antiallergic and antihistaminic effect of two extracts of capparis spinosa l. flowering buds.the antiallergic properties of two lyophilized extracts obtained from capparis spinosa l. flowering buds (capers) by methanol extraction, carried out at room temperature (cap-c) or with heating at 60 degrees c (cap-h), were investigated. the protective effects of cap-h and cap-c, orally administered (14.28 mg[sol ]kg), were evaluated against oleaceae antigen challenge-induced and histamine-induced bronchospasm in anaesthetized guinea-pigs. furthermore, the histamine skin prick test was performed ...200515799005
hypolipidemic activity of aqueous extract of capparis spinosa l. in normal and diabetic rats.the purpose of this study was to examine the effect of single and repeated oral administrations of the aqueous extract of capparis spinosa l. (cs) at a dose of 20mg/kg on lipid metabolism in normal and streptozotocin-induced diabetic rats. in normal rats, the aqueous extract of cs induced a significant decrease on plasma triglycerides concentrations 1 week (p<0.05) and 2 weeks (p<0.01) after once daily repeated oral administration. a significant decrease of plasma cholesterol levels was also obs ...200515814271
protective effect of capparis spinosa on chondrocytes.the aim of the present study was to evaluate the in vitro chondroprotective effects of the lyophilised methanolic extract from flowering buds of capparis spinosa l (lecs). this plant, common to the mediterranean basin, has been used by the traditional medicine for its diuretic and antihypertensive effects and also in certain pathological conditions related to uncontrolled lipid peroxidation. the extract contains many constituents, in particular some flavonoids (kaempferol and quercetin derivativ ...200515946691
glucosinolates and fatty acid, sterol, and tocopherol composition of seed oils from capparis spinosa var. spinosa and capparis ovata desf. var. canescens (coss.) heywood.seed oils of 11 samples of capparis ovata and capparis spinosa from different locations in turkey were characterized with regard to the composition of fatty acids, tocopherols, and sterols as well as the content of glucosinolates. the oil content of the seeds ranged from 27.3 to 37.6 g/100 g (c. spinosa) and from 14.6 to 38.0 g/100 g (c. ovata). the dominating fatty acid of both species was linoleic acid, which accounted for 26.9-55.3% in c. ovata seed oils and for 24.6-50.5% in c. spinosa seed ...200516131121
fungal endophytes from the three-leaved caper, crataeva magna (lour.) dc. (capparidaceae).fungal endophytes were isolated from crataeva magna, a medicinal plant growing along the streams and rivers, constituting riparian vegetation in karnataka, southern india. fresh bark and twig pieces were used for the isolation using standard methods. ninety-six endophytic fungal isolates were isolated from 800 bark and twig segments. mitosporic fungi represented as a major group (85%) followed by zygomycetes (10%) and ascomycetes (5%). bark samples contained more endophytes than twig samples. ve ...200515770450
in vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of capparis spinosa l buds.the aim of the present study was to evaluate the in vitro antioxidant and in vivo photoprotective activities of a lyophilized extract of capparis spinosa l. (lecs) obtained by methanolic extraction from the flowering buds of this plant. for the in vitro experiments, lecs was tested employing three different models: (a). bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical (dpph test); (b). peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydroch ...200212512010
photosynthesis modulates the plant feeding of phlebotomus papatasi (diptera: psychodidae).phlebotomus papatasi (scopoli), the vector of leishmania major (yakimoff & schokhor), feeds on plants in desert habitats in the jordan valley. at the end of the dry summer, the life span of sand flies is short and the amount of sugars in their guts is small. in this season the plants are under the stress of heat and dehydration. this stress arrests the photosynthesis and decreases the amounts of the main end products, sucrose and starch. we presumed that the paucity of sugars in the sand fly pla ...200015535571
herbs as a food source in turkey.medical benefits of herbs have been known for centuries. many examples contain powerful active components that, if used correctly, can help in healing the living organism. these herbs can also be provided in the form of capsules and powders, as dietary supplements, and thus differ from conventional foods or food ingredients. the traditional turkish kitchen is rich of various herbs which have been employed as ingredients since ancient times. the present paper provides a brief overview of some imp ...200415373716
caraway and caper: potential anti-hyperglycaemic plants in diabetic rats.the hypoglycaemic effect of aqueous extracts of carum carvi (cc) and capparis spinosa l. (cs) fruit were investigated in normal and streptozotocin (stz) diabetic rats. after a single dose or 14 daily doses, oral administration of the aqueous cc and cs extracts (20 mg/kg) produced a significant decrease on blood glucose levels in stz diabetic rats (p < 0.001); the blood glucose levels were nearly normalised 2 weeks after daily repeated oral administration of both aqueous cc and cs extracts (20 mg ...200415261975
screening of some indigenous qatari medicinal plants for antimicrobial activity.aqueous, ethanol and butanol crude extracts of the aerial parts of ten plants exhibited variable degrees of antimicrobial activity against four bacterial and two fungal species. aqueous extracts had low antimicrobial activity against e.coli, p.aeruginosa, b. cerreus, s.aureus, c.albicans and a.flavus. avicennia marina (am) aqueous extract exhibited a moderate antifungal activity. ethanol and butanol crude extracts exhibited an improved antimicrobial activity. however, butanol exhibited a superio ...200212458480
effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and cd63 expression in allergic subjects.allergic diseases represent conditions affecting millions of individuals across the world. the objective of this study was to investigate the potential anti-allergic effects of a new nutraceutical ingredient, pantescal (bionap, italy), contained in different food supplements. pantescal is a mixture of plant extracts, such as capparis spinosa, olea europaea, panax ginseng and ribes nigrum. the study was a randomized, double-blind, placebo controlled design. 60 patients allergic to common aeroalle ...200818817894
