| [investigation on echinococcosis in animals in gannan tibetan autonomous prefecture]. | to make an investigation on echinococcosis among animals in gannan tibetan autonomous prefecture. | 2009 | 19459495 |
| [regional genotyping and the geographical distribution regarding yersinia pestis isolates in china]. | to type yersinia (y.) pestis isolates under different regions (dfr) and to observe their geographical distributions in china. | 2014 | 25376688 |
| primary case of human pneumonic plague occurring in a himalayan marmot natural focus area gansu province, china. | a case of primary pneumonic plague (ppp) caused by yersinia pestis is reported. this case occurred in the largest plague area in china. the patient died after contact with a dog that had captured an infected marmot. three of 151 contacts were shown to be positive for antibody against f1 antigen by indirect hemagglutination assay, but none had clinical symptoms. there was no secondary case. | 2015 | 25555623 |
| [study of the plasmid profiles and geographical distribution of yersinia pestis in china]. | to analyze the plasmid features and geographical distribution characteristics of yersinia pestis of different plague foci in china. | 2015 | 25876488 |
| mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). | plague, a yersinia pestis infection, is a fatal disease with tremendous transmission capacity. however, the mechanism of how the pathogen stays in a reservoir, circulates and then re-emerges is an enigma. | 2017 | 28257423 |
| a novel hepatovirus identified in wild woodchuck marmota himalayana. | hepatitis a virus (hav) is a hepatotropic picornavirus that causes acute liver disease worldwide. here, we report on the identification of a novel hepatovirus tentatively named marmota himalayana hepatovirus (mhhav) in wild woodchucks (marmota himalayana) in china. the genomic and molecular characterization of mhhav indicated that it is most closely related genetically to hav. mhhav has wide tissue distribution but shows tropism for the liver. the virus is morphologically and structurally simila ... | 2016 | 26924426 |
| transcriptome analysis and comparison of marmota monax and marmota himalayana. | the eastern woodchuck (marmota monax) is a classical animal model for studying hepatitis b virus (hbv) infection and hepatocellular carcinoma (hcc) in humans. recently, we found that marmota himalayana, an asian animal species closely related to marmota monax, is susceptible to woodchuck hepatitis virus (whv) infection and can be used as a new mammalian model for hbv infection. however, the lack of genomic sequence information of both marmota models strongly limited their application breadth and ... | 2016 | 27806133 |
| helicobacter himalayensis sp. nov. isolated from gastric mucosa of marmota himalayana. | a gram-stain-negative, microaerophilic strain, 80(ys1)t, with a spiral-shaped morphology and 1-2 sheathed flagella at each end of the cells was isolated from the gastric mucosa of marmota himalayana, the animal reservoir of yersinia pestis in china, on the qinghai-tibet plateau. the strain grew at 30, 35 and 42 °c, but not at 25 °c. growth was in the form of a thinly spreading film on brain heart infusion agar containing 8 % sheep blood under microaerobic conditions. the strain did not hydrolyse ... | 2015 | 25736414 |
| the other helicobacters. | in the past year, a substantial number of (putative) novel helicobacter species have been described, including helicobacter himalayensis colonizing the himalayan marmot and helicobacter apodemus, colonizing the korean striped field mouse. in addition, a putative novel gastric helicobacter species was identified in wild gorillas and chimpanzees, for which the name "candidatus h. homininae" was proposed. a high incidence of gastric non-h. pylori helicobacter infection was described in china and mu ... | 2015 | 26372827 |
| insights into the evolution of pathogenicity of escherichia coli from genomic analysis of intestinal e. coli of marmota himalayana in qinghai-tibet plateau of china. | escherichia coli is both of a widespread harmless gut commensal and a versatile pathogen of humans. domestic animals are a well-known reservoir for pathogenic e. coli. however, studies of e. coli populations from wild animals that have been separated from human activities had been very limited. here we obtained 580 isolates from intestinal contents of 116 wild marmot marmota himalayana from qinghai-tibet plateau, china, with five isolates per animal. we selected 125 (hereinafter referred to as s ... | 2016 | 27924811 |
