| spondweni virus infection in a foreign resident of upper volta. | spondweni virus is a mosquito-borne flavivirus previously reported to cause human disease in southern and west africa. a serologically confirmed case of spondweni virus infection in a u.s. citizen residing in upper volta is reported. symptoms included fever, chills, headache, myalgia, nausea, and rash. a greyish mucoid lining was present on the posterior pharynx. the differential diagnosis included rickettsial infection, leptospirosis, typhoid fever, and numerous viral illnesses including lassa ... | 1982 | 6128599 |
| acute spotted fever rickettsiosis among febrile patients, cameroon. | although potential arthropod vectors are abundant in cameroon, acute febrile illnesses are rarely evaluated for arboviral or rickettsial infections. serum samples from 234 acutely febrile patients at clinics in tiko and buea, cameroon, were examined for antibodies to rickettsia africae and african alphaviruses and flaviviruses. these serum samples did not contain antibodies against typhoid, and blood malarial parasites were not detected. serum samples of 32% contained immunoglobulin m antibodies ... | 2004 | 15109409 |
| genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the flavivirus genus based on the 3' noncoding region. | genetic relationships among flaviviruses within the yellow fever (yf) virus genetic group were investigated by comparing nucleotide sequences of the 3' noncoding region (3'ncr). size heterogeneity was observed between members and even among strains of the same viral species. size variation between yf strains was due to duplications and/or deletions of repeated nucleotide sequence elements (ryf). west african genotypes had three copies of the ryf (ryf1, ryf2, and ryf3); the angola and the east an ... | 2004 | 15331698 |
| genetic and serologic properties of zika virus associated with an epidemic, yap state, micronesia, 2007. | zika virus (zikv) is a mosquito-borne flavivirus first isolated in uganda from a sentinel monkey in 1947. mosquito and sentinel animal surveillance studies have demonstrated that zikv is endemic to africa and southeast asia, yet reported human cases are rare, with <10 cases reported in the literature. in june 2007, an epidemic of fever and rash associated with zikv was detected in yap state, federated states of micronesia. we report the genetic and serologic properties of the zikv associated wit ... | 2008 | 18680646 |
| characterization of a novel flavivirus from mosquitoes in northern europe that is related to mosquito-borne flaviviruses of the tropics. | a novel flavivirus was isolated from mosquitoes in finland, representing the first mosquito-borne flavivirus from northern europe. the isolate, designated lammi virus (lamv), was antigenically cross-reactive with other flaviviruses and exhibited typical flavivirus morphology as determined by electron microscopy. the genomic sequence of lamv was highly divergent from the recognized flaviviruses, and yet the polyprotein properties resembled those of mosquito-borne flaviviruses. phylogenetic analys ... | 2009 | 19570865 |
| genomics and evolution of aedes-borne flaviviruses. | we analysed the complete coding sequences of all recognized species of aedes-borne flavivirus, including previously uncharacterized viruses within the yellow fever virus (yfv), spondweni virus (spov) and dengue virus (denv) groups. two major phylogenetic lineages were revealed: one included the yfv and entebbe bat virus groups, and the other included the denv, spov and culex-borne flavivirus groups. this analysis supported previous evidence that culex-borne flaviviruses have evolved from ancestr ... | 2010 | 19741066 |
| zika virus outside africa. | zika virus (zikv) is a flavivirus related to yellow fever, dengue, west nile, and japanese encephalitis viruses. in 2007 zikv caused an outbreak of relatively mild disease characterized by rash, arthralgia, and conjunctivitis on yap island in the southwestern pacific ocean. this was the first time that zikv was detected outside of africa and asia. the history, transmission dynamics, virology, and clinical manifestations of zikv disease are discussed, along with the possibility for diagnostic con ... | 2009 | 19788800 |
| structure of yellow fever virus envelope protein domain iii. | the structure of recombinant domain iii of the envelope protein (red3) of yellow fever virus (yfv), containing the major neutralization site, was determined using nmr spectroscopy. the amino acid sequence and structure of the yfv-red3 shows differences from ed3s of other mosquito-borne flaviviruses; in particular, the partially surface-exposed bc loop where methionine-304 and valine-324 were identified as being critical for the structure of the loop. variations in the structure and surface chemi ... | 2009 | 19818466 |
