| diterpenoids from cultured erythropodium caribaeorum. | the known antimitotic agent eleutherobin and the briarane diterpenoids erythrolides a and b have been isolated from cultured specimens of erythropodium caribaeorum in amounts comparable to those reported from wild-harvested reef animals. the novel diterpenoid aquariolide a, having an unprecedented highly rearranged carbon skeleton (named aquariane), has also been found. the aquariane skeleton can be formally derived from the briarane skeleton by sequential di-pi-methane and vinyl-cyclopropane re ... | 2002 | 12423092 |
| spatial and temporal investigation of the microbiome of the caribbean octocoral erythropodium caribaeorum. | the octocoral erythropodium caribaeorum is an important species in the caribbean coral reef community and a source of the cytotoxic natural product desmethyleleutherobin. we utilized 16s small subunit rrna gene amplicon pyrosequencing to characterize the microbiome of e. caribaeorum collected from florida, usa and san salvador, the bahamas at multiple time points. this coral was found to have a very high microbial richness with an average chao1 estimated richness of 1464 ± 707 operational taxono ... | 2016 | 27381833 |
| cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts. | we describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination of antimitotic activity. in the assay, cells arrested in mitosis as a result of exposure to antimitotic agents in pure form or in crude natural extracts are detected by elisa using the monoclonal antibody tg-3. the assay was used to screen >24,000 extracts of marine microorganisms and invertebrates and terrestrial plants and to guide the purification of active compounds ... | 2000 | 11016628 |
| new erythrolides from the caribbean gorgonian octocoral erythropodium caribaeorum. | seven new briarane diterpenes, erythrolides k-q (1-7), as well as the known compounds erythrolides a, b, c, f, and j have been isolated from samples of the caribbean gorgonian erythropodium caribaeorumcollected at buccoo reef and flying reef, tobago. the structures of the new compounds were determined by high-resolution 1h and 13c nmr spectroscopy utilizing cosy, hmbc, hmqc, and noesy experiments. the structures of erythrolides k and p were confirmed and their relative stereochemistry determined ... | 2002 | 11908971 |
| antimitotic diterpenes from erythropodium caribaeorum test pharmacophore models for microtubule stabilization. | [structure: see text] six new antimitotic diterpenes, 2-7, have been isolated from the caribbean octocoral erythropodium caribaeorum. structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds. | 2000 | 10814296 |
| briarane diterpenes from the gorgonian octocoral erythropodium caribaeorum from the northern caribbean | an investigation of the gorgonian octocoral erythropodium caribaeorum collected off the north coast of jamaica has yielded three new briarane diterpenes. in addition, the six known diterpenes, erythrolides a, b, d, e, f, and i were isolated. the structures of these diterpenes were established by 1h and 13c nmr spectroscopy utilizing dept, cosy, and hetcor experiments. | 1999 | 10075771 |