| exogenous mycotic infections of the eye and adnexia. | three cases of exogenous mycotic infections of the eye are presented. the first is a case of keratitis in a patient suffering from glaucoma simplex who removed a foreign body from the cornea, caused by fusarium solani, generally known as a saprophytic soil and plant inhabitant. as factors predisposing the patient to infection, trauma to the cornea like injury by a foreign body, as well as the preexisting disease of the eye, are discussed. the other case illustrates the change in the pathogenicit ... | 1978 | 308789 |
| actinomycotic mycetoma due to streptomyces somaliensis: report of a case in south africa. | the etiology of mycetomas due to aerobic actinomycetes in southern africa is still not well understood. martin and berson (1973) have suggested that trauma plays an important initial part in this and several other subcutaneous mycotic infections but adequate documentation is often sadly lacking. the following case report is the first known for southern africa in which streptomyces somaliensis has been shown by culture and by histology to be the casual organism, and one of the few where the histo ... | 1975 | 1224287 |
| mr imaging of thoracic and abdominal wall infections: comparison with other imaging procedures. | infections of the chest and abdominal wall are rare but potentially fatal disorders that can occur spontaneously or in association with diabetes mellitus, immunosuppression, or trauma. the condition (either in the form of necrotizing fasciitis and/or pyomyositis) is difficult to diagnose clinically because of poor localizing signs. prognosis depends on early recognition, extent of disease, and type of causative organism. pathologically, the infections can manifest as cellulitis, abscess, and/or ... | 1990 | 2138843 |
| in vitro studies of antibiotic sensitivities of streptomyces somaliensis--a cause of human actinomycetoma. | ten streptomyces somaliensis strains isolated from mycetoma patients were tested in vitro against 13 antibacterial agents. rifampicin was the most effective antibiotic in terms of low minimum inhibitory concentration (mic) followed by erythromycin, tobramycin, fusidic acid and streptomycin sulphate. the s. somaliensis strains were all resistant to trimethoprim, even though the combination of sulphamethoxazole and trimethoprim is commonly used as treatment. | 1989 | 2609384 |
| a mexican case of mycetoma caused by streptomyces somaliensis. | | 1968 | 4392874 |
| [mycetoma caused by streptomyces somaliensis; report of a case]. | | 1967 | 5249286 |
| case report 153. mycetoma due to streptomyces somaliensis ("madura skull"). | | 1981 | 7268468 |
| [miconazole per os in tinea and deep mycosis]. | for the last 6 years we have been using miconazole cream in the treatment of tinea and vaginal candidiasis. we think that it is at least as good as the best drugs for this purpose, but consider it difficult to decide about its superiority. therefore we refrain from describing this part of our experience in detail. we have employed miconazole "per os" at the daily doses of 24-28 mg./kg. in treating 3 cases of tinea corporis or cruris by "trichophyton rubrum". symptoms ceased in 3 days; mycologic ... | 1976 | 988459 |
| numerical taxonomy of actinomadura and related actinomycetes. | one hundred and fifty-six actinomadura strains, marker strains of related taxa, and related isolates from bagasse and fodder were the subject of numerical phenetic analyses using 90 unit characters. the data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using both single and average linkage algorithms. cluster composition was not markedly affected either by the coefficient or clustering algorithms used or by test error, esti ... | 1979 | 479835 |
| intraspinal mycetoma: report of two cases. | two cases of intraspinal mycetoma caused by madurella mycetomatis and streptomyces somaliensis presenting with paraplegia are reported. in these cases, there was neither skin or bone involvement by the disease. the route of entry of the organisms is not known; however, hematogenous blood vessel invasion by s. somaliensis was identified in the second case. | 1997 | 9063356 |
