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effects of constituents of beli (aegle marmelos) on spontaneous beating and calcium-paradox of myocardial cells.effects of methanolic extract of root bark of beli (aegle marmelos corr.), an ayurvedic crude drug used for heart diseases, and constituents isolated from the extract on spontaneous beating of cultured mouse myocardial cells were examined. the extract at a concentration of 100 micrograms/ml inhibited the beating rate by approximately 50%. among the isolated constituents, aurapten was the most potent inhibitor; the ic50 of aurapten is 0.6 microgram/ml, which is comparable with that of verapamil, ...19912062957
studies of medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs.seventy five medicinal plants of the traditional ayurvedic pharmacopoeia of sri lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. of these, crotolaria juncea l. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely aegle marmelos (l.) corr., hemidesmus indicus (l.) ait. f. and terminalia chebula retz. produced hepatic lesion ...19854058035
a preliminary communication of the action of aegle marmelos (bael) on heart. 19685658493
oral hypoglycaemic activity of some medicinal plants of sri lanka.investigations were carried out to evaluate the oral hypoglycaemic activity of some sri lankan medicinal plants. approximately 40 plants available locally are reputed to have oral hypoglycaemic activity. of these, the mostly widely used are (a) salacia reticulata (celastraceae) (b) aegle marmelos (rutaceae) and (c) momordica charantia (cucurbitaceae). aqueous decoctions of these plants were investigated for their ability to lower the fasting blood glucose level and improve the glucose tolerance ...19846492834
antiulcer activity of naturally occurring pyrano-coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa.oral administration of bergenin and norbergenin, two isocoumarins, isolated from the leaves and roots of flueggea microcarpa and luvangetin, a pyranocoumarin isolated from the seeds of aegle marmelos correa, showed significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs. the study on prostaglandins release by human colonic mucosal incubates, indicated a concentration-dependent (1-10 microgr ...19979475044
dominant lethal test in rats treated with some plant extracts.the present study was undertaken to investigate the toxic effect of aqueous extracts of aegle marmelos (am), stevia rebaudiana (sr), pouteria cambodiana (pc) and clausena excavata (ce) on rats by dominant lethal test. the data of 8-week treatment suggested that none of the extracts adversely affected male body and testicular weights as well as cauda epididymal sperm counts. no notable changes in sperm morphology and motility were observed. on the other hand, sperm count in the ce group was signi ...200011414451
effect of aegle marmelos and hibiscus rosa sinensis leaf extract on glucose tolerance in glucose induced hyperglycemic rats (charles foster).in an effort to test the hypoglycemic activity of aegle marmelos and hibiscus rosa sinensis in glucose induced hyperglycemic rats, their alcoholic leaf extracts were studied. both the groups of animals receiving either. a. marmelos or h. rosa sinensis leaf extract for seven consecutive days, at an oral dose equivalent to 250 mg kg-1 showed significant improvements in their ability to utilize the external glucose load. average blood glucose lowering caused by a. marmelos and h. rosa sinensis was ...200111480352
relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.relative importance of bacopa monnieri (200 mg/kg), aegle marmelos (1.00 g/kg) and aloe vera (125 mg/kg) leaf extracts in the regulation of thyroid hormone concentrations in male mice was investigated. while serum levels of both t(3) and t(4) were inhibited by a. vera, a. marmelos extract could decrease only t(3) concentration. on the other hand, t(4) concentration was increased by b. monnieri extract suggesting its thyroid-stimulating role. when the relative potency of each plant extract was ca ...200212065164
comparative evaluation of hypoglycaemic activity of some indian medicinal plants in alloxan diabetic rats.in our experiments 30 hypoglycaemic medicinal plants (known and less known) have been selected for thorough studies from indigenous folk medicines, ayurvedic, unani and siddha systems of medicines. in all the experiments with different herbal samples (vacuum dried 95% ethanolic extracts), definite blood glucose lowering effect within 2 weeks have been confirmed in alloxan diabetic albino rats. blood glucose values are brought down close to normal fasting level using herbal samples at a dose of 2 ...200312499084
in vitro antiproliferative effects on human tumor cell lines of extracts from the bangladeshi medicinal plant aegle marmelos correa.in the present paper we show that extracts from aegle marmelos correa are able to inhibit the in vitro proliferation of human tumor cell lines, including the leukemic k562, t-lymphoid jurkat, b-lymphoid raji, erythroleukemic hel, melanoma colo38, and breast cancer mcf7 and mda-mb-231 cell lines. molecules present within the studied aegle marmelos c. extracts were identified by gas-chromatography/mass-spectrometry analysis; three derivatives (butyl p-tolyl sulfide, 6-methyl-4-chromanone and butyl ...200312809360
hypoglycaemic effect of water extracts of aegle marmelos fruits in streptozotocin diabetic rats.aegle marmelos corr. (rutaceae) is widely used in indian ayurvedic medicine for the treatment of diabetes mellitus. the hypoglycaemic effect of the water extract of the fruits of aegle marmelos was examined in streptozotocin-induced diabetic wistar rats. oral administration of the water extract (125 and 250mgkg(-1)) twice a day for 4 weeks resulted in significant reductions in blood glucose, plasma thiobarbituric acid reactive substances, hydroperoxides, ceruloplasmin and alpha-tocopherol and a ...200312860309
effect of aegle marmelos fruits on normal and streptozotocin-diabetic wistar rats.the present study evaluates the antidiabetic effect of an aqueous extract of aegle marmelos fruits (amfet) in diabetes. female albino wistar rats were randomly divided into five groups: normal (untreated), normal + amfet, streptozotocin (stz)-treated, stz-treated + amfet, and stz-treated + glibenclamide. rats were rendered diabetic by stz (45 mg/kg) administered intraperitoneally. amfet (250 mg/kg) was given twice daily for 1 month. blood glucose, plasma insulin, glycosylated hemoglobin, liver g ...200312935319
in vitro antiviral activity of bael (aegle marmelos corr) upon human coxsackieviruses b1-b6.the in-vitro antiviral activity of a series of compounds in samples extracted from various parts of the indian holy tree, bael (aegle marmelos corr.) were evaluated for their efficacy against human coxsackieviruses b1-b6. the inhibitory concentrations (ic50) for leaves (l1 and l2) stem and stem bark (s1, s2, s3 and s4) fruit (f1 and f2micro) root and root bark (r1 and r2) and pure compound, the marmelide were 1000 microg/ml (for l1 and l2), 1000 microg/ml (for s1, s2, s3 and s4), 1000 microg/ml ...200214768825
