| fatal mucormycosis presenting as an appendiceal mass with metastatic spread to the liver during chemotherapy-induced granulocytopenia. | opportunistic fungal infections occur with increasing frequency during chemotherapy induced granulocytopenia. a 27-year-old woman developed mucormycosis in the ileocecal region with fatal dissemination to the liver while receiving consolidation therapy for acute t-lymphoblastic leukemia. the infection occurred during a period of decreased colonization resistance in the intestinal tract. early symptoms were high fever unresponsive to broad spectrum antibiotics, severe pain in the right lower abdo ... | 1990 | 2218411 |
| hepatic mucormycosis in a bone marrow transplant recipient who ingested naturopathic medicine. | this case report describes a bone marrow transplant recipient in whom hepatic zygomycosis developed after ingestion of multiple naturopathic medicines. mucor was isolated from the patient's liver aspirate and from one of the naturopathic medicines. arbitrary-primed polymerase chain reaction (pcr) analyses were performed on the mucor isolates from the patient's liver aspirate and from his naturopathic medicine to see if they were genotypically related. mucor indicus was the species identified in ... | 1996 | 8852973 |
| mucor indicus necrotizing fasciitis. | | 2001 | 11589747 |
| ethanol production from hexoses, pentoses, and dilute-acid hydrolyzate by mucor indicus. | consumption of hexoses and pentoses and production of ethanol by mucor indicus were investigated in both synthetic media and dilute-acid hydrolyzates. the fungus was able to grow in a poor medium containing only carbon, nitrogen, phosphate, potassium, and magnesium sources. however, the cultivation took more than a week and the ethanol yield was only 0.2 gg(-1). enrichment of the medium by addition of trace metals, particularly zinc and yeast extract, improved the growth rate and yield, such tha ... | 2005 | 15780667 |
| fed-batch cultivation of mucor indicus in dilute-acid lignocellulosic hydrolyzate for ethanol production. | mucor indicus fermented dilute-acid lignocellulosic hydrolyzates to ethanol in fed-batch cultivation with complete hexose utilization and partial uptake of xylose. the fungus was tolerant to the inhibitors present in the hydrolyzates. it grew in media containing furfural (1 g/l), hydroxymethylfurfural (1 g/l), vanillin (1 g/l), or acetic acid (7 g/l), but did not germinate directly in the hydrolyzate. however, with fed-batch methodology, after initial growth of m. indicus in 500 ml enzymatic whe ... | 2005 | 16215856 |
| fungemia secondary to gastrointestinal mucor indicus infection. | | 2006 | 16323109 |
| molecular identification of zygomycetes from culture and experimentally infected tissues. | mucormycosis is an emerging infection associated with a high mortality rate. identification of the causative agents remains difficult and time-consuming by standard mycological procedures. in this study, internal transcribed spacer (its) sequencing was validated as a reliable technique for identification of zygomycetes to the species level. furthermore, species identification directly from infected tissues was evaluated in experimentally infected mice. fifty-four zygomycetes strains belonging to ... | 2006 | 16455881 |
| gastrointestinal zygomycosis caused by mucor indicus in a patient with acute traumatic brain injury. | we report a gastrointestinal infection caused by mucor indicus in a patient with severe head injuries. monotherapy with high-dose liposomal amphotericin b successfully eradicated the mucormycosis. nevertheless, subsequently a hemicolectomy was necessary due to recurrent bleeding from a deep ulcer. mucor indicus is an uncommon fungal pathogen, typically found in starters used for food fermentation. reviewing other reports on mucor indicus infections, primary gastrointestinal manifestations seem t ... | 2006 | 17071566 |
| production of feed enzymes (phytase and plant cell wall hydrolyzing enzymes) by mucor indicus mtcc 6333: purification and characterization of phytase. | the production of phytase and associated feed enzymes (phosphatase, xylanase, cmcase, alpha-amylase and beta-glucosidase) was determined in a thermotolerant fungus mucor indicus mtcc 6333, isolated from composting soil. solid-substrate culturing on wheat bran and optimizing other culture conditions (c and n sources, level of n, temperature, ph, culture age, inoculum level), increased the yield of phytase from 266 +/- 0.2 to 513 +/- 0.4 nkat/g substrate dry mass. the culture extract also containe ... | 2007 | 18298046 |