hplc-uv and hplc-positive-esi-ms analysis of the diterpenoid fraction from caper spurge (euphorbia lathyris) seed oil.caper spurge (euphorbia lathyris l.) seed oil contains a series of diterpenoids known as euphorbia factors, or l-factors, l1-l9. they are esters of several polyols (lathyrol, epoxylathyrol, hydroxylathyrol and ingenol) and account for about 3-5% of the oil. the percentage of ingenol-based l-factors is very low, less than 5% of the diterpenoid fraction, but some of them (factors l5 and l6) are responsible for the irritant and co-carcinogenic activities of the oil. this paper reports an hplc-uv an ...200111705332
glucosinolate composition of young shoots and flower buds of capers (capparis species) growing wild in turkey.the content and glucosinolate composition of young shoots and raw flower buds of capparis spinosa var. spinosa and capparis ovata desf. var. canescens at three different sizes (x <or= 8 mm, 8 < x <or= 13 mm, and x > 13 mm) were investigated by hplc with uv detection. samples were harvested in august 2001 in turkey. twelve different glucosinolates were identified in the young shoots and buds of both species. total content of glucosinolates ranged from 6.55 micromol/g (large buds of c. spinosa) to ...200212452652
phlebotomus papatasi and leishmania major parasites express alpha-amylase and alpha-glucosidase.alpha-amylase and alpha-glucosidase activities were found in homogenates of young, unfed male and female phlebotomus papatasi and in gut and salivary gland preparations. a significant increase in both enzyme activities in females and of alpha-amylase in males was recorded for flies that had fed overnight on a plant (capparis spinosa). after plant feeding, alpha-amylase activity was relatively lower in female salivary glands and higher in guts, while in the males the activity in the salivary glan ...200111164750
antifungal activity of plant extracts against dermatophytes.the aqueous extracts (15 micrograms ml-1 medium) of 22 plants used in folkloric medicine in palestine were investigated for their antifungal activity and minimum inhibitory concentrations (mics) against nine isolates of microsporum canis, trichophyton mentagrophytes and trichophyton violaceum. the extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. antimycotic activity of the extract against the three dermatop ...199910680445
molecular cloning and characterization of caper, a novel coactivator of activating protein-1 and estrogen receptors.transcriptional coactivators either bridge transcription factors and the components of the basal transcription apparatus and/or remodel the chromatin structures. we isolated a novel nuclear protein based on its interaction with the recently described general coactivator activating signal cointegrator-2 (asc-2). this protein caper (for coactivator of activating protein-1 (ap-1) and estrogen receptors (ers)) selectively bound, among the many transcription factors we tested, the ap-1 component c-ju ...200211704680
[effect of capparis spinosa on fibroblast proliferation and type i collagen production in progressive systemic sclerosis].to investigate the effects of ethanolic extract from capparis spinosa (ecs) on the fibroblast proliferation and type i collagen production in normal and progressive systemic sclerosis (pss).200818536384
evaluation of extracts and isolated fraction from capparis spinosa l. buds as an antioxidant source.the antioxidant activity of extracts from capparis spinosa l. buds was evaluated using different in vitro tests: ascorbate/fe(2+)-mediated lipid peroxidation of microsomes from rat liver; bleaching of 1,1-diphenyl-2-picryl-hydrazyl radical; and autoxidation of fe(2+) ion in the presence of bathophenanthroline disulfonate. the methanolic extract showed strong activities in all of these in vitro tests. the amount of total phenols was determined in the methanolic extract. in addition, the level of ...200211853498
further new diterpene esters from the irritant and cocarcinogenic seed oil and latex of the caper spurge (euphorbia lathyris l.). 19715144835
[extraction of precipitating insulin antibodies from the goat, caper domesticus]. 19694182169
antihepatotoxic activity of p-methoxy benzoic acid from capparis spinosa.p-methoxy benzoic acid isolated from the methanolic soluble fraction of the aqueous extract of capparis spinosa l. (capparidaceae) was found to possess significant antihepatotoxic activity against carbontetrachloride and paracetamol induced hepatotoxicity in vivo and thioacetamide and galactosamine induced hepatotoxicity in isolated rat hepatocytes, using in vitro technique. the compound was characterized through physicochemical and spectral studies. isolation, identification and antihepatotoxic ...199910433476
isolation and identification of an anti-inflammatory principle from capparis spinosa.the homologous polyprenols cappaprenol-12 (1), cappaprenol-13 (2) and cappaprenol-14 (3) with 12, 13 and 14 isoprene units, respectively, could be isolated by preparative hplc from alcoholic extracts of capparis spinosa. testing 2 for its anti-inflammatory activity an inhibition of the carrageenan-induced paw edema in rats of 44 vs. 67% for the standard oxyphenbutazone was found.19883244735
lectins and toxins in the plant diet of phlebotomus papatasi (diptera: psychodidae) can kill leishmania major promastigotes in the sandfly and in culture.leishmania major promastigotes are agglutinated and die in their vector, phlebotomus papatasi, after the sandflies feed on some plants that are found in their natural habitat. in in-vitro assays, extracts of ricinus communis (euphorbiaceae), capparis spinosa (capparaceae), prosopis farcta (mimosaceae) and tamarix nilotica (tamaricaceae) agglutinated and killed the parasites. this activity could be inhibited by specific carbohydrates, indicating that it was the result of various lectins in the ex ...199910656036
mortality of leishmania major in phlebotomus papatasi caused by plant feeding of the sand flies.the plant feeding of phlebotomus papatasi and the effects of plant diets on the leishmania major infections were investigated. plant-fed flies had small free particles and membranous shreds in their gut that were stained by calcofluor as cellulosic plant tissues. they were found in 34.0% of the female and 14.3% of the male sand flies following feeding on the caper plant (capparis spinosa). no plant residues were found in 54 females that had been fed on plant-derived honeydew secretions of aphis ...19948304569
on the active principles of the spurge family. iii. skin irritant and cocarcinogenic factors from the caper spurge.the toxic and irritant principles of the seed oil and of the latex of the caper spurge (euphorbia lathyris l.) were isolated together with several non irritants of similar chemical structure. from the seed oil two irritant euphorbia factors l5 and l6 and from the latex a mixture of irritant euphorbia factors were obtained. euphorbia factor l5 was identified as 3-hexadecanoate of the new tetracyclic, poly-functional diterpene parent alcohol ingenol. euphorbia factor l6 most probably is the 3-tetr ...1975128221
