| evaluation of the anti-ulcer and antisecretory activity of extracts of aralia elata root and schizandra chinensis fruit in the rat. | | 1988 | 3419197 |
| lewis-like activities of and rabbit antisera against glycoconjugates present in edible organs of phanerogamia and cryptogamia. | 13 species of phanerogamia and cryptogamia were found to contain substances cross-reacting with anti-lewis agglutinins in ethanol precipitates from their edible organs such as leaves. crude glycoconjugates were isolated from some species by sephacryl s-200 gel filtration, immunization with some of which resulted in the production in rabbits of anti-lea-like agglutinins with a high titer. production of anti-lea-like precipitin with high specificity was also confirmed in a rabbit antiserum against ... | 1984 | 6400999 |
| elatoside e, a new hypoglycemic principle from the root cortex of aralia elata seem.: structure-related hypoglycemic activity of oleanolic acid glycosides. | a new inhibitor named elatosides e (which was shown to affect the elevation of plasma glucose level by oral sugar tolerance test in rats) was isolated from the root cortex of aralia elata seem. together with elatoside f. the structures of elatosides e and f were elucidated on the basis of chemical and physicochemical evidence. the hypoglycemic activities of oleanolic acid and nine oleanolic acid glycosides obtained from the root cortex of aralia elata have been examined, and some structure-activ ... | 1994 | 8069981 |
| elatosides a and b, potent inhibitors of ethanol absorption in rats from the bark of aralia elata seem: the structure-activity relationships of oleanolic acid oligoglycosides. | by monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides a and b were isolated from the bark of aralia elata seem. together with elatosides c and d. the structures of elatosides a, b, c, and d were elucidated on the basis of chemical and physicochemical evidence. the inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found. | 1993 | 8293533 |
| comparison of cytoprotective effects of saponins isolated from leaves of aralia elata seem. (araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury. | glycosylations of 3-o-(2,3,4-tri-o-acetyl-alpha-l-rhamnopyranosyl(1-->2)- 3,4-di-o-acetyl-alpha-l-arabinopyranosyl)-23-o-acetylhederageni n (15) with mono- (16), di- (17) and trisaccharide bromide (18) gave the bisdesmoside peracetates 19, 20 and 22, respectively, which were treated with 5% koh in meoh to give the bisdesmosides 25-27. hydrolysis of the glycosides 6 and 9 having beta-d-glucopyranose as a terminal sugar component with beta-glucosidase in acetate buffer (ph 4.7) gave compounds 28 a ... | 1993 | 8403088 |
| medicinal foodstuffs. i. hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of aralia elata seem.: elatosides g, h, i, j, and k. | five new saponins named elatosides g, h, i, j, and k were isolated from a garnish foodstuff "taranome," the young shoot of aralia elata seem., together with hederagenin-3-o-glucuronopyranoside and elatoside c. their chemical structures were elucidated on the basis of chemical and physicochemical evidence. elatosides g, h, and i were found to exhibit potent hypoglycemic activity in the oral glucose tolerance test in rats. | 1995 | 8575028 |
| bioactive saponins and glycosides. vi. elatosides a and b, potent inhibitors of ethanol absorption, from the bark of aralia elata seem. (araliaceae): the structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity. | potent inhibitors of ethanol absorption, elatosides a and b, were isolated from the bark of aralia elata seem, through bioassay-guided separation together with elatosides c and d and four known oleanolic acid glucuronide-saponins, spinasaponin a, spinasaponin a 28-o-glucoside, and stipuleanosides r1 and r2. the structures of elatosides a, b, c, and d were determined on the basis of chemical and physicochemical evidence as oleanolic acid 3-o-¿[beta-d-xylopyranosyl (1-->2)] [beta-d-galactopyranosy ... | 1996 | 8904819 |
| bioactive saponins and glycosides. vii. on the hypoglycemic principles from the root cortex of aralia elata seem.: structure related hypoglycemic activity of oleanolic acid oligoglycoside. | the hypoglycemic component, elatoside e, was isolated from the root cortex of aralia elata seem. (araliaceae) together with elatoside f and eight known oleanolic acid glycosides, elatosides a and c, oleanolic acid 3-o-[alpha-l-arabinofuranosyl (1-->4)]-beta-d-glucopyranosiduronic acid, oleanolic acid 3-o-beta-d-glucopyranosiduronic acid, stipuleanosides r1 and r2, and chikusetsusaponins iv and iva. the structures of elatosides e and f were determined on the basis of chemical and physicochemical ... | 1996 | 8904820 |
