| hymenolepis microstoma: lactate and malate dehydrogenases of the adult worm. | | 1979 | 35360 |
| effects of fat soluble vitamins (vitamin a, d3 and e) on axenically in vitro growth of hymenolepis microstoma. | | 1978 | 212890 |
| surface topography of hymenolepis microstoma, the mouse bile duct tapeworm, as determined by scanning electron microscopy. | | 1978 | 682078 |
| biliary and intestinal pathology in mice infected with hymenolepis microstoma, as determined by scanning electron microscopy. | | 1977 | 886418 |
| hymenolepis diminuta and hymenolepis microstoma: effect of ouabain on active nonelectrolyte uptake across the "epithelial" syncytium. | | 1977 | 891710 |
| the fine structure of the nervous tissue of the metacestode of hymenolepis microstoma. | | 1976 | 949662 |
| hymenolepis microstoma: effect of the mouse bile duct tapeworm on the metabolic rate of cf-1 mice. | | 1976 | 950001 |
| hymenolepis microstoma: correlation of histopathological host response and organ hypertrophy. | | 1976 | 976420 |
| lesion formation in the livers of mice caused by metabolic products of hymenolepis microstoma. | | 1975 | 1117360 |
| the gross anatomy and histology of the nervous system of the metacestode of hymenolepis microstoma. | | 1975 | 1131756 |
| studies on hymenolepis microstoma in vitro. i. effect of heme compounds on growth and reproduction. | the effect of various heme compounds on growth and maturation of hymenolepis microstoma in vitro has been determined. at 4 days p.i., worms were collected and cultured in vitro for 6 days in a medium containing various concentrations of haemoglobin, hemin, and bilirubin. addition of haemoglobin to a medium resulted in significant increases in length, wet weight, number of immature and mature proglottids as compared to the control medium. supplements of hemin did not seem to affect worm length; h ... | 1976 | 983237 |
| interaction of hymenolepis diminuta and hymenolepis microstoma with complement. | | 1988 | 3170074 |
| putative neurosecretory cells of the cestode hymenolepis microstoma. | putative neurosecretory cells were observed with the electron microscope in the nerve cords of the neck region of hymenolepis microstoma. the cells show evidence of glandular activity by the large numbers of dense-core vesicles produced by the golgi apparatus. the axons contain synaptoidlike structures with surrounding clouds of vesicles; features analogous to known neurosecretory release sites. | 1976 | 978366 |
| the growth of secondary infections of hymenolepis microstoma in mice: the effect of various primary infection regimes. | groups of mice were infected with 1, 5 or 10 cysticercoids of hymenolepis microstoma. infections were terminated with the anthelmintic 'zanil' after 5, 15 or 30 days and the mice challenged with 6 cysticercoids. the growth of the worms in the secondary infections decreased as either the intensity (number of cysticercoids administered) or duration of the primary infections increased. it is postulated that the results have an immunological basis. | 1976 | 967522 |
| qualitative distribution of neutral lipids and phospholipids in hymenolepis microstoma from the cysticercoid to the egg producing adult. | the distribution of neutral lipids and phospholipids in hymenolepis microstoma has been studied using fettrot, sudan black b, sudan iv and copper phthalocyanin staining techniques. in the cysticercoid, neutral lipids are found in the outer membrane, the lining of the cysticercoid cavity, the tegument of the larval worm and the calcareous corpuscles. a decreasing gradient of phospholipids is found starting from the acellular layer, through the circular fibrous layer, the longitudinal fibrous laye ... | 1976 | 961009 |