the evaluation of nitric oxide scavenging activity of certain indian medicinal plants in vitro: a preliminary study.the plant extracts of 17 commonly used indian medicinal plants were examined for their possible regulatory effect on nitric oxide (no) levels using sodium nitroprusside as an no donor in vitro. most of the plant extracts tested demonstrated direct scavenging of no and exhibited significant activity. the potency of scavenging activity was in the following order: alstonia scholaris > cynodon dactylon > morinda citrifolia > tylophora indica > tectona grandis > aegle marmelos (leaf) > momordica char ...200415383230
antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant salmonella typhi.screening was done of some plants of importance in the ayurvedic system of traditional medicine used in india to treat enteric diseases. fifty four plant extracts (methanol and aqueous) were assayed for their activity against multi-drug resistant salmonella typhi. strong antibacterial activity was shown by the methanol extracts of aegle marmelos, salmalia malabarica, punica granatum, myristica fragrans, holarrhena antidysenterica, terminalia arjuna and triphal (mixture of emblica of fi cinalis, ...200415476301
hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration.to unravel the possible mechanism of glucose lowering activity, effects of ten different plant extracts in the regulation of serum cortisol and glucose concentrations were evaluated in male mice. while the extracts of inula racemosa, boerhaavia diffusa and ocimum sanctum decreased the serum concentration of both cortisol and glucose, aegle marmelos, azadirachta indica and gymnema sylvestre extracts could exhibit hypoglycaemic activity without altering the serum cortisol concentration. it appears ...200415587591
aegle marmelos (l.) correa inhibits the proliferation of transplanted ehrlich ascites carcinoma in mice.the anticancer effect of hydroalcoholic extract of aegle marmelos (ame) was studied in the ehrlich ascites carcinoma bearing swiss albino mice. the spatial effect of various ame administration schedules showed that six-day administration increased the survival of tumor bearing mice. the best antineoplastic action of ame was obtained when ame administered through intraperitoneal route than the oral route at equimolar dose. administration of ame once daily for six consecutive days to the tumor bea ...200515635164
mechanisms of the contractile effect of the alcoholic extract of aegle marmelos corr. on isolated guinea pig ileum and tracheal chain.in the present work, the effect of the alcoholic extract of the leaves of aegle marmelos corr. on guinea pig isolated ileum and tracheal chain was investigated, as this plant is used traditionally to treat asthma and related afflictions. these effects were investigated using the isolated organ bath method. 1 mg/ml and 2mg/ml doses of the alcoholic extract of this plant produced a positive relaxant effect in isolated guinea pig ileum and tracheal chain, respectively. in addition, they antagonized ...200415636185
comparative effects of aegle marmelos extract and alpha-tocopherol on serum lipids, lipid peroxides and cardiac enzyme levels in rats with isoproterenol-induced myocardial infarction.we demonstrate the effect of aegle marmelos leaf extract (amlet) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (iso)-induced myocardial infarction.200515678289
a study of hypoglycemic and antioxidant activity of aegle marmelos in alloxan induced diabetic rats.the present study was performed to evaluate the hypoglycemic and antioxidant effect of aqueous extract of aegle marmelos leaves (aml) on diabetic rats. male albino rats were randomly divided into three groups: group i: control; group ii: diabetic rats; and group iii: diabetic rats administered aml. glucose, urea and glutathione-s-transferase (gst) in plasma, glutathione (gsh) and malondialdehyde (mda) levels in erythrocytes were estimated in all the groups at the end of four weeks. there was a d ...200415907058
investigation on the gastroprotective and antidiarrhoeal properties of aegle marmelos unripe fruit extract.the study was designed to verify the gastroprotective and antidiarrhoeal effects of unripe fruit extract of aegle marmelos corr. the gastroprotective function of this extract was evaluated in rats against gastric mucosal damage induced by hypothermic restraint stress, absolute ethanol, and indomethacin, whereas the antidiarrhoeal activity was investigated by studying the influence on gastrointestinal transit as measured by a charcoal marker and on castor oil-induced accumulation of intestinal fl ...200316281828
antidiarrhoeal evaluation of aegle marmelos (correa) linn. root extract.a study was undertaken to evaluate the in vitro and in vivo antidiarrhoeal potential of chloroform extract of the root of aegle marmelos (correa) linn. the in vitro activity was determined by agar dilution and disc diffusion techniques. the extract was studied in vivo in rats. of the 35 tested pathogenic diarrhoea causing strains, the extract was found to be mostly active against the strains of vibrio cholerae, followed by escherichia coli and shigella spp. the in vitro activity was found to be ...200616397850
the effect of aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study.aegle marmelos correa. (bael) fruit exhibit antidiabetic, antihyperlipidaemic and antioxidant properties. this study was designed to elucidate the protective effect of an aqueous extract of aegle marmelos fruits on the histopathology of the pancreas in streptozotocin-induced diabetic rats. oral administration of aegle marmelos fruit extract at doses of 125 and 250 mg/kg twice daily to diabetic rats for a period of 30 days resulted in a significant increase in body weight, weight of the pancreas ...200516520300
screening of traditional antidiabetic medicinal plants of mauritius for possible alpha-amylase inhibitory effects in vitro.in this study, seven exotic/indigenous medicinal plants of mauritius, namely coix lacryma-jobi (poaceae), aegle marmelos (rutaceae), artocarpus heterophyllus (moraceae), vangueria madagascariensis (rubiaceae), azadirachta indica (meliaceae), eriobotrya japonica (rosaceae) and syzigium cumini (myrtaceae) were studied for possible effects on starch breakdown by alpha-amylase in vitro. the results showed that only artocarpus heterophyllus significantly (p < 0.05) inhibited alpha-amylase activity in ...200616521114
influence of selected indian immunostimulant herbs against white spot syndrome virus (wssv) infection in black tiger shrimp, penaeus monodon with reference to haematological, biochemical and immunological changes.immunostimulants are the substances, which enhance the non-specific defence mechanism and provide resistance against the invading pathogenic micro-organism. in order to increase the immunity of shrimps against the wssv, the methanolic extracts of five different herbal medicinal plants like cyanodon dactylon, aegle marmelos, tinospora cordifolia, picrorhiza kurooa and eclipta alba were selected and mixed thoroughly in equal proportion. the mixed extract was supplemented with various concentration ...200616698283
rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using hptlc.the term 'phenolics' refers to a vast array of biologically active compounds ubiquitous in plants, many of which have been used in traditional medicine for thousands of years. umbelliferone, psoralen, and eugenol are widely occurring phenolic compounds of plant origin, for which many biological activities against chronic diseases have been reported. a simple hptlc method has been developed for the simultaneous quantification of umbelliferone, psoralen, and eugenol. these three compounds were qua ...200717628870
effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats.diabetes mellitus is known to affect collagen in various tissues. umbelliferone (7-hydroxycoumarin), a natural antioxidant and benzopyrone, is found in golden apple (aegle marmelos correa) and bitter orange (citrus aurantium). plant-derived phenolic coumarins have been shown to act as dietary antioxidants. in this study, we have investigated the influence of umbelliferone on collagen content and its effects on the tail tendon in streptozotocin-diabetic rats. male albino wistar rats (180-200 g) w ...200717651305
suppression of fertility in male albino rats following the administration of 50% ethanolic extract of aegle marmelos.plants have served as a natural source of antifertility substances. the reactivated interest in the evaluation of some lead plants for fertility prompted us to undertake studies on the antifertility potential of aegle marmelos leaves.200718061707
isolation and identification of mosquito larvicidal compound from abutilon indicum (linn.) sweet.larvicidal activity of crude hexane, ethyl acetate, petroleum ether, acetone and methanol extracts of five medicinal plants, abutilon indicum, aegle marmelos, euphorbia thymifolia, jatropha gossypifolia and solanum torvum were assayed for their toxicity against the early fourth-instar larvae of culex quinquefasciatus. the larval mortality was observed after 24 h exposure. all extracts showed moderate larvicidal effects; however, the highest larval mortality was found in petroleum ether extract o ...200818176816
radioprotective potential of plants and herbs against the effects of ionizing radiation.ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. there is a need to protect humans against such effects of ionizing radiation. attempts to protect against the deleterious effects of ionizing radiations by pharmacological intervention were made as early as 1949 and efforts are continued to search radioprotectors, which may be of great help for human application. this revi ...200718188408
anti-microfilarial activity of methanolic extract of vitex negundo and aegle marmelos and their phytochemical analysis.in the present study, methanolic extracts of roots of vitex negundo l. and extracts of leaves of vitex negundo l., ricinus communis l. and aegle marmelos corr. were explored for possible antifilarial effect against brugia malayi microfilariae. it was observed that among the herbal extracts, root extract of vitex negundo l. and leaves extract of aegle marmelos corr. at 100 ng/ml concentration showed complete loss of motility of microfilariae after 48 hr of incubation. thin layer chromatography of ...200818335811
differential expression of ompc and ompf in multidrug-resistant shigella dysenteriae and shigella flexneri by aqueous extract of aegle marmelos, altering its susceptibility toward beta-lactam antibiotics.steadily increasing resistance among shigella to beta-lactams, aminoglycosides, and tetracycline has compromised the utility of these commonly used antimicrobial agents. also, undesirable side effects of certain antibiotics have triggered immense interest in search of alternative therapies using medicinal plants. one such medicinal plant used since ancient times to cure diarrhea is aegle marmelos. the present study exemplifies the susceptibility of beta-lactam-resistant shigella dysenteriae and ...200818358664
in vitro effect of four herbal plants on the motility of brugia malayi microfilariae.disease burden due to lymphatic filariasis is disproportionately high despite mass drug administration with conventional drugs. usage of herbal drugs in traditional medicine is quite well known but largely empirical. hence the present study was designed to screen the in vitro antifilarial effect of four herbal plants on brugia malayi.200818653910
antioxidant and hepatoprotective potential of aegle marmelos correa. against ccl4-induced oxidative stress and early tumor events.the antioxidant properties and inhibitory effect on early tumor promoter markers of a. marmelos (25 and 50 mg/kg b. wt. orally) have been evaluated. male wistar rats were pre-treated for seven consecutive days with a. marmelos prior to ccl4 (1 ml kg(- 1) body weight p. o., in corn oil [1:1 v/v]) treatment. pre-treatment with a. marmelos suppressed lipid peroxidation (lpo), xanthine oxidase (xo) and release of serum toxicity marker enzymes viz, sgot, ldh, sgpt dose-dependently and significantly ( ...200918830880
seasonal variations of airborne pollen in allahabad, india.using a burkard 7-day volumetric sampler a survey of airborne pollen grains in allahabad was carried out from december 2004--november 2005 to assess the qualitative and quantitative occurrence of pollen grains during different months of the year, and to characterize the pollen seasons of dominant pollen types in the atmosphere of allahabad. 80 pollen types were identified out of the total pollen catch of 3,416.34 pollen grains/m(3). bulk of the pollen originated from anemophilous trees and grass ...200819061265
laboratory study on larvicidal activity of indigenous plant extracts against anopheles subpictus and culex tritaeniorhynchus.anopheles subpictus and culex tritaeniorhynchus have developed resistance to various synthetic insecticides, making its control increasingly difficult. insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. the leaf acetone, chloroform, ethyl acetate, hexane, and methanol extracts of aegle marmelos (linn.) correa ex roxb, andrographis lineata wallich ex nees., andrographis paniculata (burm.f.) wall. ex nees., cocculus hirsutus (l.) diels, eclipta ...200919165502
periplogenin-3-o- -d-glucopyranosyl -(1-->6)- -d-glucopyaranosyl- -(1-->4) -d-cymaropyranoside, isolated from aegle marmelos protects doxorubicin induced cardiovascular problems and hepatotoxicity in rats.doxorubicin is a common chemotherapeutic anticancer drug. its use is associated with adverse effects including cardiotoxicity. several therapeutics interventions have been attempted to reduce the toxicity and to improve the efficacy of the drug. however, on phytochemicals very few investigations have been made. in the present study we have evaluated the potential of a cardenolide, periplogenin, isolated from the leaves of aegle marmelos in protecting the doxorubicin induced cardiotoxicity and li ...200919426248
synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity.the triterpenoid, lupeol (1) has been isolated from the leaves extract of aegle marmelos. few novel derivatives (2-13) were synthesized from the naturally occurring lupeol (1) and screened for their antihyperglycemic activity (2-11) and antidyslipidemic activity (2-4 and 12-13). the derivative 4 lowered the blood glucose levels by 18.2% and 25.0% at 5h and 24h, respectively, in sucrose challenged streptozotocin induced diabetic rats (stz-s) model at the dose of 100mg/kg body weight. the compound ...200919515563