| structure and functionality in flavivirus ns-proteins: perspectives for drug design. | flaviviridae are small enveloped viruses hosting a positive-sense single-stranded rna genome. besides yellow fever virus, a landmark case in the history of virology, members of the flavivirus genus, such as west nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. additional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. nevertheless, u ... | 2010 | 19945487 |
| Tembusu virus in ducks, china. | In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%-91% identity with strains of Tembusu virus, a mosquito-borne flavivirus of the Ntaya virus group. These findings demonstrate emergence of Tembusu virus in ducks. | 2011 | 22000358 |
| an updated checklist of mosquito species (diptera: culicidae) from madagascar. | an updated checklist of 235 mosquito species from madagascar is presented. the number of species has increased considerably compared to previous checklists, particularly the last published in 2003 (178 species). this annotated checklist provides concise information on endemism, taxonomic position, developmental stages, larval habitats, distribution, behavior, and vector-borne diseases potentially transmitted. the 235 species belong to 14 genera: aedeomyia (3 species), aedes (35 species), anophel ... | 2016 | 27101839 |
| zikavr: an integrated zika virus resource for genomics, proteomics, phylogenetic and therapeutic analysis. | current zika virus (zikv) outbreaks that spread in several areas of africa, southeast asia, and in pacific islands is declared as a global health emergency by world health organization (who). it causes zika fever and illness ranging from severe autoimmune to neurological complications in humans. to facilitate research on this virus, we have developed an integrative multi-omics platform; zikavr (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the zikv genomic, proteomic and therapeutic ... | 2016 | 27633273 |
| development of one-step quantitative reverse transcription pcr for the rapid detection of flaviviruses. | the genus flavivirus includes several pathogenic agents that cause severe illness in humans. re-emergence of west nile virus in europe and continuous spread of certain flaviviruses such as dengue, yellow fever and japanese encephalitis viruses represent a global danger to public health. therefore, a rapid and accurate molecular method is required for diagnostics and epidemiological surveillance of flaviviruses. | 2013 | 23410000 |
| ecuador paraiso escondido virus, a new flavivirus isolated from new world sand flies in ecuador, is the first representative of a novel clade in the genus flavivirus. | a new flavivirus, ecuador paraiso escondido virus (epev), named after the village where it was discovered, was isolated from sand flies (psathyromyia abonnenci, formerly lutzomyia abonnenci) that are unique to the new world. this represents the first sand fly-borne flavivirus identified in the new world. epev exhibited a typical flavivirus genome organization. nevertheless, the maximum pairwise amino acid sequence identity with currently recognized flaviviruses was 52.8%. phylogenetic analysis o ... | 2015 | 26355096 |
| illustrating and homology modeling the proteins of the zika virus. | the zika virus (zikv) is a flavivirus of the family flaviviridae, which is similar to dengue virus, yellow fever and west nile virus. recent outbreaks in south america, latin america, the caribbean and in particular brazil have led to concern for the spread of the disease and potential to cause guillain-barré syndrome and microcephaly. although zikv has been known of for over 60 years there is very little in the way of knowledge of the virus with few publications and no crystal structures. no an ... | 2016 | 27746901 |
| characterization of a novel insect-specific flavivirus from brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses. | in the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. we recently described the isolation of a novel flavivirus (tentatively designated 'nhumirim virus'; nhuv) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. we characterized the in vitro growth p ... | 2014 | 25146007 |
| filovirus research in gabon and equatorial africa: the experience of a research center in the heart of africa. | health research programs targeting the population of gabon and equatorial africa at the international center for medical research in franceville (cirmf), gabon, have evolved during the years since its inception in 1979 in accordance with emerging diseases. since the reemergence of ebola virus in central africa, the cirmf "emerging viral disease unit" developed diagnostic tools and epidemiologic strategies and transfers of such technology to support the response of the national public health syst ... | 2012 | 23170174 |