| fatal zygomycosis caused by mucor indicus in a child with an implantable left ventricular assist device. | mucor indicus is a rare, emerging cause of zygomycosis with 7 cases previously reported since 1975. we report the first case of endovascular m. indicus infection in a pediatric recipient of the incor (berlin heart ag, germany) implantable left ventricular assist device, and review the literature to describe the broadening clinical spectrum of zygomycosis caused by this emerging fungal pathogen. | 2008 | 18316980 |
| wet oxidation pretreatment, enzymatic hydrolysis and simultaneous saccharification and fermentation of clover-ryegrass mixtures. | the potential of clover (trifolium repens) and ryegrass (lolium perenne) mixtures as raw materials for ethanol production was investigated. wet oxidation, at 175, 185 or 195 degrees c during 10min at two different oxygen pressures and with either addition or no addition of sodium carbonate, was evaluated as pretreatment method for clover-ryegrass mixtures. the enzymatic hydrolysis of cellulose was significantly improved after pretreatment. the highest conversion efficiency, 93.6%, was achieved f ... | 2008 | 18514510 |
| production of ethanol by filamentous and yeast-like forms of mucor indicus from fructose, glucose, sucrose, and molasses. | the fungus mucor indicus is found in this study able to consume glucose and fructose, but not sucrose in fermentation of sugarcane and sugar beet molasses. this might be an advantage in industries which want to selectively remove glucose and fructose for crystallisation of sucrose present in the molasses. on the other hand, the fungus assimilated sucrose after hydrolysis by the enzyme invertase. the fungus efficiently grew on glucose and fructose and produced ethanol in synthetic media or from m ... | 2008 | 18712551 |
| determination of glucosamine and n-acetyl glucosamine in fungal cell walls. | a new method was developed to determine glucosamine (glcn) and n-acetyl glucosamine (glcnac) in materials containing chitin and chitosan, such as fungal cell walls. it is based on two steps of hydrolysis with (i) concentrated sulfuric acid at low temperature and (ii) dilute sulfuric acid at high temperature, followed by one-step degradation with nitrous acid. in this process, chitin and chitosan are converted into anhydromannose and acetic acid. anhydromannose represents the sum of glcn and glcn ... | 2008 | 18729456 |
| spectrum of zygomycete species identified in clinically significant specimens in the united states. | several members of the order mucorales (subphylum mucoromycotina) are important agents of severe human infections. the identification of these fungi by using standard mycologic methods is often difficult and time consuming. frequently, the etiological agent in clinical cases is reported either as a mucor sp., which is not the most frequent genus of zygomycetes, or only as a member of the mucorales. for this reason, the actual spectrum of species of zygomycetes and their incidences in the clinica ... | 2009 | 19386856 |
| effects of different growth forms of mucor indicus on cultivation on dilute-acid lignocellulosic hydrolyzate, inhibitor tolerance, and cell wall composition. | the dimorphic fungus mucor indicus was grown in different forms classified as purely filamentous, mostly filamentous, mostly yeast-like and purely yeast-like, and the relationship between morphology and metabolite production, inhibitor tolerance and the cell wall composition was investigated. low concentrations of spores in the inoculum with subsequent aeration promoted filamentous growth, whereas higher spore concentrations and anaerobic conditions promoted yeast-like growth. ethanol was the ma ... | 2009 | 19631243 |
| genotypic analysis of mucor from the platypus in australia. | mucor amphibiorum is the only pathogen known to cause significant morbidity and mortality in the free-living platypus (ornithorhynchus anatinus) in tasmania. infection has also been reported in free-ranging cane toads (bufo marinus) and green tree frogs (litoria caerulea) from mainland australia but has not been confirmed in platypuses from the mainland. to date, there has been little genotyping specifically conducted on m. amphibiorum. a collection of 21 mucor isolates representing isolates fro ... | 2010 | 20090018 |