| escherichia marmotae sp. nov., isolated from faeces of marmota himalayana. | the taxonomic position of a group of seven closely related lactose-negative enterobacterial strains, which were isolated from fresh faecal samples of marmota himalayana collected from the qinghai-tibetan plateau, china, was determined by using a polyphasic approach. cells were gram-reaction-negative, non-sporulating, non-motile, short rods (0.5-1 × 1-2.5 μm). by 16s rrna gene sequences, the representative strain, ht073016(t), showed highest similarity values with escherichia fergusonii atcc 3546 ... | 2015 | 25851592 |
| evaluation of mitochondrial toxicity in marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis b virus. | metacavir (pna) is a novel synthetic nucleoside analogue for the treatment of hepatitis b virus (hbv). our recent studies showed that pna, a prodrug of 2',3'-dideoxyguanosine (ddg), exhibited lower mitochondrial toxicity in long-term cultures of hepg2 cells. in the current study, we examined the long-term effects of pna on mitochondrial toxicity in marmota himalayana (himalayan marmot). himalayan marmots were treated daily with oral pna (50 or 100 mg/kg), ziduvidine (azt) (100 mg/kg), or water ( ... | 2011 | 21282436 |
| [food habits and hunting patterns of tibetan brown bear during warm seasons in kekexili region on qinghai-tibetan plateau]. | tibetan brown bear (ursus arctos pruinosus) is an endemic subspecies of brown bear on the qinghai-tibetan plateau. we once reported a preliminary study on the summer food habit of tibetan brown bear from july to august, 2005 in the kekexili (hoh xil).. however, the hunting modes of the tibetan brawn bear have not been reported. from july to august, 2009, we collected additional data on food habits and hunting patterns of tibetan brown bear in the kekexili region. we found tibetan brown bears are ... | 2010 | 21174359 |
| establishing a new animal model for hepadnaviral infection: susceptibility of chinese marmota-species to woodchuck hepatitis virus infection. | hepatitis b virus infection (hbv) is a major medical problem in china. the lack of a suitable infection model in china is recognized as an obstacle for research on hbv in china. chinese marmota-species is phylogenetically closely related to marmota monax, thus, it might be suitable to serve as an animal model for hbv infection. therefore, we attempted to prove the claim about the existence of woodchuck hepatitis virus (whv)-like viruses in chinese marmota-species and to determine the susceptibil ... | 2010 | 21084496 |
| [study on the natural foci of marmota himalayana plague in sichuan province]. | to explore the existence of natural foci on marmota himalayana plague in sichuan province and to provide basis for prevention and control of the disease. | 2009 | 19957628 |
| the interferon-alpha gene family of marmota himalayana, a chinese marmot species with susceptibility to woodchuck hepatitis virus infection. | the interferon-alpha (ifn-alpha) gene family is an important part of the immune system. recombinant interferon-alpha is widely used to treat viral hepatitis and malignant diseases. marmota himalayana has been found to be susceptible to woodchuck hepatitis virus, a virus genetically related to hepatitis b virus (hbv), and is suitable as an animal model for studies on hbv infection. here, the ifn-alpha gene family of m. himalayana (cwifn-alpha) was characterized. sequence data indicate that the cw ... | 2008 | 17936902 |
| [study on the genotyping and microevolution of yersinia pestis in the qinghai-tibet plateau]. | to study the distribution of genomovars and microevolution of yersinia pestis in the qinghai-tibet plateau. | 2006 | 16981338 |
| [expression of interferon alpha family gene of chinese marmot in eukaryotic and prokaryotic cells]. | to investigate the function of interferon alpha (ifnalpha) in a chinese marmot model of hepatitis b, we expressed the chinese marmot (marmota himalayana) ifnalpha family gene (ifna) in eukaryotic cells and prokaryotic cells. | 2006 | 16494783 |
| karyotypic evolution of the family sciuridae: inferences from the genome organizations of ground squirrels. | cross-species chromosome painting has made a great contribution to our understanding of the evolution of karyotypes and genome organizations of mammals. several recent papers of comparative painting between tree and flying squirrels have shed some light on the evolution of the family sciuridae and the order rodentia. in the present study we have extended the comparative painting to the himalayan marmot (marmotahimalayana) and the african ground squirrel (xerus cf. erythropus), i.e. representativ ... | 2006 | 16484783 |
