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rhinosporidium seeberi: spherules and their significance.this study of the nature and functional significance of the spherules that develop in sporoblasts show them to participate in the germination of rhinosporidium seeberi and are the precursors of the trophocytes.1975168546
conjunctival rhinosporidiosis.rhinosporidium seeberi is the fungus that causes rhinosporidiosis, which affects the mucocutaneous tissue of humans and domestic animals. ten cases of conjunctival rhinosporidosis have been reported in the united states. this is a case report of conjunctival rhinosporidosis that is believed to be the 11th reported from the united states and the only case reported from arkansas. a clinical and pathologic description of the disease is given.19854004006
rhinosporidiosis.rhinosporidiosis is the disease resulting from infection by rhinosporidium seeberi, an organism endemic in the indian sub-continent, but rarely seen in the united kingdom. we describe the clinio-pathological features of a case presenting in a 14-year-old female.19921613384
rhinosporidiosis in europe.rhinosporidiosis is an inflammatory disease of the nasal mucosa caused by rhinosporidium seeberi. the disease is endemic in india but very rare in europe or other continents. the literature concerning aetiology, clinical appearance, morphology and treatment is reviewed. all reported european cases are summarized.19921613374
culture of rhinosporidium seeberi: preliminary report.every year 400 to 450 cases of rhinosporidium are reported from trivandrum medical college. twenty-five swabs were collected from patients suffering from rhinosporidiosis and cultured in standard media. positive results were obtained in 23 cases. the conidia produced from the colony were compared with the structures obtained from the patient material. light microscopy using histopathological techniques were used. the consistent appearance of the organism in patient material, the repeatability of ...19892926265
rhinosporidium seeberi and papovavirus infection of the conjunctiva: a clinical and ultrastructural study.the present study describes, for the first time, the clinical and the ultrastructural findings of a rare case presented with concurrent conjunctival infection of rhinosporidium seeberi and a papovavirus. in contradistinction to previous reports, the present case lacked the characteristic granulomatous inflammatory reaction of rhinosporidiosis. this finding, together with the frequent recurrence of the lesion, led us to postulate the presence of a local acquired immune deficiency state (laids). t ...19882846020
conjunctival rhinosporidiosis. report of three cases from zaire.the authors report three cases of conjunctival rhinosporidiosis from zaire, two of which are believed to be the first documented in the northeastern part of the country. all patients were males. two patients were very young children, respectively 5 and 6 years old. the third patient was a 35-year-old man. the diagnosis was based on histopathology which revealed the characteristic features of rhinosporidium seeberi. total excision was the elective treatment. the disease recurred eleven months lat ...19921476471
rhinoscleroma and rhinosporidiosis.for north american otolaryngologists, rhinoscleroma and rhinosporidiosis are moving more into the differential diagnosis of chronic inflammatory diseases of the upper airway, particularly the nasal cavity. this change is occasioned by the influx of immigrants from parts of the world to which the diseases are endemic. diagnosis is established by identification of the causal organisms, the readily seen rhinosporidium seeberi for rhinosporidiosis and the more elusive klebsiella rhinoscleromatis for ...19921416645
[rhinosporidiosis: clinical aspects, epidemiology and ultrastructural studies on rhinosporidium seeberi].the author revises the main clinical aspect of the disease as well as its dignosis and its treatment. rhinosporidium seeberi, first described by j.r. seeber in 1900, then exhaustively investigated by j.h. ashworth in 1923, has been accepted up to now as a phycomycete. inside of the sporangial bodies, part of the polyp characteristic of the disease, are found spores, and in the spores, spherules, considered by ashworth as food material. in 1955 the author did challenge the view of ashworth becaus ...197661137
the histological and the histopathological pattern of conjunctival rhinosporidiosis associated with papillomavirus infection.the present study describes for the first time, the clinical, light and electron microscopic findings of two cases of conjunctival rhinosporidiosis. one was with concurrent infection of papillomavirus. investigations at the ultrastructural level have provided additional information on the development of rhinosporidium seeberi and would suggest that the formation of the wall of this organism is a continuous morphological and biochemical spectrum throughout its cytological maturation. the current ...19892562465
[tissue morphology of the causative agents of visceral mycoses. studies of polysaccharide and protein histochemistry. (6. rhinosporidium seeberi and emmonsia crescens)]. 19751095926
rhinosporidium seeberi. an ultrastructural study of its endosporulation phase and trophocyte phase.the endosporulation phase of rhinosporidium seeberi is the part of the life cycle most vulnerable to drug therapy. the laminated body formed from the precleavage sporangium has double-membraned tubular and vesicular structures within concentric layers. similar tubular structures are also found in the developing sporoblast. the development of trophocytes involves three distinct phases. the early trophocyte retains many of the characteristics of the sporoblast as well as endoplasmic reticulum and ...19751111496