| a pilot study on lignocelluloses to ethanol and fish feed using nmmo pretreatment and cultivation with zygomycetes in an air-lift reactor. | a complete process for the production of bioethanol and fungal biomass from spruce and birch was investigated. the process included milling, pretreatment with n-methylmorpholine-n-oxide (nmmo), washing of the pretreated wood, enzymatic hydrolysis, and cultivation of the zygomycetes fungi mucor indicus. investigated factors included wood chip size (0.5-16 mm), pretreatment time (1-5h), and scale of the process from bench-scale to 2m high air-lift reactor. best hydrolysis yields were achieved from ... | 2010 | 21247759 |
| synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates). | novel bis cyclohexenone ester derivatives 14-19 were synthesized and characterized by their spectral data. in vitro microbiological evaluations were carried out for all the novel compounds 14-19 against clinically isolated bacterial and fungal strains. compounds 15, 16, 18 against staphylococcus aureus, 14, 15 against ß-haemolytic streptococcus, 15, 19 against micrococcus luteus, 17, 18 against salmonella typhii, 14, 17 against shigella flexneri, 15 against escherichia coli, 16 against pseudomon ... | 2011 | 21417963 |
| antimicrobial activity of protease inhibitor from leaves of coccinia grandis (l.) voigt. | antimicrobial activity of protease inhibitor isolated from coccinia grandis (l.) voigt. has been reported. a 14.3 kda protease inhibitor (pi) was isolated and purified to homogeneity by ammonium sulfate precipitation (20-85% saturation), sephadex g-75, deae sepharose column and trypsin-sepharose affinity chromatography from the leaves of c. grandis. the purity was checked by reverse phase high performance liquid chromatography. pi exhibited marked growth inhibitory effects on colon cell lines in ... | 2011 | 21615062 |
| fungal autolysate as a nutrient supplement for ethanol and chitosan production by mucor indicus. | mucor indicus can be used to produce ethanol from a variety of sugars, including pentose's. an extract of it, produced by autolysis, could replace yeast extract in culture medium with improved production of ethanol. at 10 g l(-1), the extract gave a higher ethanol yield (0.47 g g(-1)) and productivity (0.71 g l(-1) h(-1)) compared to medium containing yeast extract (yield 0.45 g g(-1); productivity 0.67 g l(-1) h(-1)). | 2011 | 21842395 |
| evaluation of luminex xtag fungal analyte-specific reagents for rapid identification of clinically relevant fungi. | invasive fungal infections (ifi) remain a serious threat to immunocompromised hosts. current diagnostic methods, including fungal culture and antigen detection, are slow and often lack specificity. rapid diagnostic tools with increased sensitivity and specificity could improve the care of patients with ifi. recently, luminex molecular diagnostics (toronto, canada) developed 23 analyte-specific reagents (asrs) for the detection of the most common clinically relevant fungi. this study's objective ... | 2011 | 21880976 |
| in vitro microbiological evaluation of 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1h-pyrazole-5,1-(4h,5h)-diyl))diethanones, novel bisacetylated pyrazoles. | novel 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1h-pyrazole-5,1-(4h,5h)-diyl))diethanones 7-12 were tested for their antimicrobial activity by disc diffusion and twofold serial dilution method against the tested bacterial and fungal strains. compounds 7 against micrococcus luteus, 8 against β-heamolytic streptococcus, m. luteus, klebsiella pneumonia, microsporum gypseum, 9 against staphylococcus aureus, shigella flexneri, vibreo cholerae, pseudomonas aeruginosa, aspergillus flavus, mucor indicus, 10 ... | 2011 | 22373408 |
| biogenic silver nanoparticles by gelidiella acerosa extract and their antifungal effects. | the synthesis, characterization and application of biologically synthesized nanomaterials are an important aspect in nanotechnology. the present study deals with the synthesis of silver nanoparticles (ag-nps) using the aqueous extract of red seaweed gelidiella acerosa as the reducing agent to study the antifungal activity. the formation of ag-nps was confirmed by uv-visible spectroscopy, x-ray diffraction (xrd) pattern, scanning electron microscopy (sem) and transmission electron microscopy (tem ... | 2011 | 23408653 |
