| antiplasmodial and cytotoxic metabolites from the maltese sponge agelas oroides. | from a maltese sample of the marine sponge agelas oroides, five compounds: oroidin (1), 2-cyano-4,5-dibromopyrrole (2), 4,5-dibromopyrrole-2-carboxylic acid (3), 4,5-dibromopyrrole-2-carboxylic acid methyl ester (4), and 4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (5) have been isolated. for compounds 1-5, completely assigned 1h- and 13c-nmr data are reported for the first time. for 2 a single crystal x-ray crystallographic analysis proved its structure unambiguously. the x-ray analysis of 2 i ... | 1998 | 9690346 |
| effects of agelas oroides and petrosia ficiformis crude extracts on human neuroblastoma cell survival. | among marine sessile organisms, sponges (porifera) are the major producers of bioactive secondary metabolites that defend them against predators and competitors and are used to interfere with the pathogenesis of many human diseases. some of these biological active metabolites are able to influence cell survival and death, modifying the activity of several enzymes involved in these cellular processes. these natural compounds show a potential anticancer activity but the mechanism of this action is ... | 2007 | 17143525 |
| marine natural products from the turkish sponge agelas oroides that inhibit the enoyl reductases from plasmodium falciparum, mycobacterium tuberculosis and escherichia coli. | the type ii fatty acid pathway (fas-ii) is a validated target for antimicrobial drug discovery. an activity-guided isolation procedure based on plasmodium falciparum enoyl-acp reductase (pffabi) enzyme inhibition assay on the n-hexane-, the chcl(3-) and the aq meoh extracts of the turkish marine sponge agelas oroides yielded six pure metabolites [24-ethyl-cholest-5alpha-7-en-3-beta-ol (1), 4,5-dibromopyrrole-2-carboxylic acid methyl ester (2), 4,5-dibromopyrrole-2-carboxylic acid (3), (e)-oroidi ... | 2007 | 17765547 |
| screening of antimicrobial activity of marine sponge extracts collected from tunisian coast. | the antibacterial activity of the ethyl acetate extracts of seven marine sponges collected from the tunisian mediterranean coast (monastir) were tested against eight human pathogenic bacteria and six human pathogenic fungi using the agar disk diffusion method. the results show that 90% of the sponge extracts present significant activity against at least one bacterial strain. extracts of the sponges agelas oroides and axinella damicornis appeared to be quite promising due to their capacity to inh ... | 2007 | 18605254 |
| inhibitory potential of strepthonium a against shiga toxin production in enterohemorrhagic escherichia coli (ehec) strain edl933. | the production of shiga toxin (stx) is a critical step in the establishment and progress of enterohemorrhagic escherichia coli (ehec) infections. the possible release of stx from dead and dying bacteria, and the risk of resistance development have restricted the usage of antibiotics against ehec. the chlorinated quaternary ammonium compound, strepthonium a, was isolated from the culture of streptomyces sp. sbt345 that was cultivated from the mediterranean sponge agelas oroides. the structure was ... | 2017 | 28287277 |
| comparative bioaccumulation kinetics of trace elements in mediterranean marine sponges. | while marine organisms such as bivalves, seagrasses and macroalgae are commonly used as biomonitors for the environment pollution assessment, widely distributed sponges received little attention as potential helpful species for monitoring programmes. in this study, the trace element and radionuclide bioaccumulation and retention capacities of some marine sponges were estimated in a species-comparative study using radiotracers technique. six mediterranean species were exposed to background dissol ... | 2012 | 22633418 |
| metabolomics approach to chemical diversity of the mediterranean marine sponge agelas oroides. | the mediterranean marine sponge agelas oroides is known to contain a large quantity of oroidin, a deterrent, antifouling and antibiofilm pyrrole-2-aminoimidazole. in contrast with other tropical specimens, the chemical composition of mediterranean agelas oroides is surprisingly relatively poor in other related metabolites. in the course of finding novel marine natural products, lc-ms based metabolomics study of the mediterranean agelas oroides, however, revealed that next to the major compound o ... | 2017 | 28278683 |
