| mycetoma in somalia - results of a survey done from 1959 to 1964. | the pasteur institute studied 103 mycetoma patients in somalia between 1959 and 1964. grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 madurella mycetomi, 1 leptosphaeria senegalensis, 7 pyrenochaeta romeroi (or madurella grisea), 3 allescheria boydii, 1 fusarium sp., 3 neotestudina (zopfia) rosatii, and 1 unidentified; 34 were actinomycetes: 24 streptomyces somaliensis, 4 actinomadura madurae, 3 a. pelletieri and 3 nocardi ... | 1977 | 23657 |
| histological and histochemical study of grain of madurella mycetomi. | | 1975 | 127013 |
| preliminary investigation of the use of the enzyme linked immunosorbent assay (elisa) in the serodiagnosis of mycetoma. | antibody levels in a small group of sudanese patients with clinically diagnosed mycetoma, and control groups were measured by countercurrent immunoelectrophoresis (cie) and enzyme linked immunosorbent assay (elisa). antigens were prepared from the following organisms: streptomyces somaliensis, actinomadura madurae, a. pelletieri, nocardia brasiliensis and madurella mycetomi. positive reactions were obtained in clinical cases against the homologous antigens in both cie and elisa; all heterologous ... | 1978 | 360443 |
| mycetomas in madras. | in 90 of 150 cases clinically diagnosed as mycetoma in the department of pathology, madras medical college, from january 1964 to june 1975, histopathological study revealed granules. besides special staining procedures, cultural methods were undertaken in recent cases. the age and sex incidence, site of lesion and the species of fungi identified on the basis of histological morphology of the granules are analysed. the disease was predominatly seen in the age group 21-40. men were more frequently ... | 1977 | 558655 |
| experimental infection of athymic nude new zealand mice, nu nu strain with mycetoma agents. | experiments with athymic nude mice "nu nu" strain showed grains of madurella mycetomi as early as 9 days, and they were well developed by 21 days, after inoculation. grains were similar to those of humans, in pigment production and tissue reaction. | 1978 | 568319 |
| black grain mycetoma: the ultrastructure of madurella mycetomi. | madurella mycetomi, the fungus pathogen of black grain mycetoma, shows an elaborate development of mesosomes as its most striking ultrastructural feature. these occur in addition to mitochondria and endoplasmic reticulum. condensations of hyphal cytoplasm and recurring intrahyphal growth of new hyphal cells are features of the pigment-producing and pathogenic phases of the organism. the abundant pigment which histochemically resembled melanin was not traceable to any ultrastructural granule, nor ... | 1979 | 571961 |
| mycetomas in north india. | of 60 clinically suspected cases of mycetoma, 20 were confirmed by cultural and histopathological methods. the feet were found to be affected in 70% of the cases. the age group most affected by the disease was 20-40 years. men were involved in 18 while females were affected in 2 cases only. actinomycetomas (70%) were found more often than eumycetomas (30%). nocardia species were identified in 35% of cases and madurella mycetomi in 25%. there were four cases (20%) where the etiological agents cou ... | 1979 | 575236 |
| black grain mycetoma. atomic absorption and spark source mass spectrophotometry of the tissue grain in madurella mycetomi infection. | the tissue grain of madurella mycetomi infection shows a spread of mineral constituents which is somewhat higher than the known values for the dermis, but differs little in relative concentrations. the unique physical resistance of the grain cannot be related to departures in concentration of calcium or of trace elements. our earlier hypothesis of a tanned protein structure for the grain therefore still holds (findlay & vismer, 1974). | 1977 | 588463 |
| [tropic-subtropic fungus infections in germany]. | observations by the author and other workers on exotic mycoses in germany are used in order to establish several groups of patients. the following mycoses from tropical and subtropical areas and their causative agents are mentioned: tinea nigra (cladosporium werneckii), south american blastomycosis (paracoccidioides brasiliensis), coccidioidomycosis (coccidioides immitis), histoplasmosis (histoplasma capsulatum), mycetoma (madurella mycetomi), dermatophytosis/tinea capitis (trichophyton soudanen ... | 1978 | 627480 |
| medical management of mycetoma. | a number of drugs and drug combinations were tested both in vitro and in vivo against pathogens causing actinomycetoma and maduromycetoma. of 144 patients with actinomycetoma treated, 63.2% were cured, 21.5% showed great improvement in their condition, and 11.1% showed some improvement. treatment was successful even when there was advanced bone involvement. the most effective treatments involved dapsone plus streptomycin sulfate or sulfamethoxazole-trimethoprim plus streptomycin. sulfadoxine-pyr ... | 1976 | 1088110 |
| [mycetoma in mauritania: species found, epidemiologic characteristics and country distribution. report of 122 cases]. | a two year investigation conducted at nouakchott's centre hospitalier national supplied 122 histologically confirmed cases of mycetoma. 75% of those were of mycotic origin, of which the most common species was madurella mycetomatis. the mean ages were 28 to 29 years at the beginning of the disease and 38 years at the time of examination. the duration of the evolution was between 6.3 and 8.4 years. madurella mycetomatis seem to appear at a lower age (mean age beginning at 21.2 years, consultation ... | 1992 | 1327344 |
