| a study on the antiviral action of a polyphenolic complex isolated from the medicinal plant geranium sanguineum l. viii. inhibitory effect on the reproduction of herpes simplex virus type 1. | the antiviral activity of a polyphenolic complex, isolated from a bulgarian medicinal plant geranium sanguineum l., on the reproduction of herpes simplex virus type 1 was studied. the substance inhibited the intracellular stages of viral replication and exhibited a virucidal effect. | 1989 | 2560321 |
| [the antiviral action of a polyphenol complex isolated from the medicinal plant geranium sanguineum l. vi. reproduction of the influenza virus pretreated with the polyphenol complex]. | | 1988 | 3247856 |
| [antiviral effect of a polyphenolic complex isolated from the medicinal plant geranium sanguineum l. v. mechanism of the anti-influenzal effect in vitro]. | | 1987 | 3439494 |
| [combined action of antiviral substances of natural and synthetic origin. i. the anti-influenza action of a combination of the polyphenol complex isolated from geranium sanguineum l. and remantadine in vitro and in ovo]. | | 1986 | 3565089 |
| [antiviral action of a polyphenol complex isolated from the medicinal plant geranium sanguineum l. i. its inhibiting action on the reproduction of the influenza virus]. | | 1986 | 3776704 |
| [antiviral action of a polyphenol complex isolated from the medicinal plant geranium sanguineum l. ii. its inactivating action on the influenza virus]. | | 1986 | 3776705 |
| inhibition of influenza virus protein synthesis by a plant preparation from geranium sanguineum l. | a polyphenolic complex (pc) with antiviral properties has been isolated from the bulgarian medicinal plant geranium sanguineum l. a study was undertaken to investigate the effect of pc on virus-specific protein synthesis in influenza virus-infected cells. the expression of viral glycoproteins on the surface of chick embryo fibroblasts infected with virus a/fpv, strain rostock (h7n1) was suppressed. virus protein synthesis was selectively inhibited as shown by sds polyacrylamide gel electrophores ... | 1995 | 7572469 |
| combined effect of selected antiviral substances of natural and synthetic origin. ii. anti-influenza activity of a combination of a polyphenolic complex isolated from geranium sanguineum l. and rimantadine in vivo. | the synergistic effect shown by the combination of a natural product, polyphenolic complex (pc) isolated from geranium sanguineum l., and rimantadine (r) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. a marked protective effect in experimental influenza virus a (h3n2) infection in mice was found when pc was applied nasally (i.n.) (1.0 mg/kg) only once 6 h before infection in combination with r applied orally in concentration 10.5 and 2.5 mg/kg 2h before and ... | 1993 | 8285131 |
| antiinfective activity of a plant preparation from geranium sanguineum l. | a methanol extract (pc) has been obtained from the bulgarian medicinal plant geranium sanguineum l. the antiinfective activity of the plant preparation was studied. the extract inhibited the reproduction of a range of viruses (influenza, herpes simplex, vaccinia, hiv-i) in cell cultures. its antiinfluenza effect was most pronounced; pc reduced the infectivity of various influenza virus strains in vitro and protected mice in experimental influenza infection. the polyphenol extract inhibited the i ... | 1997 | 9362094 |
| in vitro anti-influenza virus activity of a plant preparation from geranium sanguineum l. | a polyphenolic complex (pc), isolated from the bulgarian medicinal plant geranium sanguineum l., was shown to have selective anti-influenza activity in vitro. expression of ha on the surface of cells infected with a/chicken/rostock/34, virus-induced cytopathic effect, infectious virus yield and plaque formation were all reduced at non-toxic concentrations of pc. synthesis of virus proteins was also selectively inhibited. high concentrations of pc (> 200 microg/ml) exhibited a strong virucidal ef ... | 1998 | 9588844 |
| antiherpes virus activity of extracts from the medicinal plant geranium sanguineum l. | the herpes virus inhibitory effect of five extracts from the bulgarian medicinal plant geranium sanguineum l. (geraniaceae) was investigated. the water extract (we) from the aerial roots of the plant was the least toxic for cell cultures and inhibited significantly the replication of herpes simplex virus type 1 and type 2 (ec50 = 3.6-6.2 microg/ml) as shown by the reduction of virus induced cytopathogenic effect (cpe) and the protection of cells in mtt assay. the inhibition was dose-related, str ... | 1999 | 10075123 |
| influenza virus variants with reduced susceptibility to inhibition by a polyphenol extract from geranium sanguineum l. | a polyphenol extract obtained from the bulgarian medicinal plant geranium sanguineum l. (pc) inhibited influenza virus reproduction in vitro, in ovo and in vivo. the inhibitory activity of the plant preparation was proved to be selective and specific. two variants of the virus a/chicken/germany/34, strain rostock (h7n1) (a/rostock) with reduced drug sensitivity were selected by following passages in chicken embryo fibroblast (cef) cells in the presence of inhibitory concentrations of the substan ... | 2003 | 12622254 |
| in vitro investigation on the effect of a plant preparation with antiviral activity on the functions of mice phagocyte cells. | a polyphenol extract from the aerial roots of the medicinal plant geranium sanguineum l. (pc) inhibited the reproduction of influenza viruses type a and b in vitro and in ovo and protected mice from mortality in the experimental influenza infection. the in vivo protective effect was connected with multiple biological activities of the preparation. the present paper focuses on the in vitro effects of the polyphenol extract on the functions of peritoneal and alveolar macrophages and blood polymorp ... | 2004 | 15025186 |
