| using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from phomospis asparagi. | the isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. these compounds were produced by cultures of the marine-derived fungus phomopsis asparagi, challenged with the known f-actin inhibitor jasplakinolide. chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines. | 2005 | 16309305 |
| synthesis and antifungal properties of sulfanilamide derivatives of chitosan. | sulfanilamide derivatives of chitosan (2-(4-acetamido-2-sulfanimide)-chitosan (hsacs, lsacs), 2-(4-acetamido-2-sulfanimide)-6-sulfo-chitosan (hsacss, lsacss) and 2-(4-acetamido-2-sulfanimide)-6-carboxymethyl-chitosan (hsacmcs, lsacmcs)) were prepared using different molecular weights of chitosan (cs), carboxymethyl chitosan (cmcs) and chitosan sulfates (css) reacted with 4-acetamidobenzene sulfonyl chloride in dimethylsulfoxide solution. the structures of the derivatives were characterized by ft ... | 2007 | 17765881 |
| synthesis, fungicidal activity, and structure-activity relationship of spiro-compounds containing macrolactam (macrolactone) and thiadiazoline rings. | two series of novel spiro-compounds containing macrolactam or macrolactone and thiadiazoline rings, 1-thia-2-alkylimino-3,4,9-triaza-10-oxospiro[4.15]eicosyl-3-ene (4f) and 1-thia-2-alkylimino-3,4-diaza-9-oxa-10-oxospiro[4.15]eicosyl-3-ene (4g), were synthesized from 12-oxo-1,15-pentadecanlactam and 12-oxo-1,15-pentadecanlactone, respectively. their structures were confirmed by elemental analysis, (1)h nmr, and (13)c nmr. the conformation of compounds 4f was determined via the crystal structure ... | 2010 | 20041703 |