| [black-grain eumycetoma due to madurella grisea. a report of 2 cases]. | two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. both proceeded from the state of bahia (brazil), and in both the etiologic agent was madurella grisea mackinnon et al., 1949. the grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. it is the author's belief that these observations correspond to the 7th and 8th cases reported in the brazilian medical literature. the authors do consider the following madure ... | 1992 | 1342127 |
| [mycetoma with black granules: first case in a native of israel]. | we present a case of black grain mycetoma caused by madurella mycetomatis. the diagnosis was made on the basis of conventional light microscopy and mycological studies. after 12 months of oral therapy with ketoconazole, the patient showed partial response. this is the first native israeli case of black grain mycetoma. | 1992 | 1506204 |
| viability of fungal cultures maintained at -70 degrees c. | one thousand four hundred forty-seven clinical and environmental isolates of molds, yeasts, aerobic actinomycetes, and algae belonging to 164 genera (382 taxa) maintained on potato dextrose agar at -70 degrees c for periods ranging from 6 months to 13 years were subcultured and then incubated at 25 degrees c to determine their viabilities. thirty-three isolates, alternaria alternata (n = 1), apophysomyces elegans (n = 1), bipolaris spicifera (n = 1), blastomyces dermatitidis (n = 4), cokeromyces ... | 1992 | 1572955 |
| black grain eumycetoma (madurella mycetomatis) in the abdominal cavity of a dog. | a uterine stump granuloma was surgically removed from a sterilized bitch. histopathology and fungal culture revealed madurella mycetomatis eumycetoma. infection may have occurred through a cesarean wound dehiscence. long-term fluconazole therapy was instituted but failed to arrest and eliminate the infection. | 1991 | 1890565 |
| an evaluation of straw-extract agar media for the growth and sporulation of madurella mycetomatis. | four new media, namely wheat straw extract agar, bajra straw extract agar, jowar straw extract agar and paddy straw extract agar, were evaluated for their potential to stimulate the growth and sporulation of madurella mycetomatis in comparison with the conventional sabouraud dextrose agar and soil extract agar. vegetative growth of m. mycetomatis on the four types of straw extract agars was superior to that obtained on sabouraud dextrose agar. isolates of m. mycetomatis sporulated better and fas ... | 1991 | 1922269 |
| ultrastructural and immunogenic changes in the formation of mycetoma grains. | the differences in the fine structure and antigenic determinants of mycetoma fungi in the mycelial phase in vitro and in grains in vivo facilitate an interpretation of grain formation. aggregates of hyphal elements with multiple and thickened walls was a feature of the fungi in vivo. associated with hyphal wall material, numerous polysaccharide microfibrils were detected in grains of madurella mycetomatis. these were not seen associated with hyphal elements in vitro and it is suggested that thes ... | 1987 | 2437279 |
| humoral immune responses to mycetoma organisms: characterization of specific antibodies by the use of enzyme-linked immunosorbent assay and immunoblotting. | levels of antibodies were determined by enzyme-linked immunosorbent assay (elisa) in 13 patients with eumycetomas due to madurella mycetomatis infections. raised levels of specific igm were observed in 12 patients, compared with normal human controls. by contrast, low levels of specific igg were detected in some patients. specific responses to separated protein antigens were investigated by immunoblotting. of 10 patients' sera tested, igm in 2 recognized up to 7 of the blotted antigens between 4 ... | 1988 | 2476875 |
| studies on antigens from agents causing black grain eumycetoma. | culture filtrate and cellular antigens prepared from 14 agents which cause black grain eumycetoma were compared by double diffusion and immunoelectrophoresis. the fungal agents studied included five isolates of madurella grisea, two of madurella mycetomatis and a single isolate each of pyrenochaeta mackinnonii, pyrenochaeta romeroi, chaetosphaeronema (pseudochaetosphaeronema) larense, plenodomus avramii, phoma/phyllosticta, aureobasidium (exophiala) mansonii and leptosphaeria senegalensis. cross ... | 1989 | 2513382 |
| progressive destructive mycetoma caused by madurella mycetomi. | | 1988 | 2899292 |
| mycetoma in the republic of niger: clinical features and epidemiology. | mycetoma is a common disease in the republic of niger. in two hospitals 133 cases were observed. the major site of lesions was the foot. actinomycetomata were seen more often than eumycetomata. streptomyces somaliensis is prevalent in the north desert zone while actinomadura pelletieri is common in the southern part of the country. madurella mycetomatis, the usual etiologic agent of eumycetoma, is seen in both regions. the species incidence and distribution in niger differs from those of the wes ... | 1988 | 3354772 |
| mycetoma in saudi arabia. | the clinical and microbiological features of 31 cases of mycetoma seen in 8 years at a riyadh hospital are described. eighteen were due to streptomyces somaliensis, 10 to madurella mycetomatis and one each to actinomadura madurae, nocardia asteroides, and an unidentified species of cladosporium. no immune defects were detected in the patients. eleven had osteolytic lesions and 17 required surgery. only seven patients were cured. streptomyces infections were seen from all parts of saudi arabia ou ... | 1987 | 3550122 |
