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agrimonolide from agrimonia pilosa suppresses inflammatory responses through down-regulation of cox-2/inos and inactivation of nf-κb in lipopolysaccharide-stimulated macrophages.agrimonolide from agrimonia pilosa showed a strong anti-inflammatory activity, and the present study aims to reveal potential mechanisms on molecular level explaining its anti-inflammatory effect.201627288920
glucosidase inhibitory activity and antioxidant activity of flavonoid compound and triterpenoid compound from agrimonia pilosa ledeb.in chinese traditional medicine, agrimonia pilosa ledeb (apl) exhibits great effect on treatment of type 2 diabetes mellitus (t2dm), however its mechanism is still unknown. considering that t2dm are correlated with postprandial hyperglycemia and oxidative stress, we investigated the α-glucosidase inhibitory activity and the antioxidant activity of flavonoid compound (fc) and triterpenoid compound (tc) from apl.201424410924
experimental study on inhibition of s180 tumor cells by agrimonia pilosa extract.we evaluated the in vitro and in vivo inhibition of s180 tumor cell growth of the water extract of agrimonia pilosa. inhibitory effect of agrimonia pilosa on in vitro-cultured s180 cell proliferation was measured by mtt assay; mice model of transplanted tumor was established, after 8 days of continuous administration, the tumors were removed, weighed, and compared with the control group, and the in vivo anti-tumor effect of agrimonia pilosa on mouse sarcoma s180 was compared using inhibition rat ...201324146477
chemical constituents from agrimonia pilosa ledeb. and their chemotaxonomic significance.phytochemical investigation of the ethanol extract from the whole plant of agrimonia pilosa led to the isolation of 31 compounds, including 16 flavonoids (1-16), 5 triterpenes (17-21), 1 isocoumarin (22), 5 phenolic acids (23-27), 1 ceramide (28), 2 agrimols (29-30) and 1 fatty acid (31). their structures were determined by various spectroscopic analyses. compounds 5, 7 and 20 were firstly isolated from the genus agrimonia, and compounds 6, 10-11, 15, 26, 28 and 31 were isolated from the family ...201627313126
agrimol b suppresses adipogenesis through modulation of sirt1-ppar gamma signal pathway.studies of human genetics have implicated the role of sirt1 in regulating obesity, insulin resistance, and longevity. these researches motivated the identification of novel sirt1 activators. the current study aimed to investigate the potential efficacy of agrimol b, a polyphenol derived from agrimonia pilosa ledeb., on mediating sirt1 activity and fat metabolism. results showed that agrimol b significantly induced cytoplasm-to-nucleus shuttle of sirt1. furthermore, we confirmed that agrimol b dr ...201627320865
tiliroside, the major component of agrimonia pilosa ledeb ethanol extract, inhibits mapk/jnk/p38-mediated inflammation in lipopolysaccharide-activated raw 264.7 macrophages.in the present study, the in vivo anti-inflammatory activity of agrimonia pilosa ledeb (ap) ethanol extract was confirmed in experimental animal models, including xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. tiliroside, the major component of ap extract, was isolated and purified by high-performance liquid chromatography. the anti-inflammatory mechanism of tiliroside was then examined using lipopolysaccharide (lps)-activated raw 264.7 macrophage cells. an mtt assay ...201627347085
effects of the four-herb compound anbp on wound healing promotion in diabetic mice.wound healing is a troublesome problem in diabetic patients. besides, there is also an increased risk of postsurgical wound complications for diabetic patient. it has been revealed that traditional chinese medicine may promote healing and inhibit scar formation, while the changes of morphology and physiology of wounds on such medicine treatment still remain elusive. in this study, we first used the ultralow temperature preparation method to produce mixed superfine powder from agrimonia pilosa (a ...201525795279
