| lycorine alkaloids from hymenocallis littoralis. | from hymenocallis littoralis, one new alkaloid, named littoraline, together with 13 known lycorine alkaloids and one lignan, were isolated. the structure and nmr assignments of this new alkaloid were determined by 1d and 2d nmr techniques. littoraline showed inhibitory activity of hiv reverse transcriptase, and lycorine and haemanthamine showed potent in vitro cytotoxicity. | 1995 | 7492374 |
| antineoplastic agents, 294. variations in the formation of pancratistatin and related isocarbostyrils in hymenocallis littoralis. | by cloning hymenocallis littoralis, a practical biosynthetic procedure was developed for producing pancratistatin [1]. the plant tissue culture-->greenhouse-->field production sequence was successively utilized for increasing an original 1.5 kg of wild h. littoralis bulbs to some 60,000 bulbs at present. in the central arizona sonoran desert, the tropical h. littoralis was found to reach a maximum pancratistatin content in october and a minimum in may. generally pancratistatin [1] was accompanie ... | 1995 | 7760076 |
| antineoplastic agents, 256. cell growth inhibitory isocarbostyrils from hymenocallis. | the bulbs of hymenocallis littoralis, collected in hawaii and horticulturally grown in arizona, and bulbs of hymenocallis caribaea and hymenocallis latifolia, collected in singapore, were found to contain a cytotoxic, isocarbostyril-type biosynthetic product, 7-deoxy-trans-dihydronarciclasine [2]. this new compound inhibited the cytopathicity and/or replication of various viruses. companion cytotoxic constituents of h. littoralis and hymenocallis sp. were found to be pancratistatin [1], narcicla ... | 1993 | 8277308 |
| effects of atmospheric co(2) enrichment on the growth and development of hymenocallis littoralis (amaryllidaceae) and the concentrations of several antineoplastic and antiviral constituents of its bulbs. | two 2-yr crops of tropical spider lily (hymenocallis littoralis) plants were grown in field soil in clear-plastic-wall open-top enclosures in the sonoran desert environment of central arizona. half of the plants were exposed to ambient air of 400 ppm atmospheric co(2) concentration and half of them were exposed to air of 700 ppm co(2). this 75% increase in the air's co(2) content resulted in a 48% increase in aboveground plant biomass and a 56% increase in belowground (bulb) biomass. it also inc ... | 2000 | 10860907 |
| antineoplastic agents. 527. synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1). | the synthesis of sodium narcistatin (8) was improved (88% overall yield) and the modified reaction sequence was utilized to synthesize three new 3,4-cyclic phosphate prodrugs, sodium 7-deoxynarcistatin (5), sodium 7-deoxy-trans-dihydronarcistatin (6), and sodium trans-dihydronarcistatin (7). the human cancer cell line inhibitory isocarbostyril precursors were isolated from the bulbs of hymenocallis littoralis obtained by horticultural production or reduction of narciclasine (1a --> 4) from the s ... | 2005 | 15730244 |
| pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. | the major hurdle in the fight against cancer is the non-specific nature of current treatments. the search for specific drugs that are non-cytotoxic to normal cells and can effectively target cancer cells has lead some researchers to investigate the potential anti-cancer activity of natural compounds. some natural compounds, such as taxol, have been shown to possess some anti-cancer potential. pancratistatin (pst) is a natural compound that was isolated from the spider lily pancratium littorale a ... | 2005 | 15909123 |
| antineoplastic agents. 553. the texas grasshopper brachystola magna. | bioassay (p388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the previously chemically uninvestigated texas grasshopper brachystola magna led to isolation of the cancer cell growth inhibitory pancratistatin (1), narciclasine (2), and ungeremine (3). pancratistatin (1) was first isolated from the bulbs of hymenocallis littoralis), and the original crystal structure was deduced by x-ray analysis of a monomethyl ether derivative. in the pr ... | 2005 | 16124772 |
| induction of apoptotic cell death specifically in rat and human cancer cells by pancratistatin. | the major challenge in the battle against cancer is the specific targeting of cancer cells. most chemotherapeutics and radiotherapies induce cancer cell death by inducing dna damage. these treatments also cause severe side effects by affecting normal cells causing toxicity and mutations that may predispose them to become cancerous. some non-genotoxic drugs such as tamoxifen are useful but are of limited applicability. natural compounds such as paclitaxel have been useful in cancer treatment, but ... | 2005 | 16152693 |
| isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine. | as an extension of structure-activity relationship studies of pancratistatin (1), various techniques were first evaluated for separating the mixtures of 7-deoxynarciclasine (2b) and 7-deoxy-trans-dihydronarciclasine (3a) isolated from hymenocallis littoralis. an efficient solution for that otherwise difficult separation then allowed the lactam carbonyl group of protected (4c and 5c) alcohols 2b and 3a to be reduced employing lithium aluminum hydride. cleavage (tbaf followed by h2so4) of the sily ... | 2006 | 16441059 |