| molecular evolution of zika virus during its emergence in the 20(th) century. | zika virus (zikv) is a mosquito-borne flavivirus first isolated in uganda in 1947. although entomological and virologic surveillance have reported zikv enzootic activity in diverse countries of africa and asia, few human cases were reported until 2007, when a zika fever epidemic took place in micronesia. in the context of west africa, the who collaborating centre for arboviruses and hemorrhagic fever at institut pasteur of dakar (http://www.pasteur.fr/recherche/banques/crora/) reports the period ... | 2014 | 24421913 |
| zika virus infection after travel to tahiti, december 2013. | | 0 | 25062427 |
| zika virus: indian perspectives. | the emergence of zika virus (ziv), a mosquito borne flavivirus like dengue (den) and chikungunya (chik), in brazil in 2014 and its spread to various countries have led to a global health emergency. aedes aegypti is the major vector for ziv. fast dissemination of this virus in different geographical areas posses a major threat especially to regions where the population lacks herd immunity against the ziv and there is abundance of aedes mosquitoes. in this review, we focus on current global scenar ... | 0 | 27487998 |
| isolation of zika virus from febrile patient, indonesia. | | 0 | 27088970 |
| zika virus: new clinical syndromes and its emergence in the western hemisphere. | zika virus (zikv) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. in this review, we discuss the history and epidemiology of zikv infection, recent outbreaks in oceania and the emergence of zikv in the western hemisphere, newly ascribed complications of zikv infection, including guillain-barré syndrome and microce ... | 2016 | 26962217 |
| zika virus: the latest newcomer. | since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: west nile, influenza a, avian flu, dengue, chikungunya, sars, mers, ebola, and now zika, the latest newcomer. zika virus (zikv), a flavivirus transmitted by aedes mosquitoes, was identified in 1947 in a sentinel monkey in uganda, and later on in humans in nigeria. the virus was mainly confined to the african continent until it was detected in south-east asia the 1980's, t ... | 2016 | 27148186 |
| zika virus: diagnostics for an emerging pandemic threat. | zika virus (zikv) is anaedesmosquito-borne flavivirus that emerged in brazil in 2015 and then rapidly spread throughout the tropical and subtropical americas. based on clinical criteria alone, zikv cannot be reliably distinguished from infections with other pathogens that cause an undifferentiated systemic febrile illness, including infections with two common arboviruses, dengue virus and chikungunya virus. this minireview details the methods that are available to diagnose zikv infection. | 2016 | 26888897 |
| zika virus infection, philippines, 2012. | | 0 | 25811410 |
| genetic characterization of zika virus strains: geographic expansion of the asian lineage. | zika virus (zikv) is a mosquito-borne flavivirus distributed throughout much of africa and asia. infection with the virus may cause acute febrile illness that clinically resembles dengue fever. a recent study indicated the existence of three geographically distinct viral lineages; however this analysis utilized only a single viral gene. although zikv has been known to circulate in both africa and asia since at least the 1950s, little is known about the genetic relationships between geographicall ... | 2012 | 22389730 |
| comparative genomic analysis of pre-epidemic and epidemic zika virus strains for virological factors potentially associated with the rapidly expanding epidemic. | less than 20 sporadic cases of human zika virus (zikv) infection were reported in africa and asia before 2007, but large outbreaks involving up to 73% of the populations on the pacific islands have started since 2007, and spread to the americas in 2014. moreover, the clinical manifestation of zikv infection has apparently changed, as evident by increasing reports of neurological complications, such as guillain-barré syndrome in adults and congenital anomalies in neonates. we comprehensively comp ... | 2016 | 26980239 |
| zika virus: medical countermeasure development challenges. | reports of high rates of primary microcephaly and guillain-barré syndrome associated with zika virus infection in french polynesia and brazil have raised concerns that the virus circulating in these regions is a rapidly developing neuropathic, teratogenic, emerging infectious public health threat. there are no licensed medical countermeasures (vaccines, therapies or preventive drugs) available for zika virus infection and disease. the pan american health organization (paho) predicts that zika vi ... | 2016 | 26934531 |
| flavidb: a data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology. | the flavivirus genus is unusually large, comprising more than 70 species, of which more than half are known human pathogens. it includes a set of clinically relevant infectious agents such as dengue, west nile, yellow fever, and japanese encephalitis viruses. although these pathogens have been studied extensively, safe and efficient vaccines lack for the majority of the flaviviruses. | 0 | 25544857 |