| aralin, a new cytotoxic protein from aralia elata, inducing apoptosis in human cancer cells. | in this study, we purified a novel cytotoxic protein, aralin, from the shoots of aralia elata. aralin is composed of two subunits, a and b chains whose molecular weights are 29,100 and 32,200, respectively. in the assay using a normal human lung fibroblast cells (wi-38) and its sv40-transformed cells (va-13), aralin demonstrated selective cytotoxicity against the virus-transformed cell line; the ic50 values of wi-38 and va-13 were 10 and 0.8 ng/ml, respectively. aralin showed positive response t ... | 2003 | 12963119 |
| effect of three triterpenoid compounds isolated from root bark of aralia elata on stimulus-induced superoxide generation and tyrosyl phosphorylation and translocation of p47(phox) and p67(phox) to cell membrane in human neutrophil. | root bark of aralia elata is used as a folk medicine for neurasthenia, rheumatism, diabetes, hepatitis virus and spasm of the stomach in china, japan and russia. | 2003 | 14500036 |
| ethanol fraction of aralia elata seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo(a)pyrene. | aralia elata seemann is an edible mountain vegetable in korea containing saponin, alkaloid, palmitic acid, linoleic acid, methyl eicosanoate and hexacosol, and is known to manifest an effect on cardiac infarction, gastric ulcer, colitis, and enervation. this study has examined the effects of aralia elata seemann ethanol extract on antioxidant enzyme systems and lipid metabolism in rats along with benzo(a)pyrene (b(a)p) administration. rats were divided into four groups: control (c), an extract f ... | 2003 | 14519964 |
| production of aralin, a selective cytotoxic lectin against human transformed cells, in callus culture of aralia elata. | recently we found that aralin, a novel lectin, from aralia elata selectively induces apoptosis in human virus-transformed and cancer cells compared with normal cells. to overcome the reduction of aralin biosynthesis according to the development of leaves, we established callus tissues from the young shoots. the n-terminal amino acid sequence and immunochemical analyses revealed that ca-aralin, an aralin synthesized in the callus, was structurally identical with aralin except for the glycosylatio ... | 2004 | 15124096 |
| an apoptotic inducer, aralin, is a novel type ii ribosome-inactivating protein from aralia elata. | we recently found that aralin, a novel cytotoxic protein consisting of two subunits, from aralia elata selectively induces apoptosis in transformed cells as compared to normal cells. here we report that aralin is a lectin specific for galactose (gal) and its derivatives, and possesses rna n-glycosidase activity as a new type ii ribosome-inactivating protein (rip). the rna n-glycosidase activity of aralin was detected in cell-free and whole cell systems by the generation of an r-fragment from 28s ... | 2004 | 15493877 |
| araloside a, an antiulcer constituent from the root bark of aralia elata. | araloside a, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of aralia elata through a bioassay-guided separation procedure. the compound exhibited significant reduction of hcl.ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. these activities are comparable to those of cimetidine. | 2005 | 15744082 |
| water extract of aralia elata prevents cataractogenesis in vitro and in vivo. | the water extract of aralia elata (aralia extract) has been used in korean traditional medicine to treat diabetes mellitus. here, we investigated the aldose reductase inhibitory activity, antioxidant activity and anticataract capacity of aralia extract using various experimental systems. to determine its aldose reductase inhibitory activity and its antioxidant effect, we used rat lens homogenates. rat lens cultures and a rat model were used to observe anticataract activity. the resulting ic50 va ... | 2005 | 15905053 |
| effects of saponins from the root bark of aralia elata on the transport of chondroitin sulfate in caco-2 cell monolayers and rats. | we investigated the intestinal absorption enhancing effect of the saponins from the root bark of aralia elata (srbae) in caco-2 cell monolayers and rats. srbae at concentrations of 0.04% and 0.08% (w/v) decreased the transepithelial electrical resistance (teer) values and increased the paracellular uptake of chondroitin sulfates (css) having different molecular weights (mw 500, 4500, and 18000) in a dose-dependent manner. we also evaluated the cytotoxicity of srbae to determine its proper concen ... | 2005 | 15930742 |
| effect of five triterpenoid compounds isolated from root bark of aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils. | five triterpenoids; congmuyanoside v, x, xi, xii, and xv (cong. v, x, xi, xii, and xv) were isolated from the root bark of aralia elata. the effect of these triterpenoids on stimulus-induced superoxide generation in human neutrophils was assayed by measuring the reduction of ferricytochrome c (cyt. c) using a dual-beam spectrophotometer. translocation of p47(phox), p67(phox), and rac to the cell membrane and tyrosyl or serine/threonine phosphorylation of neutrophil proteins were investigated usi ... | 2006 | 16405902 |