| leucocyte chemotaxis to mycetoma agents--the effect of the antifungal drugs griseofulvin and ketoconazole. | polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: madurella mycetomatis and pseudallescheria boydii, both fungi, and streptomyces somaliensis, an actinomycete. there was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leu ... | 1987 | 3617197 |
| [epidemiologic study of mycetomas in mexico. apropos of 502 cases]. | the epidemiological data of 502 mycetomas studied in the department of mycology, "centro dermatológico pascua", mexico city, were analysed. mycetomas prevail in males (79.7%), they are more frequent between 16 and 45 years of age (75%) and among rural workers (62.5%); they preferentially affect lower limbs (62.5%); these data are generally similar to the known publications on the matter. actinomycetomas are the most frequent with 97.2% of the cases, distributed as follows: nocardia: 85.6% among ... | 1987 | 3621395 |
| [mycotic mycetoma (eumycetoma) caused by madurella mycetomi]. | mycotic mycetoma is a chronic, granulomatous and fistulous tropical disease caused by hyphomycetes of different families. a case caused by madurella mycetomi is presented and the diagnostic and therapeutic possibilities discussed. | 1985 | 4040129 |
| [63 cases of mycetoma in the niger republic (etiological study based on histopathology)]. | 63 samples of mycetomas were examined between 1981 and 1984. most of them (53 cases) were actinomycotic mycetomas of which 20 were due to streptomyces somaliensis, 17 to actinomadura pelletieri, 11 to nocardia sp., 4 to actinomadura madurae. the 11 mycotic mycetomas were all due to madurella mycetomi (= m. mycetomatis). | 1985 | 4085097 |
| black grain mycetoma. a study of the chemistry, formation and significance of the tissue grain in madurella mycetomi infection. | | 1974 | 4139964 |
| attempts to induce mycetoma in monkeys and mice using madurella mycetomi. | | 1974 | 4211819 |
| madurella mycetomi as a cause of maduromycosis in egypt. clinical and mycopathological studies of two cases. | | 1974 | 4474964 |
| invasion of paranasal sinuses by madurella mycetomi in a congolese child. | | 1971 | 5105901 |
| [mycetoma caused by madurella mycetomi localized in the big toe]. | | 1969 | 5393685 |
| [candida guilliermondii as an accompanying germ of madurella mycetomi. settling of yeast colonies in the depressions of the uneven black mycetoma plaques]. | | 1970 | 5464088 |
| [3 further rumanian cases of madura foot. incriminated agents: nocardia asteroides, cephalosporium falciforme and madurella mycetomi]. | | 1968 | 5690853 |
| isolation of madurella mycetomi from soil in india. | | 1968 | 5690929 |
| [experimental granules of maduromycosis and actinomycosis from cephalosporium falciforme, monosporium apiospermum, madurella mycetomi, and nocardia asteroides]. | | 1967 | 6069556 |
| maduromycosis (madurella mycetomatis) in a horse. | a case of maduromycosis mycetoma caused by madurella mycetomatis is reported. the horse presented with multiple subcutaneous swelling over the right scapula. there were no discharging fistulae present. macroscopically the lesion contained a black granular material embedded in a granulomatous mass. microscopically large numbers of microcolonies were present containing segmented hyphae. no typical chlamydospores were observed. cultures yielded a fungus identified as madurella mycetomatis. treatmen ... | 1984 | 6492057 |
| an ultrastructural study of pale eumycetoma grains. | the electron microscopic appearances of grains from seven patients with pale grain eumycetoma infections have been studied. the infecting fungi were pseudallescheria boydii (2), fusarium sp. (1), acremonium kiliense (1), a non-sporing mould (2) and trichophyton violaceum (1). p. boydii grown in vitro and grains from a madurella mycetomatis infection were used for comparison. the most important ultrastructural features of the pale eumycetoma grains were the gross thickening of the fungal cell wal ... | 1983 | 6686344 |
| [mycetomas originated from south-east bulgaria (author's transl)]. | according to investigations by the author, bulgaria occupies a major position by the number of mycomas in european countries with temperate climate and small area. from 18 cases of mycomas, 10 cases, whom 7 were maduromycetomas or eumycetomas, originated from south-east bulgaria, near black sea and asia minor, with warm and dry climate. this confirms that the climate has a definite influence on the disease. 6 maduromycetomas with black granules were caused by madurella mycetomi and the only whit ... | 1980 | 7194618 |
| [mycetoma: attempt at intra-arterial management]. | a 28 year old african student had acquired a mycetoma of his left foot after an injury in 1975. as the surgical and antimycotic therapy had no effect, he was brought to düsseldorf for the amputation of his foot. madurella mycetomi was isolated from the skin, pus and bone. before the amputation was made a last attempt to treat him with the antimycotic agent miconasol nitrate, administered intraarterially through the arteria tibialis posterior, which had been shown i arteriography to perfuse the w ... | 1981 | 7196393 |
| [madurella mycetomi maduromycosis]. | | 1981 | 7258991 |