| new insight into microbial diversity and functions in traditional vietnamese alcoholic fermentation. | the roles of microorganisms in traditional alcoholic fermentation are often assumed based on abundance in the starter and activity in pure culture. there is a serious lack of hard evidence on the behavior and activity of individual microbial species during the actual fermentation process. in this study, microbial succession and metabolite changes during 7days of traditional vietnamese alcoholic fermentation were monitored. special attention was devoted to starch degradation. in total, 22 microbi ... | 2016 | 27236224 |
| fungal infections after boston type 1 keratoprosthesis implantation: literature review and in vitro antifungal activity of hypochlorous acid. | to review the current literature describing cases of fungal keratitis and endophthalmitis after boston keratoprosthesis (kpro) implantation and to characterize the antifungal activity of 0.01% hypochlorous acid against medically relevant fungi. | 2015 | 26488624 |
| multicenter evaluation of mic distributions for epidemiologic cutoff value definition to detect amphotericin b, posaconazole, and itraconazole resistance among the most clinically relevant species of mucorales. | clinical breakpoints (cbps) have not been established for the mucorales and any antifungal agent. in lieu of cbps, epidemiologic cutoff values (ecvs) are proposed for amphotericin b, posaconazole, and itraconazole and four mucorales species. wild-type (wt) mic distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled clsi mics from 14 laboratories (argentina, australia, canada, europe, india, mexico, and the unite ... | 2015 | 25583714 |
| dna barcoding in mucorales: an inventory of biodiversity. | the order mucorales comprises predominantly fast-growing saprotrophic fungi, some of which are used for the fermentation of foodstuffs but it also includes species known to cause infections in patients with severe immune or metabolic impairments. to inventory biodiversity in mucorales its barcodes of 668 strains in 203 taxa were generated covering more than two thirds of the recognised species. using the its sequences, molecular operational taxonomic units were defined by a similarity threshold ... | 2013 | 24027345 |
| impact of phosphate, potassium, yeast extract, and trace metals on chitosan and metabolite production by mucor indicus. | in this study the effects of phosphate, potassium, yeast extract, and trace metals on the growth of mucor indicus and chitosan, chitin, and metabolite production by the fungus were investigated. maximum yield of chitosan (0.32 g/g cell wall) was obtained in a phosphate-free medium. reversely, cell growth and ethanol formation by the fungus were positively affected in the presence of phosphate. in a phosphate-free medium, the highest chitosan content (0.42 g/g cell wall) and cell growth (0.66 g/g ... | 2016 | 27589726 |
| evaluation of mucor indicus and saccharomyces cerevisiae capability to ferment hydrolysates of rape straw and miscanthus giganteus as affected by the pretreatment method. | rape straw and miscanthus giganteus was pretreated chemically with oxalic acid or sodium hydroxide. the pretreated substrates were hydrolyzed with enzymatic preparations of cellulase, xylanase and cellobiase. the highest concentration of reducing sugars was achieved after hydrolysis of m. giganteus pretreated with naoh (51.53gdm(-3)). in turn, the highest yield of enzymatic hydrolysis determined based on polysaccharides content in the pretreated substrates was obtained in the experiments with m. ... | 2016 | 27107482 |
| co-production of fungal biomass derived constituents and ethanol from citrus wastes free sugars without auxiliary nutrients in airlift bioreactor. | the potential of two zygomycetes fungi, mucor indicus and rhizopus oryzae, in assimilating citrus waste free sugars (cwfs) and producing fungal chitosan, oil, and protein as well as ethanol was investigated. extraction of free sugars from citrus waste can reduce its environmental impact by decreasing the possibility of wild microorganisms growth and formation of bad odors, a typical problem facing the citrus industries. a total sugar concentration of 25.1 g/l was obtained by water extraction of ... | 2016 | 26927089 |
| hyphal tip cytoplasmic organization in four zygomycetous fungi. | we have examined the hyphal tip structure in four zygomycetous fungi: mortierella verticillata (mortierellales), coemansia reversa (kickxellales), mucor indicus and gilbertella persicaria (mucorales) using both light and transmission electron microscopy. we have used cryofixation and freeze-substitution methods to preserve fungal hyphae for transmission electron microscopy, which yielded improved preservation of ultrastructural details. our research has confirmed studies that described the accum ... | 2016 | 26908648 |
