylated tau, are known to be the neuropathological hallmarks of ad. in addition, impaired synaptic plasticity in neuronal networks is thought to be important mechanism underlying for the cognitive deficits observed in ad. although various causative factors, including excitotoxicity, mito ... | 2015 | 26284625 |
| dieckol, a phlorotannin of ecklonia cava, suppresses ige-mediated mast cell activation and passive cutaneous anaphylactic reaction. | | 2015 | 26194398 |
| ecklonia cava polyphenol has a protective effect against ethanol-induced liver injury in a cyclic amp-dependent manner. | previously, we showed that ecklonia cava polyphenol (ecp) treatment suppressed ethanol-induced increases in hepatocyte death by scavenging intracellular reactive oxygen species (ros) and maintaining intracellular glutathione levels. here, we examined the effects of ecp on the activities of alcohol-metabolizing enzymes and their regulating mechanisms in ethanol-treated hepatocytes. isolated hepatocytes were incubated with or without 100 mm ethanol. ecp was dissolved in dimethylsulfoxide. ecp was ... | 2015 | 26096275 |
| dieckol, a component of ecklonia cava, suppresses the production of mdc/ccl22 via down-regulating stat1 pathway in interferon-γ stimulated hacat human keratinocytes. | macrophage-derived chemokine, c-c motif chemokine 22 (mdc/ccl22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. serum and skin mdc/ccl22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. a major signaling pathway in the interferon-γ (ifn-γ)-stimulated inflammation response involves ... | 2015 | 25995822 |
| winogradskyella eckloniae sp. nov., a marine bacterium isolated from the brown alga ecklonia cava. | a novel bacterial strain, designated ec29(t), was isolated from the brown alga ecklonia cava collected on jeju island, republic of korea. cells of strain ec29(t) were gram-stain-negative, aerobic, rod-shaped and motile by gliding. growth was observed at 10-30 °c (optimum, 20-25 °c), at ph 6.0-9.5 (optimum, ph 7.5) and in the presence of 1-5% (w/v) nacl. phylogenetic analyses based on the 16s rrna gene sequence revealed that the strain belonged to the genus winogradskyella. strain ec29(t) exhibit ... | 2015 | 25979633 |
| dieckol attenuates microglia-mediated neuronal cell death via erk, akt and nadph oxidase-mediated pathways. | excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. thus, the regulation of microglial activation has been evaluated as effective therapeutic strategies. although dieckol (dek), one of the phlorotannins isolated from marine brown alga ecklonia cava, has been previously reported to inhibit microglial activation, the molecu ... | 2015 | 25954126 |
| dieckol, a major phlorotannin in ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: inhibition of early adipogenesis via cell-cycle arrest and ampkα activation. | dieckol is a major polyphenol of ecklonia cava. this study demonstrates a mechanistic role for dieckol in the suppression of lipid accumulation using three models. | 2015 | 25944759 |
| first evidence that ecklonia cava-derived dieckol attenuates mcf-7 human breast carcinoma cell migration. | we investigated the effect of ecklonia cava (e. cava)-derived dieckol on movement behavior and the expression of migration-related genes in mcf-7 human breast cancer cell. phlorotannins (e.g., dieckol, 6,6'-biecko, and 2,7″-phloroglucinol-6,6'-bieckol) were purified from e. cava by using centrifugal partition chromatography. among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. radius™-well was used to assess cell migration, and ... | 2015 | 25830682 |
| phlorofucofuroeckol a isolated from ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | this study was designed to investigate whether phlorofucofuroeckol a inhibited α-glucosidase and α-amylase activities and alleviated postprandial hyperglycemia in diabetic mice. phlorofucofuroeckol a that was isolated from ecklonia cava (brown algae) demonstrated prominent inhibitory effects against α-glucosidase and α-amylase activities. the ic50 values of phlorofucofuroeckol a against α-glucosidase and α-amylase were 19.52 and 6.34μm, respectively. these inhibitory activities of phlorofucofuro ... | 2015 | 25680946 |
| multifunctional activity of polyphenolic compounds associated with a potential for alzheimer's disease therapy from ecklonia cava. | five polyphenols were isolated and purified from a brown alga ecklonia cava. these compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. this led us to investigate the potential of these compounds as alzheimer's disease drugs. all of the compounds showed moderate acetylcholinesterase inhibitory activity in a micromolar range (ic50 from 16.0 to 96.3 μm). for butyrylcholinesterase, a new target for the treatment of alzheimer's dis ... | 2015 | 25640212 |