effect of agrimonia pilosa ledeb extract on the antinociception and mechanisms in mouse.in the present study, the antinociceptive profiles of agrimonia pilosa ledeb extract were examined in icr mice. agrimonia pilosa ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. in addition, agrimonia pilosa ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance p (0.7 µg) was diminish ...201222563257
development of a liquid chromatography-mass spectrometry method for determination of agrimol b in rat plasma: application to preclinical pharmacokinetics.a sensitive and accurate liquid chromatography coupled with mass spectrometry (lc-ms) method was developed for the determination of agrimol b, a main active ingredient isolated from agrimonia pilosa ledeb., in rat plasma. chromatographic separation was achieved on a zorbax cn column (150 × 4.6 mm, 5 µm), with isocratic elution consisting of acetonitrile and water (15:85, v/v) at a flow rate of 0.6 ml/min. agrimol b and dryocrassin abba, an internal standard (is), were analyzed by selected ion mo ...201525065576
eriophyoid mites from northeast china (acari: eriophyoidea).we describe and illustrate herein one new genus and eighteen new eriophyoid mite species (acari: eriophyoidea) collected in northeast china. they are: shevtchenkella huzhongiensis sp. nov. on ulmus davidiana planch. var. japonica (sarg. ex rehder) nakai (ulmaceae), shevtchenkella jingboicus sp. nov. on acer sp. (aceraceae), calepitrimerus flexuosus sp. nov. on spiraea flexuosa fisch. ex cambess. (rosaceae), calepitrimerus maximowiczii sp. nov. on crataegus maximowiczii schneid. (rosaceae), calep ...201326146687
estrogen-like activity of aqueous extract from agrimonia pilosa ledeb. in mcf-7 cells.postmenopausal women experience estrogen deficiency-related menopausal symptoms (e.g., hot flashes and mood swings) and a dramatic increase in the incidence of chronic diseases. although estrogen-replacement therapy (ert) can reduce mortality from cardiovascular disease and improve osteoporosis and menopausal symptoms, its side effects have limited recent use. this study investigated the estrogen-like activity of aqueous extract from agrimonia pilosa ledeb.201223259680
acylphloroglucinolated catechin and phenylethyl isocoumarin derivatives from agrimonia pilosa.eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from agrimonia pilosa along with six other known compounds (9-14). the new compounds were characterized structurally by nmr, ms, and ecd analyses. compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from nature. the absolute configuration of compound 8 was elucidated by computationa ...201627588326
the potential beneficial effects of phenolic compounds isolated from a. pilosa ledeb on insulin-resistant hepatic hepg2 cells.agrimonia pilosa ledeb (ap) has already been applied in practice for the treatment of different disorders and is available to access without the provision of a medical prescription. the present study aims at investigating the effect of bioactive compounds isolated from ap on the improvement of insulin resistance, figuring out the mechanism in insulin-responsive cell lines. five compounds were isolated from ap using column chromatography, including agrimonolide (k1), desmethylagrimonolide (k2), t ...201627704066
phytochemical analysis of agrimonia pilosa ledeb, its antioxidant activity and aldose reductase inhibitory potential.the aim of this study was to determine aldose reductase (ar) inhibitory activity and 1,1-diphenyl-2-picrylhydrazyl (dpph) free radical scavenging activity of compounds from agrimonia pilosa ledeb (ap). we isolated agrimoniin (am), four flavonoid glucosides and two flavonoid glucuronides from the n-butanol fraction of ap 50% methanol extract. in addition to isolated compounds, the ar-inhibitory activity and the dpph free radical scavenging activity of catechin, 5-flavonoids, and 4-flavonoid gluco ...201728208627
new cytotoxic phloroglucinol derivatives from agrimonia pilosa.three new phloroglucinol derivatives, namely agripinol a-c (1-3), were isolated from agrimonia pilosa ledeb, along with two known ones (4-5). their structures were characterized by spectroscopic methods, including ms and nmr spectroscopic techniques. the absolute configurations of the new compounds were unambiguously established by single crystal x-ray diffraction analyses. in the cytotoxicity assay, all compounds exhibited more potent cytotoxic activities against hct-116, mda-mb-231 and pc-3, a ...201728237881