intraocular pressure-lowering activity of topical application of aegle marmelos fruit extract in experimental animal models.the present study was designed to evaluate the intraocular pressure (iop)-lowering activity of topical application of the aqueous extract of aegle marmelos fruit in experimental animal models.200919556826
a novel antifungal anthraquinone from seeds of aegle marmelos correa (family rutaceae).a new anthraquinone, 1-methyl-2-(3'-methyl-but-2'-enyloxy)-anthraquinone (1) has been isolated from seeds of aegle marmelos correa and was characterized on the basis of spectral analysis (uv, ir, 1h nmr, 13c nmr, 2d nmr and mass spectroscopy). the compound exhibited significant antifungal activity against pathogenic strains of aspergillus species and candida albicans in disc diffusion assay (mic value of 6.25 microg/disc), microbroth dilution and percent spore germination inhibition assays (mic ...201019686813
oviposition-deterrent, ovicidal, and repellent activities of indigenous plant extracts against anopheles subpictus grassi (diptera: culicidae).insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. the leaf acetone, ethyl acetate, and methanol extracts of aegle marmelos (linn.) correa ex roxb, andrographis lineata wallich ex nees, and cocculus hirsutus (l.) diels were tested for oviposition-deterrent, ovicidal, and repellent activities against anopheles subpictus grassi (diptera: culicidae). the percentage of effective oviposition repellency of 92.60 , 93.04, 95.20, 88.26, 92.80, 94.01, ...200919707789
modulation of expression of il-8 gene in bronchial epithelial cells by 5-methoxypsoralen.persistent recruitment of neutrophils in the bronchi of cystic fibrosis patients contributes to airway tissue damage, suggesting the importance of intervening on the expression of the neutrophil chemokine il-8. extracts from plants have been investigated to select components able to reduce il-8 expression in bronchial epithelial cells challenged with pseudomonas aeruginosa. extracts and purified components have been added to cells 24 h before pro-inflammatory challenge with p. aeruginosa and il- ...200919720161
essential oil of aegle marmelos as a safe plant-based antimicrobial against postharvest microbial infestations and aflatoxin contamination of food commodities.the essential oil of aegle marmelos l. correa (rutaceae) showed strong fungitoxicity against some storage fungi-causing contamination of foodstuffs. the oil also showed efficacy as aflatoxin suppressor at 500 microl/l as it completely arrested the aflatoxin b(1) production by the toxigenic strains (navjot 4nst and saktiman 3nst) of aspergillus flavus link. keeping in view the side effects of synthetic fungicides, a. marmelos oil may be recommended as an antimicrobial of plant origin to enhance t ...200919723215
evaluation of the radioprotective effect of aegle marmelos (l.) correa in cultured human peripheral blood lymphocytes exposed to different doses of gamma-radiation: a micronucleus study.the radioprotective effect of a hydroalcoholic extract of aegle marmelos (ame) was evaluated in cultured human peripheral blood lymphocytes (hpbls) by the micronucleus assay. the optimum protective dose of the extract was selected by treating hpbls with 1.25, 2.5, 5, 6.25, 10, 20, 40, 60, 80 and 100 microg/ml ame before exposure to 3 gy gamma-radiation and then evaluating the micronucleus frequency in cytokinesis blocked hpbls. treatment of hpbls with different doses of ame reduced the frequency ...200312840113
studies on the antidiarrhoeal activity of aegle marmelos unripe fruit: validating its traditional usage.aegle marmelos (l.) correa has been widely used in indigenous systems of indian medicine due to its various medicinal properties. however, despite its traditional usage as an anti-diarrhoeal there is limited information regarding its mode of action in infectious forms of diarrhoea. hence, we evaluated the hot aqueous extract (decoction) of dried unripe fruit pulp of a. marmelos for its antimicrobial activity and effect on various aspects of pathogenicity of infectious diarrhoea.200919930633
assessment of the contraceptive efficacy of the aqueous extract of aegle marmelos corr. leaves in male albino rats.the present study was conducted to evaluate the contraceptive effect of an aqueous extract from the leaves of aegle marmelos (amlaq) on the reproductive organs of male rats with an emphasis on reversibility. adult male rats were treated daily with different doses of amlaq, i.e., 150, 300 and 600 mg/kg bw/day for 60 days. the data presented in this study demonstrate that the weight of the reproductive organs was reduced significantly in all the treatment groups. amlaq induced a significant decrea ...200919802961
biological activities of crude extracts and chemical constituents of bael, aegle marmelos (l.) corr.bael (aegle marmelos (l.) corr.) is an important medicinal plant of india. leaves, fruits, stem and roots of a. marmelos have been used in ethno medicine to exploit its' medicinal properties including astringent, antidiarrheal antidysenteric, demulcent, antipyretic and anti-inflammatory activities. compounds purified from bael have been proven to be biologically active against several major diseases including cancer, diabetes and cardiovascular diseases. preclinical studies indicate the therapeu ...200920099458
screening of antioxidant potential of selected barks of indian medicinal plants by multiple in vitro assays.to evaluate the antioxidant potential in herbal extract barks of five therapeutically important medicinal plants native to india, i.e. crataeva nurvala buch.-ham., buchanania lanzan spreng., aegle marmelos corr., dalbergia sissoo roxb. ex dc., and cedrela toona roxb.200818478975
antibacterial screening of aegle marmelos, lawsonia inermis and albizzia libbeck.three medicinal plant aegle marmelos, lawsonia inermis, albizzia libbeck were extracted by soxhlet apparatus using petroleum ether, ethanol, chloroform and aqueous as solvent. among those extract, the petroleum ether was considered as effective one. the extracts were subjected to preliminary phytochemical screening and the three plants with four extracts were tested against three gram positive bacteria (b. cereus, b. subtilis, s. aureus) and three gram negative bacteria (e. coli, p. vulgaris, an ...200620162092
safety evaluation of aqueous extracts from aegle marmelos and stevia rebaudiana on reproduction of female rats.the purpose of this study was to evaluate the safety of a thai medicinal plant, aegle marmelos, and a non-caloric sweetener, stevia rebaudiana, on the reproduction of female rats. female rats were treated orally with aqueous extract of a. marmelos (6%) and s. rebaudiana at various concentrations (0, 0.2, 1, or 10%) for 60 days (1 ml/day) before mating. the control rats received only distilled water. at the end of the treatment period, treated females were mated with untreated males and the effec ...200617547081