| projecting the impacts of rising seawater temperatures on the distribution of seaweeds around japan under multiple climate change scenarios. | seaweed beds play a key role in providing essential habitats and energy to coastal areas, with enhancements in productivity and biodiversity and benefits to human societies. however, the spatial extent of seaweed beds around japan has decreased due to coastal reclamation, water quality changes, rising water temperatures, and heavy grazing by herbivores. using monthly mean sea surface temperature (sst) data from 1960 to 2099 and sst-based indices, we quantitatively evaluated the effects of warmin ... | 2015 | 25628878 |
| efficacy and safety of a dieckol-rich extract (ag-dieckol) of brown algae, ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. | the effects of 12 weeks of supplementation with a dieckol-rich extract (ag-dieckol) from brown algae, ecklonia cava, on glycemic parameters, serum biochemistry, and hematology were investigated in this study. eighty pre-diabetic male and female adults were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. subjects were randomly allocated into two groups designated as placebo and ag-dieckol (1500 mg per day). compared with the placebo group, the ag-dieck ... | 2015 | 25608849 |
| dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation. | in the current study it was found that dieckol isolated from edible brown algae, ecklonia cava (ec), as potent anti-proliferative and anti-angiogenic agent. vascular endothelial growth factor (vegf) induced ea.hy926 cell proliferation was suppressed by dieckol treatment. further, it showed a significant inhibition of cell migration via inhibiting the protein and gene expression levels of matrix metalloproteinases, mmp-2 and -9. the signaling cascade underlying these responses was found as the di ... | 2015 | 25531264 |
| brown alga ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of ampk and sirt1 in high-fat diet-induced obese mice. | obesity is considered to be a metaflammatory condition. ecklonia cava, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. this study investigated the effect of e. cava polyphenol extract (ecpe) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. after obesity was induced by a high-fat diet (hfd), the mice were administered ecpe by gavage for 5 days/12 weeks. ecpe supplementation reduced body weig ... | 2015 | 25479240 |
| brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity. | the clinical application of cisplatin is limited due to its drug resistance and side effects. we investigated the effect of a phlorotannin-rich extract from the edible brown alga ecklonia cava (prec) and its major phlorotannin (dieckol) on cisplatin responsiveness and side effects. | 2015 | 25462204 |
| effect of baechu kimchi added ecklonia cava extracts on high glucose-induced oxidative stress in human umbilical vein endothelial cells. | endothelial cell dysfunction is considered to be a major cause of vascular complications in diabetes. in the present study, we investigated the protective effect of a baechu kimchi added ecklonia cava extract (bke) against high glucose induced oxidative damage in human umbilical vein endothelial cells (huvecs). treatment with a high concentration of glucose (30 mm) induced cytotoxicity, whereas treatment with bke protected huvecs from high glucose induced damage; by restoring cell viability. in ... | 2014 | 25320714 |
| 8,8'-bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of nf-κb signaling and ros production in lps-stimulated macrophages. | ecklonia cava (e. cava) is an abundant brown alga that contains high levels of phlorotannins, which are unique marine polyphenolic compounds. it has been suggested that e. cava phlorotannins exert anti-inflammatory effects. however, the anti-inflammatory effects and underlying molecular mechanism exerted by 8,8'-bieckol isolated from e. cava have not been reported. thus, in this study, we examined the anti-inflammatory effects of 8,8'-bieckol on lipopolysaccharide (lps)-stimulated primary macrop ... | 2014 | 25261704 |