| hymenolepis microstoma: a change in susceptibility to resistance with increasing age of the parasite. | hymenolepis microstoma from secondary infections in mice were found to grow initially more slowly than h. microstoma from primary infections. eventually a similar rate of growth was attained by both kinds of worm. after transplantation, young worms (less than or equal to 4 days old) grew more slowly in previously infected than in naive mice. in contrast, 10-day-old worms grew equally well in naive or resistant mice. the administration of cortisone to mice during a secondary infection of h. micro ... | 1977 | 927890 |
| evidence for neurosecretory cells in the cestode hymenolepis microstoma. | | 1977 | 922613 |
| structure, formation, and functions of calcareous corpuscles in hymenolepis microstoma. | | 1977 | 919695 |
| the nature of the immune response of the mouse to the bile duct cestode, hymenolepis microstoma. | | 1971 | 4102076 |
| hemin as a requirement in the development in vitro of hymenolepis microstoma (cestoda: cyclophyllidea). | | 1971 | 4103847 |
| a new approach for studies on calcareous corpuscles in hymenolepis microstoma. | | 1974 | 4134539 |
| the functional significance of scolex retraction and subsequent cyst formation in the cysticercoid larva of hymenolepis microstoma. | | 1974 | 4363723 |
| ciliated sensory receptors of the unactivated metacestode of hymenolepis microstoma. | | 1974 | 4458092 |
| hymenolepis microstoma cysticercoid activation and excystation in vitro (cestoda). | | 1972 | 4560440 |
| excystation of hymenolepis microstoma. i. influence of age, population density and pre-treatment of the cysticercoids. | | 1972 | 4562891 |
| excystation of hymenolepis microstoma. ii. relative influences of proteolytic enzymes and bile salts. | | 1973 | 4582907 |
| effects of ultraviolet radiation on the growth and morphology of hymenolepis microstoma (cestoda). | | 1972 | 4670815 |
| the effect of cortisone acetate on the metabolism of hymenolepis microstoma (cestoda:cyclophyllidea). | hymenolepis microstoma grown in mice, treated with 1.25 mg cortisone acetate every second day, are heavier and have a significantly higher glycogen content than those in control mice. the dry/wet weight ratio and protein content however are unaffected. it is suggested that the increase in glycogen reserve and weight in h. microstoma from cortisone-treated mice is due to an immunosuppressive effect and better nutritional environment rather than hormonal action. inclusion of 0.1 mg of cortisone pe ... | 1977 | 906632 |
| the effect of oxyclozanide on hymenolepis microstoma and h. diminuta. | | 1973 | 4786845 |
| osmoregulation of hymenolepis microstoma. i. influence of the osmotic pressure on the gravid adult. | | 1972 | 5018200 |
| osmoregulation of hymenolepis microstoma. ii. influence of the osmotic pressure on the in vitro development of the young adult. | | 1972 | 5018201 |
| the effect of cortisone acetate treatment on the growth of hymenolepis microstoma in mice. | | 1972 | 5018482 |
| the growth of hymenolepis microstoma in the laboratory rat. | | 1972 | 5053037 |
| migratory behavior of hymenolepis microstoma. | | 1972 | 5081040 |
| resistance of chinese hamsters to hymenolepis microstoma and its reversal by immunosuppression. | | 1971 | 5157159 |
| hymenolepis microstoma: interference microscopy of embryonic lateral hooks. ii. structure and reaction to 2-mercaptoethanol. | | 1969 | 5362307 |
| hymenolepis microstoma: interference microscopy of embryonic lateral hooks. i. effects of temperature and reagent concentration on reaction with 2-mercaptoethanol. | | 1969 | 5362320 |
| the effect of concurrent infection with trichinella spiralis on hymenolepis microstoma in mice. | the intestinal changes brought about by rejection of trichinella spiralis from mice were studied in relation to their effects on a concurrent infection with hymenolepis microstoma, a cestode not normally rejected from mice. the rejection phase of t. spiralis was associated with a marked stunting of growth of h. microstoma given just before, during, or just after rejection of the nematode. the survival of h. microstoma was affected only when rejection of t. spiralis coincided with the intestinal ... | 1978 | 748836 |
| hymenolepis microstoma: retardation of growth and development of larval and pupal stages of tribolium confusum. | | 1969 | 5408382 |