| seafood wastewater treatment in constructed wetland: tropical case. | a series of investigations were conducted to evaluate the feasibility of using constructed wetlands to remove pollutants from seafood processing wastewater. six emergent plant species; cyperus involucratus, canna siamensis, heliconia spp., hymenocallis littoralis, typha augustifolia and thalia deabata j. fraser were planted in surface flow wetland. they were fed with seafood wastewater that was 50% diluted with treated seafood wastewater from an aerated lagoon. all macrophytes were found to meet ... | 2008 | 17383179 |
| phytochemical and biological investigation of hymenocallis littoralis salisb. | a phytochemical investigation of the bulbs and flowers of hymenocallis littoralis salisb., cultivated in egypt, was carried out, which resulted in the isolation of four alkaloids, lycorine (1), hippeastrine (2), 11-hydroxyvittatine (3), and (+)-8-o-demethylmaritidine (4), and of two flavonoids, quercetin 3'-o-glucoside (5), and rutin (6). the volatile constituents of the plant flowers were analyzed for the first time by gc/ms, which led to the identification of 26 known compounds (table 1). fina ... | 2008 | 18293433 |
| enzyme and root activities in surface-flow constructed wetlands. | sixteen small-scale wetlands planted with four plant species were constructed for domestic wastewater purification. the objective of this study was to determine the correlations between contaminant removal and soil enzyme activity, root activity, and growth in the constructed wetlands. the results indicated that correlations between contaminant removal efficiency and enzyme activity varied depending on the contaminants. the removal efficiency of nh4+ was significantly correlated with both urease ... | 2009 | 19497608 |
| pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells. | pancratistatin, a natural compound extracted from hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. in this ex vivo study, we evaluated the effect of pancratistatin on peripheral blood mononuclear cells obtained from 15 leukemia patients prior to clinical intervention of newly diagnosed patients, as well as others of different ages in relapse and at various disease progression states. | 2010 | 20205924 |
| sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. | the objective of this study was to determine the efficacy of the natural compound pancratistatin (pst), isolated from the hymenocallis littoralis, in human melanoma cells. melanoma is an aggressive form of skin cancer that is commonly fatal if not diagnosed in its early stage of development. melanoma is resistant to many treatments, thus drastically limiting chemotherapy options for this cancer. we have shown that exposure to pst induces apoptosis in human melanoma within 72 h using hoechst stai ... | 2010 | 20300039 |
| a novel synthetic c-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. | the natural compound pancratistatin (pst), isolated from the hymenocallis littoralis plant, specifically induces apoptosis in many cancer cell lines. unlike many other chemotherapeutics, pst is not genotoxic and has minimal adverse effects on non-cancerous cells. however, its availability for preclinical and clinical work is limited due to its low availability in its natural source and difficulties in its chemical synthesis. several synthetic analogues of 7-deoxypancratistatin with different mod ... | 2011 | 21494837 |
| fungal planet description sheets: 92-106. | novel species of microfungi described in the present study include the following from australia: diaporthe ceratozamiae on ceratozamia robusta, seiridium banksiae on banksia marginata, phyllosticta hymenocallidicola on hymenocallis littoralis, phlogicylindrium uniforme on eucalyptus cypellocarpa, exosporium livistonae on livistona benthamii and coleophoma eucalyptorum on eucalyptus piperita. several species are also described from south africa, namely: phoma proteae, pyrenochaeta protearum and l ... | 2011 | 22403481 |
| growth profile and sem analyses of candida albicans and escherichia coli with hymenocallis littoralis (jacq.) salisb leaf extract. | hymenocallis littoralis (jacq.) salisb (melong kecil) commonly known as 'spider lily' is an herbaceous plant from the family amaryllidaceae. study was carried out to determine the effect of h. littoralis leaf extract on the growth and morphogenesis of two pathogenic microbes, candida albicans and escherichia coli. the leaf extract displayed favourable anticandidal and antibacterial activity with a minimum inhibition concentration (mic) of 6.25 mg/ml. time kill study showed both microbes were com ... | 2014 | 25776614 |
| microbial density and diversity in constructed wetland systems and the relation to pollutant removal efficiency. | microbes are believed to be at the core of the wastewater treatment processes in constructed wetlands (cws). the aim of this study was to assess the microbial biomass carbon (mbc) and shannon's diversity index (sdi) in the substrate of cws planted with phragmites australis, hymenocallis littoralis, canna indica and cyperus flabelliformis, and to relate mbc and sdi to the pollutant removal in the systems. significant higher mbc was observed in cws with h. littoralis and c. indica than in cws with ... | 2016 | 26877053 |