| preliminary investigation of the use of the enzyme linked immunosorbent assay (elisa) in the serodiagnosis of mycetoma. | antibody levels in a small group of sudanese patients with clinically diagnosed mycetoma, and control groups were measured by countercurrent immunoelectrophoresis (cie) and enzyme linked immunosorbent assay (elisa). antigens were prepared from the following organisms: streptomyces somaliensis, actinomadura madurae, a. pelletieri, nocardia brasiliensis and madurella mycetomi. positive reactions were obtained in clinical cases against the homologous antigens in both cie and elisa; all heterologous ... | 1978 | 360443 |
| mycetoma in somalia - results of a survey done from 1959 to 1964. | the pasteur institute studied 103 mycetoma patients in somalia between 1959 and 1964. grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 madurella mycetomi, 1 leptosphaeria senegalensis, 7 pyrenochaeta romeroi (or madurella grisea), 3 allescheria boydii, 1 fusarium sp., 3 neotestudina (zopfia) rosatii, and 1 unidentified; 34 were actinomycetes: 24 streptomyces somaliensis, 4 actinomadura madurae, 3 a. pelletieri and 3 nocardi ... | 1977 | 23657 |
| [mycetoma due to streptomyces somaliensis seen in algeria in the south area of the atlas mountains]. | | 1965 | 5899716 |
| clinical presentation and cat scan findings in mycetoma of the head. | nine cases comprising seven males and two females with mycetoma of the cranium were studied between january 1990 and june 1997. streptomyces somaliensis was the most common causative organism. the source of the infection was thought to be known in only three cases. the common mode of presentation was headache and scalp swelling. the next common presentation was epilepsy. other focal neurological disorders also occur. ct scan findings of the cranium showed osteosclerotic rather than osteolytic ch ... | 1998 | 9745844 |
| [peritonitis caused by streptomyces somaliensis]. | | 1970 | 5513173 |
| refractory craniofacial actinomycetoma due to streptomyces somaliensis that required salvage therapy with amikacin and imipenem. | | 1999 | 10476772 |
| [63 cases of mycetoma in the niger republic (etiological study based on histopathology)]. | 63 samples of mycetomas were examined between 1981 and 1984. most of them (53 cases) were actinomycotic mycetomas of which 20 were due to streptomyces somaliensis, 17 to actinomadura pelletieri, 11 to nocardia sp., 4 to actinomadura madurae. the 11 mycotic mycetomas were all due to madurella mycetomi (= m. mycetomatis). | 1985 | 4085097 |
| perianal actinomycetoma experience of 20 cases. | actinomycetoma is a chronic infection resulting from aerobic actinomycetes. the major agents are nocardia brasiliensis, actinomadura madurae, and streptomyces somaliensis. the most frequent topographies are the lower and upper limbs. the prognosis of this disease is determined by several factors, such as etiologic agent, clinical topography, and depth of disease (degree of involvement, visceral, and bone affection). the purpose of this paper was to present our experience with actinomycetoma of t ... | 2002 | 12207764 |
| cranial and epidural mycetoma caused by streptomyces somaliensis. | the authors report a rare case of cranial and intracranial mycetoma which presented with occipital sinuses, extensive involvement of skull vault and base, an extradural granuloma and intracranial hypertension. radiological appearances are reviewed. the computerized tomography findings are the first of their kind for this condition. the diagnosis and treatment of this disease are discussed. | 1987 | 3822111 |
| actinomycetoma caused by streptomyces somaliensis. | | 1986 | 3767393 |
| numerical phenetic classification of clinically significant aerobic sporoactinomycetes and related organisms. | clinically significant aerobic sporoactinomycetes, notably agents of mycetoma, were examined for a balanced set of unit characters and the resultant data analysed using standard numerical taxonomic procedures. all save two of the one hundred and seventy three tested strains were assigned to three multimembered cluster-groups, which encompassed sixteen major (4-7 strains), ten minor (2-3 strains) and forty single membered clusters, in an analysis based on the simple matching coefficient and unwei ... | 2003 | 12906361 |
| [utilization of various carbon and sodium compounds by streptomyces madurae, streptomyces pelletieri and streptomyces somaliensis]. | | 1957 | 13461420 |
| [epidemiologic study of mycetomas in mexico. apropos of 502 cases]. | the epidemiological data of 502 mycetomas studied in the department of mycology, "centro dermatológico pascua", mexico city, were analysed. mycetomas prevail in males (79.7%), they are more frequent between 16 and 45 years of age (75%) and among rural workers (62.5%); they preferentially affect lower limbs (62.5%); these data are generally similar to the known publications on the matter. actinomycetomas are the most frequent with 97.2% of the cases, distributed as follows: nocardia: 85.6% among ... | 1987 | 3621395 |