mineral composition of different parts of capparis ovata desf. var. canescens (coss.) heywood growing wild in turkey.major and minor mineral contents of young shoots, flower buds, caperberries (fruit), and seeds of capparis ovata desf. var. canescens (coss.) heywood, used as a pickling product in turkey, were determined by inductively coupled plasma atomic emission spectrometry. twenty-one minerals were assayed in samples. all materials contained high amounts of ca, k, mg, na, p, pb, and zn. the highest levels of ca (598.34-16,947.1 ppm), k (3,093.1-28,163.9 ppm), na (57.9-444.3 ppm), p (1,690.5-4,153.9 ppm), ...200516176156
microbiological study of lactic acid fermentation of caper berries by molecular and culture-dependent methods.fermentation of capers (the fruits of capparis sp.) was studied by molecular and culture-independent methods. a lactic acid fermentation occurred following immersion of caper berries in water, resulting in fast acidification and development of the organoleptic properties typical of this fermented food. a collection of 133 isolates obtained at different times of fermentation was reduced to 75 after randomly amplified polymorphic dna (rapd)-pcr analysis. isolates were identified by pcr or 16s rrna ...200516332762
resistance to antimicrobial agents in lactobacilli isolated from caper fermentations.a collection of lactobacilli comprising species of lactobacillus plantarum (43 isolates), lactobacillus brevis (9 isolates) and lactobacillus fermentum (6 isolates) obtained from spontaneous fermentations of capers (the fruits of capparis spinosa) were investigated for resistance to antimicrobial agents. all isolates were resistant to vancomycin and teicoplanin (mic > 16 microg/ml). resistance to ciprofloxacin (mic > 2 microg/ml) was detected in all isolates of l. brevis and l. fermentum as well ...200516284934
anti-inflammatory activity of some saudi arabian medicinal plants.five plants which have been used for the treatment of rheumatism, arthritis and gout in the traditional medicine of saudi arabia, were evaluated for their anti-inflammatory properties. of these the ethanolic extract of capparis decidua and the aqueous extract of capparis spinosa were found to possess significant anti-inflammatory activity against carrageenan induced oedema in rats. these two plants were also tested for their antipyretic and analgesic activity. c. decidua was found to possess sig ...19863485894
the influence of growth regulators on shoot proliferation and rooting of in vitro propagated caper.the objectives of this study were to examine the effect of tdz and bap on shoot proliferation and to develop a satisfactory rooting procedure for in vitro propagation of caper (capparis spinosa l). tdz was found to be more effective than bap in shoot production. the highest shoot number per explant (45.7) was achieved on the media that contained 4.54 microm tdz in the absence of iaa. tdz at 4.54 microm alone or in combination with 0.57 microm iaa did not inhibit shoot elongation, although they p ...200516334286
characterization of lactobacilli isolated from caper berry determine the metabolic and functional properties of lactobacilli isolated from caper fermentation.200717241365
plasmid profile patterns and properties of pediococci isolated from caper fermentations.a collection comprising 14 isolates of pediococcus pentosaceus and one pediococcus acidilactici from the fermentation of caper fruits was studied. all isolates showed very similar fermentation profiles and produced a limited number of exoenzymes. all isolates carried large plasmids of diverse sizes between 20 and 55 kb, while some also contained smaller plasmids between 10 and 16 kb. cluster analysis of plasmid profiles revealed four main groups with various degrees of similarities. all amino ac ...200616715824
a new p-glycoprotein inhibitor from the caper spurge (euphorbia lathyris).the macrocyclic lathyrane polyester euphorbia factor l10 (1a) has been obtained from the seeds of the caper spurge (e. lathyris). the interaction of l10 (1a) and its acetyl derivative (1b) with p-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. the results established lathyrane diterpenoids as a novel chemotype for p-glycoprotein inhibitors.200312542364
the discovery of capparis spinosa l. (capparidaceae) in the yanghai tombs (2800 years b.p.), nw china, and its medicinal implications.seed clumps of capparis spinosa l. together with shoots, leaves and fruits of cannabis sativa l. were unearthed in the yanghai tombs, turpan district in xinjiang, china. this is the first time that plant remains of capparis spinosa have been discovered in china and the eastern part of central asia. based on the joint occurrence of capparis spinosa and cannabis sativa, and the pharmacological value of the seeds of capparis spinosa, it is deduced that caper was utilized for medicinal purposes.200717693045
anopheles nf-κb-regulated splicing factors direct pathogen-specific repertoires of the hypervariable pattern recognition receptor agdscam.insects rely on innate immune responses controlled by the immune deficiency (imd), toll, and other immune signaling pathways to combat infection by a broad spectrum of pathogens. these pathways signal to downstream nf-κb family transcription factors that control specific antipathogen action via direct transcriptional control of immune effectors, hematopoiesis, and melanization. here we show that in the anopheles malaria vector, imd and toll pathways mediate species-specific defenses against plas ...023084919
isolation and characterization of a lectin with potentially exploitable activities from caper (capparis spinosa) seeds.a dimeric 62-kda lectin exhibiting a novel n-terminal amino acid sequence was purified from caper (capparis spinosa) seeds. the purification protocol involved anion-exchange chromatography, cation-exchange chromatography and, finally, gel filtration by fplc on superdex 75. approx. 100-fold purification was achieved. the haemagglutinating activity of the lectin, which was stable in the ph range 1-12 and up to 40 degrees c, could be inhibited by d(+) galactose, alpha-lactose, raffinose and rhamnos ...200918847434
a protein with antiproliferative, antifungal and hiv-1 reverse transcriptase inhibitory activities from caper (capparis spinosa) seeds.a protein exhibiting an n-terminal amino acid sequence with some similarity to imidazoleglycerol phosphate synthase was purified from fresh capparis spinosa melon seeds. the purification protocol entailed anion exchange chromatography on deae-cellulose, cation exchange chromatography on sp-sepharose, and finally gel filtration by fast protein liquid chromatography on superdex 75. the protein was adsorbed using 20 mm tris-hcl buffer (ph 7.4) and desorbed using 1 m nacl in the starting buffer from ...200919019643
