transformation of chicken cells by the gene encoding the catalytic subunit of pi 3-kinase.the avian sarcoma virus 16 (asv 16) is a retrovirus that induces hemangiosarcomas in chickens. analysis of the asv 16 genome revealed that it encodes an oncogene that is derived from the cellular gene for the catalytic subunit of phosphoinositide 3-kinase (pi 3-kinase). the gene is referred to as v-p3k, and like its cellular counterpart c-p3k, it is a potent transforming gene in cultured chicken embryo fibroblasts (cefs). the products of the viral and cellular p3k genes have pi 3-kinase activity ...19979188528
the catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity.the retroviral oncogene p3k (v-p3k) of avian sarcoma virus 16 (asv16) codes for the catalytic subunit of phosphoinositide (pi) 3-kinase, p110alpha. the v-p3k protein is oncogenic in vivo and in vitro; its cellular counterpart, c-p3k, lacks oncogenicity. fusion of viral gag sequences to the amino terminus of c-p3k activates the transforming potential. activation can also be achieved by the addition of a myristylation signal to the amino terminus or of a farnesylation signal to the carboxyl termin ...200010692423
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