| leucocyte chemotaxis to mycetoma agents--the effect of the antifungal drugs griseofulvin and ketoconazole. | polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: madurella mycetomatis and pseudallescheria boydii, both fungi, and streptomyces somaliensis, an actinomycete. there was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leu ... | 1987 | 3617197 |
| the ultrastructure of actinomycetoma grains caused by streptomyces somaliensis. | this study compares the in vitro ultrastructure of streptomyces somaliensis with the grain formation seen in vivo. cultured forms were cocco-bacillary with thick cell walls and septa. individual cells stained with pas.tch and alcian blue. grains were largely composed of an electron-dense fibrillar matrix surrounding clear areas, some of which contained organisms. the ultrastructural appearances of the latter were not significantly different from those seen in vitro although the cell wall was les ... | 1987 | 3605500 |
| mycetoma in saudi arabia. | the clinical and microbiological features of 31 cases of mycetoma seen in 8 years at a riyadh hospital are described. eighteen were due to streptomyces somaliensis, 10 to madurella mycetomatis and one each to actinomadura madurae, nocardia asteroides, and an unidentified species of cladosporium. no immune defects were detected in the patients. eleven had osteolytic lesions and 17 required surgery. only seven patients were cured. streptomyces infections were seen from all parts of saudi arabia ou ... | 1987 | 3550122 |
| mycetoma in the republic of niger: clinical features and epidemiology. | mycetoma is a common disease in the republic of niger. in two hospitals 133 cases were observed. the major site of lesions was the foot. actinomycetomata were seen more often than eumycetomata. streptomyces somaliensis is prevalent in the north desert zone while actinomadura pelletieri is common in the southern part of the country. madurella mycetomatis, the usual etiologic agent of eumycetoma, is seen in both regions. the species incidence and distribution in niger differs from those of the wes ... | 1988 | 3354772 |
| therapeutic effect of a novel oxazolidinone, da-7867, in balb/c mice infected with nocardia brasiliensis. | mycetoma is a chronic infectious disease of tropical and subtropical countries. it is produced by true fungi and actinobacteria. in méxico, nocardia brasiliensis is the main causative agent of mycetoma, producing about 86% of the cases; the gold standard for the therapy of mycetoma by n. brasiliensis is the use of sulfonamides which give a 70% cure rate. the addition of amikacin to this regime increases to 95% the cure rate; however, the patients have to be monitored for creatinine clearance and ... | 2008 | 18820738 |
| comparison of antigens from agents of actinomycetoma by immunodiffusion and electrophoresis procedures. | antigenic extracts were prepared from culture filtrates of the principal agents known to cause actinomycetoma, namely actinomadura madurae, actinomadura pelletieri, nocardia asteroides, nocardia brasiliensis, nocardia otitidis-caviarum, and streptomyces somaliensis. these antigenic preparations were compared by immunodiffusion (id), counterimmunoelectrophoresis (cie), line immunoelectrophoresis (lie) and rocket line immunoelectrophoresis (rlie), with rabbit antisera prepared against each of the ... | 1990 | 2126557 |
| [cephalic mycetoma, caused by streptomyces somaliensis, involving the cranial cavity]. | a case of cephalic mycetoma caused by streptomyces somaliensis which has involved the orbit and craneal cavity with exoftalmus and symptoms of irritation and brain compression is reported. the patient has improved with a medical treatment (sulfomethoxazol-trimetoprim) associated with a descompressive craniectomy. the authors comment the geographic distribution of the agents of mycetoma especially of s. somaliensis very rare specie in america. only 10 proved cases of mycetoma caused by this actin ... | 1975 | 1240563 |
| mycetoma caused by streptomyces somaliensis. | | 1975 | 1132898 |