effect of alcoholic extracts of indian medicinal plants on the altered enzymatic activities of diabetic rats.in present study, the effect of alcoholic extract of momordica charantia, aegle marmelos and eugenia jambolana was studied on serum glutamic oxaloacetate transminase and serum glutamic pyruvate transminase activities and on serum urea, total protein and albumin concentrations of streptozotocin diabetic rats. diabetes in rats was induced by single dose of streptozotocin (30 mg/kg i. p.). on confirming the diabetes after 48 h of injection, alcoholic extracts of three plants were administered orall ...200920502588
immunomodulatory activity of aegle marmelos in freshwater fish (catla catla) by non-specific protection.context: the production of fish is limited by infectious diseases; when a fish grows in an immunosuppressed condition, it becomes highly susceptible to disease. objective: the present research work investigates immunomodulatory action of aegle marmelos (linn.) corr. serr. (rutaceae) in catla catla hamilton (cyprinidae) for enhancing immune protection of the fish against bacterial infections. material and methods: doses of 0, 5, 10, 15, 20, 25 and 30 g aqueous plant leaf extract/kg feed were admi ...201120687789
dietary medicinal plant extracts improve growth, immune activity and survival of tilapia oreochromis mossambicus.the effects of supplementing diets with acetone extract (1% w/w) from four medicinal plants (bermuda grass cynodon dactylon, h(1), beal aegle marmelos, h(2), winter cherry withania somnifera, h(3) and ginger zingiber officinale, h(4)) on growth, the non-specific immune response and ability to resist pathogen infection in tilapia oreochromis mossambicus were assessed. in addition, the antimicrobial properties of the extract were assessed against vibrio alginolyticus, vibrioparahaemolyticus, vibri ...200920735646
immunomodulatory effect of aegle marmelos leaf extract on freshwater fish cyprinus carpio infected by bacterial pathogen aeromonas hydrophila.aquatic organisms (especially fish) require potent defense mechanisms to protect themselves against pathogen invasion and disease formation. the use of immunostimulants in fish culture can prevent the diseases through augmentation of both specific and non-specific immunity.201020818950
evaluation of medicinal plant extracts against ticks and fluke.the present study was based on assessments of the antiparasitic activities to determine the efficacies of leaf hexane, chloroform, ethyl acetate, acetone and methanol extracts of aegle marmelos (linn.) correa ex roxb, andrographis lineata wallich ex nees., andrographis paniculata (burm.f.) wallich ex nees., cocculus hirsutus (l.) diels, eclipta prostrata l., and tagetes erecta l. against the adult cattle tick haemaphysalis bispinosa neumann 1897 (acarina: ixodidae), the larvae of rhipicephalus ( ...201020922419
studies on effects of indigenous plant extracts on malarial vector, anopheles subpictus grassi (diptera:culicidae).mosquitoes transmit serious human diseases, causing millions of deaths every year. use of synthetic insecticides to control vector mosquitoes has caused physiological resistance and adverse environmental effects in addition to high operational cost. insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. the present investigations were made to evaluate the repellent, ovicidal and oviposition-deterrent potential of leaf hexane and chloroform extract ...201020962710
imperatorin a furocoumarin inhibits periplasmic cu-zn sod of shigella dysenteriae their by modulates its resistance towards phagocytosis during host pathogen interaction.shigella dysenteriae continues to be a major health problem, which leads to death, due to diarrhoea and dysentery, predominantly in children below the age of 5. bacterial invasion of the colonic epithelium leads to severe inflammation together with bacterial dissemination generates abscesses and ulcerations. periplasmic copper, zinc super oxide dismutase of shigella protects it from exogenous superoxide produced by host, during its invasion. hence, in present study an attempt was made to study t ...201021194882
chemomodulatory effects of aegle marmelos against dmba-induced skin tumorigenesis in swiss albino mice.aegle marmelos is widely used in indian ayurvedic medicine for the treatment of diabetes mellitus. in the present study, cancer chemopreventive properties were evaluated on 7, 12-dimethylbenz (a) anthracene (dmba) induced skin papillomagenesis in swiss albino mice. a single topical application of dmba, followed 2 weeks later by repeated application of croton oil till the end of the experiment ( i.e. 16 weeks) caused a 100% tumor incidence. in contrast, mice treated with the ame (50 mg/kg b. wt./ ...201021198283
isolation and partial characterisation of a novel lectin from aegle marmelos fruit and its effect on adherence and invasion of shigellae to ht29 cells.lectins are a class of ubiquitous proteins/glycoproteins that are abundantly found in nature. lectins have unique carbohydrate binding property and hence have been exploited as drugs against various infectious diseases. we have isolated one such novel lectin from the fruit pulp of aegle marmelos. the isolated lectin was partially characterised and its effect against shigella dysenteriae infection was evaluated. the isolated lectin was found to be a dimeric protein with n-acetylgalactosamine, man ...201121283697
upregulation of ppar? by aegle marmelos ameliorates insulin resistance and ß-cell dysfunction in high fat diet fed-streptozotocin induced type 2 diabetic rats.the global epidemic of type 2 diabetes demands the rapid evaluation of new and accessible interventions. this study investigated whether aegle marmelos fruit aqueous extract (amf; 250, 500 and 1000?mg/kg) improves insulin resistance, dyslipidemia and ß-cell dysfunction in high fat diet fed-streptozotocin (hfd-stz)-induced diabetic rats by modulating peroxisome proliferator-activated receptor-? (ppar?) expression. the serum levels of glucose, insulin, homeostasis model assessment of insulin resis ...201121351301
anti-hiv activity of indian medicinal plants.acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. there is an urgent need for new, safe, and cheap anti-hiv agents. traditional medicinal plants are a valuable source of novel anti-hiv agents and may offer alternatives to expensive medicines in future. various medicinal plants or plant-derived natural products have shown strong anti-hiv activity and are under various stages of clinical development in different parts of the world. the prese ...201121365365
inhibition of radiation-induced clastogenicity by aegle marmelos (l.) correa in mice bone marrow exposed to different doses of gamma-radiation.the frequency of micronucleated polychromatic (mpce), normochromatic erythrocytes (mnce), and polychromatic/normochromatic erythrocyte ratio (pce/nce), was studied in the bone marrow of mice orally administered with 0, 200, 225, 250, 275 and 300 mg/kg body weight of hydroalcoholic leaf extract of aegle marmelos (ame). treatment of mice with ame, once daily for 5 consecutive days, before exposure to 2 gy resulted in a significant decline in the frequency of mpce when compared to the non-drug-trea ...200717370869