antiquorum sensing and antibiofilm potential of capparis spinosa.emergence of antibiotic resistance among bacterial pathogens often leads to the failure of existing antibiotics to treat bacterial infections; thus, there is a need to seek alternative treatment measures. the aim of this study was to evaluate the anti-quorum sensing (anti-qs) and antibiofilm potential of capparis spinosa to prevent the onset of bacterial infections as an alternate to antibiotics.201122222491
genetic variation of eggplant mottled dwarf virus from annual and perennial plant hosts.the genetic diversity of eggplant mottled dwarf virus (emdv), a member of the family rhabdoviridae, was studied using isolates collected from different herbaceous and woody plant species and remote geographic areas. sequences corresponding to the n, x, p, y, m and g orfs as well as the untranslated regions (utrs) between orfs were determined from all isolates. low genetic diversity was found in almost all genomic regions studied except for the x orf and the utrs, which were more variable, while ...201626660163
investigation on the mineral contents of capers (capparis spp.) seed oils growing wild in turkey.minor and major mineral contents of seed oils of capparis ovata desf. var. canescens (coss.) heywood and capparis spinosa var. spinosa used as pickling products in turkey were determined by inductively coupled plasma atomic emission spectrometry. the seed oils contained al, p, na, mg, fe, and ca, in addition to fatty acids. the highest mineral concentrations measured were 14.91-118.81 mg/kg al, 1,489.34-11,523.74 mg/kg p, 505.78-4,489.51 mg/kg na, 102.15-1,655.33 mg/kg mg, 78.83-298.14 mg/kg fe, ...200818800913
signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, pcbp1.transcription, splicing, and translation are potentially coordinately regulatable in a temporospatial-dependent manner, although supporting experimental evidence for this notion is scarce. yeast two-hybrid screening of a mammary gland cdna library with human p21-activated kinase 1 (pak1) as bait identified polyc-rna-binding protein 1 (pcbp1), which controls translation from mrnas containing the dice (differentiation control element). mitogenic stimulation of human cells phosphorylated pcbp1 on t ...200717389360
carotenoid and tocopherol composition of leaves, buds, and flowers of capparis spinosa grown wild in tunisia.high-performance liquid chromatography was used to determine carotenoids (beta-carotene, lutein, neoxanthin, and violaxanthin) and tocopherols of leaves, buds, and flowers of tunisian capparis spinosa. this plant shows strong resistance to hard environmental conditions, and it is one of the most commonly found aromatics in the mediterranean kitchen. in this study, the means of the total carotenoids were 3452.5 +/- 1639.4, 1002 +/- 518.5, and 342.7 +/- 187.9 microg/g fresh weight (fw) in leaves, ...200919473002
a scoring system for the follow up study of nuclear receptor coactivator complexes.we have systematically isolated a variety of coactivator complexes from hela s3 cells using proteomic approaches. in the present report, we have evaluated twelve coactivator complexes involved in nuclear receptor-dependent gene transcription that have been purified by using an immunoprecipitation method. the twelve purified coactivator complexes are src-1, src-2, src-3, cbp, p300, caper, e6-ap, asc-1, corest, crsp3, crsp2, and cdk7 containing complexes. we have identified 153 protein components ...200616862220
genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of dcis-like mammary lesions.caveolin-1 (cav-1) loss-of-function mutations are exclusively associated with estrogen receptor-positive (er(+)) human breast cancers. to dissect the role of cav-1 loss-of-function in the pathogenesis of human breast cancers, we used cav-1(-/-) null mice as a model system. first, we demonstrated that cav-1(-/-) mammary epithelia overexpress two well-established er co-activator genes, caper and foxa1, in addition to er-alpha. thus, the functional loss of cav-1 may be sufficient to confer estrogen ...200919342371
effect of ethnomedicinal plants used in folklore medicine in jordan as antibiotic resistant inhibitors on escherichia coli.escherichia coli occurs naturally in the human gut; however, certain strains that can cause infections, are becoming resistant to antibiotics. multidrug-resistant e. coli that produce extended-spectrum beta lactamases (esbls), such as the ctx-m enzymes, have emerged within the community setting as an important cause of urinary tract infections (utis) and bloodstream infections may be associated with these community-onsets. this is the first report testing the antibiotic resistance-modifying acti ...201020187978
anti-inflammatory effects of caper (capparis spinosa l.) fruit aqueous extract and the isolation of main phytochemicals.caper (capparis spinosa l.) fruits have been used as food as well as folk medicine in the treatment of inflammatory disorders, such as rheumatism. the present study was carried out to study the anti-inflammatory activities of c. spinosa l. fruit (csf) aqueous extract and to isolate main phytochemicals from its bioactive fractions. the csf aqueous extract were separated into three fractions (csf1-csf3) by macroporous adsorption resins. the fractions csf2 and csf3 effectively inhibited the carrage ...201021105652
on the antibacterial activity of roots of capparis spinosa l.a decoction of capparis spinosa l. roots, widely used in the traditional folk medicine of southern italy, was prepared and submitted to antibacterial activity tests, which showed an interesting bacteriostatic activity on the growth of deinococcus radiophilus. heterocyclic compounds were also recovered from the chloroformic extract of the roots.201121328135
antiviral and immunomodulatory effect of a lyophilized extract of capparis spinosa l. buds.herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are common human pathogens that in particular cases can also cause severe problems especially in immunodeficient patients. the present paper reports the antiviral and immunomodulatory properties of a methanolic extract of c. spinosa buds (cap), rich in flavonoids, including several quercetin and kaempferol glycosides. in particular we have investigated whether the in vitro exposure of human peripheral blood mononuclear c ...200818058988
exposure to euphorbia lathyris latex resulting in alkaline chemical injury: a case report.we report the case of a patient with extreme pain following accidental exposure to the latex of euphorbia lathyris.200919946593