| mycetomas in mali: causative agents and geographic distribution. | although mali is situated in the african zone endemic for mycetomas, no report has been published on the characteristics of the disease in this country. we report a series of 54 cases observed in bamako. the causative agents were madurella mycetomatis in 20 patients, leptosphaeria sp. in one patients, actinomadura madurae in 12 patients, a. pelletieri in 15 patients, and streptomyces somaliensis in three patients. in this series, the observed geographic distribution of the causative agents was i ... | 1996 | 8651376 |
| mycetomas in northern yemen: identification of causative organisms and epidemiologic considerations. | fifteen cases of mycetomas from four locations in northern yemen were studied. on the basis of morphologic characteristics and staining properties of the granules in discharges from the draining sinus tracts (a narrow elongated cavity that extends from a focus of suppuration or other inflammatory softening to a free surface and through which pus discharges) in the affected appendages and in tissue sections, three causative organisms were identified: streptomyces somaliensis, actinomadura madurae ... | 1993 | 8333574 |
| [actinomycotic mycetoma. apropos of 27 cases in dakar; medical treatment with cotrimoxazole]. | actinomycotic mycetoma is frequent in senegal and the treatment has changed greatly over the last decades. we observed 27 cases due to actinomadura pelletieri (n = 21), actinomadura madurae (n = 5) and streptomyces somaliensis (n = 1). the diagnosis was based on clinical and histological arguments. all the patients were treated with cotrimoxazole for several months. the mycetoma was situated on the foot in 15/27 patients. extrapodal localizations were frequent for red grains due to a. pelletieri ... | 1994 | 7979030 |
| unusual manifestations of deep mycoses due to streptomyces somaliensis. | the incidence of deep mycotic infection due to streptomyces somaliensis in kenya and the sudan is referred to and the common radiological appearance reviewed. two patients having unusual manifestations are reported. in one skull vault involvement caused raised intracranial pressure. the other patient presented with a pathological fracture of the femur and subsequently acquired a further infection at the opposite ankle. | 1980 | 7389576 |
| the first reported case of mycetoma caused by streptomyces somaliensis in malaysia. | | 1982 | 7181789 |
| numerical classification of sporoactinomycetes containing meso-diaminopimelic acid in the cell wall. | one hundred and thirty actinomycetes representing 19 genera and 50 species were compared in a numerical phenetic survey using 108 unit characters. data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using both the single and unweighted pair group average algorithms. cluster composition was barely affected by the statistics used or by test error, estimated at 2.1%. over 80% of the strains were assigned to 2 clusters containing ... | 1982 | 7077300 |
| a serological survey of antibodies to streptomyces somaliensis and actinomadura madurae in the sudan enzyme linked immunosorbent assay (elisa). | sera from 160 individuals resident in the gezira, and 40 living in khartoum, sudan, were screened for antibodies to streptomyces somaliensis and actinomadura madurae using enzyme linked immunosorbent assay (elisa). antibodies were detected in 11.2% of those from the gezira (6.8% to s. somaliensis, 4.3% to a. madurae, and 0.6% to both) compared to 2.5% of those resident in khartoum. the ratio of men with antibodies compared to women was about 2:1 in those from gezira. the results encouraged furth ... | 1983 | 6679364 |
| nocardia, nocardiosis and mycetoma. | the recent emergence of invasive infections due to nocardia spp., including nosocomial outbreak, is now evident. newer molecular diagnostic and typing methods are developed. although sulfonamide-based therapy is generally effective, optimal treatment may be guided by antimicrobial susceptibility testing of isolates. the improved classification of nocardiae and other related genera such as actinomadurae, using the 16s ribosomal rna sequencing, provide a sound basis for improved diagnostic methods ... | 1998 | 9988489 |
| the immunopathology of actinomycetoma lesions caused by streptomyces somaliensis. | the immune responses in actinomycetoma lesions caused by streptomyces somaliensis in sudan were characterized by immunohistochemistry during 1997-1998. in sections stained with haematoxylin and eosin, the inflammatory reaction around the grain was of 2 types. in type i there were 3 zones: a neutrophil zone immediately around the grain, an intermediate zone containing mainly macrophages, and a peripheral zone consisting of lymphocytes and plasma cells. zone 1 stained positively for cd15 (neutroph ... | 2001 | 11280076 |