| amino acids of hymenolepis microstoma and host bile. | | 1970 | 5434261 |
| hymenolepis microstoma: ultrastructural localization of adeny cyclase in the tegument. | | 1978 | 729695 |
| the effect of streptomycin and penicillin on the growth and differentiation in vitro of hymenolepis microstoma. | | 1978 | 667758 |
| biochemical alterations in organs of mice infected with hymenolepis microstoma, the mouse bile duct tapeworm. | | 1978 | 641670 |
| the differential sensitivity of hymenolepis microstoma (cestoda: cyclophyllidea) cysticercoid stages to x-rays. | | 1971 | 5553459 |
| prolonged selfing in hymenolepis microstoma (cestoda). | | 1971 | 5556288 |
| hymenolepis microstoma: tegumentary disks. | | 1978 | 75112 |
| membrane (contact) digestion in the three species of tapeworm hymenolepis diminuta, hymenolepis microstoma and moniezia expansa. | | 1968 | 5740543 |
| establishment of tribolium confusum populations after stress by parasitism with hymenolepis microstoma. | | 1966 | 5909675 |
| histochemistry of hymenolepis microstoma (cestoda: hymenolepididae). ii. regional distribution of succinic dehydrogenase. | | 1966 | 5912233 |
| studies on hymenolepis microstoma in vitro. ii. effect of yeast extract on development and maturation. | four day old in vivo hymenolepis microstoma were cultured in vitro for 6 days in media containing 2, 1, 0.5 and 0.1% yeast extract. worms from all groups including control group increased in length and produced nearly equivalent numbers of proglottids. however, worms grown in yeast extract added media produced significantly more mature proglottids and were heavier than those in the control medium. the possibility of pyridoxin involvement has been contemplated. effects of osmotic pressure and ph ... | 1976 | 8894 |
| lumen phase specific cross immunity between hymenolepis microstoma and h. nana in mice. | | 1988 | 2975639 |
| development of the cestode hymenolepis microstoma in mus musculus. | | 1966 | 5982701 |
| action of cyclosporin a on the tapeworms hymenolepis microstoma, h. diminuta and mesocestoides corti in vivo. | the in vivo activity of two cyclosporins, cyclosporin a (csa) and a non-immunosuppressive derivative of dihydrocylosporin a (dhcsa-d) against three tapeworms, hymenolepis microstoma, h. diminuta and mesocestoides corti, has been assessed. csa reversibly reduced the dry weight of h. microstoma in the mouse, briefly delayed oviposition and had a statistically significant effect on worm numbers recovered. oral and subcutaneous treatments of both csa and dhcsa-d were effective in reducing worm weigh ... | 1989 | 2762040 |
| maintenance and growth of hymenolepis microstoma (cestoda: cyclophyllidea) in vitro. | | 1967 | 6022393 |
| concurrent infections of the trematode echinostoma caproni and the tapeworms hymenolepis diminuta and hymenolepis microstoma in mice. | superimposing the intestinal tapeworm hymenolepis diminuta on an established infection with the trematode echinostoma caproni or simultaneous infection of mice with h. diminuta and hymenolepis microstoma caused destrobilation and expulsion of h. diminuta, whereas establishment and growth of h. microstoma under the same infection regimes were not affected. in contrast, simultaneous superimposition of h. diminuta and h. microstoma on an established e. caproni infection caused destrobilation and ex ... | 1990 | 2380867 |
| effects of cyclophosphamide and dexamethasone on mast cell populations in hymenolepis microstoma-infected mice. | antineoplastic cyclophosphamide (cy) significantly reduced the survival and the weight of hymenolepis microstoma in mice. corticosteroid dexamethasone (dex), on the other hand, did not influence the worm survival and the worms in dex-treated mice became significantly heavier. both immunosuppressants abolished h. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (mc) in these regions. cy appeared to be more effective in depleting the bile duct m ... | 1990 | 2345666 |