in vitro activities of plant extracts from saudi arabia against malaria, leishmaniasis, sleeping sickness and chagas disease.the in vitro activity of the methanol extracts of 51 plants randomly collected from the kingdom of saudi arabia and some of their fractions (petroleum ether, chloroform, ethyl acetate and aqueous) were evaluated against plasmodium falciparum, trypanosoma brucei brucei, t. cruzi and leishmania infantum, as well as toxicity against mrc-5 fibroblast cells. ten crude methanolic extracts that demonstrated potent and adequately selective antiprotozoal activity were subjected to solvent fractionation u ...201020127723
structure identification of euphorbia factor l3 and its induction of apoptosis through the mitochondrial this article, we have focused on the structure identification of euphorbia factor l3 belonging to the lathyrane diterpenoids isolated from caper euphorbia seed. its anticancer activity in vitro against lung cancer a549 cells was also investigated and the ic(50) values were 34.04 ± 3.99 μm. furthermore, euphorbia factor l3 could induce apoptosis in a549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.201121499222
phenolic composition and antioxidant activity of aqueous infusions from capparis spinosa l. and crithmum maritimum l. before and after submission to a two-step in vitro digestion model.this study investigated the phenolic composition and antioxidant activities of aqueous infusions from wild-grown caper (capparis spinosa l.) and sea fennel (crithmum maritimum l.) from the dalmatia region (croatia) before and after their submission to an in vitro digestion process. hplc/uv-vis-dad/esi-ms analysis of the caper infusion identified rutin, kaempferol 3-o-rutinoside, and isorhamnetin 3-o-rutinoside as dominant flavonoids in the matrix together with a series of cinnamoylquinic acid de ...201122017607
innate immune and growth promoting responses to caper (capparis spinosa) extract in rainbow trout (oncorhynchus mykiss).cytokine responses, non-specific immune activity and growth promotion effect of dietary caper (capparis spinosa) supplementation were examined in rainbow trout (oncorhynchus mykiss). rainbow trout (12.04 ± 0.71 g) were fed diets containing three doses of caper methanolic extract [0 (control), 0.1 and 0.5 g kg(-1) of feed] for 30 days. at the end of the feeding trial, expression levels of cytokine genes that included il-1β, il-8, tgf-β, il-12p40, tnf-α1 and il-10 in head kidney was analyzed using ...201627546553
phylogeographic structure of a tethyan relict capparis spinosa (capparaceae) traces pleistocene geologic and climatic changes in the western himalayas, tianshan mountains, and adjacent desert regions.complex geological movements more or less affected or changed floristic structures, while the alternation of glacials and interglacials is presumed to have further shaped the present discontinuous genetic pattern of temperate plants. here we consider capparis spinosa, a xeromorphic tethyan relict, to discuss its divergence pattern and explore how it responded in a stepwise fashion to pleistocene geologic and climatic changes. 267 individuals from 31 populations were sampled and 24 haplotypes wer ...201627314028
capparis spinosa leaves extract: source of bioantioxidants with nephroprotective and hepatoprotective effects.capparis spinosa, capparidaceae, is largely distributed all over the mediterranean basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. the aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of capparis spinosa leaves (mecs) associated with its phytochemical content. the levels of total phenolics, flavonoids and condensed tannins were 23.37mggae/g, 9.05mgqe/g and 9.35mgtae/g, respecti ...201728056421
capparis spinosa fruit ethanol extracts exert different effects on the maturation of dendritic cells.capparis spinosa l. (c. spinosa) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. here, we prepared the c. spinosa fruit ethanol extracts (cses) using different procedures and investigated the effects of cse on the maturation of mouse bone marrow-derived dendritic cells (dcs) in the absence or presence of lipopolysaccharide (lps). dc maturation and cytokine production were detected by flow cytometry and elisa, respectively. we obtained three ...201728067853
ferdinand hasbrouck's nitrous oxide caper--which one? 201626978140
optimised method for the analysis of phenolic compounds from caper (capparis spinosa l.) berries and monitoring of their changes during this work, an ad hoc method to identify and quantify polyphenols from caper berries was developed on high-performance liquid chromatography/electrospray ionisation source/mass spectrometry (hplc-esi-ms). the method was applied during fermentation carried out with lactobacillus pentosus om13 (trial s) and without starter (trial c). a total of five polyphenols were identified. all samples contained high concentrations of rutin. epicatechin was found in untreated fruits, on the contrary querceti ...201626593604
nematicidal activity of 2-thiophenecarboxaldehyde and methylisothiocyanate from caper (capparis spinosa) against meloidogyne pesticides based on plant extracts have recently gained interest in the development of nontoxic crop protection chemicals. numerous research studies are focused on the isolation and identification of new active compounds derived from plants. in this manuscript we report about the use of the mediterranean species capparis spinosa as a potent natural nematicidal agent against the root knot nematodes meloidogyne incognita. leaves, stems, and caper buds of capparis spinosa were used to obtain th ...201222769561
metabolomic study of wild and cultivated caper (capparis spinosa l.) from different areas of sardinia and their comparative evaluation.capparis spinosa l. (capparidaceae), also known as caper, is widely known for its very aromatic flower buds (capers),that are largely employed as a flavouring in cooking. capparis species are regarded as a potential source of important bioactive compounds, in fact, due to their botanical relationship with brassica species; they contain glucosinolates, secondary plant metabolites, that have been studied for their potential anticarcinogenic properties. in addition, the presence of other numerous b ...201627489055
natural products for the treatment of type 2 diabetes mellitus.type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. high blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from galega officin ...201526132858
