| an experimental subunit vaccine based on bluetongue virus 4 vp2 protein fused to an antigen-presenting cells single chain antibody elicits cellular and humoral immune responses in cattle, guinea pigs and ifnar(-/-) mice. | bluetongue virus (btv), the causative agent of bluetongue disease (bt) in domestic and wild ruminants, is worldwide distributed. a total of 27 serotypes have been described so far, and several outbreaks have been reported. vaccination is critical for controlling the spread of btv. in the last years, subunit vaccines, viral vector vaccines and reverse genetic-based vaccines have emerged as new alternatives to conventional ones. in this study, we developed an experimental subunit vaccine against b ... | 2015 | 25858859 |