| hymenolepis microstoma: oncospheres invade the intestinal tissue of the definitive host. | | 1990 | 2143769 |
| carbohydrate intermediary metabolism in hymenolepis microstoma (cestoda). | | 1982 | 6804404 |
| effects of cyclosporin a on the morphology and tegumentary ultrastructure of hymenolepis microstoma in vivo. | cyclosporin a (csa) induced significant changes in parasite morphology when administered to mice infected with hymenolepis microstoma. gross morphological damage consisted of proglottis swelling and the formation of protuberances from the worm surface, visible with a low-power dissecting microscope, occurring most frequently in the posterior third of the strobila. gross morphology and ultrastructure were examined further using scanning and transmission electron microscopy. swollen proglottides e ... | 1992 | 1641251 |
| efficacy of albendazole and mebendazole against hymenolepis microstoma and hymenolepis diminuta. | an investigation of the chemotherapeutic effects of 2 anthelmintics, albendazole (abz, methyl 5-[propylthio]benzimidazole-2- carbamate) and mebendazole (mbz, methyl 5-[benzoyl]benzimidazole-2-carbamate), on hymenolepis microstoma and hymenolepis diminuta in experimentally infected mice and rats is reported. single (50 mg/kg) or multiple daily oral doses (50 mg kg-1 day-1 for 3 consecutive days) of mbz had no effect on h. microstoma; at necropsy, the drug treated mice harbored appreciable numbers ... | 1992 | 1557321 |
| the effect of transplanted hymenolepis microstoma, the mouse bile duct tapeworm, on cf-1 mice. | | 1976 | 1263050 |
| adsorption of bile salts by the cestodes, hymenolepis diminuta and h. microstoma. | the accumulation of purified sodium taurocholate (natc) and sodium glycocholate (nagc) by hymenolepis diminuta and hymenolepis microstoma (cestoda: cyclophyllidea) was determined using radioactive bile salts. h. diminuta reached equilibrium levels of approximately 120 nmoles natc/g dry wt and 300 nmoles nagc/g dry wt. presentation of the bile salts in mixed micelles with 0.35 mm oleic acid did not alter these values. with h. microstoma, the maxima were 195 nmoles natc/g dry wt and 614 nmoles nac ... | 1976 | 1255388 |
| ultrastructural changes in an unciliated sensory receptor during activation of the metacestode of hymenolepis microstoma. | the fine structure of an unciliated sensory receptor of the metacestode of hymenolepis microstoma is described. each receptor contains a basal body inserted into an electron dense matrix; a terminal cilium is lacking. at this stage of development neurotubules were lacking, but rapidly appeared following excystation. it is suggested that neurotubules play a role in the functioning of the putative proprioceptor. | 1975 | 1179413 |
| the life cycle in vitro of hymenolepis microstoma (cestoda). | the cestode hymenolepis microstoma was grown axenically from oncosphere to infective cysticercoid. reducing agents were not essential for development and produced structural abnormalities in the organisms. cysticercoids grown in vitro were excysted, placed in culture, and developed into adults containing gravid segments, thus completing the life cycle in vitro. | 1975 | 1165551 |
| hymenolepis muris-sylvaticae and h. microstoma: immunological cross-reaction in mice. | a primary infection with hymenolepis microstoma strongly protects against cross-infection with h. muris-sylvaticae and also against secondary infection with h. microstoma in nmri mice, resulting in an accelerated loss of worms and a weight reduction of the remaining worms. a primary infection with h. muris-sylvaticae causes an accelerated rejection of secondary infection with h. muris-sylvaticae but it has no effect on cross-infection with h. microstoma, neither with regard to worm recovery nor ... | 1988 | 3338548 |