effects of aegle marmelos (l.) correa on the peripheral blood and small intestine of mice exposed to gamma radiation.the radioprotective effect of bael (aegle marmelos, ame) extract was studied in swiss albino mice against radiation-induced changes in the peripheral blood, spleen colony forming units, and intestinal mucosa. the mice were treated with 250 mg/kg body weight of ame orally once daily for five consecutive days before exposure to an acute dose of 7 gy of gamma radiation after the last administration. the peripheral blood was collected and evaluated for red blood cell (rbc), hemoglobin, total leukocy ...200617341202
evaluation of the anti-inflammatory activity of aegle marmelos (bilwa) root.the purpose of this study was to evaluate and compare the anti-inflammatory activity of the aqueous root bark extract of aegle marmelos (bilwa) in experimental acute and chronic inflammatory animal models.201121844992
possible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against brugia malayi microfilariae.tropical disease research scheme of world health organization has duly recognized traditional medicine as alternative for antifilarial drug development. polyphenolic compounds present in traditionally used herbal medicines are natural antioxidants; however, paradoxically they may exert pro-oxidant effect. popular drug diethyl carbamazine citrate harnesses the innate inflammatory response and the consequent oxidative assault to combat invading microbes.201021713137
effects of aegeline, a main alkaloid of aegle marmelos correa leaves, on the histamine release from mast cells.aegeline or n-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from aegle marmelos correa collected in yogyakarta indonesia. in our study, we investigated the effects of aegeline on the histamine release from mast cell. the study was performed by using (1) rat basophilic leukemia (rbl-2h3) cell line, and (2) rat peritoneal mast cells (rpmcs). dnp(24)-bsa, thapsigargin, ionomycin, compound 48/80 and pma were used as inducers for histamine release from mast c ...201121715270
antihyperglycemic and antidyslipidemic agent from aegle marmelos.the plant aegle marmelos belongs to the family of rutaceae. from the leaves of a. marmelos an alkaloidal-amide, aegeline 2, was isolated and found to have antihyperglycemic activity as evidenced by lowering the blood glucose levels by 12.9% and 16.9% at 5 and 24h, respectively, in sucrose challenged streptozotocin induced diabetic rats (stz-s) model at the dose of 100mg/kg body weight. aegeline 2 has also significantly decreased the plasma triglyceride (tg) levels by 55% (p<0.001), total cholest ...200717197179
Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea.Marmin or 7-(6',7'-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of marmin to potentiate the relaxation effect of isoprenaline was also studied. Marmin added in the org ...201121959801
ameliorative effect of aegle marmelos leaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats.the pathogenesis of diabetic cardiomyopathy (dcm) is complex, and the therapeutic options available to treat dcm are limited. the present study was designed to investigate the effect of aegle marmelos (l.) correa (rutaceae) leaf extract on early stage dcm in alloxan-induced diabetic rats.201122014262
biochemical evaluation of antidiabetogenic properties of some commonly used indian plants on streptozotocin-induced diabetes in experimental rats.1. diabetes mellitus is a serious metabolic disorder with micro- and macrovascular complications that results in significant morbidity and mortality. 2. the aim of the present study was to evaluate the hypoglycaemic efficacy of commonly used traditional indian plants, such as murraya koenigii, mentha piperitae, ocimum sanctum and aegle marmelos, in streptozotocin (stz)-induced experimental rats. 3. oral administration of the ethanolic extract of these plants resulted in a significant decrease in ...200617184494
antimicrobial activity and phytochemical screening of serial extracts from leaves of aegle marmelos (linn.).the in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of aegle mawmelos were investigated against bacterial and fungal species. all the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: staphylococcus aureus, beta streptococcus haemolyticus group a, proteus mimrabilis, klebsiella pneumoniae, pseudomonas aenrginosa, escherichia coli, salmonella typhi, fungi: candida alb ...201121928713
mitochondrial respiration inhibitors suppress protein translation and hypoxic signaling via the hyperphosphorylation and inactivation of translation initiation factor eif2α and elongation factor eef2.over 20,000 lipid extracts of plants and marine organisms were evaluated in a human breast tumor t47d cell-based reporter assay for hypoxia-inducible factor-1 (hif-1) inhibitory activity. bioassay-guided isolation and dereplication-based structure elucidation of an active extract from the bael tree (aegle marmelos) afforded two protolimonoids, skimmiarepin a (1) and skimmiarepin c (2). in t47d cells, 1 and 2 inhibited hypoxia-induced hif-1 activation with ic50 values of 0.063 and 0.068 μm, respe ...201121875114
radioprotection by oral administration of aegle marmelos (l.) correa in vivo.the radioprotective effect of an extract of aegle marmelos (l.) correa (ame), family rutaceae, was investigated in mice exposed to different doses of gamma-radiation. mice were administered orally ame 250 mg/kg b.wt. orally daily for 5 consecutive days before exposure to 6, 7, 8, 9, 10, or 11 gy of gamma-radiation. the animals were monitored daily up to 30 days after irradiation for the development of symptoms of radiation sickness or death. treatment of mice with ame before irradiation reduced ...200516393124
Isolation and identification of antibacterial compound from the leaves of Cassia auriculata.Antimicrobial properties of medicinal plants and plant parts such as flowers, roots, fruits, seeds and oils are being used to cure some chronic and acute diseases throughout the world. In the present study, an attempt has been made to isolate and identify the antibacterial compound present in the leaves of the Cassia auriculata.201122013726
immunomodulatory potential of methanol extract of aegle marmelos in animals.the aim of the current research was to evaluate the immunomodulatory potential of methanol extract of aegle marmelos in an experimental animal model of cellular and humoral immunity. administration of methanol extract of aegle marmelos (500 and 1000 mg/kg, p.o.) and ocimum sanctum (100 mg/kg, p.o.), produced significant increase in adhesion of neutrophils and an increase in phagocytic index in carbon clearance assay. both doses of aegle marmelos prevented the mortality induced by bovine pasteure ...201122303072
antifungal activity of aegle marmelos (l.) correa (rutaceae) leaf extract on dermatophytes.to evaluate the in vitro antifungal activity of aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, microsporum gypseum and epidermophyton floccosum.201123569781
