| [agglutinating and immobilizing activity of an ethanol extract of bursera fagaroides on human and other mammalian spermatozoa]. | human spermatozoa and those obtained from mouse epididymis incubated in ethanolic from mouse epididymis incubated in ethanolic extracts of the cortex of bursera fagaroides became agglutinated and immobilized in 100% with 30% of viability decrease. this double effect occurred in 50% of pig'ssperm and 50% of rabbit sperm when the concentration was increased tenfold. the pattern of progressive motility was affected 80% of rat's spermatocytes without agglutination. the values remained the same when ... | 1990 | 1669231 |
| bursera fagaroides, effect of an ethanolic extract on ornithine decarboxylase (odc) activity in vitro and on the growth of entamoeba histolytica. | the effect of an ethanolic extract from the stem bark of bursera fagaroides on ornithine decarboxylase (odc) activity in vitro and on the growth of entamoeba histolytica was evaluated. for this purpose, increasing concentrations of the extract, up to 8.0mg/ml, were added to amoeba cultures or odc reaction mixtures, which were incubated at 37 degrees c. metronidazole and g418 were added as controls. after 1.5 and 72 h, the odc activity in vitro and growth, respectively, were determined. results r ... | 2008 | 18501354 |
| absolute configuration of podophyllotoxin related lignans from bursera fagaroides using vibrational circular dichroism. | the ethanol extract from the dried exudate of bursera fagaroides (burseraceae) showed significant cytotoxic activity in the ht-29 (human colon adenocarcinoma) test system. the extract provided four podophyllotoxin related lignans, identified as (7'r,8r,8'r)-(-)-deoxypodophyllotoxin (3), (7'r,8r,8'r)-(-)-morelensin (4), (8r,8'r)-(-)-yatein (5), and (8r,8'r)-(-)-5'-desmethoxyyatein (6), whose spectroscopic and chiroptical properties were compared with those of (7r,7'r,8r,8'r)-(-)-podophyllotoxin ( ... | 2011 | 21840559 |
| cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from bursera fagaroides var. fagaroides on breast cancer cell lines. | despite prevention and treatment options, breast cancer (bc) has become one of the most important issues in the present day. therefore, the need for more specific and efficient compounds remains paramount. we evaluated four previously isolated aryltetralin lignans: 5'-demethoxy-β-peltatin-a-methylether (1), acetylpodophyllotoxin (2), 5'-demethoxydeoxypodophyllotoxin (3), and 7',8'-dehydroacetylpodophyllotoxin (4) for cytotoxicity, clonogenicity, and selectivity against three bc cell lines: mcf-7 ... | 2016 | 27527135 |
| structural and biochemical characterization of the interaction of tubulin with potent natural analogues of podophyllotoxin. | four natural analogues of podophyllotoxin obtained from the mexican medicinal plant bursera fagaroides, namely, acetyl podophyllotoxin (2), 5'-desmethoxy-β-peltatin a methyl ether (3), 7',8'-dehydro acetyl podophyllotoxin (4), and burseranin (5), have been characterized, and their interactions with tubulin have been investigated. cytotoxic activity measurements, followed by immunofluorescence microscopy and flow cytometry studies, demonstrated that these compounds disrupt microtubule networks in ... | 2016 | 27518758 |
| cytotoxic podophyllotoxin type-lignans from the steam bark of bursera fagaroides var. fagaroides. | the hydroalcoholic extract of the steam bark of b. fagaroides var. fagaroides displayed potent cytotoxic activity against four cancer cell lines, namely kb (ed50 = 9.6 × 10(-2) μg/ml), pc-3 (ed50 = 2.5 × 10(-1) μg/ml), mcf-7 (ed50 = 6.6 μg/ml), and hf-6 (ed50 = 7.1 × 10(-3) μg/ml). this extract also showed anti-tumour activity when assayed on mice inoculated with l5178y lymphoma cells. bioactivity-directed isolation of this extract, afforded seven podophyllotoxin-type lignans identified as podop ... | 2012 | 22878225 |
| three new diarylbutane lignans from the resin of bursera fagaroides. | three new diarylbutane lignans, named 9-acetyl-9'-pentadecanoil-dihydroclusin (1), 2,3-demethoxy-secoisolintetralin monoacetate (4) and dihydroclusin monoacetate (5), have been isolated from the resin of bursera fagaroides, together with two known ones, 2,3-demethoxy-secoisolintetralin diacetate (2) and dihydroclusin diacetate (3). the complete structure assignments were obtained by means of (1)h and (13)c nmr spectra. | 2013 | 22838394 |
| antitumor agents from bursera fagaroides (burseraceae). (beta-peltatin-a-methylether and 5'-desemethoxy-beta-peltatin-a-methylether). | | 1969 | 5802385 |