| nonstructural proteins are preferential positive selection targets in zika virus and related flaviviruses. | the flavivirus genus comprises several human pathogens such as dengue virus (denv), japanese encephalitis virus (jev), and zika virus (zikv). although zikv usually causes mild symptoms, growing evidence is linking it to congenital birth defects and to increased risk of guillain-barré syndrome. zikv encodes a polyprotein that is processed to produce three structural and seven nonstructural (ns) proteins. we investigated the evolution of the viral polyprotein in zikv and in related flaviviruses (d ... | 2016 | 27588756 |
| zika virus genomic rna possesses conserved g-quadruplexes characteristic of the flaviviridae family. | zika virus has emerged as a global concern because neither a vaccine nor antiviral compounds targeting it exist. a structure for the positive-sense rna genome has not been established, leading us to look for potential g-quadruplex sequences (pqs) in the genome. the analysis identified >60 pqss in the zika genome. to minimize the pqs population, conserved sequences in the flaviviridae family were found by sequence alignment, identifying seven pqss in the prm, e, ns1, ns3, and ns5 genes. next, ali ... | 2016 | 27737553 |
| background review for diagnostic test development for zika virus infection. | to review the state of knowledge about diagnostic testing for zika virus infection and identify areas of research needed to address the current gaps in knowledge. | 0 | 27516635 |
| a literature review of zika virus. | zika virus is a mosquitoborne flavivirus that is the focus of an ongoing pandemic and public health emergency. previously limited to sporadic cases in africa and asia, the emergence of zika virus in brazil in 2015 heralded rapid spread throughout the americas. although most zika virus infections are characterized by subclinical or mild influenza-like illness, severe manifestations have been described, including guillain-barre syndrome in adults and microcephaly in babies born to infected mothers ... | 2016 | 27070380 |
| dengue virus rna structure specialization facilitates host adaptation. | many viral pathogens cycle between humans and insects. these viruses must have evolved strategies for rapid adaptation to different host environments. however, the mechanistic basis for the adaptation process remains poorly understood. to study the mosquito-human adaptation cycle, we examined changes in rna structures of the dengue virus genome during host adaptation. deep sequencing and rna structure analysis, together with fitness evaluation, revealed a process of host specialization of rna el ... | 2015 | 25635835 |
| assay optimization for molecular detection of zika virus. | to examine the diagnostic performance of real-time reverse transcription (rt)-polymerase chain reaction (pcr) assays for zika virus detection. | 0 | 27994281 |
| the mysterious zika virus: adding to the tropical flavivirus mayhem. | until now, known as the demure cousin of dengue virus (denv) inhabiting africa, zika virus (zikv) has reinvented itself to cause explosive epidemics captivating the western hemisphere. the outbreak causing potential for zikv was realized when it made its way from africa to yap island micronesia in 2007, and in french polynesia in 2013. from there, it moved on to brazil in 2015. now zikv has infected people in more than 33 countries in central and south america and the caribbean. moreover the epi ... | 0 | 27763483 |
| a comprehensive systems biology approach to studying zika virus. | zika virus (zikv) is responsible for an ongoing and intensifying epidemic in the western hemisphere. we examined the complete predicted proteomes, glycomes, and selectomes of 33 zikv strains representing temporally diverse members of the african lineage, the asian lineage, and the current outbreak in the americas. derivation of the complete selectome is an 'omics' approach to identify distinct evolutionary pressures acting on different features of an organism. employment of the m8 model did not ... | 2016 | 27584813 |
| zika virus outbreak, bahia, brazil. | | 0 | 26401719 |
| zika virus and the never-ending story of emerging pathogens and transfusion medicine. | in the last few years, the transfusion medicine community has been paying special attention to emerging vector-borne diseases transmitted by arboviruses. zika virus is the latest of these pathogens and is responsible for major outbreaks in africa, asia and, more recently, in previously infection-naïve territories of the pacific area. many issues regarding this emerging pathogen remain unclear and require further investigation. national health authorities have adopted different prevention strateg ... | 2015 | 26674815 |