cultivation of rhinosporidium seeberi in vitro: interaction with epithelial cells.rhinosporidium seeberi, a fungus that is associated with polyp-like tumors in animals and man, was successfully cultivated. this organism stimulated proliferation of epithelial cells in vitro, producing polyp-like structures. spores produced in culture required a period of aging or development, or both, before they were capable of reinitiating the growth cycle.19863764422
[epistaxis and obstruction of the nasal passage caused by rhinosporidium seeberi]. 19725025816
histochemical studies of rhinosporidium seeberi. 19704193550
canine rhinosporidiosis in arkansas.rhinosporidiosis is a fungal infection caused by rhinosporidium seeberi, a microorganism of complicated, undetermined life cycle. many species of animals are susceptible to rhinosporidiosis, including human beings. the frequency of occurrence of the disease in domestic animals is unknown. a one-year-old male collie dog from northeast arkansas was found to have rhinosporidiosis presenting as an intranasal polypoid mass. we believe this is the first documented report of rhinosporidiosis from the s ...19863959536
[rhinosporidiosis: a study of 33 cases diagnosed using biopsies at the central hospital of maputo, since 1944 through 1986].a statistical review of the archives of the laboratory of pathologic anatomy of maputo central hospital is made with the view to determine the frequency of occurrence of rhinosporidiosis in biopsies in the years 1944-86. diagnosis was made based on the specific microscopic picture shown by the lesions induced by rhinosporidium seeberi. of 91,000 reports only 33 cases of the disease were found, which accounts for 0.036% of the total biopsies made in the department. tissular examinations showed th ...19892701189
rhinosporidiosis.rhinosporidium seeberi, the causative organism of rhinosporidiosis of the nasal mucosa and skin was reviewed with regard to its pathogenesis and histopathology, histochemistry, ultrastructure, life cycle, and cultivation. the pathological findings from infected tissues reveal a granulomatous reaction comprising mixed cell granuloma, pseudocystic abscesses, fibrosis around the causative organism (r. seeberi), and transepidermal elimination. the cell walls of trophocytes and sporangia exhibit the ...19892688923
rhinosporidium seeberi; a preliminary study of the morphology and life cycle. 19705418306
rhinosporidiosis in bovines of kanyakumari district, tamil nadu, india.a survey on rhinosporidiosis in animals was conducted in kanyakumari (k.k.) district of tamil nadu, india. among 103 animals (40 bullocks, 45 cows, 15 heifers, 2 bulls and a buffalo), 19 (9 bullocks, 8 cows, 1 heifer and a she-buffalo) were found to be infected with rhinosporidium seeberi. the study revealed the endemic nature of the disease in bovines of k.k. district. agastheeswaram taluk contributed 52.6 per cent of positive cases followed by kalkulam (26.2 per cent). the disease was also fou ...19873683510
rhinosporidiosis at king edward viii hospital, durban--1976-1985. a report of 6 cases.six cases of the fungal infection, rhinosporidiosis, are documented. clinical, light microscopic and electron microscopic features of the causative organism (rhinosporidium seeberi) are presented.19873603320
conjunctival polyp caused by rhinosporidium seeberi. report of a case. 19695766477
the value of calcofluor white in the diagnosis of mycotic and acanthamoeba infections of the eye and ocular adnexa.in search of an easy and quick method for the diagnosis of fungal and acanthamoeba infections of the eye, the authors have used calcofluor white (cfw), a fluorescent brightener with marked affinity for chitin and cellulose which are present in the cell walls of fungi and cysts of acanthamoeba. paraffin-embedded tissues containing mycotic organisms were stained with cfw and examined under a fluorescent microscope. several fungi such as candida sp, aspergillus sp, phycomycetes, fusarium solani, hi ...19872436125
nasal rhinosporidiosis in the dog.rhinosporidiosis was diagnosed in six dogs from the southeastern united states. all six dogs had unilateral nasal polyps with multiple small white sporangia visible beneath the surface. microscopically, the polyps consisted of organisms and fibrovascular tissue with a surface of columnar or squamous epithelium. juvenile sporangia were unilamellar, 15-75 microns in diameter, nucleated, and accounted for about 65% of sporangia seen. approximately 5% of the sporangia were in intermediate stages of ...19862418574
a technique for harvesting intact sporangia from rhinosporidium seeberi. 19665966965
rhinosporidiosis in bankura.rhinosporidiosis is a chronic granulomatous disease caused by rhinosporidium seeberi. although a variety of sites may be affected, the principal site of infection is the nasal mucosa, the disease is endemic in india and sri lanka, smaller series are also described from east africa and parts of america, but it is very rare in europe. the 116 cases seen in the medical college at bankura during january 1983 to december 1987 are presented here. the disease is more prevalant in males and in the secon ...19902391143
[rhinosporidiosis: presentation of 4 cases].we report 4 cases of rhinosporidiosis in the province of cáceres. two had nasal localization and in two ocular conjunctiva was involved. three patients, two of which came from the same village, had the antecedent of bathing in the same stagnant water. the diagnosis was made by the microscopic observation of characteristic sporangia of rhinosporidium seeberi in the histopathological study. the lesions did not respond to antibiotic and antiinflammatory treatment. after excision there were no recur ...19902388493
rhinosporidium seeberi: light, phase contrast, fluorescent and scanning electron microscopic study.phase contrast microscopic study indicated the multilayered structure of the sporangial wall of r. seeberi while the scanning electronmicroscopic study revealed a trilaminated wall compared to a thick double walled light microscopic structure. the scanning electronmicroscopy revealed the spores of varying sizes which were found either discretely or in groups interconnected and seen attached to the inner aspect of the sporangial wall. autofluorescence of sporangia and spores was observed under mi ...19911857398