flavonoids from agrimonia pilosa ledeb: free radical scavenging and dna oxidative damage protection activities and analysis of bioactivity-structure relationship based on molecular and electronic structures.to clarify the substantial basis of the excellent antioxidant capacity of agrimonia pilosa ledeb. fourteen flavonoids were isolated and identified from agrimonia pilosa ledeb, seven of which have notable dpph radical scavenging activities, i.e., catechin, luteolin, quercetin, quercitrin, hyperoside, rutin, luteolin-7-o-β-glucoside with ic50 values of 5.06, 7.29, 4.36, 7.12, 6.34, 6.36 and 8.12 µm, respectively. the dna nicking assay showed that five flavonoids from agrimonia pilosa ledeb-taxifol ...201728245624
virtual screening of traditional chinese medicine (tcm) database: identification of fragment-like lead molecules for filariasis target asparaginyl-trna synthetase.lymphatic filariasis (lf) is a vector borne infectious disease caused by the nematode wuchereria bancrofti, brugia malayi, and brugia timori. over 120 million people are affected by lf in the world, of which two-thirds are in asia. the infection restricts the normal flow of lymph from the infected area resulting in swelling of the extremities and causing permanent disability. as the available drugs for the treatment of lf are becoming ineffective due to the development of resistance, there is an ...201424842326
phenolic glycosides from agrimonia pilosa.phytochemical investigation of the methanolic extract from the aerial parts of agrimonia pilosa led to the isolation of three compounds, (-)-aromadendrin 3-o-β-d-glucopyranoside, desmethylagrimonolide 6-o-β-d-glucopyranoside, and 5,7-dihydroxy-2-propylchromone 7-o-β-d-glucopyranoside, together with nine known compounds, agrimonolide 6-o-glucoside, takanechromone c, astragalin, afzelin, tiliroside, luteolin, quercetin, isoquercetrin, and quercitrin. their structures were determined by various spe ...201020810135
inhibitory effect of agrimonia pilosa ledeb. on inflammation by suppression of inos and ros production.herbal medicines including agrimonia pilosa ledeb. (apl) have been traditionally used to treat inflammations including allergic disease as valuable medicinal properties. to investigate the attenuating ability of apl on inflammation, the no release and ros production, which play a key role in inflammatory and immune responses, was first tested using in vitro assay. the 80% ethanol extract of apl showed a significant activity to inhibit no release and ros production. in additional extracts from 80 ...201020136621
broad-spectrum antiviral effect of agrimonia pilosa extract on influenza viruses.influenza virus continues to emerge and re-emerge, posing new threats for humans. here we tested various korean medicinal plant extracts for potential antiviral activity against influenza viruses. among them, an extract of agrimonia pilosa was shown to be highly effective against all three subtypes of human influenza viruses including h1n1 and h3n2 influenza a subtypes and influenza b virus. the ec(50) value against influenza a virus, as tested by the plaque reduction assay on mdck cells, was 14 ...201020055938
evaluation of the phototoxic potential of plants used in oriental medicine.phototoxicity can be either harmful or beneficial. yet the phototoxicity of oriental medicinal plants is an understudied area. the purpose of this study is to fill in this gap.201019818392
antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats.we investigated the effects of herb extracts, rhus verniciflua, agrimonia pilosa, sophora japonica, and paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (tbars) in streptozotocin (stz)-induced diabetic rats. after 4 weeks, oral administration of rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (p<0.05). blood tbars concentrations, the products of glucose oxidation in blood, were ...200617031059