| effect of five triterpenoid compounds from the buds of aralia elata on stimulus-induced superoxide generation, tyrosyl phosphorylation and translocation of cytosolic compounds to the cell membrane in human neutrophils. | the buds of aralia elata (miq.) seem (japanese angelica tree) have long been used as a tonic, antiarthritic and antidiabetic agent in china and japan. we have isolated five triterpenoids, congmuyanosides a, c, d, echinocystic acid and 3-o-[beta-d-glucopyranosyl(1-->2)-beta-d-glucopyranosyl]-hederagenin from the buds of aralia elata , and investigated their effects on stimulus-induced superoxide generation in human neutrophils. congmuyanoside a, echinocystic acid and 3-o-[beta-d-glucopyranosyl(1- ... | 2006 | 17021995 |
| triterpenoid saponin, oleanolic acid 3-o-beta-d-glucopyranosyl(1-->3)-alpha-l-rhamnopyranosyl(1-->2)-alpha-l-arabinopyranoside (oa) from aralia elata inhibits lps-induced nitric oxide production by down-regulated nf-kappab in raw 264.7 cells. | it is well known that the pro-inflammatory mediators such as nitric oxide (no) and prostaglandin (pg)e(2) are involved in several inflammatory diseases and lipopolysaccharide (lps) can stimulate these inflammatory responses. oleanolic acid 3-o-beta-d-glucopyranosyl(1-->3)-alpha-l-rhamnopyranosyl(1-->2)-alpha-l-arabinopyranoside (oa) was purified from edible plant aralia elata. oa inhibited lps-induced no and pge(2) production in raw 264.7 murine macrophages in a dose-dependent manner and rt-pcr ... | 2007 | 17910942 |
| the pollen metamorphosis phenomenon in panax ginseng, aralia elata and oplopanax elatus; an addition to discussion concerning the panax affinity in araliaceae. | to find more morphological characteristics useful for discussion on aralian or non-aralian panax affinity, pollen morphological diversity was comparatively analysed in p. ginseng, aralia elata and oplopanax elatus collected during their pollination periods. in the anthers of both the buds and open flowers, the pollen average diameter varied between some species-specific maximum and minimal measurement. however, the larger pollen grains were typically found in the buds whereas the smaller pollen ... | 2009 | 19025728 |
| protective effect of total aralosides of aralia elata (miq) seem (tasaes) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. | total aralosides of aralia elata (miq) seem (tasaes) from chinese traditional herb longya aralia chinensis l was found to improve cardiac function. the present study was to determine the protective effects of tasaes on diabetic cardiomyopathy, and the possible mechanisms. therefore, a single dose of streptozotocin was used to induce diabetes in wister rats. diabetic rats were immediately treated with low, medium and high doses of tasaes at 4.9, 9.8 mg/kg and 19.6 mg/kg body weight by gavage, res ... | 2009 | 19381071 |
| [clone and construction of plant expression vector of aess gene in aralia elata]. | to clone aralia elata squalene synthase gene (designated as aess) and construct plant expression vector for transgenic research. | 2010 | 21243763 |
| cardioprotective and antioxidant activities of a polysaccharide from the root bark of aralia elata (miq.) seem. | a water-soluble polysaccharide (aep-w1) was isolated from the root bark of aralia elata and its molecular weight was about 4.5×10(4)da. monosaccharide component analysis indicated that aep-w1 appeared to be arabinogalactan, consisting of arabinose, galactose and trace glucose with molar ratios of 6.3:3.5:0.2. the antioxidant and cardioprotective potential of aep-w1 were evaluated in vitro for the first time. aep-w1 showed potent superoxide and hydroxyl radical scavenging activities and reducing ... | 2012 | 23499081 |
| cloning and characterization of a β-amyrin synthase gene from the medicinal tree aralia elata (araliaceae). | aralia elata is an important medicinal plant in china; it produces large amounts of oleanane type triterpene saponins. a full-length cdna encoding β-amyrin synthase (designated as aeas) was isolated from young leaves of a. elata by reverse transcription-pcr. the full-length cdna of aeas was found to have a 2292-bp open reading frame, encoding a protein with 763 amino acid residues. the deduced amino acid sequence of aeas showed the highest identity (97%) to panax ginseng β-amyrin synthase. when ... | 2012 | 22911600 |
| isolation and characterization of saponin-producing fungal endophytes from aralia elata in northeast china. | the purpose of this study was to investigate the diversity of endophytic fungi of aralia elata distributed in northeast china as well as their capacity to produce saponins. ninety-six strains of endophytic fungi were isolated, and polymerase chain reaction (pcr) and sequencing were employed to identify the isolates. the saponin concentrations of the culture filtrates of representative strains were measured. the agar diffusion method was used to test antimicrobial activity, while high-performance ... | 2012 | 23203194 |