| mast cell responses to hymenolepis microstoma infection in mice. | murine mast cells (mc) responded strongly to hymenolepis microstoma infection. starting day 7 postinfection (pi) and continuing until the end of the experiment (35 days pi), significantly larger numbers of mc were present in both the duodenum and bile duct of infected mice than in uninfected controls. in animals challenged with 5 cysticercoids 2 wk after primary infection, the mc response in the duodenum, but not in the bile duct, was of even greater degree than in naive hosts. the majority of m ... | 1988 | 3357107 |
| fatty acid and cholesterol synthesis in mice infected with the tapeworm hymenolepis microstoma. | infection with hymenolepis microstoma significantly affected the lipid metabolism of young male balb/c mice. infection increased the rates of hepatic fatty acid and cholesterol synthesis and cholesterol synthesis by the gut. decreases were recorded in testicular fatty acid synthesis and in the weights of testes and white epididymal adipose tissue. plasma glucose decreased rapidly during infection. the observed changes in lipogenesis could not be attributed to changes in food intake or body tempe ... | 1987 | 3670901 |
| complement-mediated lysis in vitro of newly excysted tapeworms: hymenolepis diminuta, hymenolepis microstoma, hymenolepis nana and hymenolepis citelli. | | 1986 | 3721705 |
| effects of environmental temperature, sex, and infection with hymenolepis microstoma on the liver and bile duct weights of mice. | liver weight of mice was significantly influenced, in order of decreasing prominence, by environmental temperature, infection with hymenolepis microstoma and sex. livers of infected and uninfected mice (both sexes) maintained at 5 c for 20 days were proportionally larger (alpha less than or equal to 0.05) than those from corresponding groups of mice kept at 35 c and, except for uninfected males, at 21 c. regardless of temperature, h. microstoma (single-worm infections) produced significant (alph ... | 1985 | 3981335 |
| hymenolepis microstoma: histopathological changes in mice maintained at different environmental temperatures. | livers of uninfected mice maintained at 5 c did not differ histologically from mice kept at 21 c, but the hepatocytes of mice kept at 35 c were depleted of glycogen. regardless of temperature, infection with a single hymenolepis microstoma induced inflammatory changes in the livers of all mice. however, the degree of histopathology was less in mice kept at 21 c than in mice at 5 c or 35 c. infected mice in the hot and cold environments developed necrotic lesions in their liver parenchyma. livers ... | 1985 | 4093806 |
| interspecific interactions between hymenolepis microstoma (cestoda) and heligmosomoides polygyrus (nematoda) in mice. | | 1973 | 4711669 |
| chromosome analysis of hymenolepis microstoma. | | 1969 | 5362601 |
| the in vitro cultivation of hymenolepis microstoma from cysticercoid to egg-producing adult. | | 1970 | 5471783 |
| electron microscopy of the peribiliary connective tissues in mice infected with the tapeworm hymenolepis microstoma. | | 1970 | 5504540 |
| effect of x rays on developing cysticercoids of hymenolepis microstoma. | | 1971 | 5539704 |
| studies on the biology of hymenolepis microstoma (dujardin, 1845). | | 1961 | 13888781 |
| observations on hymenolepis microstoma in three laboratory hosts: mesocricetus auratus, mus musculus, and rattus morvegicus. | | 1963 | 13930954 |
| the chromosomes of hymenolepis microstoma (dujardin 1845). | | 1963 | 13964161 |
| sensitivity of cysticercoids of hymenolepis microstoma (cestoda: cyclophyllidea) to high temperature stress. | | 1963 | 13997617 |
| histochemical studies on hymenolepis microstoma (cestoda: hymenolepididae). | | 1963 | 14084214 |
| in vivo incorporation of tritiated cytidine and tritiated thymidine by the cestode, hymenolepis microstoma. | | 1963 | 14099843 |
| development of hymenolepis microstoma (cestoda: cyclophyllidea) in the intermediate host tribolium confusum. | | 1964 | 14125172 |
| motility and hatching of hymenolepis microstoma oncospheres in sera, beetle extracts, and salines. | | 1965 | 14296059 |
| resistance of mice to reinfection with the bile-duct cestode, hymenolepis microstoma. | | 1968 | 5652502 |