rhinosporidium seeberi: cell wall formation in sporoblasts. 19744423221
cytological study of rhinosporidium seeberi by electron microscopy. 19744435934
conjunctival rhinosporidiosis. light and electron microscopic study.two cases of conjunctival rhinosporidiosis were studied by light and electron microscopy. two distinct phases of the tissue life cycle were present: trophic and endosporulating. young trophocytes contained a single nucleus. as the trophocyte matured chromatin was dispersed throughout the cyst. during the next phase of the life cycle, sporangial cyst walls acquired a new inner layer that appeared to give rise to endospores. histochemical and ultrastructural features of rhinosporidium seeberi are ...19836677849
conjunctival oculosporidiosis in east africa caused by rhinosporidium seeberi.conjunctival rhinosporidiosis is an infectious disease rarely recorded outside the indian subcontinent. the disease is caused by rhinosporidium seeberi, an endosporulating microorganism of uncertain taxonomic classification. we report a series of cases manifesting this infection.19969140291
ultrastructure of rhinosporidium seeberi. 19734571604
infection of the conjunctiva by rhinosporidium seeberi.rhinosporidiosis is an unusual fungal disease that rarely affects the eye. it was first described as a pathogen in humans at the turn of the century. the etiologic agent, rhinosporidium seeberi, commonly produces granulomatous inflammation of the upper respiratory mucosa. most reported ocular infections have occurred in hot, dry climatic regions. we present a case of conjunctival rhinosporidiosis in an 11-year-old boy from western new york state, the first such report from the temperate zones of ...19979163838
[a case of rhinosporidiosis].rhinosporidiosis is due to fungal infection by rhinosporidium seeberi, which affects predominantly the mucous membrane of the nose and nasopharynx. this disease is characterized by the formation of papillomatous and polypoid lesions and is known to be endemic in india and sri lanka. the first case of rhinosporidiosis in japan is reported in this paper. a 25-year-old male indian, born in india, living in japan for a year, visited the outpatient clinic complaining of nasal obstruction and swallowi ...19948176535
rhinosporidiosis: a description of an unprecedented outbreak in captive swans (cygnus spp.) and a proposal for revision of the ontogenic nomenclature of rhinosporidium seeberi.rhinosporidiosis is a mucocutaneous zooanthroponotic disease caused by rhinosporidium seeberi, a fungal-like organism of uncertain classification with an unknown mode of transmission. over a 3 year period, 41 captive swans (cygnus olor and c. atratus) developed conjunctival and cutaneous polypoid lesions diagnosed as rhinosporidiosis by histopathological examination including light and electron microscopy. investigation of this avian outbreak, the first of its kind, provides additional insight i ...19957666295
rhinosporidiosis. report of a case with an unusual presentation with bony involvement.rhinosporidiosis, a fungal infection due to rhinosporidium seeberi, frequently produces polypoidal lesions in the nose. sites like the conjunctiva, larynx, trachea, nasopharynx, skin and genitourinary tract are less frequently involved. generalized rhinosporidiosis with skin and visceral involvement is extremely rare. this report describes the fine needle aspiration cytology (fnac) of rhinosporidiosis occurring as a solitary lesion with erosion of cortical bone.19979167721
[rhinosporidium seeberi. comments on its isolation]. 19645900040
prevalence of rhinosporidiosis of the eye and its adnexa in nepal.this study describes the clinical features, diagnosis, and treatment of rhinosporidiosis of the eye and its adnexa in a series of 76 cases in nepal and six originating in india. the disease caused by the fungus rhinosporidium seeberi was seen most frequently in young children between eight and 10 years of age. males were infected more than females (2.5:1). the conjunctiva was the most common site of infection in 76 (92.68%) of the cases. the lacrimal sac was affected only in six (7.32%) cases. s ...19989715938
rhinosporidiosis presenting with two soft tissue tumors followed by dissemination.rhinosporidiosis is caused by rhinosporidium seeberi. most mycologists believe that r. seeberi is either a chytridium related to the olpidiaceae (order chytridialis, class chytridiomycetes) or a synchytrium. this is the first documented case of tumoral rhinosporidiosis in a sri lankan and the third documented case in the world literature. a 44 year old male presented with a large mass above the thigh and a similar mass over the anterior chest wall, both masses contained r. seeberi. later examina ...199910212926
rhinosporidiosis: a study that resolves etiologic controversies.we have been able to isolate the cyanobacterium microcystis aeruginosa from water samples of ponds and river where patients of rhinosporidiosis were bathing. it is likely that this cyanobacterium is the causative agents of this disease. the bluish-green cells of m. aeruginosa also have a colorless small cell stage called nanocyte which has been detected in clear waters of all the pond and river samples studied. both large cells and nanocytes of m. aeruginosa could be recognized inside the round ...19979438062
immunolocalization of an endogenous antigenic material of rhinosporidium seeberi expressed only during mature sporangial development.we investigated the immunolocalization of rhinosporidium seeberi's antigens using sera from individuals infected with r. seeberi and tissue from sri lankan patients with rhinosporidiosis. the tissues were fixed in lr white resin, thin sectioned fixed onto nickel grids and evaluated by transmission electron microscopy for the presence of r. seeberi's sporangia. the tissue samples were reacted with the patients's sera and then labeled with protein a colloidal gold (pacg) for immunolocalization. it ...199910219592