protein tyrosine phosphatase 1b (ptp1b) inhibitory activity and glucosidase inhibitory activity of compounds isolated from agrimonia pilosa.despite phytochemical studies of agrimonia pilosa ledeb. (rosaceae), the antidiabetic effects of this plant are unknown.201626084800
an isocoumarin with hepatoprotective activity in hep g2 and primary hepatocytes from agrimonia pilosa.phytochemical investigation of the aqueous extract of the roots of agrimonia pilosa ledeb. (rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-o-beta-d-glucoside (3), and (+)-catechin (2). compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived hep g2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with ec50 values of 88.2 +/- 2.8 and 37.7 +/- ...200415473665
[textural research on "shidachuan" and "shijianchuan" in "ben cao gang mu shi yi" (a supplement to the compendium of materia medica)].to investigate the historical origins of folk herbal medicines "shidachuan" and "shijianchuan"200012205975
moderate inhibition of mutagenicity and carcinogenicity of benzo[a]pyrene, 1,6-dinitropyrene and 3,9-dinitrofluoranthene by chinese medicinal herbs.the activity of six chinese medicinal herbs against the environmental mutagens and carcinogens benzo[a]pyrene (b[a]p), 1,6-dinitropyrene (1,6-dinp) and 3,9-dinitrofluoranthene (3,9-dinf) was determined. samples of prunella spica, rheum palmatum, polygonum multiflorum, agrimonia pilosa, ephedra sinica and teitoutou were tested in an in vitro system. antimutagenic activity against b[a]p was marked in the presence of extracts (boiled for 2 h in a water bath) whereas that against 1,6-dinp and 3,9-di ...19947854143
herbal medicine guan chang fu fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.guan chang fu fang (gcff) is a natural compound, which is extracted from three medicinal plants, agrimonia pilosa ledeb., patrinia scabiosaefolia and solanum nigrum l. gcff has demonstrated clinical efficacy in the treatment of colon cancer. at present, 5-fluorouracil (5-fu) is the primary active chemotherapeutic agent used for treating colon cancer. using median-effect and apoptosis analyses, fluorescence microscopy and western blotting, the present study analyzed the association between gcff a ...201525621039
use of a novel herbal medicine in a 75-year-old woman with multi-metastatic pancreatic cancer: a case report and review of the literature.pancreatic cancer is one of the most aggressive types of malignant tumors and is associated with an extremely poor prognosis. despite numerous research efforts over the last few years, little progress has been made in the understanding and treatment of the disease. gemcitabine-based regimens are considered as the first-line treatment for pancreatic cancer, but the effects of chemotherapy on the disease are limited. natural products extracted from herbs represent a valuable resource for novel bio ...201526171011
agrimoniin, an antitumor tannin of agrimonia pilosa ledeb., induces interleukin-1.the induction of interleukin-1 (il-1) by agrimoniin, a tannin of agrimonia pilosa ledeb., in human peripheral blood mononuclear cells (pbmc) in vitro and in mouse adherent peritoneal exudate cells (pec) in vivo was studied. a significant amount of il-1 beta in the culture supernatant of the human pbmc stimulated with agrimoniin was detected with an enzyme-linked immunoadherent assay. agrimoniin induced il-1 beta secretion dose- and time-dependently. the adherent pec from mice intraperitoneally i ...19921444208
preparative purification of five bioactive components from agrimonia pilosa ledeb by high-speed counter-current chromatography.high-speed counter-current chromatography (hsccc) coupled with ultraviolet (uv) detection or evaporative light-scattering detection was successfully applied for preparative separation of five bioactive compounds from agrimonia pilosa ledeb. in preliminary process, d101 macroporous resin was used to separate the crude extract of the plant and four fractions (20, 40, 50, and 60% aqueous ethanol elutions) were produced. then, these fractions were directly subjected to hsccc purification. five chemi ...201222865760