| fasciola hepatica and hymenolepis microstoma in the laboratory mouse. | | 1967 | 6017231 |
| autoelimination by means of x-rays: distinguishing the crowding factor from others in premunition caused by the mouse bile duct cestode, hymenolepis microstoma. | | 1967 | 6036477 |
| hymenolepis microstoma: mouse strain differences in resistance to a challenge infection. | antibody responses and host resistance to the tapeworm, hymenolepis microstoma, were investigated using akr/j and c3heb/fej strains of mice. akr mice were significantly more resistant than controls to a secondary infection following exposure to a 3-, 21-, or 40-day primary infection. during a primary infection, intestinal anti-worm antibody responses measured by an enzyme-linked immunosorbent assay were elevated in the more resistant akr strain, whereas serum antibody titers did not differ betwe ... | 1984 | 6500003 |
| effects of ox bile on the growth and organogenesis of hymenolepis microstoma in vitro. | hymenolepis microstoma has been cultured in vitro from 4 to 11 days of age using eagle's medium (bme) supplemented with horse serum, lamb's liver extract and ox gall (dehydrated bile) in five different concentrations (0.025%, 0.1%, 0.2%, 0.5% and 1% all in bme) including a control without the added ox gall. the results of these experiments demonstrated that growth is related inversely to the concentration of ox gall in the media. however, the number of proglottids containing fertilized ova in th ... | 1984 | 6546463 |
| 5-hydroxytryptamine, glucose uptake, glycogen utilization and carbon dioxide fixation in hymenolepis microstoma (cestoda). | 1. in vitro glucose uptake and glycogen utilization by hymenolepis microstoma decreased under high oxygen concentrations. 2. 5-hydroxytryptamine did not stimulate in vitro glucose uptake but did increase glycogen utilizations by h. microstoma. 3. the reduced glucose uptake under high oxygen concentrations (21 and 95%) resulted in a reduction in excretory products. 4. 14co2-incorporation studies confirmed that, under both 95% o2:5% co2 and air-minus-co2 (identical to 21% o2). co2-fixation by phos ... | 1982 | 6817965 |
| mitochondrial malate dehydrogenase, decarboxylating ("malic" enzyme) and transhydrogenase activities of adult hymenolepis microstoma (cestoda). | adult h. microstoma mitochondria catalyzed a malate dehydrogenase, decarboxylating ("malic" enzyme) activity. this "malic" enzyme was found as a soluble component of the mitochondrion, was specific for nadp, and required a divalent cation with mn++ ion yielding the greatest activity. the h. microstoma "malic" enzyme could fulfill the need for generating intramitochondrial reducing equivalents required for electron transport. the h. microstoma mitochondria also exhibited an nadph:nad transhydroge ... | 1982 | 7077455 |
| a comparison of the effect of albendazole, cambendazole, and thiabendazole on the larval development of three hymenolepidid cestodes. | flour beetles (tribolium confusum) parasitized either by hymenolepis diminuta, h. nana, or h. microstoma were fed continuously on flour mixed either with thiabendazole, cambendazole, or albendazole (drug concentration was always 10%) from day 1 (24 hr) to day 10 postinfection when the experiments were terminated. all drugs markedly inhibited the development of h. diminuta and h. nana. populations of these species recovered from beetles fed anthelmintics were composed mostly of under-developed fo ... | 1980 | 7218116 |
| testosterone propionate and the growth of hymenolepis microstoma in intact and orchiectomized mice. | | 1981 | 7324537 |
| the growth of hymenolepis microstoma in intact and gonadectomized mice. | gonadectomy or sex of the host had no effect on the mean dry weight of hymenolepis microstoma examined on day 12 postinfection (p.i.). however, on day 20 p.i. worms from intact or sham-operated male mice were significantly heavier than those recovered from the corresponding groups of female hosts. orchiectomy of hosts lowered the average weight of these older worms, but ovariectomy had no effect. | 1980 | 7368775 |