| [the 102 kb pigmentation (pgm) locus of yersinia pestis isolated from microtus brandti]. | to find out the differences between 102 kb pgm locus of yersinia pestis isolated from microtus brandti with of other types, and the characters of yersinia pestis isolated from microtus brandti caused by their makeup of the 102 kb pgm locus. | 2003 | 12820948 |
| streptococcus halotolerans sp. nov. isolated from the respiratory tract of marmota himalayana in qinghai-tibet plateau of china. | two gramstaining-positive, catalase-negative, α-hemolytic, coccus-shaped organisms were isolated separately from the respiratory tracts of two marmota himalayana animals from the qinghai-tibet plateau, pr china. morphological, biological, biochemical, and molecular genetic studies were performed on these two isolates (hts9t and hts12). their biochemical characteristics, such as acid production from different sugars and enzymatic activities, indicated that they represented a member of the genus s ... | 2016 | 27469933 |
| streptococcus himalayensis sp. nov., isolated from the respiratory tract of marmota himalayana. | five strains of gram-positive-staining, catalase-negative, coccus-shaped, chain-forming organisms isolated separately from the respiratory tracts of five marmota himalayana animals in the qinghai-tibet plateau of china were subjected to phenotypic and molecular taxonomic analyses. comparative analysis of the 16s rrna gene indicated that these singular organisms represent a new member of the genus streptococcus, being phylogenetically closest to streptococcus marmotae dsm 101995t (98.4 % similari ... | 2017 | 27902227 |
| permanent genetic resources added to molecular ecology resources database 1 june 2012-31 july 2012. | this article documents the addition of 96 microsatellite marker loci to the molecular ecology resources database. loci were developed for the following species: clarias batrachus, marmota himalayana, schizothorax richardsonii, sitophilus zeamais and syagrus romanzoffiana. these loci were cross-tested on the following species: clarias dussumeri, clarias gariepinus, heteropneustus fossilis, sitophilus granarius and sitophilus oryzae. | 2012 | 23006415 |
| two novel bocaparvovirus species identified in wild himalayan marmots. | bocaparvovirus (bov) is a genetically diverse group of dna viruses and a possible cause of respiratory, enteric, and neurological diseases in humans and animals. here, two highly divergent bovs (tentatively named as himalayan marmot bov, hmbov1 and hmbov2) were identified in the livers and feces of wild himalayan marmots in china, by viral metagenomic analysis. five of 300 liver samples from himalayan marmots were positive for hmbov1 and five of 99 fecal samples from these animals for hmbov2. th ... | 2017 | 29218438 |
| genetic evidence for subspecies differentiation of the himalayan marmot, marmota himalayana, in the qinghai-tibet plateau. | the primary host of plague in the qinghai-tibet plateau (qtp), china, is marmota himalayana, which plays an essential role in the maintenance, transmission, and prevalence of plague. to achieve a more clear insight into the differentiation of m. himalayana, complete cytochrome b (cyt b) gene and 11 microsatellite loci were analyzed for a total of 423 individuals from 43 localities in the northeast of the qtp. phylogenetic analyses with maximum likelihood and bayesian inference methods showed tha ... | 2017 | 28809943 |
| hypoxic and cold adaptation insights from the himalayan marmot genome. | the himalayan marmot (marmota himalayana) is a hibernating mammal that inhabits the high-elevation regions of the himalayan mountains. here we present a draft genome of the himalayan marmot, with a total assembly length of 2.47 gb. phylogenetic analyses showed that the himalayan marmot diverged from the mongolian marmot approximately 1.98 million years ago. transcriptional changes during hibernation included genes responsible for fatty acid metabolism in liver and genes involved in complement an ... | 2019 | 30581096 |
| isolation and characterization of streptococcus respiraculi sp. nov. from marmota himalayana (himalayan marmot) respiratory tract. | two bacterial strains were individually isolated from marmota himalayana respiratory tracts; the animals were from the tibet-qinghai plateau, pr china. the isolates were gram-stain-positive, catalase-negative, coccus-shaped, chain-forming organisms. analysis of 16s rrna gene sequences indicated that the type strain hts25t shared 98.0, 97.4, 97.2 and 97.1 % similarity with streptococcus cuniculi, streptococcus acidominimus, streptococcus marmotae and streptococcus himalayensis respectively. seque ... | 2018 | 29717973 |