| protective effects of araloside c against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90. | the present study was designed to investigate whether araloside c, one of the major triterpenoid compounds isolated from aralia elata known to be cardioprotective, can improve heart function following ischaemia/reperfusion (i/r) injury and elucidate its underlying mechanisms. we observed that araloside c concentration-dependently improved cardiac function and depressed oxidative stress induced by i/r. similar protection was confirmed in isolated cardiomyocytes characterized by maintaining ca(2+) ... | 2017 | 28225183 |
| simultaneous determination of four triterpenoid saponins in aralia elata leaves by hplc-elsd combined with hierarchical clustering analysis. | aralia elata leaves are known to have several biological activities, including anti-arrythmia, antitumor, anti-inflammatory, anti-fatigue, antimicrobial and antiviral effects. our previous study found that triterpenoid saponins from the leaves of a. elata had antitumor effects. quantification of the triterpenoids is important for the quality control of a. elata leaves. | 2017 | 28071864 |
| application of a solvent-free solid injection technique coupled with gc-ms for discrimination between the secondary metabolites of wild and cultivated south korean medicinal foods. | solvent-free solid injection was applied to differentiate between wild and cultivated south korean medicinal foods, including dureup (aralia elata), deodeok (codonopsis lanceolata) and doraji (platycodon grandiflorus). a number of compounds were identified in wild and cultivated dureup (53 and 46), deodeok (47 and 51) and doraji (43 and 38). secondary metabolites, including butanal,2-methyl-, β-caryophyllene, neoclovene, α-humulene, γ-curcumene, β-bisabolene, and phytol, were identified in dureu ... | 2016 | 27859496 |
| development of highly transferable microsatellites for panax ginseng (araliaceae) using whole-genome data. | highly transferable expressed sequence tag (est) microsatellites were developed for panax ginseng (araliaceae), one of the most celebrated traditional chinese medicines and an endangered species in east asia, using whole-genome data. | 2016 | 27843725 |
| a polysaccharide from the leaves of aralia elata induces apoptosis in u-2 os cells via mitochondrial-dependent pathway. | in the present study, we isolated and characterized one purified polysaccharide (aep-1) from the leaves of aralia elata, and investigated its effect on human osteosarcoma (os) u-2 os cell line and analyzed its mechanism. mtt assays showed that aep-1 markedly inhibited the growth of u-2 os cells in a dose- and time-dependent fashion, suggesting a cytotoxic effect. the aep-1 also dose-dependently induced dna fragmentation and caused apoptotic death in u-2 os cells. the event of apoptosis was accom ... | 2016 | 27591923 |
| simultaneous quantification of triterpenoid saponins in rat plasma by uhplc-ms/ms and its application to a pharmacokinetic study after oral total saponin of aralia elata leaves. | a rapid, sensitive, and reliable analytical ultra performance liquid chromatography with tandem mass spectrometry method was developed for the simultaneous determination of aralia-saponin iv, 3-o-β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl oleanolic acid 28-o-β-d-glucopyranoside, aralia-saponin a and aralia-saponin b after the oral administration of total saponin of aralia elata leaves in rat plasma. plasma samples were pretreated by protein precipitation with methanol. ... | 2016 | 27670645 |
| aralia elata var. mandshurica (rupr. & maxim.) j.wen: an overview of pharmacological studies. | aralia elata var. mandshurica (rupr. & maxim.) j.wen syn. a. mandshurica rupr. & maxim is evaluated for its medicinal application. the aim of this study is to analyze pharmacological studies on a. elata var. mandshurica published until december 2015. | 2016 | 27765361 |
| sub-chronic safety evaluation of the ethanol extract of aralia elata leaves in beagle dogs. | aralia elata seem. (a. elata) is a traditional chinese medicine to treat some diseases. this investigation aims to evaluate the pharmaceutical safety of the ethanol extract of a. elata leaves, namely ethanol leaves extract (ele), in beagle dogs. in sub-chronic oral toxicity study, dogs were treated with the ele at doses of 50, 100 and 200 mg/kg for 12 weeks and followed by 4 weeks recovery period. during experimental period, clinical signs, mortality, body temperature, food consumption and body ... | 2016 | 27156779 |
| acute and sub-chronic toxicity study of the ethanol extract from leaves of aralia elata in rats. | aralia elata seem. (a. elata) is a well-known medicinal plant which has been used as a tonic, anti-arthritic and anti-diabetic agent in traditional chinese medicine. this investigation aimed to evaluate the potential toxicological properties of the ethanol extract from leaves of a. elata, namely ethanol leaves extract (ele), in rats by acute and sub-chronic toxicity studies. | 2015 | 26456344 |