phylogenetic analysis of rhinosporidium seeberi's 18s small-subunit ribosomal dna groups this pathogen among members of the protoctistan mesomycetozoa clade.for the past 100 years the phylogenetic affinities of rhinosporidium seeberi have been controversial. based on its morphological features, it has been classified as a protozoan or as a member of the kingdom fungi. we have amplified and sequenced nearly a full-length 18s small-subunit (ssu) ribosomal dna (rdna) sequence from r. seeberi. using phylogenetic analysis, by parsimony and distance methods, of r. seeberi's 18s ssu rdna and that of other eukaryotes, we found that this enigmatic pathogen o ...199910449446
culture of the organism that causes rhinosporidiosis.the causative agent of rhinosporidiosis is a microscopic round body in polypoidal masses that is believed to be the sporangium of a fungus rhinosporidium seeberi. but fungal aetiology can not be proved with certainty. attempts to culture the fungus on various media have also been unsuccessful. in a recent study pond water samples, from water in which patients had been bathing, were analysed and a unicellular prokaryotic cyanobacterium microcystis aeruginosa was isolated. the same cyanobacterium ...199910605581
phylogenetic analysis of lacazia loboi places this previously uncharacterized pathogen within the dimorphic onygenales.lacazia loboi is the last of the classical fungal pathogens to remain a taxonomic enigma, primarily because it has resisted cultivation and only causes cutaneous and subcutaneous infections in humans and dolphins in the new world tropics. to place it in the evolutionary tree of life, as has been done for the other enigmatic human pathogens pneumocystis carinii and rhinosporidium seeberi, we amplified its 18s small-subunit ribosomal dna (ssu rdna) and 600 bp of its chitin synthase-2 gene. our phy ...200111136789
purification of the endospores and sporangia of rhinosporidium seeberi on percoll columns.human rhinosporidial tissue was used as the source of the various developmental stages of rhinosporidium seeberi--endospores with electron dense bodies, juvenile, and immature sporangia. after homogenisation in phosphate buffered saline (pbs) and removal of tissue fragments by centrifugation, the rhinosporidial bodies were isolated on centrifuged percoll columns with gradients of densities or on triple-layered columns of varying density. the separated bands, after repeated washing in pbs gave bo ...199910685445
rhinosporidiosis: ultrastructural study of an infection in south carolina.we have morphologically described and ultrastructurally analyzed rhinosporidium seeberi, the causative agent of rhinosporidiosis, obtained from a nasal polyp of a man who had never traveled to india or ceylon. the morphology, endosporulation phases, and cell wall were similar to those in previously described infections. a common etiology is suggested and potential therapy is discussed.19846505769
in vitro studies on the mechanisms of endospore release by rhinosporidium seeberi.studies of rhinosporidium seeberi have demonstrated that this organism has a complex life cycle in infected tissues. its in vivo life cycle is initiated with the release of endospores into a host's tissues from its spherical sporangia. however, little is known about the mechanisms of sporangium formation and endospore release since this pathogen is intractable to culture. we have studied the in vitro mechanisms of endospore release from viable r. seeberi's sporangia. it was found that watery sub ...199911086480
rhinosporidiosis in a dog.rhinosporidiosis was diagnosed in a black and tan coonhound. clinical signs were characterized by 6 to 8 months of intermittent sneezing. numerous polypoid nodules were removed from the nasal cavity. histologic examination of the nodules revealed chronic pyogranulomatous inflammation caused by infection with rhinosporidium seeberi. rhinosporidiosis has been reported in human beings, dogs, and several other domestic species. it is an uncommon disease in the united states.19846511635
conjunctival lesion caused by rhinosporidium seeberi.we have described the first known reported case of rhinosporidiosis from the state of south carolina and possibly the ninth reported conjunctival infection in the united states. differential diagnosis of focal lesions on the conjunctiva, eyelid, or sclera includes cystic inclusions or adenoma of the various glandular structures, pterygium, pedunculated granuloma due to retained foreign body, or end-stage chalazion. histopathologic differential diagnosis includes spherules of coccidioides immitis ...19807403922
cytologic and differential diagnosis of rhinosporidiosis.rhinosporidiosis is a mycotic infection caused by rhinosporidium seeberi. the fungus occurs in tissues as spherules measuring 0.25-3 mm. the spherules contain endospores. diagnosis is usually made histologically on biopsy specimens from polypoid lesions on the mucous membranes of the nasopharynx, larynx, trachea, bronchus and conjunctiva. in our experience two cases of rhinosporidiosis were diagnosed by cytology. the cytologic features are typical. on direct examination the spherules are well-ci ...19947514831
rhinosporidiosis in a cat.a polypoid nasal mass from an adult cat was submitted for routine biopsy examination and was found to contain sporangia and sporangiospores consistent with rhinosporidium seeberi. inflammatory infiltrates were moderate and pyogranulomatous to lymphohistiocytic and were associated with hyperplasia of the transitional nasal epithelium. apparently, this is the first reported case of rhinosporidiosis in a cat.200111478611
phylogenetic spectrum of fungi that are pathogenic to humans.recent phylogenetic studies based on ribosomal rna sequences have confirmed that the organisms traditionally treated as fungi include those that have evolved from several different lines (multiphyletic organisms), as has been suspected. even organisms causing disease in humans represent at least two evolutional lines. pythium insidiosum and prototheca species are both believed to have evolved from one line, while the rest of the pathogens have evolved from another line. p. insidiosum is more clo ...19947948565