| effects of plant growth hormones on mucor indicus growth and chitosan and ethanol production. | the objective of this study was to investigate the effects of indole-3-acetic acid (iaa) and kinetin (kin) on mucor indicus growth, cell wall composition, and ethanol production. a semi-synthetic medium, supplemented with 0-5 mg/l hormones, was used for the cultivations (at 32 °c for 48 h). by addition of 1 mg/l of each hormone, the biomass and ethanol yields were increased and decreased, respectively. at higher levels, however, an inverse trend was observed. the glucosamine fraction of the cell ... | 2015 | 26204839 |
| downstream optimization of fungal-based simultaneous saccharification and fermentation relevant to lignocellulosic ethanol production. | to support the inefficient limitation of long-term biosystem by well-known simultaneous saccharification and fermentation (ssf), electron beam irradiated rice straw (at 80 kgy, 1 mev, and 0.12 ma) was fermented using fungal-based simultaneous saccharification and fermentation (fbssf) by saprophytic zygomycetes mucor indicus. based on the growth optimization (by response surface methodology), this eco-friendly bioprocess either without metabolic inhibitors (especially furfurals and acetic acids) ... | 2015 | 25713757 |
| successful treatment of a necrotizing fasciitis patient caused by mucor indicus with amphotericin b and skin grafting. | cutaneous mucormycosis, an uncommon disease caused by mucorales, predominantly occurs in immunocompromised host. the present case is a primary cutaneous mucormycosis due to mucor indicus in an immunocompetent individual. it is with the features of necrotizing fasciitis over the right pretibial area. we are presenting this case owing to its rarity and the successful treatment with amphotericin b and skin grafting. | 2014 | 24570041 |
| effect of phosphate on glucosamine production by ethanolic fungus mucor indicus. | in this study, the effect of phosphorous compound concentration on the production of glucosamine by mucor indicus was investigated. changes in the yield of ethanol, the major metabolite of the fungus, were also followed besides. the alkali insoluble material of the biomass of the fungus mainly contained phosphates and polymers of glucosamine and n-acetyl glucosamine, i.e., chitin and chitosan. yields of glucosamine (78-113 g/kg dry fungal biomass) and ethanol (200-370 g/kg glucose) were signific ... | 2013 | 23963717 |
| [fatal zygomycosis caused by mucor indicus after haplo-identical stem cell transplantation]. | a 62-year-old woman with acute lymphoblastic leukemia in first complete remission was treated with unrelated cord blood transplantation, but exhibited primary graft failure. she then underwent hla-haploidentical peripheral blood stem cell transplantation from her daughter. the conditioning regimen consisted of fludarabine 30 mg/m(2)/day for 6 days, intravenous busulfan 3.2 mg/kg/day for 2 days, and thymoglobulin 1 mg/kg/day for 2 days. voriconazole was administered to prevent fungal infections. ... | 2013 | 23676649 |
| mucor indicus: biology and industrial application perspectives: a review. | mucor indicus, one of the most important strains of zygomycetes fungi, has been the subject of several studies since a couple of hundred years ago. this fungus, regarded as a non-pathogenic dimorphic microorganism, is used for production of several beers and foods. morphology of the fungus can be manipulated and well controlled by changing a number of parameters. furthermore, m. indicus can grow on a variety of substrates including lignocellulosic hydrolysates which are mixtures of hexoses, pent ... | 2013 | 23376652 |
| determination of glucosamine in fungal cell walls by high-performance liquid chromatography (hplc). | glucosamine (glcn) is a major and valuable component in the cell wall of zygomycetes fungi. in this study, a time independent and accurate method was developed for the determination of glcn. in this method, the cell wall was treated via a two-stage sulfuric acid process, and chitin and chitosan were fully deacetylated, partially depolymerized, and converted to glcn oligosaccharides. then, the oligosaccharides were deaminated to 2,5-anhydromannose using nitrous acid. finally, 2,5-anhydromannose w ... | 2012 | 23038987 |