| extracts from aralia elata (miq) seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. | non-alcoholic fatty liver disease (nafld) is a common liver disease that is strongly associated with obesity and dysregulation of insulin in the liver. however, currently no pharmacological agents have been established for the treatment of nafld. in this regard, we sought to evaluate the anti-nafld effects of aralia elata (miq) seem (ae) extract and its ability to inhibit hepatic lipid accumulation and modulate cellular signaling in a high fat diet (hfd)-induced obese mouse model. | 2015 | 26438035 |
| aralia elata prevents neuronal death by downregulating tonicity response element binding protein in diabetic retinopathy. | the present study addresses the role of tonicity response element binding protein (tonebp) in retinal ganglion cell (rgc) death in diabetic retinopathy and the impact of aralia elata extract on the tonebp/rgc interaction. | 2015 | 26278282 |
| determination and pharmacokinetic study of two triterpenoid saponins in rat plasma after oral administration of the extract of aralia elata leaves by uhplc-esi-ms/ms. | aralia elata (miq.) seems (a. elata) grow in northeast china and the total saponins of a. elata is used to auxiliary treatment for the acute hepatitis, chronic hepatitis and the transaminase on the high side. aralia-saponinv and aralia-saponinvi are the major bioactive saponins in a. elata leaves. a selective and sensitive uhplc-ms/ms method was developed and validated for the determination and pharmacokinetic study of aralia-saponinv and aralia-saponinvi indwelling the extract in rat plasma in ... | 2015 | 25687802 |
| total aralosides of aralia elata (miq) seem (tasaes) ameliorate nonalcoholic steatohepatitis by modulating ire1α-mediated jnk and nf-κb pathways in apoe-/- mice. | total saponins of aralia elata (miq) seem (tasaes) from the chinese traditional herb long ya aralia chinensis l. is popularly used as a folk medicine to treat rheumatism, neurasthenia, diabetes, hepatitis and antivirus in asian countries. however, there was poor study of tasaes on non-alcoholic steatohepatitis (nash), which is characterized by inflammatory responses and hepatocellular apoptosis exacerbating liver injury. this study aimed to clarify whether or not the anti-inflammatory and anti-a ... | 2015 | 25655997 |
| elatoside c protects against hypoxia/reoxygenation-induced apoptosis in h9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on stat3 activation. | endoplasmic reticulum (er) stress-induced apoptosis has been suggested to contribute to myocardial ischemia-reperfusion (i/r) injury. elatoside c is one of the major triterpenoid compounds isolated from aralia elata that is known to be cardioprotective. however, its effects on i/r injury to cardiac myocytes have not been clarified. this study aimed to investigate the possible protective effect of elatoside c against hypoxia/reoxygenation (h/r)-induced h9c2 cardiomyocyte injury and its underlying ... | 2014 | 25326083 |
| aralin, a type ii ribosome-inactivating protein from aralia elata, exhibits selective anticancer activity through the processed form of a 110-kda high-density lipoprotein-binding protein: a promising anticancer drug. | aralin from aralia elata is a newly identified type ii ribosome- inactivating protein, which preferentially induces apoptosis in cancer cells. in this study, we identified that the aralin receptor is a 110-kda high-density lipoprotein-binding protein (hdlbp), which functions as a hdl receptor. the sensitivities of tumor cell lines to aralin were dependent on the expression levels of the 110-kda hdlbp and its forced expression in aralin-resistant huh7 cells conferred aralin sensitivity. hdlbp-kno ... | 2014 | 25261720 |
| [simultaneous determination of five triterpenoid saponins in different parts of aralia elata by high performance liquid chromatography-tandem mass spectrometry]. | a method was developed for the simultaneous determination of congmunoside ii, congmunoside iv, congmunoside v, congmunoside x and congmuyenoside ii in different parts of aralia elata by high performance liquid chromatography-tandem mass spectrometry (hplc-ms/ms). the chromatographic separation was performed on an alltima c18 analytical column (250 mm x 4.6 mm, 5 microm) using the mobile phases of acetonitrile and 0.1% (v/v) formic acid aqueous solution with gradient elution. the separated compou ... | 2014 | 25255570 |
| effect of the total saponins of aralia elata (miq) seem on cardiac contractile function and intracellular calcium cycling regulation. | total saponins of aralia elata (miq) seem (as) from the chinese traditional herb longya aralia chinensis l. can improve cardiac function, although the active mechanism remains poorly understood. the present study aimed to determine the direct effect of as on cardiac function in dogs and the effects on ca2+ transient and contractions in isolated rat cardiomyocytes. | 2014 | 24875646 |