1β-hydroxy-2-oxopomolic acid isolated from agrimonia pilosa extract inhibits adipogenesis in 3t3-l1 cells.in order to determine anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (hoa) isolated from agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (pparγ), ccaat-enhancer-binding protein α (c/ebpα), glucose transporter 4 (glut4), adiponectin, adipocyte fatty acid-binding protein 2 (ap2), adipocyte determination and differentiation factor 1/sterol regulatory element binding prot ...201222687396
comparative chemical composition of the essential oils obtained by microwave-assisted hydrodistillation and hydrodistillation from agrimonia pilosa ledeb. collected in three different regions of china.conventional hydrodistillation (hd) and microwave-assisted hydrodistillation (mahd) were performed to obtain the volatile oils of agrimonia pilosa ledeb. harvested in three different regions of china, which were subsequently characterized by gc-fid and gc/ms analyses. compared with hd, mahd was advantageous in terms of energy savings and extraction time (60 vs. 240 min for mahd and hd, resp.). the chemical composition varied among the different oils obtained, and the variations in the contents o ...201222422533
anti-inflammatory and anti-allergic effects of agrimonia pilosa ledeb extract on murine cell lines and ova-induced airway inflammation.agrimonia pilosa ledeb (rosaceae, ap) has long been used as a traditional medicine in korea and other asian countries to treat various diseases.201222289347
suppression of nitric oxide production on lps/ifn-γ-stimulated raw264.7 macrophages by a novel catechin, pilosanol n, from agrimonia pilosa ledeb.a novel catechin, pilosanol n (1), was isolated from agrimonia pilosa ledeb and its structure was determined by (1)h, (13)c nmr and hresi-ms analyses. compound 1 inhibited nitric oxide (no) production in lps/ifn-γ -induced raw264.7 macrophages, and then the inos gene expression and its protein production with lps/ifn-γ treatment cells were also suppressed in the presence of 1. in addition, compound 1 scavenged no or nitrogen radicals generated from nor3 (4-ethyl-2-hydroxyamino-5-nitro-3-hexenami ...201222281186
agrimonia pilosa ethanol extract induces apoptotic cell death in hepg2 cells.agrimonia pilosa (ap) has been used as a traditional herbal medicine for treating various cancers and diseases in asian countries.201121945237
[discrimination of seven species of agrimonia pilosa ledeb and its extracts by ftir and 2d-ir].the objective of the present study is to discriminate seven species of agrimonia pilosa ledeb herbs and their total tannin extracts by fourier transform infrared spectroscopy (ftir), second derivative infrared spectroscopy, and two-dimensional correlation infrared spectroscopy (2d-ir) under thermal perturbation. the structural information of the samples indicated that agrimonia pilosa ledeb and their extract residues contain a large amount of starch and calcium oxalate, since some characteristic ...201021322210
limited phenotypic plasticity in range-edge populations: a comparison of co-occurring populations of two agrimonia species with different geographical distributions.increased importance of genetic drift and selection for stress resistance have been predicted to lead to a reduction in the degree of phenotypic plasticity in populations at margins of a species' geographical range, relative to those in the centre. we examined the effect of population positioning within the species range on degree of active morphological plasticity to vegetation shade. importantly, we discriminated between active, size-independent morphological adjustments in response to shade a ...201121143739
[agrimophol structure--the taenifugal constituent from root-sprout of agrimonia pilosa ledeb]. 19744211292
[studies on the standardization of crude drugs. xi. constituents of agrimonia pilosa var. japonica]. 19685751318
antitumor activity of methanol extract from roots of agrimonia pilosa ledeb.to evaluate the antitumor activity of agrimonia pilosa ledeb., the effects of the methanol extract from roots of the plant (ap-m) on several transplantable rodent tumors were investigated. ap-m significantly prolonged the life span of s180-, meth-a fibrosarcoma- and mm-2 mammary carcinoma-bearing mice by intraperitoneal (i.p.) pre- or postmedication. ap-m also inhibited the growth of s-180 solid type tumor. on the other hand, the prolongation of life span induced by ap-m on s-180 ascites type tu ...19854040585