| mycetoma caused by streptomyces somaliensis in north india. | | 1970 | 5470704 |
| mycetoma in yemen: clinicoepidemiologic and histopathologic study. | mycetoma is widespread in yemen, but has not been fully documented. | 2002 | 12358829 |
| [mycetoma: 130 cases]. | mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. it follows penetrating injury inoculating soil organisms, occurring preferentially in rural areas usually among labourers who work barefoot. mycetoma is a localized chronic, and deforming infectious disease of subcutaneous tissues, skin and bones. we report 130 cases of mycetoma in senegal from 1983 to 2000. | 2003 | 12605151 |
| immunoglobulin profile in mycetoma. | serum samples obtained from 25 patients of mycetoma caused by madurella mycetomi in 18, streptomyces somaliensis in 5, streptomyces madurae and streptomyces palletierii from 1 each and also from 25 healthy controls were evaluated for immunoglobulins igg, igm and iga by radial immunodiffusion method using tripartigen plates. all the three classes of immunoglobulins showed increased concentration in cases of mycetoma by m. mycetomi and s. pelletierii. the raised levels of igg and igm in cases of m ... | 1996 | 8972149 |
| rapid identification of clinically significant species and taxa of aerobic actinomycetes, including actinomadura, gordona, nocardia, rhodococcus, streptomyces, and tsukamurella isolates, by dna amplification and restriction endonuclease analysis. | a previously described pcr-restriction fragment length polymorphism (rflp) identification schema for nocardia that used an amplified 439-bp segment (amplicon) of the 65-kda heat shock protein gene was evaluated for potential use with isolates of all clinically significant aerobic actinomycetes. the study included 28 reference (american type culture collection) strains and 198 clinical isolates belonging to 20 taxonomic groups. of these 198 isolates, 188 could be differentiated by this pcr-rflp m ... | 1997 | 9157134 |
| synergy of antibiotics against streptomyces somaliensis isolates in vitro. | eight dual antibiotic combinations were used to investigate possible synergic effects against different isolates of streptomyces somaliensis. the antibiotic combinations that showed synergic activity against the isolates were, in decreasing order, fusidic acid-rifampicin, erythromycin-penicillin, erythromycin-fusidic acid, rifampicin-sulphamethoxazole, fusidic acid-sulphamethoxazole and erythromycin-rifampicin. sulphamethoxazole-trimethoprim and rifampicin-trimethoprim combinations were not syne ... | 1998 | 9533473 |
| [streptomyces somaliensis mycetoma with craniofacial involvement]. | mycetoma is a chronic granulomatous infection of the skin from which grains of the causative organism are eliminated via the sinus tracts. we report a rare case of cephalic mycetoma, which presented with an extensive involvement of the skull vault, base and an extradural granuloma. the diagnosis and treatment of the disease are discussed. | 1998 | 9690294 |
| actinomycetoma and advances in its treatment. | actinomycetoma is a chronic subcutaneous infection caused by aerobic branching actinomycetes. its clinical features are firm tumefaction of the affected site and the presence of abscesses, nodules, and sinuses that drain a seropurulent exudate containing filamenting granules. the disease is caused by inoculation of the infectious agent through minor trauma in susceptible individuals. nocardia brasiliensis, actinomadura madurae, and streptomyces somaliensis are among the most frequent agents in t ... | 2015 | 22682184 |
| [mycetomas diagnosed in senegal from 2008 to 2010]. | mycetomas are inflammatory pseudotumours of subcutaneous and possibly osseous soft fabrics, generally polyfistulas with chronic mode of evolution. | 2011 | 24451559 |
| activation of a plasmid-situated type iii pks gene cluster by deletion of a wbl gene in deepsea-derived streptomyces somaliensis scsio zh66. | actinomycete genome sequencing has disclosed a large number of cryptic secondary metabolite biosynthetic gene clusters. however, their unavailable or limited expression severely hampered the discovery of bioactive compounds. the whib-like (wbl) regulatory genes play important roles in morphological differentiation as well as secondary metabolism; and hence the wbla so gene was probed and set as the target to activate cryptic gene clusters in deepsea-derived streptomyces somaliensis scsio zh66. | 2016 | 27350607 |