committee on air pollution effects research: 40 years of uk air pollution.the uk committee on air pollution effects research (caper) was established 40 years ago. this special section was compiled to mark this anniversary. during this time there have been dramatic changes in the composition of the air over the uk. the four papers in this special section of environmental pollution represent the current air pollution effects research focus on ozone and nitrogen deposition, two related issues and are proving from a policy perspective to be quite intractable issues. the u ...201626586631
anti-diabetic effect of capparis spinosa l. root extract in diabetic rats.diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. to our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. in the present study the effects of the c. spinosa root extract on diabetic metabolic disorders have been studied in experimental diabetes.201726445712
influence of capparis spinosa and acacia arabica on certain biochemical haemolymph parameters of biomphalaria alexandrina.the work investigated the molluscicidal potency of dried capparis spinosa and acacia arabica leaves on selected biochemical parameters of bionimphalaria alexandrina, in order to render them, physiologically, unsuitable for s. mansoni infection or at least disturb the life-cycle of the parasite within its respective snail host. the effect of the two plants on lactate dehydrogenase (ldh), 5'-nucleotidase, acid phosphatase (ap), aspartate and alanine aminotransferases (ast & alt), alkaline phosphat ...200415287187
capparis spinosa l. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of cs in diabetic mice.201728348974
effect of capparis spinosa extract on sutural ossification: a stereological investigate the effects of systemically administered capparis spinosa extract (cse) on expanded sutures in rats via three dimensionally morphometric method (stereological method).201526043444
shifting tides in the emigration patterns of canadian physicians to the united states: a cross-sectional secondary data analysis.the relative ease of movement of physicians across the canada/us border has led to what is sometimes referred to as a 'brain drain' and previous analysis estimated that the equivalent of two graduating classes from canadian medical schools were leaving to practice in the us each year. both countries fill gaps in physician supply with international medical graduates (imgs) so the movement of canadian trained physicians to the us has international ramifications. medical school enrolments have been ...201627903252
anti-inflammatory potential of capparis spinosa l. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.several chronic inflammatory diseases are characterized by inappropriate cd4+ t cell response. in the present study, we assessed the ability of capparis spinosa l. (cs) preparation to orientate, in vivo, the immune response mediated by cd4+ t cells towards an anti-inflammatory response.201728143472
euphorbia factor l2 induces apoptosis in a549 cells through the mitochondrial pathway.euphorbia factor l2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of euphorbia lathyris l.), has been traditionally applied to treat cancer. this article focuses on the cytotoxic activity of euphorbia factor l2 against lung carcinoma a549 cells and the mechanism by which apoptosis is induced. we analyzed the cytotoxicity and related mechanism of euphorbia factor l2 with an mtt assay, an annexin v-fitc/pi test, a colorimetric assay, and immunoblotting. euphorbia factor l2 ...201728119809
caper 3.0: a scalable cloud-based system for data-intensive analysis of chromosome-centric human proteome project data sets.the chromosome-centric human proteome project (c-hpp) aims to catalog genome-encoded proteins using a chromosome-by-chromosome strategy. as the c-hpp proceeds, the increasing requirement for data-intensive analysis of the ms/ms data poses a challenge to the proteomic community, especially small laboratories lacking computational infrastructure. to address this challenge, we have updated the previous caper browser into a higher version, caper 3.0, which is a scalable cloud-based system for data-i ...201525794139
dynamic assessment of capparis spinosa buds on survival of periodontal ligament cells using a real-time cell analysis method.tooth avulsion is the most severe type of traumatic dental injuries and it results in the complete displacement of the tooth out of its socket in alveolar bone. reimplantation of the tooth is considered to be a best treatment modality due to its biological and psychological advantages. its prognosis depends on the extra alveolar time, the storage medium, and the patient's general health.201525772925
streptomyces capparidis sp. nov., a novel endophytic actinobacterium isolated from fruits of capparis spinosa l.a novel endophytic actinobacterial strain, designated egi 6500195t, was isolated from fruits of capparis spinosa. growth occurred at 10-45 °c (optimum 30 °c), at ph 6-8 (optimum ph 7) and in the presence of 0-1 % (w/v) nacl. strain egi 6500195t shared highest 16s rrna gene sequence similarity (97.74 %) with streptomyces vitaminophilus dsm 41686t and less than 97 % sequence similarity with other members of the genus streptomyces. the diagnostic amino acid in the peptidoglycan was ll-diaminopimeli ...201727902318
bacillus capparidis sp. nov., an endophytic bacterium isolated from roots of capparis spinosa l.a novel endophytic bacterium, designated strain egi 6500252t, was isolated from the surface-sterilized roots of a medicinal plant (capparis spinosa l.) collected from urumqi city, xinjiang, north-west china. cells were gram-stain-positive, non-motile, aerobic, catalase- and oxidase-positive, rod-shaped and did not display spore formation. strain egi 6500252t grew at 10-40 °c (optimum 25-30 °c), at ph 6.0-8.0 (optimum ph 7.0) and in the presence of 0-10 % (w/v) nacl (optimum 0-3 %). the major cel ...201727902223
antioxidant and antitumor activities of capparis spinosa l. and the related mechanisms.the 'ethnodrug' capparis spinosa l. has several pharmacological activities. first, it was found in previous experiments that an ethyl acetate extract of capparis spinosa l. (cse) exhibited antioxidant activity. in order to further research this finding, the present study investigate the blood biochemical indices, injury, energy metabolism, oxidative damage and mitochondrial membrane potential (δψm) level of cardiac cells to study the effect of cse on doxorubicin-induced cardiac toxicity. cse had ...201727878299
investigating the effects of capparis spinosa on hepatic gluconeogenesis and lipid content in streptozotocin-induced diabetic rats.the present study aimed to investigate the effects of administration of capparis spinosa (cs) fruit aqueous extract on liver metabolism in streptozotocin (stz)-induced diabetic rats. the aqueous extract of cs was orally administered at a dose of 20mg/kg for 28 consecutive days and then its effects on blood glucose, lipid and insulin levels in normal and stz diabetic rats were comparatively investigated. furthermore, the effects of cs on the activity and expression of the key enzymes of gluconeog ...201627810780