| development of maduromycosis (madurella mycetomi) after nailing of a closed tibial fracture: a case report. | maduromycosis is a rare fungal infection in the northern united states, most frequently caused by allescheria boydii, usually in debilitated or immunosuppressed patients. an 18-year-old mexican-american, in excellent health, developed multiple draining sinuses at the sites of insertion of ender nails for a closed tibial fracture. madurella mycetomi was cultured from black granules in a biopsy specimen. the source of fungal infection remained unknown, although it probably did not occur during the ... | 1981 | 7471560 |
| studies on siderophore production and effect of iron deprivation on the outer membrane proteins of madurella mycetomatis. | the purpose of this investigation was to determine whether madurella mycetomatis, the most frequent agent of eumycotic mycetomas, produces siderophores and synthesizes new outer membrane proteins under iron-starvation conditions. siderophore production, only of the hydroxamate type, was demonstrated in all nine strains tested. it was regulated by extracellular iron concentrations. under iron-restricted conditions, m. mycetomatis expressed various outer membrane iron-regulated proteins, particula ... | 1995 | 7549767 |
| the host tissue reaction to madurella mycetomatis: new classification. | in this prospective study, three types of tissue reaction to mycetoma grains are described. type i reaction is characterized by the adherence of neutrophils to the surface of the grain leading to its disintegration. in type ii reaction, the fragmented grain and the dead neutrophils are cleared by macrophages and multinucleated giant cells, while in type iii reaction there is a discrete well developed epithelioid granuloma with langhans's giant cells. the three types of reaction are usually seen ... | 1995 | 7650573 |
| treatment of tropical mycoses. | several subcutaneous and deep-seated mycoses are either observed more frequently in the tropical areas or are restricted to certain regions within the tropics. these mycoses include sporotichosis, chromoblastomycosis, entomophthoromycosis, eumycetoma, lobomycosis, and paracoccidioidomycosis. in sporotrichosis and paracoccidioidomycosis, therapy often results in either complete resolution or marked improvement. for decades sporotrichosis has been treated successfully with potassium iodide, but re ... | 1994 | 8077517 |
| treatment of eumycetoma with ketoconazole. | ten patients with eumycetoma were treated with oral ketoconazole in the dosage of 400mg/day for 8 to 24 months. in eight cases the foot was affected: four were due to madurella mycetomatis and one each due to m grisea, pyrenochaeta romeroi, acremonium kiliense and a falciorme. one mycetoma which affected the back and perineum was due to a kiliense, and one case presented with multiple sebaceous cysts and the scalp and m mycetomatis was isolated from the lesion. clinical and laboratory tests show ... | 1993 | 8240184 |
| microbiological study of mycetoma patients from bombay with special reference to actinomyces immunofluorescence. | 17 of the 21 clinically diagnosed mycetoma and actinomycosis cases studied yielded positive cultures. foot, leg, inguinal region, chest wall, jaw and scalp were the affected sites. 15 of the patients were from bombay, 13 of them had infection due to nocardia species and 2 had actinomyces israelii infection. the other two patients from south india had madurella mycetomi infection. n.brasiliensis was commonest isolate (8). other isolates were n.asteroides (2), n.pelletieri (2), n.caviae (1) and a. ... | 1993 | 8300170 |
| mycetomas in northern yemen: identification of causative organisms and epidemiologic considerations. | fifteen cases of mycetomas from four locations in northern yemen were studied. on the basis of morphologic characteristics and staining properties of the granules in discharges from the draining sinus tracts (a narrow elongated cavity that extends from a focus of suppuration or other inflammatory softening to a free surface and through which pus discharges) in the affected appendages and in tissue sections, three causative organisms were identified: streptomyces somaliensis, actinomadura madurae ... | 1993 | 8333574 |
| mycetoma: a retrospective study of 41 cases seen in são paulo, brazil, from 1978 to 1989. | clinical and epidemiological aspects of 41 cases of mycetoma seen in são paulo city from january 1978 to december 1989 are presented. twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. in only 22 (78%) actinomycetoma cases was it possible to identify the agent. nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. among eumycetomata, madurella grisea was isolated from 3 cases, scedosporium apiospermum from 2 ... | 1993 | 8366881 |
| antimycotic susceptibility testing of agents of black grain eumycetoma. | antimycotic susceptibility testing of 17 strains of eumycetes including madurella mycetomatis, madurella grisea, pyrenochaeta romeroi, exophiala jeanselmei and leptosphaeria tompkinsii, isolated from cases of black grain mycetoma, was carried out against ketoconazole, itraconazole, miconazole and econazole by broth microdilution and agar dilution methods. itraconazole and ketoconazole were more active inhibiting 50% of the strains (mic 50) at 0.5 and 1 microgram ml-1 and 90% (mic 90) at 2.5 and ... | 1993 | 8389847 |