| [management of mycetoma in west-africa]. | mycetoma is still endemic in the northern areas of west-africa. this infection is more common in males, rural inhabitants, between 20 and 40 years of age. mycetoma is generally easy to identify on clinical presentation, it is a chronic subcutaneous inflammatory tumor with discharging sinuses. the commonest affected site is the foot (70%), leg, knee, thigh, hand and arm are the most frequent extrapodal localizations. diagnosis must be confirmed by the presence of grains at direct and histological ... | 2003 | 15015843 |
| [actinomycetomas in senegal: study of 90 cases]. | mycetoma is a pathological process during which eumycetomic (fungal) or actinomycotic causative agents from exogenous source produce grains. medical treatment is available for actinomycetomas and surgery is still the main treatment for eumycetoma. we report 90 cases of actinomycetoma occuring in male adult patients coming mainly from central senegal. patients living far from health structures consult after a long evolution period for tumors and pains which prevent them from carrying out their ac ... | 2005 | 15915967 |
| production of industrially important enzymes by some actinomycetes producing antifungal compounds. | seventeen strains of actinomycetes antagonistic to yeast and moulds have been tested for their ability to produce amylase, lipase, gelatinase and caseinase using solid media containing starch, tween-20, gelatin and skimmed milk, respectively, enzyme producing potential of test strains is expressed in ternis of relative enzyme activity (rea). actinomycetes strain streptomyces somaliensis gs 1242 and streptomyces sampsonii gs 1322 showed higher amylase production (rea 6.5) while maximum lipase act ... | 2003 | 16281826 |
| [clinical and microbiological study of mycetomas at the muñiz hospital of buenos aires between 1989 and 2004]. | this work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the muñiz hospital from 1989 to 2004. forty-nine patients were male and 27 female; the mean age was 43.4 years. the majority of the patients acquired the infection in argentina: the most affected provinces were santiago del estero with 31 cases, and chaco with 11; 8 cases came from other countries (bolivia 6 and paraguay 2). the mean evolution of the disease was 9.2 years. the most frequent ... | 2006 | 16784127 |
| streptomyces sudanensis sp. nov., a new pathogen isolated from patients with actinomycetoma. | nine strains isolated from mycetoma patients and received as streptomyces somaliensis were the subject of a polyphasic taxonomic study. the organisms shared chemical markers consistent with their classification in the genus streptomyces and formed two distinct monophyletic subclades in the streptomyces 16s rrna gene tree. the first subclade contained four organisms, including the type strain of s. somaliensis, and the second clade the remaining five strains which had almost identical 16s rrna se ... | 2008 | 18157699 |
| isolation and characterization of medically important aerobic actinomycetes in soil of iran (2006 - 2007). | the aerobic actinomycetes are a large group of soil-inhabiting bacteria that occur worldwide. some of them are the main cause of two important diseases, nocardiosis and actinomycetoma. to identify the prevalence and geographic distribution of aerobic actinomycetes in soil of qazvin province, a study was carried out during 2006-2007. in this study, the incidence and diversity of medically important aerobic actinomycetes was determined in 300 soil samples of different parts of qazvin. the suspensi ... | 2009 | 19440253 |
| Streptomyces as symbionts: an emerging and widespread theme? | Streptomyces bacteria are ubiquitous in soil, conferring the characteristic earthy smell, and they have an important ecological role in the turnover of organic material. More recently, a new picture has begun to emerge in which streptomycetes are not in all cases simply free-living soil bacteria but have also evolved to live in symbiosis with plants, fungi and animals. Furthermore, much of the chemical diversity of secondary metabolites produced by Streptomyces species has most likely evolved as ... | 2011 | 22091965 |