| geranium sanguineum (geraniaceae) seed oil: a new source of petroselinic and vernolic acid. | the occurrence of petroselinic acid (18:1delta6cis) in seed oils was believed to be limited to the umbelliferae or apiaceae, and a few other members of the umbelliflorae. a major occurrence of petroselinic acid outside the umbelliflorae must therefore be regarded as highly unusual and surprising. the seed oil of geranium sanguineum, a member of the family geraniaceae, has now been found to contain petroselinic and vernolic acids as major fa in its seed oil tag. these unusual fa have not been rep ... | 2004 | 15554157 |
| a plant polyphenol-rich extract restores the suppressed functions of phagocytes in influenza virus-infected mice. | influenza infection was induced in white icr mice by intranasal (i.n.) inoculation of the virus a/aichi/2/68 (h3n2). the number, migration and phagocyte indices of alveolar and peritoneal macrophages (pmø) and of blood polymorphonuclear leukocytes (pmns), as well as the inhibition of the pmn adherence in the presence of a specific antigen were followed for 9 days after infection. the effect of the i.n. application of a polyphenol-rich extract, designated as polyphenolic complex (pc), isolated fr ... | 2005 | 15780977 |
| in vitro antioxidant activity of polyphenol extracts with antiviral properties from geranium sanguineum l. | recent evidence shows that plant polyphenols exhibit antioxidant and radical scavenging properties. by three separate and complementary methods--dpph assay, beta-carotene-linoleic acid assay and nbt-reduction assay it was established that a polyphenol-rich extract from the medicinal plant geranium sanguineum l. with strong anti-influenza virus activity, possessed antioxidant and radical scavenging capacities. for comparative reasons caffeic acid and the synthetic antioxidant bht were used. total ... | 2005 | 15820508 |
| biologically active constituents of a polyphenol extract from geranium sanguineum l. with anti-influenza activity. | from the aerial roots of the medicinal plant geranium sanguineum l. a polyphenol-rich extract with strong anti-influenza activity has been isolated. to investigate its active fractions, the extract was partitioned by solvents with increasing polarity. the n-buoh fraction contained the majority of the in vitro antiviral activity; the etoac fraction was the most effective one in vivo. a bioassay-directed fractionation of the n-buoh and etoac fractions was performed to obtain information about the ... | 2006 | 16989309 |
| effect of a plant polyphenol-rich extract on the lung protease activities of influenza-virus-infected mice. | influenza infection was induced in white mice by intranasal inoculation of the virus a/aichi/2/68 (h3n2). the lung protease and the protease-inhibitory activities were followed for 9 days after infection. the intranasal application of a polyphenol-rich extract (pc) isolated from geranium sanguineum l. induced a continuous rise in the anti-protease activity but did not cause substantial changes in the lung protease activity of healthy mice. influenza virus infection triggered a slight reduction i ... | 2007 | 17542152 |
| protective efficacy of an aerosol preparation, obtained from geranium sanguineum l., in experimental influenza infection. | a polyphenol-rich extract from the aerial roots of the medicinal plant geranium sanguineum l. (pc) protected mice from mortality in the experimental influenza a/aichi/2/68 (h3n2) virus infection. to provide evidence how a maximum therapeutic benefit can be derived of this preparation, it was inoculated by 6 different routes. it was found that the aerosol application of pc was highly effective. in the dose 5.4 mg/ml, applied according to a prophylactic-therapeutic schedule, the extract exhibited ... | 2008 | 18380405 |
| antioxidant and prooxidant properties of a polyphenol-rich extract from geranium sanguineum l. in vitro and in vivo. | a polyphenol-rich extract from geranium sanguineum l. (pc) protected biological membranes due to its antioxidant capacity. pc caused a dose-dependent decrease of the osmotic hemolysis of human erythrocytes and increased their resistance against the toxic effect of h(2)o(2); no effect on catalase activity was observed. while pc reduced the accumulation of tba-reactive products in rat liver microsomes in inducible lipid peroxidation (lpo), the non-induced lpo was not affected. further the effect o ... | 2008 | 18446846 |
| synergistic inhibition of influenza a virus replication by a plant polyphenol-rich extract and epsilon-aminocaproic acid in vitro and in vivo. | a combined antiviral effect of a polyphenol-rich extract of the medicinal plant geranium sanguineum l. (pc) and a protease inhibitor, epsilon-aminocaproic acid (aca) was examined in influenza a virus (iav)-infected mdck cell cultures and mice. synergistic, antagonistic, or indifferent antiviral effects were distinguished on the basis of virus yields, namely fractional yields of individual compounds and yields of both compounds in combination. combinations of pc and aca in particular concentratio ... | 2010 | 20545444 |
| a fungal cu/zn-containing superoxide dismutase enhances the therapeutic efficacy of a plant polyphenol extract in experimental influenza virus infection. | the combined protective effect of a polyphenol-rich extract, isolated from geranium sanguineum l. (pc), and a novel naturally glycosylated cu/zn-containing superoxide dismutase, produced from the fungal strain humicula lutea 103 (hl-sod), in the experimental influenza a virus infection (eivi) in mice, induced with the virus a/aichi/2/68 (h3n2), was investigated. the combined application of hl-sod and pc in doses, which by themselves do not defend significantly mice in eivi, resulted in a synergi ... | 2010 | 20653246 |
| [six-month follow-up of the effect of neomenor in patients with painful menstruation]. | neomenor is herbal medication especially created to permanently relieve painful menstruation symptoms in girls and women with primary dysmenorrhea. it supplies the organism with substances essential for the metabolic processes that guarantee normal menstrual cycles. in some women these substances are out of balance, there is an excess of prostaglandins, which leads to painful periods, menstrual cramps and even migraine. each neomenor tablet contains 400 mg of standardized extracts from stalks of ... | 2011 | 21695945 |