Publications

identification of the bacterial symbiont entotheonella sp. in the mesohyl of the marine sponge discodermia sp.	the lithistid sponge discodermia dissoluta (family theonellidae), is found in deep-waters throughout the caribbean sea and is the source of discodermolide, a natural product with potential anticancer properties, and other secondary metabolites. as with other sponges, large numbers of microbes are harbored in the sponge mesohyl. the microbial population of the sponge mesohyl shows an abundance of large filamentous microbes. fractionation of the dissociated sponge allowed enrichment of this microb ...	2008	18256706
metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge discodermia dissoluta.	sponge-associated bacteria are thought to produce many novel bioactive compounds, including polyketides. pcr amplification of ketosynthase domains of type i modular polyketide synthases (pks) from the microbial community of the marine sponge discodermia dissoluta revealed great diversity and a novel group of sponge-specific pks ketosynthase domains. metagenomic libraries totaling more than four gigabases of bacterial genomes associated with this sponge were screened for type i modular pks gene c ...	2005	16085882