| medicinal plants of the russian pharmacopoeia; their history and applications. | due to the location of russia between west and east, russian phytotherapy has accumulated and adopted approaches that originated in european and asian traditional medicine. phytotherapy is an official and separate branch of medicine in russia; thus, herbal medicinal preparations are considered official medicaments. the aim of the present review is to summarize and critically appraise data concerning plants used in russian medicine. this review describes the history of herbal medicine in russia, ... | 2014 | 24742754 |
| two new triterpenoid saponins from the leaves of aralia elata. | phytochemical investigation of the leaves of aralia elata has led to the isolation of two new compounds 3-o-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl echinocystic acid (1) and 3-o-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl oleanolic acid 28-o-β-d-glucopyranoside (2), together with four known compounds 3-6, which were isolated for the first time from this genus. structural determination was accomplished by spectroscopic analysis, partic ... | 2013 | 23796188 |
| cardioprotective effect of aralia elata polysaccharide on myocardial ischemic reperfusion (ir) injury in rats. | based on the previous studies revealing antioxidant activities of a water-soluble polysaccharide (aep-w1) from the root bark of aralia elata, the present study was designed to determine if chronic administration of aep-w1 could reduce ischemic reperfusion (ir) induced myocardial injury. wistar rats were given three different doses of aep-w1 (50, 100 and 200mg/kg/day) or vehicle for 30 days, after which myocardial ir injury was induced by the occlusion of left anterior descending (lad) coronary a ... | 2013 | 23624163 |
| protective role of aralia elata polysaccharide on mercury(ii)-induced cardiovascular oxidative injury in rats. | mercury(ii) is a highly toxic environmental pollutant leading to oxidative stress in animals and human beings. in this study we aimed to investigate the possible protective effect of a water-soluble polysaccharide (aep-w1) from the root bark of aralia elata against experimental mercury(ii)-induced cardiovascular oxidative injury in rat model. the results showed that delayed aep-w1 supplement to hgcl2-treated mice not only decreased serum lactate dehydrogenase (ldh) and tumor necrosis factor-α (t ... | 2013 | 23612361 |
| triterpene glucosides from the leaves of aralia elata and their cytotoxic activities. | three new triterpene glucosides, named congmuyenosides c-e (1-3, resp.), along with four known ones, were isolated from an etoh extract of aralia elata (miq.) seem. leaves. the structures of the new compounds were identified as 3-o-{β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl-(1→3)-[β-d-glucopyranosyl-(1→2)]-β-d-glucopyranosyl}caulophyllogenin (1), 3-o-{β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl-(1→3)-[β-d-glucopyranosyl-(1→2)]-β-d-glucopyranosyl}hederagenin 28-o-β-d-glucopyranosyl ester (2), 3 ... | 2013 | 23576356 |
| studies on cytotoxic triterpene saponins from the leaves of aralia elata. | aralia elata has long been used as a tonic, anticancer and antidiabetic agent in china and japan, and is widely consumed as food. phytochemical investigation of the leaves of a. elata has led to the isolation of four new compounds, 3-o-[β-d-glucopyranosyl(1 → 3)-β-d-glucopyranosyl] echinocystic acid 28-o-β-d-glucopyranosyl ester (congmuyenoside i, 1), 3-o-[β-d-glucopyranosyl(1 → 2)-β-d-glucopyranosyl] hederagenin 28-o-β-d-glucopyranosyl ester (congmuyenoside ii, 2), 3-o-{[β-d-glucopyranosyl(1 → ... | 2013 | 23265478 |
| cytotoxic triterpene saponins from the leaves of aralia elata. | phytochemical investigation of the leaves of aralia elata has led to the isolation of four new compounds, 3-o-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl oleanolic acid (1), 3-o-[β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)]-[β-d-glucopyranosyl (1→2)]-β-d-glucopyranosyl hederagenin 28-o-β-d-glucopyranoside (2), 3-o-{[β-d-glucopyranosyl (1→2)]-[β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)]-β-d-glucopyranosyl} oleanolic acid 28-o-β-d-glucopyranosyl ester (3) and ... | 2012 | 22465503 |
| antagonistic effect of the ainu-selected traditional beneficial plants on the transformation of an aryl hydrocarbon receptor. | transformation of an aryl hydrocarbon receptor (ahr) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (hahs and pahs) including dioxins. therefore, it has been suggested that suppression of the transformation induced by hahs and pahs leads to reduce their toxicological effects. in this study, the antagonistic effect of 110 indigenous plants (192 plant parts) used as medicine and/or food by the ainu on the 2,3,7,8-tetrachlorodibenzo-p-dioxin ... | 2012 | 22394227 |