pharmacological effects of capparis spinosa l.medicinal plants have been known as one of the most important therapeutic agents since ancient times. during the last two decades, much attention has been paid to the health-promoting effects of edible medicinal plants, because of multiple beneficial effects and negligible adverse effects. capparis spinosa l. is one of the most common medicinal plants, used widely in different parts of the world to treat numerous human diseases. this paper aims to critically review the available scientific liter ...201627406313
polysaccharide of caper (capparis spinosa l.) leaf: extraction optimization, antioxidant potential and antimicrobial activity.three-variable-three-level box-behnken design-response surface methodology (bbd-rsm) based on the single-factor experiments was used to optimize the extracting parameters of crude polysaccharides (cpss) from the capparis spinosa leaves (csl) including extraction time (eti, 60-120min), extraction temperature (ete, 60-80°c), and the water/solid ratio (w/s, 6-16). the optimal process conditions in order to the highest yield (6.73%) of csl-cpss were 119.8min eti, 72.84°c ete, and 15.97:1w/s.structur ...201727865953
effect of flavonoids rich extract of capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of alzheimer's disease.alzheimer's disease (ad) is one of the most common forms of neurodegenerative diseases. despite vast ongoing researches focusing on the area, little is known about novel treatments. in this study, we aimed to survey the effects of capparis spinosa (c. spinosa) extract on amyloid-beta peptide (aβ)-injected rat.201627778760
effect of capparis spinosa linn. extract on lipopolysaccharide-induced cognitive impairment in rats.cognitive disorders in mankind are not uncommon. apart from neurodegenerative diseases such as alzheimer's (ad), various stresses also affect cognitive functions. plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. here, we evaluated effect of aqueous extract of caper (capparis spinosa) buds on lipopolysaccharide-induced cognitive impairment in rats using two different oral doses i.e. 10 (pre-treatment) and 30 mg/rat(post-treatmen ...201626934780
capparis spinosa l. promotes anti-inflammatory response in vitro through the control of cytokine gene expression in human peripheral blood mononuclear cells.capparis spinosa l. is an aromatic plant growing wild in dry regions around the mediterranean basin. capparis spinosa was shown to possess several properties such as antioxidant, antifungal, and anti-hepatotoxic actions. in this work, we aimed to evaluate immunomodulatory properties of capparis spinosa leaf extracts in vitro on human peripheral blood mononuclear cells (pbmcs) from healthy individuals.201627483999
a novel pattern of leaf movement: the case of capparis spinosa l.a novel type of heliotropic leaf movement is presented for capparis spinosa l., a summer perennial shrub of mediterranean and arid ecosystems. in contrast to plants that demonstrate uniform diaheliotropic and/or paraheliotropic movement for all their foliage, the alternate leaves of c. spinosa follow different movement patterns according to their stem azimuth and the side of the stem that they come from (cluster). additionally, leaf movement for each cluster may not be uniform throughout the day ...201627406206
patterns in volatile emission of different aerial parts of caper (capparis spinosa l.).we analyzed the spontaneous volatile emission of different aerial parts of the caper (capparis spinosa l.) by hs-spme-gc/ms. we identified 178 different compounds of which, in different proportions based on the sample type, the main ones were (e)-β-ocimene, methyl benzoate, linalool, β-caryophyllene, α-guaiene, germacrene d, bicyclogermacrene, germacrene b, (e)-nerolidol, isopropyl tetradecanoate, and hexahydrofarnesyl acetone. the multivariate statistical analyses seem to point out that the par ...201627276076
inhibitory effect on lipid absorption and variability of chemical constituents from capparis sicula subsp. sicula and capparis continuation of our research program on mediterranean dietary plants, a bioassay-guided fractionation of extracts from several accessions of capparis sicula subsp. sicula and capparis orientalis aerial parts was carried out. antilipidemic activity of samples was assayed using inhibition of pancreatic lipase. to study the metabolic variability in capparis species, hptlc analyses were performed in order to characterize the species through the detection, isolation, and quantitative evaluation of ...201627138247
an insight on the alkaloid content of capparis spinosa l. root by hplc-dad-ms, ms/ms and (1)h qnmr.the capparis spinosa l. has a wide distribution in the old world from south europe, north and east africa, madagascar, southwest and central asia to australia and oceania. the consolidated traditional use of c. spinosa root as remedy against different pains in human is well known since the antiquity. various secondary metabolites have been found in caper plant, nevertheless, few studies have been focused to the analysis of root constituents. to date, several free and glycosilated spermidine alka ...201626874255
effect of capparis spinosa l. on cognitive impairment induced by d-galactose in mice via inhibition of oxidative determine the phenolic acid levels and dna damage protection potential of capparis spinosa l. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an alzheimer disease mice model.201526738358
in vitro analysis of the role of the mitochondrial apoptosis pathway in csbe therapy against human gastric cancer.the caper plant (capparis spinosa l.) was a common uyghur folk medicine, and is a member of the capparidaceae family. in a previous study, the n-butanol extract of c. spinosa l. (csbe) was demonstrated to exert anti-tumor activity; however, the underlying mechanism is currently not understood. the present study aimed to elucidate the mechanism underlying the csbe-induced mitochondrial apoptotic pathway, in order to investigate the anti-tumor effects of this plant extract. csbe-induced apoptosis ...201526668648
genetic diversity analysis of capparis spinosa l. populations by using issr markers.capparis spinosa l. is an important medicinal species in the xinjiang province of china. ten natural populations of c. spinosa from 3 locations in north, central, and south xinjiang were studied using morphological trait inter simple sequence repeat (issr) molecular markers to assess the genetic diversity and population structure. in this study, the 10 issr primers produced 313 amplified dna fragments, with 52% of fragments being polymorphic. unweighted pair-group method with arithmetic average ...201526662446