the ultrastructure and life history of rhinosporidium seeberi. 19715112361
cell-mediated immune responses (cmir) in human rhinosporidiosis.cell mediated immune responses (cmir) to rhinosporidium seeberi in human patients with rhinosporidiosis have been studied. with immuno-histochemistry, the cell infiltration patterns in rhinosporidial tissues from 7 patients were similar. the mixed cell infiltrate consisted of many plasma cells, fewer cd68+ macrophages, a population of cd3+ t lymphocytes, and cd56/57+ nk lymphocytes which were positive for cd3 as well. cd4+ t helper cells were scarce. cd8+ suppressor/cytotoxic-cytolytic cells wer ...200111761146
cell-mediated immune responses (cmir) to rhinosporidium seeberi in mice.there is no published data on cell mediated immune responses in experimental animals to rhinosporidium seeberi the causative agent of human and animal rhinosporidiosis. the quantitative mouse foot-pad model was used to assay the delayed-type hypersensitivity (dth) cell-mediated immune response to extracts of purified endospores and sporangia of r. seeberi. histological examination was used to confirm that the foot-pad reactions were compatible with dth reactions in the mouse. we report that soni ...200111761147
[intranasal rhinosporidiosis: presentation of the 1st case seen in the congo].rhinosporidiosis, granulomatosis affection due to rhinosporidium seeberi, is rare in africa. we report the first congolese case observed in a 37 year old adult, who presented a tumorous formation obstructing the left nasal fossa, having developed over more than 5 years, occasionally accompanied by epistaxis. diagnosis was made through an anatomo-pathological examination of the exeresis biopsy. the treatment essentially consisted in surgical tumorous exeresis, followed by electrocoagulation of th ...200212145963
rhinosporidiosis--a clinicopathological study of 34 cases.rhinosporidiosis was the commonest (68%) fungal lesion encountered during the period of 11 1/2 years from january 1987 to july 1998. men in 2nd, 3rd, 4th decade were commonly affected. nose and nasopharynx were the commonest (85%) sites involved followed by ocular tissue (9%). one patient had involvement of bone (tibia). generally a lymphoplasmacytic response was observed in all cases. polymorphonuclear leukocytic response mostly observed at the site of rupture of sporangia. epithelioid cell gra ...200112561989
[conjunctivitis proliferans caused by rhinosporidium seeberi]. 195313172597
lymphadenitis, trans-epidermal elimination and unusual histopathology in human rhinosporidiosis.from a study of rhinosporidial tissues of 64 human cases of ocular, urethral and nasopharyngeal disease, unusual histopathological features of 27 cases are described. histopathological evidence of lymphadenitis in rhinosporidiosis is presented for the first time. the phenomenon of 'trans-epidermal elimination' of sporangia of the causative pathogen rhinosporidium seeberi is illustrated and it is argued that this phenomenon is rather the pathogen's mechanism for endospore-dispersal than a non-spe ...200212000127
[nasal rhinosporidiosis in children].rhinosporidiosis is a rare fungal disease resulting from infection by rhinosporidium seeberi. there seems to be a relationship between the disease and agriculture, suggesting that rhinosporidium lives in soil, and many authors agree that water is a necessary medium of transmission. the sites of infection are the nose (most common), eye, nasopharynx, penile urethra and external ear. nasal cases generally present obstruction, epistaxis, watery or mucopurulent discharge, presence of tumoral peduncu ...199414688853
failure to infect congenitally immunodeficient scid and nude mice with rhinosporidium seeberi.congenitally t and b cell-deficient scid mice and t cell-deficient nude mice, with balb/c mice as immunologically normal controls, were inoculated with rhinosporidium seeberi. at 3 and 16 weeks after inoculation, no evidence of rhinosporidiosis was detected. the reasons for the failure to establish rhinosporidiosis in immunodeficient or normal mice remain obscure.200011092388
rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites.rhinosporidium seeberi, a microorganism that can infect the mucosal surfaces of humans and animals, has been classified as a fungus on the basis of morphologic and histochemical characteristics. using consensus polymerase chain reaction (pcr), we amplified a portion of the r. seeberi 18s rrna gene directly from infected tissue. analysis of the aligned sequence and inference of phylogenetic relationships showed that r. seeberi is a protist from a novel clade of parasites that infect fish and amph ...200010827117
rhinosporidiosis in egypt: a case report and review of literature.rhinosporidiosis is an infection caused by rhinosporidium seeberi that frequently presents as a polypoidal nasal lesions. here, we report the first indigenous case of tumoral rhinosporidiosis in egypt. in this case, a 25-year-old male patient from a rural background of assuit city presented with epistaxis and a nasal polyp. the patient had not traveled abroad. the diagnosis was established on the morphological basis by the identification of 5- to 10-microm endospores and 50- to 1000-microm spora ...200515770444
rhinosporidiosis presenting as recurrent nasal polyps.rhinosporidiosis is a chronic granulomatous disease of the mucous membrane, predominantly of the nose and nasopharynx. it is uncommon in malaysia but has been seen in immigrant workers from endemic areas like india and sri lanka. a case seen in johor is reported here to highlight the need of awareness among clinicians at a time where there is increasing numbers of immigrant workers in our country. the causative organism of this disease is rhinosporidium seeberi, which is found in stagnant waters ...200314569751