| in vitro bioactivity studies of ceramic structures isolated from marine sponges. | in this work, we focused on the potential of bioceramics from different marine sponges-namely petrosia ficiformis, agelas oroides and chondrosia reniformis-for novel biomedical/industrial applications. the bioceramics from these sponges were obtained after calcination at 750 °c for 6 h in a furnace. the morphological characteristics were evaluated by scanning electron microscopy (sem). the in vitro bioactivity of the bioceramics was evaluated in simulated body fluid (sbf) after 14 and 21 d. obse ... | 2016 | 27481449 |
| restructuring of the sponge microbiome favors tolerance to ocean acidification. | ocean acidification is increasing and affects many marine organisms. however, certain sponge species can withstand low-ph conditions. this may be related to their complex association with microbes. we hypothesized that species with greater microbial diversity may develop functional redundancy that could enable the holobiont to survive even if particular microbes are lost at low-ph conditions. we evaluated the effects of acidification on the growth and associated microbes of three ubiquitous medi ... | 2016 | 27264698 |
| mitochondrial group i and group ii introns in the sponge orders agelasida and axinellida. | self-splicing introns are present in the mitochondria of members of most eukaryotic lineages. they are divided into group i and group ii introns, according to their secondary structure and splicing mechanism. being rare in animals, self-splicing introns were only described in a few sponges, cnidarians, placozoans and one annelid species. in sponges, three types of mitochondrial group i introns were previously described in two demosponge families (tetillidae, and aplysinellidae) and in the homosc ... | 2015 | 26653218 |
| synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin. | oroidin (1), (e)-n-(3-(2-amino-1h-imidazol-4-yl)allyl)-4,5-dibromo-1h-pyrrole-2-carboxamide, is a pyrrole alkaloid isolated from the marine sponge agelas oroides. routine screening in a panel of twelve cancer cell lines revealed 1 to be poorly cytotoxic with the 50% growth inhibition concentration (gi50) of 42 μm in mcf-7 (breast) cells and 24 μm in a2780 (ovarian) cells and >50 μm in all other cell lines tested. the development of eight focused libraries comprising thirty compounds total identi ... | 2014 | 24508308 |
| functional convergence of microbes associated with temperate marine sponges. | most marine sponges establish a persistent association with a wide array of phylogenetically and physiologically diverse microbes. to date, the role of these symbiotic microbial communities in the metabolism and nutrient cycles of the sponge-microbe consortium remains largely unknown. we identified and quantified the microbial communities associated with three common mediterranean sponge species, dysidea avara, agelas oroides and chondrosia reniformis (demospongiae) that cohabitate coralligenous ... | 2012 | 22335606 |
| differences between bacterial communities associated with the surface or tissue of mediterranean sponge species. | bacterial communities associated with the surfaces of several mediterranean sponge species (agelas oroides, chondrosia reniformis, petrosia ficiformis, geodia sp., tethya sp., axinella polypoides, dysidea avara, and oscarella lobularis) were compared to those associated with the mesohyl of sponges and other animate or inanimate reference surfaces as well as with those from bulk seawater. denaturing gradient gel electrophoresis (dgge) analysis of pcr-amplified bacterial 16s ribosomal rna genes ob ... | 2011 | 21246194 |
| an unprecedented compound from the dichloromethane solubles of the tropical marine sponge agelas oroides. | further investigation into the natural product chemistry of the tropical marine sponge agelas oroides has yielded the new compound 2,4,6,6-tetramethyl-3(6 h)-pyridone (1), and 2,2,6,6-tetramethyl-4-piperidone (2). both compounds are volatile. the structures of 1 and 2 were determined from the interpretation of their 1d and 2d nmr, uv, ir, and mass spectral data. | 1998 | 17253228 |