preventive effect of aegle marmelos leaf extract on isoprenaline-induced myocardial infarction in rats: biochemical evidence.we have evaluated the preventive effects of an aqueous aegle marmelos leaf extract (amlet) in isoprenaline (isoproterenol)-induced myocardial infarction in rats. rats were pretreated with amlet (50, 100 or 200 mg kg(-1)) for 35 days. after the treatment period, isoprenaline (200 mg kg(-1)) was administered subcutaneously to rats at an interval of 24 h for two days. the activity of creatine kinase (ck) and lactate dehydrogenase (ldh) was significantly increased in serum and significantly decrease ...200516259765
expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by bangladeshi natural plant extracts.the aim of the present study was to determine whether the expression of the estrogen receptor alpha (eralpha) gene may be a possible target for compounds present in plant extracts from aegle marmelos and emblica officinalis, used in traditional asian medicine in the treatment of tissue inflammation and cancer. to this aim, we evaluated the potential of the selected plant extracts to affect proliferation and differentiation of eralpha-negative mda-mb-231 breast cancer cells, which become eralpha ...200516119004
biosynthesis of silver nanoparticles using aegle marmelos (bael) fruit extract and its application to prevent adhesion of bacteria: a strategy to control microfouling.marine biofilms formed due to adhesion of bacteria and other microorganisms on submerged surfaces are generally considered to be a major form of microfouling. subsequent attachment of larvae of higher organisms like barnacles, mussels, and so forth, on marine biofilms, causes macrofouling. several approaches have been used to prevent micro- and macrofouling. silver nanoparticles (agnps) are known to exhibit strong inhibitory and antimicrobial activity. biological synthesis of agnps is rapidly ga ...201425258620
ovicidal and oviposition deterrent activities of medicinal plant extracts against aedes aegypti l. and culex quinquefasciatus say mosquitoes (diptera: culicidae).to evaluate the ovicidal and oviposition deterrent activities of five medicinal plant extracts namely aegle marmelos (linn.), limonia acidissima (linn.), sphaeranthus indicus (linn.), sphaeranthus amaranthoides (burm.f), and chromolaena odorata (linn.) against culex quinquefasciatus and aedes aegypti mosquitoes. three solvents, namely hexane, ethyl acetate, and methanol, were used for the preparation of extracts from each plant.201425737834
antibacterial activity of aegle marmelos against leaf, bark and fruit extracts.the antibacterial activity of the methanol, chloroform and aqueous extracts from the leaves, bark and fruit of a. marmelos was studied using disc diffusion method against bacillus subtilis, staphylococcus aureus (gram positive), klebsiella pneumoniae, proteus mirabilis, escherichia coli, salmonella paratyphi a and salmonella paratyphi b (gram negative). results suggest that the methanolic extract has significant antibacterial activity against tested bacteria. the present study justifies the clai ...200822557272
effect of aegle marmelos correa. (bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats.a study was undertaken to evaluate the anti-lipid peroxidative activity of an aqueous extract of a. marmelos fruits (amfet) in streptozotocin diabetic rats in heart and pancreas. oral administration of amfet for 30 days (125 and 250 mg kg(-1) body weight twice daily) produced a significant decrease in the elevated levels of peroxidation products, viz. thiobarbituric acid reactive substances and hydroperoxides in the tissues of diabetic rats. the depressed activities of superoxide dismutase, cata ...200315332498
screening of herbal-based bioactive extract against carbapenem-resistant strain of acinetobacter baumannii.acinetobacter baumannii is grouped in the eskape pathogens by infectious disease society of america, which is linked to high degree of morbidity, mortality, and increased costs. the high level of acquired and intrinsic resistance mechanisms of these bacteria makes it an urgent requirement to find a suitable alternative to carbapenem, a commonly prescribed drug for acinetobacter infection. in this study, methanolic extracts of six medicinal plants were subjected to phytochemical screening and the ...201626910023
bioprospecting endophytic fungi and their metabolites from medicinal tree aegle marmelos in western ghats, india.the increasing emergence of lead drugs for the resistance produced by the pathogenic strains and arrival of new diseases have initiated the need for searching novel metabolites with best anticancer and antimicrobial properties than the existing one. with this view, the investigation was conducted for the isolation, identification, and biological evaluation of potential endophytic fungi of aegle marmelos, a medicinal tree used for more than three decades, for curing various disorders. a total of ...201526539047
biological activities and identification of bioactive metabolite from endophytic aspergillus flavus l7 isolated from aegle marmelos.aegle marmelos, a well-known indian plant with medicinal and religious importance, has been extensively used in indian traditional medicine. the present study aimed to isolate, identify, and evaluate the biological activities of endophytic fungi from a. marmelos. one of the isolates, labeled as l7, was identified as aspergillus flavus using morphology and its gene sequence. total phenolic and flavonoid contents in the culture filtrate were found to be 65.77 mg gae/ml and 158.33 mg quercetin/ml o ...201525860867
in-vitro antimicrobial, antibiofilm, cytotoxic, antifeedant and larvicidal properties of novel quinone isolated from aegle marmelos (linn.) correa.plant metabolites have wide applications and have the potential to cure different diseases caused by microorganisms. the aim of the study was to evaluate the antimicrobial, antibiofilm, cytotoxic, antifeedant and larvicidal properties of novel quinine isolated from aegle marmelos (linn.) correa.201425359605
evaluation of aromatic plants and compounds used to fight multidrug resistant infections.traditional medicine plays a vital role for primary health care in india, where it is widely practiced to treat various ailments. among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity. methanol extract of plants (100  μ g of residue) was tested against the multidrug resistant (mdr) gram-negative and gram-positive bacteria. forty-seven plants showed strong activity against burkholderia pseudomallei (strain tes and khw) and staphylococc ...201324223059
evidence of functional cross talk between the notch and nf-κb pathways in nonneoplastic hyperproliferating colonic epithelium.the notch and nf-κb signaling pathways regulate stem cell function and inflammation in the gut, respectively. we investigate whether a functional cross talk exists between the two pathways during transmissible murine colonic hyperplasia (tmch) caused by citrobacter rodentium (cr). during tmch, nf-κb activity and subunit phosphorylation in colonic crypts of nih swiss mice at days 6 and 12 were associated with increases in downstream target cxc chemokine ligand (cxcl)-1/keratinocyte-derived chemok ...201323203159