rhinosporidiosis and peripheral keratitis.report of a case of peripheral keratitis caused by rhinosporidium seeberi. the patient was seen in a referral practice. corneal scraping was performed on a middle-aged female patient presenting with peripheral keratitis and progressive nasal obstruction that revealed spores suggestive of rhinosporidiosis. the patient was started on topical amphotericin b 0.15% eye drops. ear, nose, and throat (ent) examination showed presence of a polypoid lesion in the left nostril for which a polypectomy was p ...200111475404
the taxonomic status of lacazia loboi and rhinosporidium seeberi has been finally resolved with the use of molecular tools. 200115487915
an erosive mass involving the nasal cavity and maxillary sinus: rhinosporidiosis.rhinosporidiosis is a chronic granulomatous inflammatory disease of the mucous membranes caused by rhinosporidium seeberi. the disease is endemic in india, but is very rare in other countries. a review of the literature shows that our patient is the second documented case from turkey. involvement and erosion of the anterior wall of the maxillary sinus as in this case is very rare. a 47-year-old-male is presented with the clinicopathological features and transmission of the disease is discussed.200416056001
[tumor of the nasal cavity unusual in our region. apropos of a case of rhinosporidiosis].rhinosporidiosis is an ailment of the mucous membranes provoked by a microorganism described by seeber in 1900. it is found in africa, south america, india, ceylan, phillipines and iran. rhinosporidium seeberi provokes the appearance of sessile polyps, friable on the mucous membranes. the nasal mucous membrane is affected in 72% of the cases. the symptoms in otorhinolaryngology are in most cases mucous or mucopurulent rhinorrhea, chronic epistaxis and a progressive nasal obstruction. the etiolog ...19827170945
molecular evidence for multiple host-specific strains in the genus rhinosporidium.the taxonomic relationship of rhinosporidium seeberi with other organisms remained controversial for over a century. recently, molecular studies have shown r. seeberi to be a protistal microbe in the newly described class mesomycetozoea at the animal-fungal boundary. phylogenetic analyses of r. seeberi using 18s small-subunit (ssu) rrna genes from several hosts suggested rhinosporidium as a monotypic genus. to test this hypothesis, the internal transcribed spacer 1 (its1), 5.8s, and its2 from ei ...200515815010
the class mesomycetozoea: a heterogeneous group of microorganisms at the animal-fungal boundary.when the enigmatic fish pathogen, the rosette agent, was first found to be closely related to the choanoflagellates, no one anticipated finding a new group of organisms. subsequently, a new group of microorganisms at the boundary between animals and fungi was reported. several microbes with similar phylogenetic backgrounds were soon added to the group. interestingly, these microbes had been considered to be fungi or protists. this novel phylogenetic group has been referred to as the drip clade ( ...200212142489
[rhinosporidiosis. a rare cause of nosebleed].due to an increasing number of non-european patients and tourists travelling in endemic aras, "exotic" mycosis and other tropical diseases must be considered in differential diagnosis. in this report we present a patient with epistaxis caused by rhinosporidiosis, an endemic disease in south india and sri lanka (ceylon) and quite rare in europe. this chronic inflammatory disease characterized by hyperplastic polypoid lesions of the mucous membrane, predominantly nasal, is caused by rhinosporidium ...200111699146
lacazia loboi and rhinosporidium seeberi: a genomic perspective.in the past five years, with the use of molecular strategies the phylogenetic affinities of the two more resilient pathogens studied in medical mycology, lacazia loboi and rhinosporidium seeberi were finally deciphered. these studies found that l. loboi was the sister taxon to paraccidioides brasiliensis, and r. seeberi was closely related to protistan spherical aquatic fish pathogens, located at the point were animals diverged from the fungi, in the class mesomycetozoea. these initial studies i ...200516499413
human anti-rhinosporidial antibody does not cause metabolic inactivation or morphological damage in endospores of rhinosporidium seeberi, in vitro.this report describes the use of the mtt-reduction and evan's blue-staining tests for the assessment of the viability and morphological integrity, respectively, of rhinosporidial endospores after exposure to sera from rhinosporidial patients with high titres of anti-rhinosporidial antibody. sera from three patients, with nasal, ocular and disseminated rhinosporidiosis respectively were used, with human serum without anti-rhinosporidial antibody for comparison, with or without added fresh guinea ...200515928415
rhinosporidiosis in a domestic cat.rhinosporidiosis was diagnosed in a domestic shorthair cat from a suburb of washington dc, usa. the clinical presentation of protracted sneezing and epistaxis was associated with a polypoid lesion in the right nostril. light microscopic examination revealed a polypoid lesion with numerous sporangia containing maturing endospores. free endospores were present in the stroma of the polyp and lumen of the nasal cavity. transmission electron microscopy revealed ultrastructural features typical of rhi ...200111270402
anti-rhinosporidial antibody levels in patients with rhinosporidiosis and in asymptomatic persons, in sri lanka.the only report hitherto, from india in 1982, on anti-rhinosporidial antibody levels in patients with rhinosporidiosis recorded that antibody was not detected in indian patients. the present report describes the use of the dot-elisa assay of serum anti-rhinosporidial igg, igm and iga and salivary siga in patients with diverse clinical presentations, in rural asymptomatic persons who had bathed in ground waters that probably harboured the causative pathogen, rhinosporidium seeberi, and in laborat ...200415518343