| streptococcusmarmotae sp. nov., isolated from the respiratory tract of marmota himalayana. | five strains of a gram-stain-positive, catalase-negative, α-haemolytic, coccus-shaped chain-forming organism were isolated separately from the lower respiratory tracts of five animals of marmota himalayana in the endemic area of plague, the qinghai-tibet plateau, china. based on their morphological characteristics, biochemical features and molecular phylogenetic studies, the strains were placed as representing a new member of the genus streptococcus. comparative 16s rrna gene sequence studies in ... | 2016 | 27473166 |
| bionic design for mars sampling scoop inspired by himalayan marmot claw. | cave animals are often adapted to digging and life underground, with claw toes similar in structure and function to a sampling scoop. in this paper, the clawed toes of the himalayan marmot were selected as a biological prototype for bionic research. based on geometric parameter optimization of the clawed toes, a bionic sampling scoop for use on mars was designed. using a 3d laser scanner, the point cloud data of the second front claw toe was acquired. parametric equations and contour curves for ... | 2016 | 28127229 |
| molecular characterization of the type i ifn receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (whv). | type i interferons (ifn-α/β) serve as the first line of defense against viral infection and share the same type i ifn receptor (ifnar) complex, which is composed of ifnar1 and -2. the eastern woodchuck (marmota monax) and chinese woodchuck (marmota himalayana) are suitable for studying hepatitis b virus (hbv) infection. here, the complete or partial sequences of the ifnars of both species were obtained and analyzed. small interference rnas targeting wifnar1 and -2 specifically down-regulated the ... | 2012 | 22705153 |
| nucleoside analogues alone or combined with vaccination prevent hepadnavirus viremia and induce protective immunity: alternative strategy for hepatitis b virus post-exposure prophylaxis. | the current strategies for hepatitis b virus (hbv) post-exposure prophylaxis (pep) are not generally available in remote and rural areas of developing countries and/or carry potential risks for infection with blood-borne transmitted pathogens. nucleotide analogues (nas) are successfully used for human immunodeficiency virus pep, and maybe effective for hbv pep. in this study, we tested the na-based strategies for hbv pep using the chinese woodchuck model. | 2014 | 24583157 |
| diverse novel astroviruses identified in wild himalayan marmots. | with advances in viral surveillance and next-generation sequencing, highly diverse novel astroviruses (astvs) and different animal hosts had been discovered in recent years. however, the existence of astvs in marmots had yet to be shown. here, we identified two highly divergent strains of astvs (tentatively named qinghai himalayanmarmot astvs, hhmastv1 and hhmastv2), by viral metagenomic analysis in liver tissues isolated from wild marmota himalayana in china. overall, 12 of 99 (12.1 %) m. himal ... | 2017 | 28100306 |
| niche modeling predictions of the potential distribution of marmota himalayana, the host animal of plague in yushu county of qinghai. | after the earthquake on 14, april 2010 at yushu in china, a plague epidemic hosted by himalayan marmot (marmota himalayana) became a major public health concern during the reconstruction period. a rapid assessment of the distribution of himalayan marmot in the area was urgent. the aims of this study were to analyze the relationship between environmental factors and the distribution of burrow systems of the marmot and to predict the distribution of marmots. | 2016 | 26912171 |
| mapping risk of plague in qinghai-tibetan plateau, china. | qinghai-tibetan plateau of china is known to be the plague endemic region where marmot (marmota himalayana) is the primary host. human plague cases are relatively low incidence but high mortality, which presents unique surveillance and public health challenges, because early detection through surveillance may not always be feasible and infrequent clinical cases may be misdiagnosed. | 2014 | 25011940 |
| complete mitochondrial genome of a chipmunk species, tamias sibiricus (rodentia: sciuridae) in korea. | we sequenced the complete mitochondrial genome (kf668525) of tamias sibiricus in south korea. the mitogenome of the korean chipmunk t. sibiricus was 16,558 bp long with base composition of 33.8% a, 31.1% t, 22.9% c and 12.2% g. total nucleotide similarity of t. sibiricus and marmota himalayana (jx069958) genomes was 80.4% ranging from 66.9% (d-loop region) to 97.3% (trna(leu)((cun))). the present study will contribute to understanding taxonomic status and genetic divergence of northeast asian t. ... | 2015 | 24228685 |