| [mycetoma of the neck and the nape of the neck due to madurella mycetomatis. apropos of a case in mauritania]. | fungous mycetoma of the nape of the neck due to madurella mycetomatis is an unusual localisation (four cases in mondial literature) and severe affection. this reports deals with a case occurred after traumatism. despite five months of itraconazole and chirurgical treatment, the therapeutic escape was evident. | 1995 | 8555761 |
| mycetomas in mali: causative agents and geographic distribution. | although mali is situated in the african zone endemic for mycetomas, no report has been published on the characteristics of the disease in this country. we report a series of 54 cases observed in bamako. the causative agents were madurella mycetomatis in 20 patients, leptosphaeria sp. in one patients, actinomadura madurae in 12 patients, a. pelletieri in 15 patients, and streptomyces somaliensis in three patients. in this series, the observed geographic distribution of the causative agents was i ... | 1996 | 8651376 |
| mycetoma. | mycetoma is a chronic infectious disease, most commonly caused by madurella mycetomatis, that remains localized, involves cutaneous and subcutaneous tissue, fascia, and bone, and is noncontagious. the disease is characterized by tumefaction, draining sinuses, and the presence of sclerotia. the 31 fungi known to cause mycetoma are associated with soil and woody plants. a chronic, tumor-like deforming disease develops during subsequent years following the introduction of the etiologic agent via lo ... | 1996 | 8821162 |
| internal fistula formation: an unusual complication of mycetoma. | this paper reports 2 hitherto undescribed complications of mycetoma, urinary extravasation and expectoration of mycetoma grains due to cutaneo-urethral and cutaneo-pleuro-bronchial fistulae, respectively. the first patient had an infection with actinomadura madurae which started in the foot and had spread progressively to involve the whole limb, anterior abdominal wall, perineum and urethra. the second patient had madurella mycetomatis infection of the hand and, in spite of extensive treatment, ... | 1996 | 8944271 |
| immunoglobulin profile in mycetoma. | serum samples obtained from 25 patients of mycetoma caused by madurella mycetomi in 18, streptomyces somaliensis in 5, streptomyces madurae and streptomyces palletierii from 1 each and also from 25 healthy controls were evaluated for immunoglobulins igg, igm and iga by radial immunodiffusion method using tripartigen plates. all the three classes of immunoglobulins showed increased concentration in cases of mycetoma by m. mycetomi and s. pelletierii. the raised levels of igg and igm in cases of m ... | 1996 | 8972149 |
| intraspinal mycetoma: report of two cases. | two cases of intraspinal mycetoma caused by madurella mycetomatis and streptomyces somaliensis presenting with paraplegia are reported. in these cases, there was neither skin or bone involvement by the disease. the route of entry of the organisms is not known; however, hematogenous blood vessel invasion by s. somaliensis was identified in the second case. | 1997 | 9063356 |
| clinical cure of fungal madura foot with oral itraconazole. | we report the case of a 26-year-old malian patient who presented with mycetoma of the foot and frank bone involvement caused by madurella mycetomatis. long-term itraconazole therapy was clinically effective and well tolerated. | 1997 | 9347233 |
| cystic mycetoma: an unusual clinical presentation of madurella mycetomatis infection. | | 1998 | 9692156 |
| antimicrobial activity of some 1,2-benzisothiazoles having a benzenesulfonamide moiety. | some sulfonamide and sulfonylurea derivatives of unsubstituted and 5-methylsubstituted 1,2-benzisothiazole were studied in vitro for their antimicrobial properties against bacteria and fungi. compounds 7 and 8 exhibited good antibacterial activity against gram positive bacteria. a strong synergism was observed when their growth-inhibitory effect was assayed in combination with trimethoprim by using bacillus subtilis and staphylococcus aureus as test microorganisms. the antimycotic action of benz ... | 1998 | 9713255 |
| nocardia, nocardiosis and mycetoma. | the recent emergence of invasive infections due to nocardia spp., including nosocomial outbreak, is now evident. newer molecular diagnostic and typing methods are developed. although sulfonamide-based therapy is generally effective, optimal treatment may be guided by antimicrobial susceptibility testing of isolates. the improved classification of nocardiae and other related genera such as actinomadurae, using the 16s ribosomal rna sequencing, provide a sound basis for improved diagnostic methods ... | 1998 | 9988489 |
| development of a species-specific pcr-restriction fragment length polymorphism analysis procedure for identification of madurella mycetomatis. | madurella mycetomatis is the commonest cause of eumycetoma in sudan and other countries in tropical africa. currently, the early diagnosis of mycetoma is difficult. in attempting to improve the identification of m. mycetomatis and, consequently, the diagnosis of mycetoma, we have developed specific oligonucleotide primers based on the sequence of the internal transcribed spacer (its) regions spacing the genes encoding the fungal ribosomal rnas. the its regions were amplified with universal prime ... | 1999 | 10488173 |