[studies on the constituents of agrimonia pilosa ledeb. i. biological activities of the acidic fraction soluble in n-hexane of the roots (author's transl)]. 19807205560
preparative separation of axifolin-3-glucoside, hyperoside and amygdalin from plant extracts by high-speed countercurrent chromatography.high-speed countercurrent chromatography (hsccc) was successfully used to isolate three bioactive compounds, i.e., amygdalin from bitter almond and taxifolin-3-glucoside and quercetin-3-galactoside (hyperoside) from water extract of agrimonia pilosa ledeb, respectively. from 1 g of the crude extract 65 mg of amygdalin was isolated at 97% purity using a two-phase solvent system composed of ethyl acetate-n-butanol-water (5:2:5, v/v) by preparative hsccc. from a 400 mg amount of crude extract of ag ...200920046896
antioxidant activities of aqueous extract from agrimonia pilosa ledeb and its fractions.agrimonia pilosa ledeb is used as the tonic for asthenia and fatigue in china. considering that the energizing effect might be correlated with antioxidant properties, we investigated the antioxidant activities of aqueous extract (ae) from agrimonia pilosa ledeb by assessing radical-scavenging and anti-lipid-peroxidation abilities. we found that ae shows a moderate antioxidant activity to scavenge dpph*, o2(-)* and *oh and inhibit beta-carotene bleaching with ic(50) values of 13.0, 33.2, 351, and ...200919842137
[studies on isolation and identification of flavonoids in herbs of agrimonia pilosa].to study the chemical constituents in agrimonia pilosa.200819294852
antioxidant activity of 45 chinese herbs and the relationship with their tcm characteristics.here, 45 chinese herbs that regulate blood circulation were analyzed for antioxidant activity using the oxygen radical absorbance capacity (orac) assay. a recent publication by ou et al. identified a close relationship between in vitro antioxidant activity and classification of chinese herbs as yin or yang. the 45 chinese herbs in this study could be assigned the traditional characteristics of natures (cold, cool, hot and warm), flavors (pungent, sweet, sour, bitter and salty) and functions (arr ...200818955214
acetylcholinesterase inhibition by flavonoids from agrimonia pilosa.in a bioassay-guided search for acetylcholinesterase (ache) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). we report herein for the first time that all four flavonol compounds showed significant inhibitory effects on ache, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (dhed).200717962731
separation and determination of flavonoids in agrimonia pilosa ledeb. by capillary electrophoresis with electrochemical detection.five flavonoids (catechin, hyperoside, quercitrin, quercetin, and rutin) were separated and determined by capillary electrophoresis with electrochemical detection. effects of several important factors, such as the ph and concentration of running buffer, separation voltage, injection time, and detection potential were investigated to determine the optimum conditions. the five flavonoids were baseline separated within 20 min in a 60 cm length capillary at a separation voltage of 19.5 kv with a run ...200515912734
[experimental study on decoctum agrimonia pilosa ledeb-induced apoptosis in hl-60 cells in vitro].in this study, mtt assay, cell morphology and flow cytometry were used to explore agrimonia pilosa ledeb on hl-60 cells in vitro. the data suggested that agrimonia pilosa ledeb had the effects of growth inhibition in hl-60 cells. after treated with decoctum agrimonia pilosa ledeb, cells underwent apoptosis with typical morphological feature. dna histograms by flow cytometric analysis displayed distinct apoptotic peak.200012575284
