| platelet activating factor (paf) antagonists contained in medicinal plants: lignans and sesquiterpenes. | hot aqueous extracts of medicinal plants were tested for their inhibitory effect on the binding of platelet activating factor (paf) to rabbit platelets. the extracts of forsythia suspensa vahl. (oleaceae), arctium lappa l. (compositae) and centipeda minima (l.) a. braun et aschers (compositae) showed significant activities. since the main constituents of f. suspensa and a. lappa are lignans, 30 lignans were tested for their inhibitory effects on paf binding to platelets and 9 lignans were found ... | 1992 | 1394633 |
| biologically active constituents of centipeda minima: sesquiterpenes of potential anti-allergy activity. | ether, methanol and aqueous extracts of centipeda minima (compositae) herbs were found to have significant anti-allergy activities in passive cutaneous anaphylaxis (pca) test. three flavonoids, two sesquiterpene lactones and an amide were isolated from this plant material as inhibitors to induced histamine release from mast cells. the sesquiterpenes were identified as isobutyroylplenolin and senecioylplenolin by spectral investigations. the flavonoids and sesquiterpenes exhibited significant ant ... | 1991 | 1726075 |
| the formation of hydrogen sulfide and methyl mercaptan by oral bacteria. | the capacity to form volatile sulfur compounds was tested in bacteria isolated from subgingival microbiotas and in a representative number of reference strains. a majority of the 75 tested oral bacterial species and 7 unnamed bacterial taxa formed significant amounts of hydrogen sulfide from l-cysteine. the most active bacteria were found in the genera peptostreptococcus, eubacterium, selenomonas, centipeda, bacteroides and fusobacterium. methyl mercaptan from l-methionine was formed by some mem ... | 1990 | 2082242 |
| isolation and characterization of lipopolysaccharide from centipeda periodontii atcc 35019. | lipopolysaccharide (lps) was extracted from cells of centipeda periodontii atcc 35019 by a hot phenol-water method, purified by nuclease treatment and by repeated ultracentrifugations. the lps was composed of 21.7% hexose, 9.1% hexosamine, 10.3% fatty acid, 0.5% protein, 2.5% phosphorus, 4.3% 2-keto-3-deoxyoctonate(kdo) and 2.3% heptose. the major fatty acids of the lps were 3oh c13:0 and c13:0. c. periodontii lps was able to gelatinize limulus amebocyte and to produce the local schwartzman reac ... | 1990 | 2087348 |
| biologically active constituents of centipeda minima: isolation of a new plenolin ester and the antiallergy activity of sesquiterpene lactones. | | 1985 | 2418993 |
| ultrastructure of the flagellar basal body complex of centipeda periodontii. | the morphology and insertion of the flagellar basal body complex into the cell wall of centipeda periodontii was studied by electron microscopy of both negatively and positively stained specimens. freshly harvested cells were examined either after treatment with 0.2% sodium dodecyl sulfate (sds) for 2 min and negatively stained with phosphotungstic acid, or after treatment according to standard electron microscopy procedures that included positive staining. small numbers of flagella were disloca ... | 1988 | 3171249 |
| antimutagenic activity of extracts from anticancer drugs in chinese medicine. | the antimutagenic activities of extracts of 36 commonly used anticancer crude drugs from chinese herbs were studied by using the salmonella/microsomal system in the presence of picrolonic acid or benzo[a]pyrene to test whether they contain direct or indirect antimutagens. each crude drug was extracted with boiling water for 2 h, the method which is commonly used by chinese people to prepare the drug for oral intake. the extracts of pteris multifida p. showed the highest antimutagenic activity ag ... | 1988 | 3278214 |
| immunosuppressive effects of centipeda periodontii: selective cytotoxicity for lymphocytes and monocytes. | we have examined soluble sonic extracts prepared from several strains of centipeda periodontii for their ability to alter human lymphocyte function. these organisms were isolated from subgingival plaque of patients with periodontal disease. we found that sonicates from several, but not all, strains of c. periodontii caused a dose-dependent inhibition of lymphocyte responsiveness to concanavalin a, phytohemagglutinin, pokeweed mitogen, and formalinized staphylococcus aureus. inhibition was associ ... | 1987 | 3653981 |
| [studies on the constituents of centipeda minima o. kuntze. i]. | | 1970 | 5465397 |
| helical flagellation in centipeda periodontii, a gram-negative, anaerobic bacillus from periodontitis lesions. | the insertion pattern of flagellation of centipeda periodontii was determined from electron micrographs of negatively stained cells treated with various detergents to remove their outer cell wall layer(s) selectively. the best results were obtained with 0.2% sodium dodecyl sulphate and a treatment time of 1-2 min. detergent-treated cells displayed a unique helical pattern of flagellation which we designate as helicotrichous (gk n. helix, helix + gk n. thrix, hair). flagella originated from an el ... | 1984 | 6707608 |