| potential utility of random amplified polymorphic dna (rapd) and restriction endonuclease assay (rea) as typing systems for madurella mycetomatis. | two molecular methods were compared, random amplified polymorphic dna (rapd) and restriction endonuclease analysis (rea), in order to evaluate their ability to discriminate, and to characterize madurella mycetomatis strains isolated from human mycetomas in different parts of the world. both methods were able to cluster the madurella mycetomatis isolates into the same number of distinct typing groups. however, rapd, presenting several advantages over rea such as its rapidity, simplicity, and the ... | 2000 | 10568795 |
| madura's foot: report of a case caused by madurella mycetomatis. | we present a case of mycetoma by madurella mycetomatis on the foot of a chinese young man, living in italy for more than ten years. clinically the lesion closely resembled and was initially misinterpreted as a vascular neoformation. we analyze the histological and morphological features of the madurella mycetomatis infection through which we managed to type the etiological agent. our case is worth reporting because of the rarity of this disease in europe and the unusual clinical presentation. it ... | 2000 | 11125328 |
| atypical presentation of madurella mycetomatis mycetoma in a renal transplant patient. | a renal transplant patient presented with a swelling on his foot. fungal hyphae were found in the abscess, and culture demonstrated madurella mycetomatis, an agent of mycetoma. there were no black grains in the pus and no overlying sinuses. this was an atypical presentation of maduromycosis in a renal transplant patient. | 2000 | 11429018 |
| environmental occurrence of madurella mycetomatis, the major agent of human eumycetoma in sudan. | madurella mycetomatis is the main causative agent of human eumycetoma, a severe debilitating disease endemic in sudan. it has been suggested that eumycetoma has a soil-borne or thorn prick-mediated origin. for this reason, efforts were undertaken to culture m. mycetomatis from soil samples (n = 43) and thorn collections (n = 35) derived from areas in which it is endemic. however, ribosomal sequencing data revealed that the black fungi obtained all belonged to other fungal species. in addition, w ... | 2002 | 11880433 |
| eumycetoma due to madurella mycetomatis acquired in jamaica. | we report a case of eumycetoma due to madurella mycetomatis affecting the left dorsal forefoot in a 35-year-old woman. she had spent her childhood in jamaica, and had been resident in the u.k. for 20 years prior to her presentation. she gave a highly suggestive history for a mycetoma, having observed the intermittent discharge of black grains from the lesion. the diagnosis was confirmed by histological and mycological analysis of the grains, and a magnetic resonance imaging scan excluded osteomy ... | 2001 | 11899126 |
| mycetoma in yemen: clinicoepidemiologic and histopathologic study. | mycetoma is widespread in yemen, but has not been fully documented. | 2002 | 12358829 |
| [mycetoma: 130 cases]. | mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. it follows penetrating injury inoculating soil organisms, occurring preferentially in rural areas usually among labourers who work barefoot. mycetoma is a localized chronic, and deforming infectious disease of subcutaneous tissues, skin and bones. we report 130 cases of mycetoma in senegal from 1983 to 2000. | 2003 | 12605151 |
| a murine model of madurella mycetomatis eumycetoma. | eumycetoma due to madurella mycetomatis is a major mycological health problem in endemic areas. we infected balb/c mice (male or female) with various amounts of m. mycetomatis mycelium, containing sterilized soil as a natural adjuvant or freund's incomplete adjuvant. mice differed with respect to age and immune status. intraperitoneal, subcutaneous and intravenous inoculation was explored and survival was monitored. mice were killed at various intervals after inoculation, checked for the presenc ... | 2003 | 12770757 |
| [mycetomas in central tunisia]. | mycetomas are inflammatory pseudo-tumors containing fungal or actinomycosic-type grains. they are frequent in tropical and subtropical countries and unknown in tunisia. | 2003 | 12843827 |
| branched filaments no fungus, ovoid bodies no bacteria: two unusual cases of mycetoma. | we describe a 58-year-old man presenting with necrotizing panniculitis of the lower right leg and a 64-year-old woman with a clinically similar lesion combined with pustular eruptions and subsequent ulceration on the forehead. in the first patient, giemsa staining showed small ovoid bodies and grocott staining revealed hyphae. histology from the process on the forehead showed branched filaments in the periodic acid-schiff (pas) staining. in the first case, madurella mycetomatis, a fungus, was th ... | 2003 | 12894113 |
| isolation and identification of madurella mycetomatis from two cases of black grain mycetoma in libya. | two cases of mycetoma of the foot caused by madurella mycetomatis are reported in which identification of the etiologic agents was confirmed by culture. a libyan male aged 40 years and a chadian female aged 30 years, exhibited eumycetoma of the foot 1 and 2 years, respectively, after a local injury. the diagnoses were based on the clinical presentation and confirmed by mycologic analysis of the grains and culture isolation of the etiologic agent. prior to this report m. mycetomatis has not been ... | 2003 | 12950906 |
| [observations on two cases of maduromycosis of foot and hand respectively, caused by madurella mycetomi]. | | 1956 | 13359323 |
| [mycetoma of the foot caused by madurella mycetomi in venezuela]. | | 1956 | 13462037 |