| phylogenetic analysis reveals two genotypes of the emerging fungus mucor indicus, an opportunistic human pathogen in immunocompromised patients. | mucormycosis is a rare fungal infection caused by mucor indicus. phylogenetic analysis of many m. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, i and ii, based on its and d1/d2 lsu rdna sequences. a retrospective review of the literature revealed 13 cases. eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. a pulmonary infection caused by m. indicus genotype i in a liver ... | 2017 | 28698667 |
| characterization of microbial communities in chinese rice wine collected at yichang city and suzhou city in china. | two typical microbial communities from chinese rice wine fermentation collected in yichang city and suzhou city in china were investigated. both communities could ferment glutinous rice to rice wine in 2 days. the sugar and ethanol contents were 198.67 and 14.47 mg/g, respectively, for rice wine from yichang city, and 292.50 and 12.31 mg/g, respectively, for rice wine from suzhou city. acetic acid and lactic acid were the most abundant organic acids. abundant fungi and bacteria were detected in ... | 2017 | 28621110 |
| structural features influential to enzymatic hydrolysis of cellulose-solvent-based pretreated pinewood and elmwood for ethanol production. | dissolution of lignocelluloses in n-methylmorpholine-n-oxide (nmmo or nmo) at moderate conditions, e.g., 120 °c for 3 h under atmospheric pressure, and regeneration with water, is among the most effective nonderivatization pretreatment for the improvement of enzymatic hydrolysis and ethanol production. the effects of the pretreatment on two different types of wood, hardwood elm and softwood pine, were compared via physicochemical structural analyses, i.e., ftir, xrd, sem, tga, and enzyme adsorpt ... | 2018 | 29177719 |
| evaluation of antioxidant, dna targeting, antimicrobial and cytotoxic studies of imine capped copper and nickel nanoparticles. | in this work, we have synthesized pyrimidine derivatives of schiff base ligand 2-(4,6-dimethoxypyrimidin-2-ylimino)methyl)-6-methoxyphenol (dpmm) stabilized copper nanoparticles (dpmm-cunps) and nickel nanoparticles (dpmm-ninps) by modified brust-schiffrin technique as two step phase transfer assisted method and confirmed by uv-visible, sem and tem analysis. the free radical scavenging activity of dpmm, dpmm-cunps &dpmm-ninps with 2, 2'-diphenylpicryl hydrazyl (dpph), hydrogen peroxide (h2o2) su ... | 2018 | 29154198 |
| identification by pcr-dgge, sds-page, and maldi-tof ms of lab and fungi in laru, a fermented starter. | laru samples obtained from the upper part of borneo island were analyzed for their lactic acid bacterial (lab) and fungal diversity using both a culture-independent method (pcr-dgge) and culture-dependent methods (sds-page and maldi-tof ms). pediococcus pentosaceus, lactobacillus brevis, saccharomycopsis fibuligera, hyphopichia burtonii, and kodamaea ohmeri were detected by all three methods. in addition, weissella cibaria, weissella paramesenteroides, leuconostoc citreum, leuconostoc mesenteroi ... | 2017 | 29081085 |
| new pyrimidine based ligand capped gold and platinum nano particles: synthesis, characterization, antimicrobial, antioxidant, dna interaction and in vitro anticancer activities. | in this research work, we have synthesized new pyrimidine based schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (dpmm) capped gold (au) and platinum (pt) nanoparticles (nps) by modified brust-schiffrin method. the characteristics of dpmm-au nps and dpmm-pt nps have been examined by uv-visible, ftir, sem, tem and powder xrd analysis. sem analysis result shows that surface morphology of the dpmm-au nps and dpmm-pt nps are in granular and spherical shape, corr ... | 2017 | 28941777 |
| antifungal and anticancer potential of argemone mexicana l. | background: medicinal plants are widely used to treat infectious diseases, metabolic disorders and cancer. argemone mexicana l. (a. mexicana), commonly found on desolate land of marathwada (maharashtra, india) has been used to treat oral cavity infections. methods: in this study, cold aqueous and methanolic extracts were prepared from a. mexicana stem and leaves. these extracts were tested for their antifungal and anticancer activities. the antifungal activity was tested using the agar well diff ... | 2016 | 28930138 |