anti-arthritic and antiinflammatory effects of the traditional uighur formula kursi caper in vivo.kursi caper (kc) is a uighur medicine based on caper which is widely used to treat arthritis and rheumatism, and preliminary studies in our laboratory showed that this traditional formula may possess potent antiinflammatory effects. this study confirms the antiinflammatory effect of kc in the adjuvant induced arthritis (aia) model, the carrageenan and cotton-pellet induced granuloma rat models, and further investigates in vivo the mechanism of action by measuring relevant indicators of anti-arth ...201526434647
correction: caper is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via err-α-gabpa and stress-induced adaptive responses via nf-κb-cmyc. 201526075908
field approach to mining-dump revegetation by application of sewage sludge co-compost and a commercial approach was devised for revegetation of a mining dump soil, sited in a semiarid region, with basic ph as well as fe and mn enrichment. a field experiment was conducted involving the use of co-compost (a mixture of urban sewage sludge and plant remains) along with a commercial biofertilizer (a gel suspension which contains arbuscular mycorrhizal fungus) to reinforce the benefits of the former. four treatments were studied: unamended soil; application of conditioners separately and in combinat ...201525979296
genetic diversity and host alternation of the egg parasitoid ooencyrtus pityocampae between the pine processionary moth and the caper bug.the increased use of molecular tools for species identification in recent decades revealed that each of many apparently generalist parasitoids are actually a complex of morphologically similar congeners, most of which have a rather narrow host range. ooencyrtus pityocampae (op), an important egg parasitoid of the pine processionary moth (ppm), is considered a generalist parasitoid. op emerges from ppm eggs after winter hibernation, mainly in spring and early summer, long before the eggs of the n ...201525856082
caper is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via err-α-gabpa and stress-induced adaptive responses via nf-κb-cmyc.ever since we developed mitochondria to generate atp, eukaryotes required intimate mito-nuclear communication. in addition, since reactive oxygen species are a cost of mitochondrial oxidative phosphorylation, this demands safeguards as protection from these harmful byproducts. here we identified a critical transcriptional integrator which eukaryotes share to orchestrate both nutrient-induced mitochondrial energy metabolism and stress-induced nuclear responses, thereby maintaining carbon-nitrogen ...201525830341
capparis spinosa reduces doxorubicin-induced cardio-toxicity in cardiomyoblast cells.doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose) exhibits potent antioxidant activity. so, in this study, we explored the protective effect of hydro-alcoholic extract of c. spinosa against dox-induced cytotoxicity in h9c2 cells.201727761417
screening of immunomodulatory activity of total and protein extracts of some moroccan medicinal plants.herbal and traditional medicines are being widely used in practice in many countries for their benefits of treating different ailments. a large number of plants in morocco were used in folk medicine to treat immune-related disorders. the objective of this study is to evaluate the immunomodulatory activity of protein extracts (pes) of 14 moroccan medicinal plants. this activity was tested on the proliferation of immune cells. the prepared total and pes of the plant samples were tested using mtt ( ...201322301818
genetic diversity and population structure of six species of capparis in tunisia using aflp order to study the genetic diversity, the phylogeographic pattern and hybridization between six tunisian capparis species, 213 accessions of caper were genotyped with three primer combinations of amplified fragment length polymorphism (aflp) markers. out of 750 fragments generated, 636 were polymorphic and 407 of them were restricted to a single species. structure and pcoa analyses clearly separated morphologically different populations into six distinct genetic ones. the upgma analysis group ...201727697367
acute effect of capparis spinosa root extracts on rat articular pain.capparis spinosa l. originates from dry regions of asia and mediterranean basin. in traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains.201627647009
the use of erlotinib in daily practice: a study on adherence and patients' experiences.adherence to pharmacological therapy is a complex and multi-factorial issue that can substantially alter the outcome of treatment. it has been shown that cancer patients, especially when using long-term medication, have similar adherence rates to those of patients with other diseases. the consequences of poor adherence are poor health outcomes and increased health care costs. only few studies have focused on the use of oral anticancer agents in daily practice. information about the reasons for n ...201121722354
[tissue culture and rapid propogation of seeds of uyghur traditional herbal capparis spinosa].to optimize the tissue culture and rapid proliferation techniques of seeds of capparis spinosa for producing large scale seedlings.201021548355
physicochemical properties of seeds of capparis species growing wild in turkey.while capparis spinosa var. herbaceace (2009) seeds collected from the mardin-midyat region contains the highest protein (22.25%), c. spinosa var. spinosa seeds (2009) collected from the muğla-milas region contained the lowest protein (18.25%). in addition, oil contents of c. spinosa and capparis ovata seeds changed between 27.74 to 31.09 and 28.66 to 31.40%, respectively. crude cellulose contents of c. spinosa and c. ovata seeds were found as 28.24 and 29.67%, respectively. it was found that as ...201424276494
correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in calabria (south italy).twenty samples of two caper species were collected from various natural habitats of calabria (south italy). a sample program was designed in order to cover all taxa and morphotypes present in the studied area, trying to correlate ecological conditions, phytochemical content, and biological activities. these species were characterized through the detection, isolation, and capillary gc-gc/ms quantitative evaluation of chemical markers (phytosterols and vitamin e). the antioxidant activity of meoh ...201121404435
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