| oleanane-type triterpene saponins from the bark of aralia elata and their nf-κb inhibition and ppar activation signal pathway. | two new oleanane-type triterpene saponins, tarasaponin iv (1) and elatoside l (2), and four known; stipuleanoside r(2) (3), kalopanax-saponin f (4), kalopanax-saponin f methylester (5), and elatoside d (6) were isolated from the bark of aralia elata. kalopanax-saponin f methyl ester was isolated from nature for the first time. their chemical structures were elucidated using the chemical and physical methods as well as good agreement with those of reported in the literature. oleanane-type triterp ... | 2011 | 21889336 |
| [optimal extraction of effective constituents from aralia elata by central composite design and response surface methodology]. | to optimize the process of extracting effective constituents from aralia elata by response surface methodology. | 2010 | 20681312 |
| suppressive effects on the biosynthesis of inflammatory mediators by aralia elata extract fractions in macrophage cells. | the aim of this study is to elucidate the anti-inflammatory effects of aralia elata extract fractions (aeefs). a. elata-ethyl acetate fraction (aeef) had the strongest antioxidant activity. a. elata-chloroform fraction (aecf) and a. elata-butanol fraction (aebf) inhibited potently lps-induced nitrite production from raw 264.7 macrophage cells. the inhibition of nitric oxide (no) production by aeefs was partially due to chemical scavenge of no and the suppression of inducible nos (inos) transcrip ... | 2009 | 21784024 |
| isolation and tandem mass fragmentations of an anti-inflammatory compound from aralia elata. | one-step isolation of a saponin from aralia elata was undertaken using high-speed countercurrent chromatography coupled with evaporative light scattering detection. a triterpenoid saponin, elatoside f, was purified with 96.8% purity using a two-phase-system comprising chloroform-methanol-water-isopropanol. the yield was 35.0 mg from 348.2 mg of the enriched saponin fraction. in vitro anti-inflammatory study demonstrated that elatoside f inhibited lipopolysaccharide-induced nitric oxide productio ... | 2009 | 19557359 |
| analysis of saponins from leaves of aralia elata by liquid chromatography and multi-stage tandem mass spectrometry. | four saponins were isolated from the leaves of aralia elata, and established using nmr and other spectroscopic methods, as well as data reported in the literature. three aralia saponins from the leaves of aralia elata sharing the same structures as those isolated from the root bark suggested that the leaves would be a good substitute for the root bark of aralia elata. these four aralia saponins were then extensively investigated using complementarily positive and negative electrospray ionization ... | 2009 | 19531882 |
| effects of smoke, heat, darkness and cold stratification on seed germination of 40 species in a cool temperate zone in northern japan. | the effects of smoke, heat, darkness and cold stratification on seed germination were examined for 40 species with various life history attributes. these species establish in early successional stages on a volcano and are distributed in cool temperate zones of northern japan. smoke decreased seed germination in 11 species and increased it in one species, leucothoe grayana. germination of polygonum longisetum was enhanced by a combination of smoke and cold, and that of aralia elata by smoke and h ... | 2009 | 19470108 |
| [response processes of aralia elata photosynthesis and transpiration to light and soil moisture]. | by using ciras-2 portable photosynthesis system, the light response processes of aralia elata photosynthesis and transpiration under different soil moisture conditions were studied, aimed to understand the adaptability of a. elata to different light and soil moisture conditions. the results showed that the response processes of a. elata net photosynthetic rate (pn), transpiration rate (tr), and water use efficiency (wue) to photon flux density (pfd) were different. with the increasing pfd in the ... | 2008 | 18808006 |
| morphological study of pollen grains in mature anthers of aralia elata, a. continentalis, and a. cordata (araliaceae). | | 2016 | 18274493 |
| two new saponins from the bud of aralia elata (miq.) seem. | two new saponins, named congmuyanoside a and congmuyanoside b, have been isolated from the buds of aralia elata (miq.) seem. their structures have been determined on the basis of chemical and spectroscopic evidence. | 2005 | 16308197 |