| report of a case of black grain maduromycosis of the foot caused by an aberrant strain of madurella mycetomi (laveran) brumpt on curacao, netherlands antilles. | | 1957 | 13504111 |
| [the phialides and phialospores produced by madurella mycetomi]. | | 1958 | 13561648 |
| skin sensitivity to madurella mycetomi in guineapigs. | | 1961 | 13727018 |
| mycetoma pedis due to madurella mycetomi. | | 1965 | 14329502 |
| [madura foot due to maduromyces (madurella mycetomi) (non-suppurative form)]. | | 1965 | 14335376 |
| experimental infection of mice with madurella mycetomi. | | 1960 | 14425433 |
| [coexistence of "madurella mycetomi" and "madurella grisea" in the same case of black-grain maduromycosis]. | | 1962 | 14479920 |
| madurella mycetomatis strains from mycetoma lesions in sudanese patients are clonal. | molecular diversity among clinical isolates of madurella mycetomatis, the prime fungal agent of human mycetoma in sudan, could possibly explain the diverse clinical presentations of this severely debilitating infectious disease. in addition, culture-independent dna-mediated typing tests need to be developed for this organism, since m. mycetomatis dna, but not the organism itself, can be identified in soil, the material from which infections are thought to originate. a collection of 38 different ... | 2003 | 14532179 |
| molecular detection and identification of agents of eumycetoma: detailed report of two cases. | we describe two cases of eumycetoma in the legs. the infections could not be adequately diagnosed by classical mycology, but the causative agents were successfully identified as madurella mycetomatis by species-specific pcr and dna sequencing. | 2003 | 14662990 |
| [management of mycetoma in west-africa]. | mycetoma is still endemic in the northern areas of west-africa. this infection is more common in males, rural inhabitants, between 20 and 40 years of age. mycetoma is generally easy to identify on clinical presentation, it is a chronic subcutaneous inflammatory tumor with discharging sinuses. the commonest affected site is the foot (70%), leg, knee, thigh, hand and arm are the most frequent extrapodal localizations. diagnosis must be confirmed by the presence of grains at direct and histological ... | 2003 | 15015843 |
| phylogeny and typification of madurella mycetomatis, with a comparison of other agents of eumycetoma. | the genus madurella, described for non-sporulating agents of human mycetoma, is proven to be heterogeneous on the basis of rdna small subunit (ssu) and internal transcribed spacer (its) sequencing data. madurella mycetomatis, the main agent of mycetoma in arid zones of central and east africa, probably belongs to the ascomycete order sordariales. madurella mycetomatis, the generic type species, is neotypified. madurella grisea, with worldwide occurrence, is likely to be a member of the order ple ... | 2004 | 15078428 |
| in vitro activity of anidulafungin against selected clinically important mold isolates. | in this study, we evaluated the in vitro activity of anidulafungin against selected mold isolates. anidulafungin showed promising activity against bipolaris spicifera, exophiala jeanselmei, fonsecaea pedrosoi, madurella mycetomatis, penicillium marneffei, phialophora verrucosa, pseudallescheria boydii, sporothrix schenckii, and wangiella dermatitidis. | 2004 | 15105159 |
| in vitro susceptibilities of madurella mycetomatis to itraconazole and amphotericin b assessed by a modified nccls method and a viability-based 2,3-bis(2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino)carbonyl]-2h-tetrazolium hydroxide (xtt) assay. | susceptibilities of madurella mycetomatis against amphotericin b and itraconazole in vitro were determined by protocols based on nccls guidelines (visual reading) and a 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2h-tetrazolium hydroxide (xtt) assay for fungal viability. the xtt assay was reproducible and sensitive for both antifungals. itraconazole (mic at which 50% of the isolates tested are inhibited [mic(50)]) of 0.06 to 0.13 mg/liter) was superior to amphotericin b ... | 2004 | 15215141 |
| mycetoma caused by madurella mycetomatis: a neglected infectious burden. | tropical eumycetoma is frequently caused by the fungus madurella mycetomatis. the disease is characterised by extensive subcutaneous masses, usually with sinuses draining pus, blood, and fungal grains. the disease affects individuals of all ages, although disability is most severe in adults who work outdoors. compared with major diseases such as tuberculosis, malaria, and hiv, disease from m mycetomatis is underestimated but socioeconomically important. many scientific case reports on mycetoma e ... | 2004 | 15336224 |
| [madurella mycetomatis antigen for the serodiagnosis of mycetoma]. | the aim of this work was to standardize metabolic and cytoplasmic madurella mycetomatis antigen to be applied in the immunodiagnosis of mycetoma. growth curves were established growing the mold in two broth media with weekly measures of protein and carbohydrate levels and of dry weight. sera from immunized rabbits and patient's sera were used in immunoprecipitation to test the antigens. three weeks old shaken cultures in sabouraud broth at 37 degrees c were established as the optimal conditions ... | 1997 | 15482023 |