| bacterial community structure in treated sewage sludge with mesophilic and thermophilic anaerobic digestion. | stabilized sewage sludge is applied to agricultural fields and farmland due to its high organic matter content. the aim of this study was to investigate the effects of two types of sludge stabilization, mesophilic anaerobic digestion (mad) and thermophilic anaerobic digestion (tad), on bacterial communities in sludge, including the presence of pathogenic microorganisms. bacterial community structure and phylogenetic diversity were analyzed in four sewage sludge samples from the czech republic. a ... | 2015 | 25921720 |
| global burden of human mycetoma: a systematic review and meta-analysis. | mycetoma is a chronic infectious disease of the subcutaneous tissue with a high morbidity. this disease has been reported from countries between 30°n and 15°s since 1840 but the exact burden of disease is not known. it is currently unknown what the incidence, prevalence and the number of reported cases per year per country is. in order to estimate what the global burden of mycetoma is, a meta-analysis was performed. in total 50 studies were included, which resulted in a total of 8763 mycetoma ca ... | 2013 | 24244780 |
| a new dioic acid from a wbl gene mutant of deepsea-derived streptomyces somaliensis scsio zh66. | the wblaso gene functions as a global regulatory gene in a negative manner in deepsea-derived streptomyces somaliensis scsio zh66. a new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the δwblaso mutant strain of s. somaliensis scsio zh66. the structure of 1 was elucidated by a combination of spectroscopic analyses, including ms and nmr techniques. in the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma ce ... | 2016 | 27763499 |
| streptomyces atlanticus sp. nov., a novel actinomycete isolated from marine sponge aplysina fulva (pallas, 1766). | the taxonomic position of a novel marine actinomycete isolated from a marine sponge, aplysina fulva, which had been collected in the archipelago of saint peter and saint paul (equatorial atlantic ocean), was determined by using a polyphasic approach. the organism showed a combination of morphological and chemotaxonomic characteristics consistent with its classification in the genus streptomyces and forms a distinct branch within the streptomyces somaliensis 16s rrna gene tree subclade. it is clo ... | 2016 | 27566709 |
| withdrawn: identification of an antimycin gene cluster and characterization of the tryptophan 2,3-dioxygenase from the deep sea-derived streptomyces somaliensis hnd1201. | this article has been withdrawn at the request of the author(s) and/or editor. the publisher apologizes for any inconvenience this may cause. the full elsevier policy on article withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. | 2015 | 26525851 |
| activation and enhancement of fredericamycin a production in deepsea-derived streptomyces somaliensis scsio zh66 by using ribosome engineering and response surface methodology. | marine microorganisms are an important source of new drug leads. however, the discovery and sustainable production of these compounds are often hampered due to the unavailable expression of cryptic biosynthetic gene clusters or limited titer. ribosome engineering and response surface methodology (rsm) integrated strategy was developed in this study to activate cryptic gene cluster in the deepsea-derived streptomyces somaliensis scsio zh66, and subsequently isolation, structural analysis, and the ... | 2015 | 25927229 |
| draft genome sequence of the human pathogen streptomyces somaliensis, a significant cause of actinomycetoma. | we report the draft genome sequence of the human pathogen streptomyces somaliensis (dsm 40738), a pathogen within a genus of largely saprophytic organisms. s. somaliensis causes severe and debilitating deep tissue and bone infections. the genome sequence is deposited in ddbj/embl/genbank with the accession number ajjm01000000. | 2012 | 22689234 |
| streptomyces somalinesiscausing mycetomas in south india. | biopsy specimens from 102 patients with mycetoma were examined histologically; streptomyces somaliensis was found in 5 cases. the clinical features, radiology and histology of actinomycotic mycetoma due to s. somaliensis ar ' e described. the geographic distribution of the organism, its incidence and prevalence in india and the importance of histological examination in the diagnosis of the infection are discussed. | 2017 | 28193987 |