[determination of trace elements in several hemostatic medicinal plants and their boiling water extracts].the experimental results indicate that the amounts of cu, zn, fe and mn in rubia cordifolia and agrimonia pilosa var. japonica are very small in boiling water extracts (only 6%). but after digestion they may rise to 30%. it was found that the amounts of four trace elements decreased with the increase of extracting time, but the ratios of mn/zn and zn/cu were almost the same.19938216788
[studies on the structure of a new flavanonol glucoside of the root-sprouts of agrimonia pilosa ledeb].three compounds were isolated from benzene and acetone extracts of the root-sprouts of agrimonia pilosa ledeb. on the basis of physicochemical properties, spectroscopy (uv, ir, nmr, ms, cd, gc) and chemical degradation, two known compounds were identified as palmitic acid (viii) and daucosterol (ix), one new compound was elucidated as (2s,3s)-(-)-taxifolin-3-o-beta-d-glucopyranoside (x).19902281787
[studies on the structure of a new ellagic acid glycoside from the root-sprouts of agrimonia pilosa ledeb].four compounds were isolated from the root-sprouts of agrimonia pilosa ledeb. on the basis of physico-chemical properties, spectroscopy (uv, ir, nmr, ms) and chemical degradation, a new compound was elucidated as ellagic acid-4-o-beta-d-xylopyranoside (xv), and three known compounds were identified as agrimonolide (xiii), tormentic acid (xiv), and ellagic acid (xvi).19902099598
antimicrobial principles of xian he cao (agrimonia pilosa).from the antimicrobially active extract of the chinese crude drug, xian he cao ( agrimonia pilosa ledb.), four active compounds were isolated. they were all phloroglucinol derivatives and their structures were elucidated on the basis of spectroscopic data.198917262333
[studies on the structure of a new isocoumarin glucoside of the root sprouts of agrimonia pilosa ledeb].trans-p-hydroxycinnamic esters vi and an isocoumarin glucoside vii were isolated from the benzene and acetone extracts of the root sprouts of agrimonia pilosa ledeb. on the basis of physicochemical properties, spectral data (uv, ir, nmr, ms, ci-ms-ms), gc and chemical degradation, vi was elucidated as trans-p-hybroxycinnamic esters of n-c22, n-c24-32, n-c34, alcohols, vii was elucidated as agrimonolide-6-q-beta-d-glucopyranoside. vii and trans-p-hydroxycinnamic esters of n-c29-32 and n-c34 alcoh ...19892618681
agrimonia pilosa ledeb., cinnamomum cassia blume, and lonicera japonica thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats.the water extracts of cinnamomum cassia blume bark (ccb; lauraceae), lonicera japonica thunb. flower (ljt; caprifoliaceae), and agrimonia pilosa ledeb. leaves (apl; rosaceae) prevented amyloid-β (25-35)-induced cell death in pc12 cells in our preliminary study. we evaluated whether long-term oral consumption of ccb, ljt, and apl improves cognitive dysfunction and glucose homeostasis in rats with experimentally induced ad-type dementia.201726842885
[studies on the chemical constituents from the root-sprouts of agrimonia pilosa ledeb].five compounds were isolated from the petroleum ether extract of the root-sprouts of agrimonia pilosa ledob. a new compound, (r)-(-)-agrimol b (iii), was elucidated by means of physical and chemical properties, spectroscopy (ms, ir, pmr, uv) and total synthesis. four known compounds were identified as agrimophol (i), n-nonacosane (ii), beta-sitosterol (iv) and pseudo-aspidin (v), the last one being previously known only as a synthetic entity. (s)-(+)-agrimol b also was synthesized.19892609982
induction of cytotoxicity of peritoneal exudate cells by agrimoniin, a novel immunomodulatory tannin of agrimonia pilosa ledeb.the cytotoxic activities of the pec after an i.p. injection of agrimoniin, a tannin contained in agrimonia pilosa ledeb. were studied. the plastic nonadherent pec had significantly higher nk cell activity than the untreated control, and the adherent pec were cytostatic toward mm2 and mh134 cells. the adherent pec did not cause tumor cell lysis by themselves, but were cytolytic against mm2 cells in the presence of anti-mm2 sera. in the course of these effects of pec after the i.p. injection of ag ...19883396026