| testing of the in vitro susceptibilities of madurella mycetomatis to six antifungal agents by using the sensititre system in comparison with a viability-based 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5- [(phenylamino)carbonyl]-2h-tetrazolium hydroxide (xtt) assay and a modified nccls method. | the in vitro susceptibilities of 36 clinical isolates of madurella mycetomatis, the prime agent of eumycetoma in africa, to ketoconazole, itraconazole, fluconazole, voriconazole, amphotericin b, and flucytosine were determined by the sensititre yeastone system. this system appeared to be a rapid and easy test, and by use of hyphal suspensions it generated results comparable to those of a modified nccls method. after 10 days of incubation, the antifungal activities of ketoconazole (mic at which 9 ... | 2005 | 15793113 |
| madurella mycetomatis mycetoma treated successfully with oral voriconazole. | | 2005 | 15888176 |
| genotyping of madurella mycetomatis by selective amplification of restriction fragments (amplified fragment length polymorphism) and subtype correlation with geographical origin and lesion size. | one of the causative organisms of mycetoma is the fungus madurella mycetomatis. previously, extensive molecular typing studies identified sudanese isolates of this fungus as clonal, but polymorphic genetic markers have not yet been identified. here, we report on the selective amplification of restriction fragment (aflp) analysis of 37 sudanese clinical isolates of m. mycetomatis. of 93 aflp fragments generated, 25 were polymorphic, and 12 of these 25 polymorphic fragments were found in a large f ... | 2005 | 16145076 |
| [clinical and microbiological study of mycetomas at the muñiz hospital of buenos aires between 1989 and 2004]. | this work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the muñiz hospital from 1989 to 2004. forty-nine patients were male and 27 female; the mean age was 43.4 years. the majority of the patients acquired the infection in argentina: the most affected provinces were santiago del estero with 31 cases, and chaco with 11; 8 cases came from other countries (bolivia 6 and paraguay 2). the mean evolution of the disease was 9.2 years. the most frequent ... | 2006 | 16784127 |
| translationally controlled tumor protein from madurella mycetomatis, a marker for tumorous mycetoma progression. | about 40 years ago abs against the fungus madurella mycetomatis were first demonstrated to be present in eumycetoma patients, a disease characterized by tumorous swellings. to date nothing is known about the individual immunoreactive ags present in this fungus. in the present study, we identify its first immunogenic ag, a protein homologous to the translationally controlled tumor protein (tctp), a well-conserved histamine release factor in a range of eukaryotes. the gene for this ag was demonstr ... | 2006 | 16849514 |
| molecular identification of black-grain mycetoma agents. | black-grain mycetomas are subcutaneous devastating chronic infections due to several dematiaceous fungi. they are diagnosed mostly in tropical countries. identification of these fungi with standard mycological procedures is difficult because of their poor or delayed sporulation. the aim of this study was thus to assess the accuracy of molecular identification of these fungi. a total of 54 strains, mostly of clinical origin, were used, including 15 madurella mycetomatis, 6 madurella grisea, 12 le ... | 2006 | 17021076 |
| mycetoma in children: experience with 15 cases. | mycetoma is a chronic infection caused by aerobic actinomycetes and filamentous fungi. it is an occupational disease frequent in tropical countries and is uncommon in children. | 2007 | 17195706 |
| in vitro susceptibility of madurella mycetomatis, prime agent of madura foot, to tea tree oil and artemisinin. | eumycetoma caused by madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. these agents are toxic, and new therapies are required. | 2007 | 17324961 |
| abdominal wall mycetoma presented as obstructed incisional hernia of cesarean section in eastern sudan. | mycetoma a worldwide disease frequently occurs in the tropics with the highest prevalence being in africa. madurella mycetomatis is the main causative organism of human eumycetoma in sudan. the legs and feet were commonly the sites of the infection. a 22-year-old lady was presented with painful abdominal swelling around a previous caesarian section scar. a provisional diagnosis of obstructed incisional hernia was put. histopathological examination revealed macroscopically four masses of soft tis ... | 2009 | 17485822 |
| madurella mycetomatis compounds cross-reactive with galactomannan are detectable in culture supernatant but not in serum. | | 2007 | 17510278 |
| melanin biosynthesis in madurella mycetomatis and its effect on susceptibility to itraconazole and ketoconazole. | one of the hallmarks of eumycetoma is the formation of fungal grains, which are secreted by multiple sinuses in infected tissues. madurella mycetomatis grains are black. this black colour was shown to be due to the presence of melanin. melanin can be produced through various biochemical pathways. it appeared that m. mycetomatis melanisation could be blocked by inhibitors of the pyo- and dihydroxynaphthalene (dhn)-melanin pathways but not by inhibitors of the dihydroxyphenylalanine (l-dopa)-melan ... | 2007 | 17644456 |
| [eumycetic mycetoma due to madurella mycetomatis. report of six cases.]. | we report six cases of mycetoma due to madurella mycetomatis. five men and a woman from 28 to 70 years of age, and a history of one to ten years. in four of them the foot was affected, in another the wrist, and one exceptional case with neck involvement after an iguana bite. the response to treatment was irregular and not satisfactory. | 1998 | 17655418 |