| zika virus: an emergence of a new arbovirus. | the world is facing a new pandemic in progress due to a mosquito-borne flavivirus popularly known as zika virus. the emergence of this new virus is really alarming with the sudden increment in the cases of microcephaly reported from brazil. the findings attributing the involvement of zika virus as the reason for congenital deformations in the babies born in afflicted areas have really shocked the world. the present knowledge about this virus is very limited and in the absence of further studies ... | 2016 | 27630846 |
| genetic characterization of spondweni and zika viruses and susceptibility of geographically distinct strains of aedes aegypti, aedes albopictus and culex quinquefasciatus (diptera: culicidae) to spondweni virus. | zika virus (zikv) has extended its known geographic distribution to the new world and is now responsible for severe clinical complications in a subset of patients. while substantial genetic and vector susceptibility data exist for zikv, less is known for the closest related flavivirus, spondweni virus (sponv). both zikv and sponv have been known to circulate in africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. furthermore, the susceptibi ... | 2016 | 27783682 |
| distinguishing between zika and spondweni viruses. | | 0 | 27843157 |
| increasing genetic diversity of zika virus in the latin american outbreak. | | 2016 | 27381219 |
| concern over zika virus outbreak: another alarming global threat. | zika virus, as highlighted by the world health organization in february 2016, has emerged as a public health emergency of international concern. zika virus is enveloped and icosahedral, and has a nonsegmented, single-stranded, positive-sense rna genome. it belongs to flaviviridae family. aedes aegypticus mosquito is the known vector. transmission is anthroponotic (human to vector to human) during outbreaks, or occurs perinatally in utero, sexually, and via transfusion of infected blood. zika vir ... | 2016 | 27418843 |
| detection of autochthonous zika virus transmission in sincelejo, colombia. | | 0 | 27089253 |
| complete coding sequence of zika virus from martinique outbreak in 2015. | zika virus is an aedes-borne flavivirus causing fever, arthralgia, myalgia rash, associated with guillain-barré syndrome and suspected to induce microcephaly in the fetus. we report here the complete coding sequence of the first characterized caribbean zika virus strain, isolated from a patient from martinique in december, 2015. | 2016 | 27274849 |
| detection of zika virus infection in thailand, 2012-2014. | zika virus (zikv) is an emerging mosquito-borne pathogen with reported cases in africa, asia, and large outbreaks in the pacific. no autochthonous zikv infections have been confirmed in thailand. however, there have been several cases reported in travelers returning from thailand. here we report seven cases of acute zikv infection in thai residents across the country confirmed by molecular or serological testing including sequence data. these endemic cases, combined with previous reports in trav ... | 2015 | 26101272 |
| complete coding sequence of zika virus from a french polynesia outbreak in 2013. | zika virus is an arthropod-borne flavivirus member of the spondweni serocomplex, transmitted by aedes mosquitoes. we report here the complete coding sequence of a zika virus strain belonging to the asian lineage, isolated from an infected patient returning from french polynesia, an epidemic area in 2013/2014. | 2014 | 24903869 |
| imported zika virus infection from the cook islands into australia, 2014. | a female resident of townsville, queensland, australia has been diagnosed with zika virus infection following a recent trip to the cook islands. an initial serum sample collected in march, 2014 was positive by two separate zika virus taqman real-time rt-pcrs and a pan-flavivirus rt-pcr. nucleotide sequencing and phylogenetics of the complete cook islands zika virus envelope gene revealed 99.1% homology with a previous cambodia 2010 sequence within the asian lineage. in addition, igg and igm anti ... | 2014 | 24944843 |
| aedes (stegomyia) albopictus (skuse): a potential vector of zika virus in singapore. | zika virus (zikv) is a little known arbovirus until it caused a major outbreak in the pacific island of yap in 2007. although the virus has a wide geographic distribution, most of the known vectors are sylvatic aedes mosquitoes from africa where the virus was first isolated. presently, ae. aegypti is the only known vector to transmit the virus outside the african continent, though ae. albopictus has long been a suspected vector. currently, ae. albopictus has been shown capable of transmitting mo ... | 2013 | 23936579 |