the pathogen of frogs amphibiocystidium ranae is a member of the order dermocystida in the class mesomycetozoea.the pathogen of frogs amphibiocystidium ranae was recently described as a new genus. due to its spherical shape, containing hundred of endospores, it was thought to be closely related to the pathogens of fish, mammals, and birds known as dermocystidium spp., rhinosporidium seeberi, and sphaerothecum destruens in the mesomycetozoea, but further studies were not conducted to confirm this relationship. to investigate its phylogenetic affinities, total genomic dna was extracted from samples collecte ...200515634971
lacrimal sac rhinosporidiosis: a case report.rhinosporidiosis is a disease caused by rhinosporidium seeberi. it usually affects the nasal mucosa and rarely the conjunctiva, lacrimal sac, tonsils, and skin. we present a case study of an isolated lacrimal sac rhinosporidiosis in an 8-year-old girl who was a migrant from orissa, an eastern coastal state of india. the mode of presentation and management of this case with a review of literature is discussed in brief.200415547812
metastatic rhinosporidioma in a child.rhinosporidiosis is a chronic granulomatous disease caused by rhinosporidium seeberi. it commonly affects nasal mucosa and conjunctiva. subcutaneous disease is unusual and it is often mistaken for soft-tissue sarcoma. such tumoral rhinosporidiosis has never been reported in children. this report describes, for the first time, an 11-year-old girl who presented with nasal polyp and multiple metastatic swellings of rhinosporidial origin. fine-needle aspiration cytology and histopathology were diagn ...200616567209
disseminated cutaneous rhinosporidiosis.rhinosporidiosis is a chronic granulomatous disorder caused by rhinosporidium seeberi. it frequently involves the nasopharynx and occasionally affects the skin. we herewith report a 55-year-old man who has disseminated cutaneous rhinosporidiosis. he presents with multiple reddish lesions over the nose of 10 year's duration. in the past year, he develops skin lesions over the right arm and over back. histopathological examination of the skin biopsy specimen from the representative cutaneous lesio ...200515748560
the effect of hydration on the morphology of rhinosporidium seeberi inparaffin sections. 196314058294
cytologic identification of immature endospores in a dog with rhinosporidiosis.an 8-year-old, intact, male labrador retriever was presented to the boren veterinary medical teaching hospital at oklahoma state university with a 2-month history of severe sneezing episodes that resulted in epistaxis and bilateral sanguineous discharge. rhinoscopy revealed a small polypoid mass, and specimens were obtained for histopathology. microscopic examination of formalin-fixed tissue specimens revealed organisms consistent with rhinosporidium seeberi. the mass was surgically excised and ...200616967425
rhinosporidiosis: what is the cause?significant advances in knowledge on rhinosporidiosis and rhinosporidium seeberi were made in 1999, 2000, 2003 and 2004. these advances are reviewed on account of the continuing sporadic occurrence of the disease universally, and because of the availability of new approaches that could resolve persisting enigmas of both the disease and its causative pathogen.200515735413
ocular rhinosporidiosis.rhinosporidium seeberi, the causative organism causing rhinosporidiosis, also affects extranasal sites. a 1 5-year-old male presented with a conjunctival fleshy swelling near the inner canthus of the left eye. his visual acuity was within normal range. conjunctival papilloma was the provisional diagnosis for which he was operated on. histopathology proved to be a case of ocular rhinosporidiosis. six months follow-up of the case showed no recurrence.200415871364
rhinosporidiosis in a dog.a dog with a nasal papilloma due to rhinosporidium seeberi is presented. the causative organism was found using cytopathology and histopathology. the young doberman dog had never travelled out of the province of ontario and is the first case of rhinosporidiosis reported in canada.198617422665
nasal rhinosporidiosis in a mule.a mass was removed from the nostril of a mule that exhibited unilateral epistaxis and nasal discharge. impression smears revealed oval structures consistent with spores of rhinosporidium seeberi. microscopically, the mass was composed of fibrovascular granulomatous tissue containing sporangia r. seeberi. surgical excision and antifungal treatment proved curative.200717436910
human nasal rhinosporidiosis: an italian case report.rhinosporidiosis is a disease affecting primarily the mucosa of nose, conjunctiva and urethra. it is endemic in some asiatic regions, affecting people of any age and sex. its manifestation is a polypoid mass growing inside the affected cavity and the only treatment is surgical excision. rhinosporidium seeberi is the aetiological agent. many discussions arouse regarding the taxonomic classification of the microorganism, recent studies established it is an aquatic protistan parasite. the lesion ma ...200616945122
nature and significance of the electron-dense bodies of the endospores of rhinosporidium seeberi: their reactions with mtt (3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2h-tetrazolium bromide) and tmre (tetramethyl-rhodamine ethyl ester).the most conspicuous internal structures of the endospore of rhinosporidium seeberi are the 10-16 spherical, 1.0-1.5-microm bodies that have been termed electron-dense bodies (edb) or lipid bodies (lb); some authors have regarded them as nutritive stores of lipid or protein while others have regarded them as dna-containing, ultimate generative units of r. seeberi. the literature is reviewed as supporting either view. we report, for the first time, (i) reactions of the endospores with the salt mt ...200516010853