antitumor effect of agrimoniin, a tannin of agrimonia pilosa ledeb., on transplantable rodent tumors.the effect of agrimoniin, a tannin contained in agrimonia pilosa ledeb., on ascites type and solid type rodent tumors was investigated. when agrimoniin was intraperitoneally (i.p.) administered at dosages over 10 mg/kg before or after the mm2 cell i.p. inoculation, this tannin almost completely rejected the tumor growth in the mice. this tannin prolonged the life span of mice bearing mm2 or cured by the intravenous or per oral pre- or postmedication. agrimoniin also inhibited the growth of mh134 ...19873573425
effect of hsien-ho-t'sao (agrimonia pilosa) on experimental thrombosis in mice.the water extract of hsien-ho-t'sao (hht) prolonged the tail bleeding time in conscious mice. this antihemostatic effect was dose-dependent and exhibited a biphasic pattern; i.e. its activity declined at doses higher than 0.5 mg/kg. the prolonged bleeding time persisted for at least 12 hr and maximal effect was observed at 3 hr after the oral administration of hht 500 mg/kg. hht was effective in preventing adp-induced acute pulmonary thromboembolic death in mice, while aspirin and indomethacin h ...19873687839
antiviral activities of medicinal herbs traditionally used in southern mainland china.the aqueous extracts from 21 medicinal herbs traditionally used in southern mainland china were screened for antiviral activities against human herpes simplex virus type 1 (hsv-1) and human respiratory syncytial virus (rsv) using a cytopathic effect (cpe) reduction assay. three extracts from agrimonia pilosa, pithecellobium clypearia and punica granatum, respectively, showed anti-hsv-1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. six of the extra ...200415478204
promoting effect of triterpenoid compound from agrimonia pilosa ledeb on preadipocytes differentiation via up-regulation of pparγ expression.agrimonia pilosa ledeb (apl), a traditional chinese medicine, has been reported a variety of biological activities, including treating t2dm.201725709235
a new triterpenoid from the aerial parts of agrimonia pilosa.(1s,3r,17r,18r,19r,20r,22r)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2-6), were isolated from the aerial parts of agrimonia pilosa ledeb. their structures were established based on extensive spectroscopic and ms analysis. the absolute configuration of compound 1 was deduced by circular dichroism (cd). compound 1 was the first example of a 28-norursene backbone isolated from the genus agrimonia. compounds 2-6 were tested for anti-inflammatory activities ...201526882660
antihemostatic effect of hsien-ho-t'sao (agrimonia pilosa).bleeding time in rats was markedly prolonged after the administration of the water extract of hsien-ho-t'sao. this antihemostatic effect was more marked in the group of i.p. injection of the drug than in the group of p.o. administration for 2 or 7 consecutive days. blood coagulation studies showed that plasma prothrombin time, activated partial thromboplastin time and stypven time were prolonged, while thrombin time and fibrinogen level were not changed. the thromboelastographic recording showed ...19846496395
antiplatelet effect of hsien-ho-t'sao (agrimonia pilosa).the water extract of hsien-ho-t'sao (hht) produced a dose-dependent inhibition on collagen-induced aggregation of platelet-rich plasma (prp). the ic50 was about 3.5 mg/ml. in addition, hht inhibited also the aggregation induced by adp, a23187 or arachidonate in prp. greater inhibition was observed in the preparation of washed platelets. increase of the calcium concentration in medium could not overcome the inhibitory effect of hht. atp release from platelets induced by collagen or a23187 was inh ...19853927704
inhibitory effects of korean plants on hiv-1 activities.in the search for novel anti-human immunodeficiency virus type 1 (anti-hiv-1) agents from natural sources, 49 meoh extracts of korean plants were screened for their inhibitory effects against rna-dependent dna polymerase (rt) and ribonuclease h (rnase h) activities of hiv-1 reverse transcriptase and hiv-1 protease, and anti-hiv-1 activity. regarding the hiv-1 reverse transcriptase, agrimonia pilosa (whole plant), cornus kousa (stem and leaf), limonium tetragonum (root) and mallotus japonicus (st ...200111536375
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