| oral susceptibility of singapore aedes (stegomyia) aegypti (linnaeus) to zika virus. | zika virus (zikv) is a little known flavivirus that caused a major outbreak in 2007, in the south-western pacific island of yap. it causes dengue-like syndromes but with milder symptoms. in africa, where it was first isolated, zikv is mainly transmitted by sylvatic aedes mosquitoes. the virus has also been isolated from ae. aegypti and it is considered to be the vector involved in the urban transmission of the virus. transmission of the virus by an african strain of ae. aegypti has also been dem ... | 2012 | 22953014 |
| zika virus targets human stat2 to inhibit type i interferon signaling. | the ongoing epidemic of zika virus (zikv) illustrates the importance of flaviviruses as emerging human pathogens. all vector-borne flaviviruses studied thus far have to overcome type i interferon (ifn) to replicate and cause disease in vertebrates. the mechanism(s) by which zikv antagonizes ifn signaling is unknown. here, we report that the nonstructural protein ns5 of zikv and other flaviviruses examined could suppress ifn signaling, but through different mechanisms. zikv ns5 expression resulte ... | 2016 | 27212660 |
| infection with the chuku strain of spondweni virus. | | 1965 | 14269994 |
| isolation of spondweni virus from four species of culicine mosquitoes and a report of two laboratory infections with the virus. | | 1961 | 13774006 |
| studies on arthropod-borne viruses of tongaland. viii. spondweni virus, an agent previously unknown, isolated from taeniorhynchus (mansonioides) uniformis. | | 1957 | 13506708 |
| pathogenesis and sexual transmission of spondweni and zika viruses. | the spondweni serogroup of viruses (flaviviridae, flavivirus) is comprised of spondweni virus (sponv) and zika virus (zikv), which are mosquito-borne viruses capable of eliciting human disease. numerous cases of zikv sexual transmission in humans have been documented following the emergence of the asian genotype in the americas. the african zikv genotype virus was previously implicated in the first reported case of zikv sexual transmission. reports of sponv infection in humans have been associat ... | 2017 | 28985234 |
| monocyte-derived dendritic cells as model to evaluate species tropism of mosquito-borne flaviviruses. | several mosquito-borne flaviviruses such as japanese encephalitis virus (jev), west nile virus (wnv), dengue virus (denv), and zika virus (zikv) can cause severe clinical disease. being zoonotic, flaviviruses infect a wide variety of terrestrial vertebrates, which dependent of the virus-host interactions, can enhance ongoing epidemics and maintain the virus in the environment for prolonged periods. targeted species can vary from amphibians, birds to various mammals, dependent on the virus. for m ... | 2019 | 30746342 |
| multiplex real-time rt-pcr for detection and distinction of spondweni and zika virus. | zika (zikv) and spondweni viruses (spov) are closely related mosquito borne flaviviruses in the spondweni serogroup. the co-circulation and similar disease presentation following zikv and spov infection necessitates the development of a diagnostic tool for their simultaneous detection and distinction. we developed a one-step multiplex real-time rt-pcr (zikspov) to detect and distinguish between spov and zikv by utilizing a single primer set combined with virus specific hydrolysis probes. the zik ... | 2019 | 30731153 |
| dengue and zika virus cross-reactive human monoclonal antibodies protect against spondweni virus infection and pathogenesis in mice. | spondweni virus (spov) is the flavivirus that is most closely related to zika virus (zikv). although spov causes sporadic human infections in africa, recently it was found in culex mosquitoes in haiti. to investigate the pathogenic spectrum of spov, we developed infection models in mice. although two spov strains failed to cause disease in immunocompetent mice, each accumulated in the brain, spleen, eye, testis, and kidney when type i interferon signaling was blocked and unexpectedly caused infe ... | 2019 | 30726740 |
| spondweni virus in field-caught culex quinquefasciatus mosquitoes, haiti, 2016. | spondweni virus (sponv) and zika virus cause similar diseases in humans. we detected sponv outside of africa from a pool of culex mosquitoes collected in haiti in 2016. this finding raises questions about the role of sponv as a human pathogen in haiti and other caribbean countries. | 2018 | 30124422 |
| spondweni virus causes fetal harm in ifnar1-/- mice and is transmitted by aedes aegypti mosquitoes. | spondweni virus (sponv) is the most closely related known flavivirus to zika virus (zikv). its pathogenic potential and vector specificity have not been well defined. sponv has been found predominantly in africa, but was recently detected in a pool of culex quinquefasciatus mosquitoes in haiti. here we show that sponv can cause significant fetal harm, including demise, comparable to zikv, in a mouse model of vertical transmission. following maternal inoculation, we detected infectious sponv in p ... | 2020 | 32560903 |