| characteristics of himalayan marmots and their response to an atherogenic diet. | the purpose of the present study was to characterize himalayan marmot lipoprotein profiles and investigate their response to an atherogenic diet. sixteen marmots were randomly divided into two groups. the control group was fed with a standard chow diet, and the other group was fed with a chow diet containing 0.3% cholesterol, 6.7% lard, and 3.3% corn oil (designated as hfcd) for 16 weeks. the plasma lipids were measured, and lipoprotein profiles were analyzed. with the chow diet, the major lipop ... | 2012 | 22850646 |
| [characterization of the expression of ldh isozymes genes during non-hibernation himalayan marmots]. | the lactate dehydrogenase (ldh) isozymes from heart, liver, kidney and skeletal muscle in himalayan marmots (marmota himalayana robusta) in non-hibernation were investigated in the present experiment. the isozyme patterns were analyzed by means of disc electrophoresis and the ultraviolet enzymatic determination. the following conclusions were obtained: 1. it was found that two expression patterns of ldh genes presented in the skeletal muscle of himalayan marmots. there was a ldh-b4 band only in ... | 1990 | 2242276 |
| marmota himalayana in the qinghai-tibetan plateau as a special host for bi-segmented and unsegmented picobirnaviruses. | wildlife has been considered the main source of novel viruses causing emerging infectious diseases. marmota himalayana is endemic to the qinghai-tibetan plateau, china. here, based on a high-throughput method using illumina rna sequencing, we studied the rna virome of m. himalayana and discovered multiple novel viruses, especially picobirnaviruses (pbvs), which have a bi-segmented genome and belong to the family picobirnaviridae. a total of 63% of the viral contigs corresponded to pbvs, comprisi ... | 2018 | 29511159 |
| experimental infection of marmota monax with a novel hepatitis a virus. | to establish an animal model for the newly identified marmota himalayana hepatovirus, mhhav, so as to develop a better understanding of the infection of hepatitis a viruses. five experimental woodchucks (marmota monax) were inoculated intravenously with the purified mhhav from wild woodchuck feces. one animal injected with pbs was defined as a control. feces and blood were routinely collected. after the animals were subjected to necropsy, different tissues were collected. the presence of viral r ... | 2018 | 29387970 |
| a new subtype of eastern tick-borne encephalitis virus discovered in qinghai-tibet plateau, china. | tick-borne encephalitis virus (tbev) has been classified into three subtypes, namely the european (eu-tbev), far eastern (fe-tbev), and siberian (sib-tbev). in this study, we discovered a new subtype of tbev in wild rodent marmota himalayana in qinghai-tibet plateau in china, proposed as subtype himalayan (him-tbev). two complete genomes of tbev were obtained from respiratory samples of 200 marmots. the phylogenetic analysis using the e protein and polyprotein demonstrated that the two strains o ... | 2018 | 29691370 |
| identification and genotyping of enterocytozoon bieneusi in wild himalayan marmots (marmota himalayana) and alashan ground squirrels (spermophilus alashanicus) in the qinghai-tibetan plateau area (qtpa) of gansu province, china. | enterocytozoon bieneusi is the most frequently detected microsporidian species in humans and animals. currently, to the best of our knowledge, no information on e. bieneusi infection in himalayan marmots (marmota himalayana) and alashan ground squirrels (spermophilus alashanicus) is available worldwide. the aim of the present study was to understand the occurrence and genetic characterizations of e. bieneusi in himalayan marmots and alashan ground squirrels in the qinghai-tibetan plateau area (q ... | 2020 | 32698833 |
| genetic and molecular features for hepadnavirus and plague infections in the himalayan marmot. | the himalayan marmot (marmota himalayana), a natural host and transmitter of plague, is also susceptible to the hepadnavirus infection. to reveal the genetic basis of the hepadnavirus susceptibility and the immune response to plague, we systematically characterized the features of immune genes in himalayan marmot with those of human and mouse. we found that the entire major histocompatibility complex region and the hepatitis b virus pathway genes of the himalayan marmot were conserved with those ... | 2020 | 32308030 |
