| electronystagmographic study in rabbits on the vestibular effect of vincamine. | vincamine (vincapront), the alcaloid isolated from vinca minor l, was tested in rabbits at three dosages (1 mg/kg, 5 mg/kg, 10 mg/kg i.m.) in an electronystagmographic study. the parameters evaluated were: duration, rate and frequency of the post-rotatory nystagmus and the frequency of the per-rotatory nystagmus. while the post-rotatory nystagmus was found to show a reduction in duration and rate, the frequencies did not respond to vincamine. the 1 mg/kg dose had the strongest effect while that ... | 1979 | 312648 |
| [alerting effect of vincamine in rats (author's transl)]. | the alerting effect of vincamine, an indole alkaloid of vinca minor, has been demonstrated using three electropharmacological tests: 1) the sleep-wakefulness cycle of freely moving rats implanted with cortical electrodes, 2) the sleep induced by 200 mg/kg i.v. sodium 4-hydroxy-butyrate (ghb) in the curarized rat, 3) the duration of spindle activity in the e.e.g. of curarized rats provoked by an acute asphyxia in which the e.e.g. activity was abolished for 20 sec. vincamine increased the total du ... | 1977 | 594456 |
| [comparative pharmacodynamic properties of apolar alkaloids of vinca minor l. (apocynaceae) (vincamine, vinca fraction and vinacamine free vinca fraction)]. | | 1977 | 877588 |
| the influence of herbs of vinca minor l. on the leukocytic system and electrophoretic composition of serum proteins in healthy rabbits. | | 1972 | 4115627 |
| studies on the erythrocytic system and 59fe iron turnover in healthy rabbits treated with herbs of vinca minor l. | | 1973 | 4747056 |
| halflife of erythrocytes in rabbits treated with vinca minor l. | | 1973 | 4747057 |
| role of drugs in recovery of metabolic function of rat brain following severe hypoglycemia. | severe hypoglycemia with isoelectric eeg induced extensive deterioration of the energy state and gross alteration of amino acid contents on the rat cerebral and cerebellar cortex. during recovery, tissue glucose concentration returned to normal, while both lactate and pyruvate concentrations increased to above normal. in the recovery period, the atp concentration increased but the adenine nucleotide pool remained reduced, even if the adp and amp contents were close to normal. phosphocreatine was ... | 1984 | 6504232 |
| cerebral and cerebellar metabolic changes induced by drugs during the recovery period after profound hypoglycemia. | on rat cerebral and cerebellar cortex, severe hypoglycemia with isoelectric eeg induced extensive deterioration of the energy state and gross alteration of amino acid contents. during recovery, tissue glucose concentration returned to normal, while the rate of glycogen synthesis was slow, both lactate and pyruvate concentrations increasing to above normal. in the recovery period, the atp concentration increased but the adenine nucleotide pool remained reduced, even if the adp and amp contents we ... | 1984 | 6705914 |
| vinpocetine for cognitive impairment and dementia. | vinpocetine is a synthetic ethyl ester of apovincamine, a vinca alkaloid obtained from the leaves of the lesser periwinkle (vinca minor) and discovered in the late 1960s. although used in human treatment for over twenty years, it has not been approved by any regulatory body for the treatment of cognitive impairment. basic sciences studies have been used to claim a variety of potentially important effects in the brain. however, despite these many proposed mechanisms and targets, the relevance of ... | 2003 | 12535455 |
| [pharmacology of material isolated from vinca minor l. ii. on the problem of the effect of vincamin on the nervous system]. | | 1963 | 14062466 |
| [11c]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate pet studies. | vinpocetine, a synthetic derivative of the vinca minor alkaloid vincamine, is a widely used drug in neurological practice. we tested the hypothesis that vinpocetine binds to peripheral benzodiazepine binding sites (pbbs) and is therefore a potential ligand of pbbs. positron emission tomography (pet) measurements in two cynomolgous monkeys showed that pretreatment with vinpocetine markedly reduced the brain uptake of [11c]pk11195, a known pbbs radioligand. on the other hand, whereas pretreatment ... | 2004 | 15760643 |
| measurement and pharmacokinetics of vincamine in rat blood and brain using microdialysis. | vincamine is an alkaloid compound derived from the vinca minor plant. since little is known concerning its pharmacokinetics and appropriate analytical method, this study focuses on its pharmacokinetics as well the possible roles of the multidrug transporter p-glycoprotein on its distribution and disposition. we develop a rapid and sensitive method using a microdialysis coupled with liquid chromatography for the concurrent determination of unbound vincamine in rat blood and brain. microdialysis p ... | 2005 | 16130744 |
| acholeplasma laidlawii pg8 culture adapted to unfavorable growth conditions shows an expressed phytopathogenicity. | mycoplasmas are the smallest, self-replicating, prokaryotic organisms with avid biochemical potential and spreading in higher eukaryotes in nature. in this study, acholeplasma laidlawii pg8 cells were cultivated on a deficient medium for 480 days resulting in a mycoplasma culture that was adapted in vitro to unfavorable growth conditions. cells that survive this condition had decreased sizes (about 0.2 microm) and increased phytopathogenicity. this resulted in more frequent appearance of various ... | 2007 | 17221137 |
| effects of vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons. | vinpocetine (ethyl apovincaminate), a synthetic derivative of the vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. one of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. glutamate excitotoxicity leads to the disregulation of mitochondrial function and neuronal metabolism. as vinpocetine has a binding affinity to the peripheral-type benzodiazepine receptor (pbr) involved in th ... | 2008 | 18793690 |
| neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on nmda-induced neurotoxicity in a rat entorhinal cortex lesion model. | vinpocetine (ethyl-apovincaminate, cavinton), a synthetic derivative of the vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. both vinpocetine and its main metabolite cis-apovincaminic acid (cava) exert a neuroprotective type of action. bilateral n-methyl-d-aspartate (nmda)-induced neurodegeneration in the entorhinal cortex of rat was used as a dementia model to confirm the neuroprotecti ... | 2009 | 19492990 |
| in vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in turkey. | to investigate antibacterial and antitumor activities of 51 different extracts prepared with 3 types of solvents (water, ethanol and methanol) of 16 different plant species (ajuga reptans (a. reptans) l., phlomis pungens (p. pungens) willd., marrubium astracanicum (m. astracanicum) jacq., nepeta nuda (n. nuda) l., stachys annua (s. annua) l., genista lydia (g. lydia) boiss., nuphar lutea (n. lutea) l., nymphaea alba (n. alba) l., vinca minor (v. minor) l., stellaria media (s. media) l., capsella ... | 2013 | 23790332 |
| fischer's lexicon of slavic beliefs and customs: a previously unknown contribution to the ethnobotany of ukraine and poland. | historical ethnobotanical studies are important, even if they are only descriptive, because they help to throw light on the missing chains needed for diachronic analysis. however, the documentation of traditional uses of plants in some countries, e.g. ukraine, is still fragmentary. the aim of this contribution is to fill the gap and present a portion of the data set, from western ukraine, which was collected by adam fischer, a polish ethnographer from lviv, in the 1930s. these data were original ... | 2015 | 26704421 |
| differential detergent stability of the major light-harvesting complex ii in thylakoids isolated from monocotyledonous and dicotyledonous plants. | a survey of isolated thylakoids from 11 different higher plant species (spinacia oleracea l., pisum sativum l., vicia faba l., brassica napus l., vigna sinensis l., vinca minor l., secale cereale l., triticum aestivum l., triticosecale wittn., hordeum vulgare l., zea mays l.) indicated that the ratio of the oligomeric:monomeric form of the light-harvesting complex ii was twofold higher for the dicots (3.16 +/- 0.35) than the monocots (1.64 +/- 0.25) examined under identical separation procedures ... | 1992 | 16669008 |
| preclinical and potential applications of common western herbal supplements as complementary treatment in parkinson's disease. | parkinson's disease (pd) is a neurological disorder with a complex pathological etiology, which is not fully understood. progression of pd may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. current medication used in the treatment of pd aims to prevent the b ... | 2017 | 28095073 |
| a picrinine n-methyltransferase belongs to a new family of γ-tocopherol-like methyltransferases found in medicinal plants that make biologically active monoterpenoid indole alkaloids. | members of the apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (mias) with different substitution patterns that are responsible for their various biological activities. a novel n-methyltransferase involved in the vindoline pathway in catharanthus roseus showing distinct similarity to γ-tocopherol c-methyltransferases was used in a bioinformatic screen of transcriptomes from vinca minor, rauvolfia serpentina, and c. roseus to identify 10 γ-tocopherol-like n-methy ... | 2016 | 26848097 |
| over-expression of catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of vinca minor. | tryptophan decarboxylase (tdc) and strictosidine synthase (str) genes from catharanthus roseus have been successfully over-expressed in the rol gene integrated cell suspensions of v. minor. thirty seconds saat (sonication-assisted agrobacterium transformation) treatment of plant cell suspension with lba1119 having construct (<hpt-<tdc2-<str-gus>) generated three stable tdc + str over-expressing cell lines--pvg1, pvg2, and pvg3. the transgenes were confirmed by β-glucuronidase gus histochemical a ... | 2015 | 25106473 |
| cytotoxicity of vinca minor. | vinca minor l. (apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in european folk medicine. furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in catharanthus roseus (l.) g. don (apocynaceae). in this study, the plant's alkaloid extract was divided into three fractions and the cytotoxic effects on cell proliferation of ht-29, caco-2, t47d, and nih/3t3 cell lines were ... | 2010 | 20645762 |
| isolation and characterization of intergeneric somatic hybrids in the apocynaceae family. | protoplasts were isolated from callus cultures of rauwolfia serpentina benth., rhazya stricta decaisne, and catharanthus roseus (l.) g. don, or from leaves of vinca minor l. protoplast isolation, culture, and fusion techniques as well as hybrid screening systems were developed for these species, and hybrids were obtained. hybrid combinations were rauwolfia + vinca, rauwolfia + catharanthus, rauwolfia + rhazya, and catharanthus + vinca. for hybrid isolation, the physiological complementation meth ... | 1991 | 24213445 |
| assessing chilling and drought tolerance of different plant genera on extensive green roofs in an arid climate region in iran. | the harsh and stressful growing environment of extensive green roofs especially in arid environments allows a limited range of plant species to survive. therefore, achieving plantings to survive in such conditions is a significant challenge. this paper describes an experiment investigating plant selections for extensive green roofs based on chilling (cold season) and drought (warm season) conditions of iran. nine species were selected from the three major taxonomic and functional plant groups th ... | 2017 | 28171833 |
| a review of nutrients and botanicals in the integrative management of cognitive dysfunction. | dementias and other severe cognitive dysfunction states pose a daunting challenge to existing medical management strategies. an integrative, early intervention approach seems warranted. whereas, allopathic treatment options are highly limited, nutritional and botanical therapies are available which have proven degrees of efficacy and generally favorable benefit-to-risk profiles. this review covers five such therapies: phosphatidylserine (ps), acetyl-l-carnitine (alc), vinpocetine, ginkgo biloba ... | 1999 | 10383479 |