| saponins and other constituents from the leaves of aralia elata. | a new triterpenoid saponin, together with five known saponins, were isolated from the nonpolar n-hexane fraction of the leaves of aralia elata. the structure of the new saponin, durupcoside c, was elucidated as hederagenin 3-o-beta-d-glucopyranosyl(1-->3)-beta-d-glucopyranosyl(1-->3)-alpha-l-arabinopyranoside on the basis of spectroscopic analysis. the known saponins were characterized as 3-o-alpha-l-rhamnopyranosyl(1-->2)-alpha-l-arabinopyranosyl hederagenin 28-o-beta-d-xylopyranosyl(1-->6)-bet ... | 2005 | 15930787 |
| [somatic embryogenesis and plant regeneration in vitro from young shoots of aralia elate (miq.) seem]. | explants excised from the young shoots of aralia elata (miq.) seem. were cultured on ms media. calli were induced from the explants on ms medium supplemented with 0.5 mg/l 2, 4-d, 0.5 mg/l ba and 0.5 mg/l naa. then these calli were transferred onto the ms medium containing 2.0 mg/l 2,4-d + 0.5 mg/l ba + 0.5 mg/l naa and 0.2% activated charcoal. under these conditions the somatic embryoids were observed and regenerated plants were obtained from somatic embryogenesis. then, a experimental system w ... | 2001 | 12549107 |
| five saponins from the root bark of aralia elata. | five saponins, 3-o-[beta-d-glucopyranosyl (1-->2)-[beta-d-glucopyranosyl (1-->3)]-beta-d-glucopyranosyl]-oleanolic acid 28-o-beta-d-glucopyranosyl ester (aralia-saponin v), 3-o-[beta-d-glucopyranosyl (1-->2)-[beta-d-glucopyranosyl (1-->3)]-beta-d-glucopyranosyl]-echinocystic acid 28-o-beta-d-glucopyranosyl ester (aralia-saponin vi), 3-o-beta-d-glucopyranosyl (1-->2)-[beta-d-glucopyranosyl (1-->3)]-beta-d-glucopyranosyl]-hederagenin 28-o-beta-d-glucopyranosyl ester (aralia-saponin vii), 3-o-[beta ... | 2001 | 11261582 |
| four new saponins from the root bark of aralia elata. | four new saponins, 3-o-[beta-d-glucopyranosyl(1-->3)-alpha-l-arabinopyranosyl]-16a lpha-hydroxyoleanolic acid 28-o-beta-d-glucopyranosyl ester (called aralia-saponin i), 3-o-[beta-d-glucopyranosyl(1-->3)-alpha-l-arabinopyranosyl]-16a lpha-hydroxyhederagenin 28-o-beta-d-glucopyranosyl ester (aralia-saponin ii), 3-o-[beta-d-glucopyranosyl(1-->3)-beta-d-glucopyranosyl(1-->3)-alpha-l-+ ++arabinopyranosyl]-16alpha-hydroxyoleanolic acid 28-o-beta-d-glucopyranosyl ester (aralia-saponin iii), 3-o-[beta- ... | 2000 | 10866145 |
| isolation of a new cerebroside from the root bark of aralia elata | a new cerebroside, named aralia cerebroside (1), was isolated from the root bark of aralia elata. the structure of 1 was determined to be 1-o-beta-d-glucopyranosyl-(2s,3s,4r, 8e)-2-[(2'r)-2'-hydroxypalmitoylamino]-8-octadecene-1,3,4-triol on the basis of physicochemical and spectroscopic studies. | 1999 | 10425144 |
| two new saponins, congmuyenosides a and b, from the leaves of aralia elata collected in heilongjiang, china. | two new triterpenoidal saponins, congmuyenosides a and b, were isolated from the leaves of aralia elata collected in heilongjiang province, china, and established as 3-o-[beta-d-glucopyranosyl(1-->2)][beta-d-glucopyranosyl-(1-->3)]- beta-d-glucopyranosyl hederagenin and 3-o-[beta-d-glucopyranosyl(1-->2))] [beta-d-glucopyranosyl(1-->3)-beta-d-glucopyranosyl(1-->3 )]-beta-d-glucopyranosyl hederagenin, respectively, on the basis of chemical and spectral evidence. | 1996 | 8945786 |
| oleanolic acid saponins from root-bark of aralia elata. | five new oleanolic acid glycosides, tarasaponins iii-vii, were isolated from the dried root-bark of aralia elata together with stipuleanoside r2, in addition to eight saponins previously reported. they were characterized as oleanolic acid 3-o-[beta-d-xylopyranosyl(1-->2)] [beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside, beta-d-glucopyranosyl oleanolate 3-o-[beta-d-glucopyranosyl(1-->2)][alpha-l-arabinofuranosyl (1-->4)]-beta-d-glucuronopyranoside, beta-d-glucopyranosyl oleanolate 3-o-[b ... | 1994 | 7764839 |
| oleanolic acid saponins from root bark of aralia elata. | three new oleanolic acid glycosides, tarasaponins i-iii, were isolated as their methyl esters from the root bark of aralia elata together with four known glycosides, the methyl esters of chikusetsusaponins iva, iv, 28-desglucosyl-chikusetsusaponin iv and pseudoginsenoside rt1. tarasaponins i-iii were characterized as oleanolic acid 3-o-[beta-d-glucopyranosyl(1-->3)][alpha-l-arabinofuranosyl(1-->4)[- beta-d-glucuronopyranoside, oleanolic acid 3-o-[beta-d-xylopyranosyl(1-->2)][beta-d-galactopyrano ... | 1994 | 7764823 |
| [determination of oleanolic acid in aralia elata (miq.) seem. by tlc-densitometry]. | | 1993 | 8323685 |
| [studies on the chemical constituents from aralia elata]. | eight compounds have been isolated from the root bark of aralia elata. their structures have been identified by means of physico-chemical and spectral analysis. they are (6'-o-palmitoyl)-beta-sitosterol-3-o-beta-d-glucoside (a5), silphiosidea (a9), chikusetusaponin ib (a11), araloside a (a12), araloside c (a15), acanthoside d (b1). compound a10 is a new natural product, named as araloside a methyl-ester. 3-o-beta-d-glucopyranosyl (1----3)[beta-d-glucopyranosy (1----4)]-beta-d-glucopyranosyl-olea ... | 1992 | 1442085 |