| microbiology of the pericoronal pouch in mandibular third molar pericoronitis. | the microorganisms associated with mandibular third molar pericoronitis were investigated using direct microscopy and anaerobic culture method. the pericoronal pouch was sampled with paper points in a) 8 patients without mandibular third molar pericoronitis and b) 6 patients with mandibular third molar pericoronitis. under the microscope, the microflora was found to be a complex mixture comprising gram-positive and gram-negative cocci, rods and filaments (including fusiform and curved rods), mot ... | 1993 | 8265205 |
| antibacterial constituents of the nepalese medicinal herb, centipeda minima. | centipeda minima, a herb used medicinally to treat sinus infections in nepal, was found to contain three antibacterial sesquiterpene lactones, identified as 6-o-methylacrylylplenolin, 6-o-isobutyroylplenolin, and 6-o-angeloylplenolin. 6-o-methylacrylylplenolin had not been previously isolated from c. minima. all three had activity against bacillus subtilis and staphylococcus aureus, with 6-o-isobutyroylplenolin being the most active. | 1998 | 9461679 |
| identification and analyses of periodontal pathogens in taiwan by microbiological tests. | the purpose of this study was to use microbiological tests for diagnosis of periodontal diseases in taiwan. anaerobic culture, direct microscopy, indirect immunofluorescence (if), and biochemical tests were used to examine 336 samples for the specific microorganisms in subgingival plaque. the results indicated that gram-negative species and motile bacteria were less frequently detected, and in lower proportion, in samples from healthy sites. the bacteria found frequently in healthy group were th ... | 1994 | 9747334 |
| phylogenetic characterization of centipeda periodontii, selenomonas sputigena and selenomonas species by 16s rrna gene sequence analysis. | the nearly complete 16s rrna gene sequences for oral gram-negative anaerobic motile bacteria, centipeda periodontii, selenomonas sputigena and selenomonas species (formerly s. sputigena type strain), were determined in order to unveil their relationship to other oral motile bacteria. to determine the phylogenetic characterization of these bacteria, their 16s rrna gene sequences were obtained and compared with those from the ribosomal sequence databases previously reported. the 16s rrna gene sequ ... | 1999 | 10464949 |
| development of 16s rdna-based pcr assay for detecting centipeda periodontii and selenomonas sputigena. | to detect oral motile bacteria directly from dental plaque, specific pcr primers for centipeda periodontii and selenomonas sputigena were designed based on the sequence analysis of their 16s rdna. the primers were specific and sensitive enough to amplify dna fragments from the available oral bacteria. the detection limit was fewer than 10 bacterial cells per sample. it was also possible to detect these bacteria in dental plaque. the prevalence of these bacteria varied in each sample. the specifi ... | 2000 | 10849269 |
| nested pcr detection of centipeda periodontii in primary endodontic infections. | in recent years, molecular genetic methodologies have provided significant additional knowledge about components of the microbiota associated with infections of endodontic origin. following this research line, the purpose of the present study was to investigate the prevalence of centipeda periodontii in primary endodontic infections using a species-specific nested pcr assay. samples were collected from fifty teeth having carious lesions, necrotic pulps, and different forms of periradicular disea ... | 2004 | 15055428 |
| [histopathological study on allergic rhinitis treated with centipeda minima]. | the aim of this study was to investigate the mechanisms of c. minima in the treatment of allergic rhinitis. | 2005 | 15724411 |
| [effects of the volatile oil of centipeda minima on acute pleural effusion in rats induced by an intrapleural injection of car]. | to study the anti-inflammation effect of volatile oil of centipeda minima and the mechanism of action. | 2005 | 16201699 |
| inhibitory activity of 6-o-angeloylprenolin from centipeda minima on farnesyl protein transferase. | the methanolic extract of the aerial parts of centipeda minima was found to show inhibitory activity on farnesyl protein transferase (fptase). bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-o-angeloylprenolin, as an inhibitor on fptase. this compound inhibited fptase activity in a dose-dependent manner, and the ic50 value of 6-o-angeloylprenolin was 18.8 microm. | 2006 | 16491845 |
| anaerobic bacteria cultured from the tongue dorsum of subjects with oral malodor. | the bacteria on the dorsum of the tongue are the most frequent cause of oral malodor; however, the bacterial flora of the tongue has not been well defined. although recent studies have used dna probes to detect the presence of certain periodontal pathogens, cultural studies have been limited because of the complexity of the flora of the tongue dorsum. the purpose of this study was to grow and to identify maximum numbers of capnophylic gram-negative bacilli and anaerobic micro-organisms by cultur ... | 2003 | 16887710 |