| immunopathological responses of dba/2 mice to primary infections of the bile duct tapeworm, hymenolepis microstoma and the effect of anthelmintic treatment. | | 1995 | 7502937 |
| microscopical observations on immune precipitates formed in vitro on the surface of hymenolepid tapeworms. | four-day-old worms of the tapeworms hymenolepis microstoma, h. diminuta and h. nana and newly excysted h. microstoma were exposed in vitro at 37 degrees c to immune serum from mice infected for 4-12 weeks with h. microstoma. worms were fixed for electron microscopy after intervals of 5 min to 96 h. within 10-15 min an homogeneous precipitate occurred between the microtriches of 4-day-old h. microstoma and h. nana, while on some areas of h. microstoma the precipitate extended distal to the microt ... | 1994 | 8084669 |
| cyclosporin a: drug treatment in vivo affects the kinetics of [14c]glucose transport in hymenolepis microstoma in vitro. | the transport of [14c]glucose by hymenolepis microstoma in vitro following in vivo treatment with cyclosporin a (csa) was determined over a range of concentrations. for untreated (control) worms glucose uptake showed saturation kinetics with a small diffusion component. estimates of the maximum velocity of glucose uptake (vmax) and the affinity of substrate for the glucose transporter (kt) revealed that untreated 8-day-old worms had a vmax twice that of 15-day-old worms and that younger worms ha ... | 1994 | 8159467 |
| phosphorus metabolites of liver from mice infected with hymenolepis microstoma. | 31p nmr in vivo spectra of mouse livers infected with hymenolepis microstoma for 130 or 265 days showed modifications in phosphorus-containing metabolite ratios when compared to those of normal liver. after 130 days of infection the metabolite ratio of inorganic phosphate (pi)/beta atp significantly increased whereas that of phosphocreatine (pcr)/beta atp significantly decreased. in older, 265 day infections, the increase in pi/beta atp and decrease in pcr/beta atp persisted. changes in the grou ... | 1993 | 8468141 |
| hymenolepis diminuta and h. microstoma: uptake of cyclosporin a and drug binding to parasite cyclophilins. | cyclosporin a (csa) acts as a powerful immunosuppressant through its binding to the cytosolic isomerase, cyclophilin (cyp), forming a complex which inhibits the phosphatase activity of calcineurin. the drug is also selectively anti-parasitic but its mode of action remains unknown. the mouse tapeworm, hymenolepis microstoma is sensitive to csa, but the rat tapeworm, h. diminuta is not susceptible either in rats, mice or in vitro. using these two tapeworm models, the uptake and binding of csa were ... | 1995 | 8559592 |
| analysis of structure, function and epitopes of spirometra erinaceieuropaei casein kinase i. | spirometra erinaceieuropaei casein kinase i (secki) was analyzed using bioinformatical methods to predict its structure and function based on the deduced amino acid sequence from full length cdna sequence of secki gene with online sites and software programs. the longest open reading frame contains 448 amino acids, 50 kda and theoretical pi of 4.73, with a complete tubulin domain, a smart tubulin_c domain and a low complexity region. secki has no signal sequence and no transmembrane domain, but ... | 2015 | 25801267 |
| the anthelmintic efficacy of natural plant cysteine proteinases against hymenolepis microstoma in vivo. | little is known about the efficacy of cysteine proteinases (cp) as anthelmintics for cestode infections in vivo. hymenolepis microstoma is a natural parasite of house mice, and provides a convenient model system for the assessment of novel drugs for anthelmintic activity against cestodes. the experiments described in this paper indicate that treatment of h. microstoma infections in mice with the supernatant of papaya latex (pls), containing active cysteine proteinases, is only minimally efficaci ... | 2015 | 25226116 |