| dieckol, isolated from the edible brown algae ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth. | ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. however, the anticancer effects of dieckol, a major active compound in e. cava, are poorly understood. in the present study, we investigated the anti-tumor activity of dieckol and its molecular mechanism in ovarian cancer cells and in a xenograft mouse model . | 2015 | 25216701 |
| fucodiphlorethol g purified from ecklonia cava suppresses ultraviolet b radiation-induced oxidative stress and cellular damage. | fucodiphlorethol g (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from ecklonia cava, a brown alga that is widely distributed offshore of jeju island. this study investigated the protective effects of fucodiphlorethol g against oxidative damage-mediated apoptosis induced by ultraviolet b (uvb) irradiation. fucodiphlorethol g attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in ... | 2014 | 25143808 |
| 6,6'-bieckol isolated from ecklonia cava protects oxidative stress through inhibiting expression of ros and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells. | hyperglycemia-induced oxidative stress accelerates endothelial cell dysfunctions, which cause various complications of diabetes. the protective effects of 6,6'-bieckol (bek), one of phlorotannin compound purified from ecklonia cava against high-glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (huvecs), which is susceptible to oxidative stress. high glucose (30 mm) treatment induced huvecs' cell death, but bek, at concentration 10 or 50 μg/ml, signifi ... | 2014 | 25086922 |
| comparison of ecklonia cava, ecklonia stolonifera and eisenia bicyclis for phlorotannin extraction. | phlorotannins are polyphenols of marine algae, particularly brown seaweed, having multiple biological activities. a reverse phase-high performance liquid chromatography method was developed for rapid and routine quantification of two major phlorotannins, dieckol and phlorofucofuroeckol-a (pfe-a), from boiling water- and organic solvent-extracts of brown seaweeds ecklonia cava, e. stolonifera and eisenia bicyclis. the regression equations for dieckol and pfe-a were as follows: the concentration ( ... | 2014 | 25004758 |
| the edible brown seaweed ecklonia cava reduces hypersensitivity in postoperative and neuropathic pain models in rats. | the current study was designed to investigate whether edible brown seaweed ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (sni) rats. to evaluate pain-related behavior, we performed the mechanical withdrawal threshold (mwt) and thermal hypersensitivity tests measured by von frey filaments and a hot/cold plate analgesia meter. pain-related behavior was also determined through analysis of ultrasonic vocalization. the results of experiments showed mwt ... | 2014 | 24918539 |
| enrichment and purification of marine polyphenol phlorotannins using macroporous adsorption resins. | phlorotannins are one of the most important bioactive polyphenols; however, their purification using chromatographic methods has not been explored. here, we studied purification of phlorotannins from the crude phlorotannin extract (cphe) of the brown seaweed ecklonia cava using macroporous adsorption resins. for purification of phlorotannins, four resins (hp-20, sp-850, xad-7hp, and xad-2) were screened. among them, hp-20 resin showed the highest adsorption and desorption capacities. in static a ... | 2014 | 24874368 |
| antioxidant marine algae phlorotannins and radioprotection: a review of experimental evidence. | radiation has been widely used for cancer therapy in human medicine. however, the side effects of radiation are problematic and can limit its application. radiation generates reactive oxygen species, leading to cell death via multiple signaling pathways. the blocking of certain signaling cascades using antioxidants represents a compensatory therapy of radiation-induced tissue injury. although synthetic chemicals have been investigated in recent decades, anti-oxidants from natural resources have ... | 2014 | 24751171 |
| suppression of nf-κb by dieckol extracted from ecklonia cava negatively regulates lps induction of inducible nitric oxide synthase gene. | dieckol, extracted from brown algae, ecklonia cava, is suggested to elicit anti-inflammatory or anti-tumorigenic activities. however, dieckol-mediated regulatory mechanism for inflammatory response still remains elusive. here, we show that dieckol suppressed lipopolysaccharide (lps)-induced inducible nitric oxide synthase (inos) expression in mouse leukemic macrophage raw264.7 cells. also, dieckol decreased lps-induced both nitric oxide (no) production and inos promoter-driven transcriptional ac ... | 2014 | 24744158 |