| complete mitochondrial genome sequence of marmota himalayana (rodentia: sciuridae) and phylogenetic analysis within rodentia. | this is the first report of a complete mitochondrial genome sequence from himalayan marmot (marmota himalayana, class marmota). we determined the m. himalayana mitochondrial (mt) genome sequence by using long-pcr methods and a primer-walking sequencing strategy with genus-specific primers. the complete mt genome of m. himalayana was 16,443 bp in length and comprised 13 protein-coding genes, 2 ribosomal rna (rrna) genes, 22 transfer rna (trna) genes, and a typical control region (cr). gene order ... | 2014 | 24782088 |
| the complete mitochondrial genome of ictidomys tridecemlineatus (rodentia: sciuridae). | the complete mitochondrial genome of the thirteen-lined ground squirrel, ictidomys tridecemlineatus (rodentia: sciuridae) was sequenced to analyze the gene arrangement. it is a circular molecule of 16,458 bp in length including 37 genes typically found in other squirrels. the at content of the overall base composition is 63.7% and the length of the control region is 1016 bp with 63.0% at content. in bi and ml phylogenetic trees, i. tridecemlineatus is a sister clade to the genus cynomys, and tam ... | 2016 | 26024127 |
| hypoxic and cold adaptation insights from the himalayan marmot genome. | | 2019 | 30684495 |
| a guinea pig ifna1 gene with antiviral activity against human influenza virus infection. | we previously reported a natural antisense (as) rna as an important modulator of human interferon-alpha1 (ifna1) mrna levels. here, we identified the guinea pig (cavia porcellus) ifna1 gene to enable a proof-of-concept experiment to be performed to confirm that the as-mrna regulatory axis exerts in vivo control over innate immunity. we selected a guinea pig model system for influenza virus infection because guinea pigs encode a functional mx1 gene, an important anti-viral effector in the type i ... | 2019 | 30844713 |
| human plague associated with tibetan sheep originates in marmots. | the qinghai-tibet plateau is a natural plague focus and is the largest such focus in china. in this area, while marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with tibetan sheep (78 cases with 47 deaths) have been reported on the qinghai-tibet plateau since 1956. all of the index infectious cases had an exposure history of slaughtering or skinning diseased or dead tibetan sheep. in this study, we sequenced and compared 38 strains of yersinia pestis isolat ... | 2018 | 30114220 |
| serological epidemiological investigation of tibetan sheep (ovis aries) plague in qinghai, china. | the plague, which is caused by the gram-negative coccobacillus bacterium yersinia pestis, has been classified as a reemerging infectious disease by the world health organization. the qinghai-tibet plateau natural plague focus is the largest plague focus in china, and marmota himalayana is the primary host of the plague. tibetan sheep (ovis aries) were first identified as naturally infected hosts of y. pestis based on etiological evidence in 1975, and activities such as slaughtering or skinning t ... | 2019 | 30256745 |
| brucella in himalayan marmots (marmota himalayana). | brucella abortus biovar 1 and atypical rough brucella were isolated from himalayan marmot (marmota himalayana). multiple-locus variable-number tandem-repeat analysis-16 typing indicated that the isolates both for smooth and atypical rough phenotypes had a common novel multiple-locus variable-number tandem-repeat analysis-16 type (panel 1: 3-2-7-5-3-4-12-3; panel 2a: 6-40-8; panel 2b: 5-2-3-3-3). | 2020 | 32195643 |
| lactobacillus xujianguonis sp. nov., isolated from faeces of marmota himalayana. | two novel strains (ht111-2t and ht170-2) of the genus lactobacillus were isolated from marmota himalayana faecal samples collected on the qinghai-tibet plateau, pr china. the isolates were gram-stain-positive, rod-shaped, non-spore-forming bacteria with irregular circular colonies. phylogenetic analysis and comparison of the 16s rrna gene sequences demonstrated that the two strains form a subcluster and are closest to lactobacillus hamsteri jcm 6256t (97.3 %) and lactobacillus amylolyticus dsm 1 ... | 2020 | 31560297 |
| genomic and molecular characterisation of escherichia marmotae from wild rodents in qinghai-tibet plateau as a potential pathogen. | wildlife is a reservoir of emerging infectious diseases of humans and domestic animals. marmota himalayana mainly resides 2800-4000 m above sea level in the qinghai-tibetan plateau, and is the primary animal reservoir of plague pathogen yersinia pestis. recently we isolated a new species, escherichia marmotae from the faeces of m. himalayana. in this study we characterised e. marmotae by genomic analysis and in vitro virulence testing to determine its potential as a human pathogen. we sequenced ... | 2019 | 31337784 |