critical roles of notch and wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.notch and wnt/β-catenin signals play essential roles in intestinal development and homeostasis. citrobacter rodentium induces transmissible murine colonic hyperplasia (tmch) and various degrees of inflammation, depending upon the genetic background. we aimed at delineating the role of the notch and wnt/β-catenin pathways in the regulation of colonic crypt hyperplasia and/or colitis following c. rodentium infection. during tmch, relative levels of the notch intracellular domain (nicd) increased s ...201222710872
effects of extracts from bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene.in this study we determined the activity of extracts from bangladeshi medicinal plants (emblica officinalis, aegle marmelos, vernonia anthelmintica, oroxylum indicum, argemone mexicana) on human breast tumor cell lines. extracts from e. officinalis and o. indicum displayed anti-proliferative activity on mcf7 and mda-mb-231 breast cancer cell lines, while extracts from a. mexicana were active on mcf7 cells, exhibiting on the contrary low antiproliferative effects on mda-mb-231 cells. extracts fro ...200414719119
bactericidal effect of selected antidiarrhoeal medicinal plants on intracellular heat-stable enterotoxin-producing escherichia coli.diarrhoeal diseases due to enterotoxigenic escherichia coli continue to be a cause of global concern. medicinal plants have been gaining popularity as promising antidiarrhoeal agents. in the present study, four antidiarrhoeal plants, viz. aegle marmelos, cyperus rotundus, psidium guajava and zingiber officinale were screened against a heat-stable toxin-producing enterotoxigenic e. coli strain. decoctions of these plants were studied for their effect on intracellular killing of the bacterial stra ...201425035535
identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant emblica officinalis: effects on in vitro cell growth of human tumor cell lines.in this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid k562, b-lymphoid raji, t-lymphoid jurkat, erythroleukemic hel cell lines. extracts from emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from terminalia arjuna, aphanamixis polystachya, oroxylum indicum, cuscuta reflexa, aegle marmelos, saraca asoka, rumex maritimus, lagerstro ...200212063567
screening of selected medicinal plants for in vitro antidermatophytic activity.different solvent extracts of leaves of achyranthes aspera, aegle marmelos, cleistanthus collinus, curcuma aromatica and strychnos nux-vomica were screened against dermatophytes viz., trichophyton mentagrophytes, t. rubrum, microsporum gypseum, m. canis and epidermophyton floccossum var. nigricans. the mean zones of inhibition were between 7.1 and 26.5mm. minimum inhibitory concentrations (mic) and minimum fungicidal concentrations (mfc) were from 7.81 to 500 and from 15.62 to 1000μg/ml respecti ...201324135649
antimicrobial activity of some indian medicinal plants.the antimicrobial potential of seventy-seven extracts from twenty-four plants was screened against eight bacteria and four pathogenic fungi, using microbroth dilution assay. lowest concentration of the extract, which inhibits any visual microbial growth after treatment with p-iodonitrotetrazolium violet, was considered to be minimum inhibitory concentration (mic). water extracts of acacia nilotica, justicia zelanica, lantana camara and saraca asoca exhibited good activity against all the bacteri ...200720161895
lipid lowering activity of ethanolic extract of leaves of aegle marmelos (linn.) in hyperlipidaemic models of wistar albino rats.lipid lowering effect of 50% ethanolic extract of the leaves of a. marmelos (linn.) was evaluated in triton and diet induced hyperlipidaemic models of wistar albino rats. the extract at 125 and 250 mg/kg dose levels inhibited the elevation in serum cholesterol and triglycerides levels on triton wr 1339 administration in rats. the extract at the same dose levels significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in the high-density lipoprotein cholest ...200919405383
ethnomedicinal plants of kathua district, j&k, india.natural products, especially those derived from plants, continue to provide new and important leads in the drug discovery process. the first step in drug discovery is to document material traditionally used to treat an ailment. documentation of such knowledge will lead to its conservation and facilitate future research on medicinal plant safety and efficacy to validate traditional use. the present study was undertaken with an aim to document the ethnomedicinal plants of kathua district.201526023030
reversible changes in the antifertility induced by aegle marmelos in male albino rats.to study the effects of aegle marmelos on the testicular reproductive system, a 50% ethanolic extract of aegle marmelos leaves (amlet) was fed orally to male albino rats at the dose levels of 200 and 300 mg/kg body wt./day for 60 days. recovery was assessed for an additional 120 days. oral administration of amlet did not cause body weight loss. the motility and sperm concentration were significantly reduced along with complete inhibition of fertility at a dose of 300 mg/kg. the level of serum te ...200819052962
fetal hemoglobin inducers from the natural world: a novel approach for identification of drugs for the treatment of {beta}-thalassemia and sickle-cell anemia.the objective of this review is to present examples of lead compounds identified from biological material (fungi, plant extracts and agro-industry material) and of possible interest in the field of a pharmacological approach to the therapy of beta-thalassemia using molecules able to stimulate production of fetal hemoglobin (hbf) in adults. concerning the employment of hbf inducers as potential drugs for pharmacological treatment of beta-thalassemia, the following conclusions can be reached: (i) ...200918955291
larvicidal activities of six plants extracts against two mosquito species, aedes aegypti and anopheles stephensi.larvicidal activity of crude chloroform, dichloromethane and methanol extracts of the leaves and roots of six indian plants, aegle marmelos l., balanites aegyptica l., calotropis gigantica l., murraya koenigii l., nyctanthes arbor-tristis l. and plumbago zeylanica l., were tested against the early fourth instar larvae of aedes aegypti l. and anopheles stephensi. the larval mortality was observed after 24 h of exposure. all extracts showed moderate larvicidal effects. however, the highest larval ...201021399575
modulation of doxorubicin-induced genotoxicity by aegle marmelos in mouse bone marrow: a micronucleus study.the effect of various concentrations of aegle marmelos (ame) on the doxorubicin (dox)-induced genotoxic effects in mice bone marrow was studied. treatment of mice with different concentrations of dox resulted in a dose-dependent elevation in the frequency of micronucleated polychromatic (mpce) as well as normochromatic (mnce) erythrocytes in mouse bone marrow. the frequencies of mpce and mnce increased with scoring time, and the greatest elevation for mpce was observed at 48 hours post-dox treat ...200717351026
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