| anti-mitotic properties of resveratrol analog (z)-3,5,4'-trimethoxystilbene. | (z)-3,5,4'-trimethoxystilbene is a natural polyphenol present in five different plants, virola cuspidata, virola elongata, centipeda minima, schoenus nigricans and rheum undulatum. this molecule was prepared in a three-step sequence in good overall yield. the isomerisation from the (e)- to (z)-isomer is performed using uv irradiation. biological investigations were conducted on a human colon cancer cell line (caco-2) with anti-mitotic activities. growth was completely arrested at an added 0.4 mi ... | 2006 | 17012762 |
| antibacterial thymol derivatives isolated from centipeda minima. | two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from centipeda minima. their structures were identified by means of spectroscopic analyses. interestingly, compound 2 is not an extraction artifact ... | 2007 | 17960076 |
| 6-o-angeloylenolin induces apoptosis through a mitochondrial/caspase and nf-kappab pathway in human leukemia hl60 cells. | 6-o-angeloylenolin, a sesquiterpene lactone from centipeda minima, has been known to have anti-tumor activity against human colorectum, liver, stomach, lung, and skin tumor cells. however, its molecular mechanism is still obscure and insufficient in in vivo tests. in this study, we demonstrated that 6-o-angeloylenolin could induce apoptosis in human leukemia hl60 cells through stimulating the generation of reactive oxygen species, decreasing mitochondrial trans-membrane potential (deltapsim) and ... | 2008 | 18077129 |
| two new antibacterial sesquiterpenoids from centipeda minima. | two new guaiane-type sesquiterpene lactones, compounds 1 and 2, along with three known guaianolide- or pseudoguaianolides, were isolated from centipeda minima (whole plant). their structures were identified by spectroscopic and mass-spectrometric analyses. the configuration at c5 of the guaiane framework of 1 was rationalized by quantum-mechanical calculations (table 2). all compounds were found to be active against eight different microbial pathogens (table 3), with mic values in the range of 6 ... | 2007 | 18081091 |
| [pharmacognostic identification of centipeda minima]. | to conduct pharmacognostic identification of centipeda minima. | 2009 | 19504961 |
| 2beta-(isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant centipeda minima, induces apoptosis in human nasopharyngeal carcinoma cne cells. | centipeda minima is a medicinal plant reputed in china as a remedy for nasopharyngeal carcinoma (npc). in this study, bioactivity-guided fractionation of the anti-npc compound(s) from c. minima led to the isolation of 2beta-(isobutyryloxy)florilenalin (if), a sesquiterpene lactone. if showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (cne). it induced apoptosis in cne cells, as shown by the accumulation of sub-g1 cell popu ... | 2009 | 19553887 |
| [chemical constituents from centipeda minima]. | to study the chemical constituents from centipeda minima. | 2009 | 19777837 |
| [preliminary study on molluscicidal effect of active components from centipeda minima]. | the active components from centipeda minima were extracted by water or ethanol, and identified by ftir spectroscopy and uv-visible spectrophotometer. the molluscicidal effect of aqueous extract and ethanol extract from centipeda minima against oncomelania hupensis was determined as referring to the who guidelines for laboratory molluscicidal test. treated with over 2.0 g/l aqueous extract and ethanol extract for five days, the mortality of o. hupensis was up to 100%, and their lc50, for snails w ... | 2009 | 20067005 |
| two new terpene glucosides and antitumor agents from centipeda minima. | one new monoterpene glucoside minimaoside a (1) and one new sesquiterpene glucoside minimaoside b (2), together with four known terpenoids, were isolated from the whole plants of centipeda minima (l.) a. braun et ashers. their structures were determined by spectroscopic methods. compounds 5 and 6 showed weak or moderate cytotoxic activity toward several tumor cell lines. | 2009 | 20183316 |
| antiproliferative effects of volatile oils from centipeda minima on human nasopharyngeal cancer cne cells. | volatile oils from centipeda minima extracted by steam distillation (sd) and supercritical fluid extraction (sfe) were investigated for their antiproliferative effects on the human nasopharyngeal cancer cne cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) assay results showed that cne cells were more susceptible to the sfe oil than to the sd oil. the ic50 values of the sfe oil were 56.6, 8.7 and 5.2 microg/ml after 24-, 48- and 72-h of treatment, respectively, whereas t ... | 2010 | 20184042 |
| screening of herbal medicines for the recovery of cisplatin-induced nephrotoxicity. | the goal of this study was to quantitatively determine the recovery effects of herbal medicines (hm) on the cisplatin-induced nephrotoxicity. in the present study, the recovery effects of 239 hm on hek 293 cells that had been damaged by cisplatin were evaluated by a mitochondrial activity mts assay. after the first round of screening, candidate hm were selected based on a recovery rate of greater than 20%. the efficacy of the selected herbs was then determined by dose response kinetic analysis. ... | 2009 | 21784004 |