| biocatalyzed cross-coupling of sinomenine and guaiacol by antrodiella semisupina. | in search of more potent derivatives of sinomenine (1), a clinically available natural alkaloid for the treatment of rheumatoid arthritis (ra), biocatalyzed cross-coupling of sinomenine and guaiacol (2) by antrodiella semisupina, provided two unique c-c coupled (3 and 4) and one c-o linked (5) novel metabolites. the structures of the metabolites were elucidated by means of ms, 2d nmr techniques and x-ray analysis. 4 exhibited more potent inhibitory activity on il-6 production than 1 in human syn ... | 2008 | 18284247 |