rhinosporidiosis presenting as an urethral polyp.rhinosporidiosis is an inflammatory disease caused by rhinosporidium seeberi, a protoctistan mesomycetozoa, member of a group of novel aquatic parasites, characterized by hyperplastic polypoid lesions of the nasal cavity and rarely other mucous membranes. we report an unusual presentation of rhinosporidiosis as an urethral polyp, which is only the second case of rhinosporidiosis reported from pakistan.200818541092
oculosporidiosis in a tertiary care hospital of western orissa, india: a case series.the authors present a case series of 54 subjects of rhinosporidium. they were reported in two years at a tertiary care hospital of western orissa. the clinically diagnosed cases by ophthalmologists were confirmed by histopathological samples following surgery. in our series, we noted rhinosporidium seeberi organisms as the main causative agent. males were affected three times more than females. children less than 10 years of age comprised more than 50% of our series. in 91% of cases, the conjunc ...200717595481
the effects of biocides (antiseptics and disinfectants) on the endospores of rhinosporidium seeberi.no data exists on the activity of biocides (antiseptics and disinfectants) on rhinosporidium seeberi that causes rhinosporidiosis in humans and animals. on account of the inability to culture r. seeberi, in vitro, dyes were used to assess the morphological integrity and viability of biocide-treated endospores that are considered to be the infective stage of this pathogen. evan's blue (evb) identifies the morphological integrity of the endospores while mtt (3-[4, 5-dimethylthiazol-2yl]-2, 5-diphe ...200616687856
[mycoses of the head and neck].in recent years, mycoses have emerged as important infections in clinical practice. this phenomenon is explained by the ever growing number of immunocompromised patients and the increasing number of people travelling in areas where fungal diseases are endemic. head and neck infections are common in disseminated mycoses and may simulate carcinoma or cause upper airway obstruction. the most frequent causative yeasts or yeast-like organisms include candida albicans, cryptococcus neoformans, histopl ...200516142162
rhinosporidium seeberi: a case clinically mimicking a soft tissue sarcoma. 200616879404
rhinosporidiosis: gigantic cells with engulfed sporangia of rhinosporidium seeberi in the case of dermosporidiosis.rhinosporidiosis in an indian male with a tumorous skin lesion is reported. histopathology from the skin lesion revealed gigantic foreign body giant cells bloated with multiple, engulfed sporangia of rhinosporidiosis, which has not been reported earlier. the term "dermosporidiosis", should be used to denote such predominant skin lesions of rhinosporidiosis.200818613875
primary cutaneous rhinosporidiosis diagnosed on fnac: a case report with review of literature.rhinosporidium seeberi causes granulomatous inflammation of mucocutaneous sites, presenting most frequently as polypoidal lesions in the nose. sites like the conjunctiva, trachea, nasopharnyx, skin, and genitourinary tract are less frequently involved. primary cutaneous lesion is extremely rare. we report the fine needle aspiration cytology (fnac) of rhinosporidiosis occurring as a primary cutaneous lesion. fnac of polypoidal and warty skin growths on leg in a 28-year-old male revealed numerous ...200919021218
[mycoses of the head and neck].the ever growing number of immunocompromized patients and increasing travel to areas where fungal diseases are endemic explain why in recent years mycoses have emerged as important infections in clinical practice. it is essential that pathologists and clinicians be knowledgeable about them.200516439931
nasal rhinosporidiosis.rhinosporidiosis is a rare chronic granulomatous infection caused by rhinosporidium seeberi. it affects mainly the mucosa of the nose, nasopharynx, palate, conjunctiva and the urethra. a seven-year-old girl presented with intranasal polypoid growth with recurrent nose bleeding for one year. excision biopsy was done, and the tissue was subjected to routine histological processing and stained with hematoxylin and eosin stains with additional mucicarmine special stain. variable-sized sporangia cont ...200818595574
rhinosporidiosis in raipur, chhattisgarh: a report of 462 cases.rhinosporidiosis is endemic in the state of chhattisgarh. 462 cases were encountered during the period of 12 years from january 1994 to december 2005. maximum incidence was seen in men in the age group of 21-30 years. nose and nasopharynx were the commonest site (81.1%), followed by ocular tissue (14.2%). many rare sites of involvement were encountered. seven cases of generalized rhinosporidiosis were seen. rhinosporidium seeberi could be easily identified in haematoxylin and eosin stained secti ...200718306535
the assessment of the viability of the endospores of rhinosporidium seeberi with mtt (3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2h-tetrazolium bromide).this report describes tests with evan's blue and mtt (3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2h-tetrazolium bromide) for the assessment of the viability of rhinosporidial endospores. mtt stained a proportion of the spherical bodies that we regard as the electron dense bodies (edbs), and the cytoplasm of freshly prepared endospores or ones that were stored at 4 degrees. slow-freezing at -20 degrees c, exposure to 10% formalin, or 0.1% sodium azide of the endospores abolished mtt-staining in ...200415757178
recent advances in rhinosporidiosis and rhinosporidium seeberi.rhinosporidiosis and its causative pathogen rhinosporidium seeberi have been known for over a hundred years. yet unresolved enigmas in rhinosporidiosis include the mode of infection, mechanisms of spread, mechanisms of immunity, some aspects of histopathology e.g. the significance of transepidermal elimination of sporangia, the cause of the variation in cell infiltration patterns in rhinosporidial tissues and their correlations with immune status, and the absence of the splendore-hoeppli reactio ...200217657050
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