Publications

complex tissue regeneration in mammals is associated with reduced inflammatory cytokines and an influx of t cells.	while mammals tend to repair injuries, other adult vertebrates like salamanders and fish regenerate damaged tissue. one prominent hypothesis offered to explain an inability to regenerate complex tissue in mammals is a bias during healing toward strong adaptive immunity and inflammatory responses. here we directly test this hypothesis by characterizing part of the immune response during regeneration in spiny mice (acomys cahirinus and acomys percivali) vs. fibrotic repair in mus musculus. by dire ...	2020	32849592
ear wound regeneration in the african spiny mouse acomys cahirinus.	while regeneration occurs in a number of taxonomic groups across the metazoa, there are very few reports of regeneration in mammals, which generally respond to wounding with fibrotic scarring rather than regeneration. a recent report described skin shedding, skin regeneration and extensive ear punch closure in two rodent species, acomys kempi and acomys percivali. we examined these striking results by testing the capacity for regeneration of a third species, acomys cahirinus, and found a remarka ...	2016	27499879