| isolation of type-c viruses from the asian feral mouse mus musculus molossinus. | n-tropic and xenotropic type-c viruses have been isolated from the wild asian mouse subspecies m. musculus molossinus. by host range, morphologic and some immunologic criteria these viruses appear closely related to the previously studied murine type-c viruses isolated from highly inbred laboratory strains of mice. | 1975 | 47844 |
| isolation of an endogenous c-type rna virus from mus musculus molossinus. | we isolated a type-c rna virus from the japanese field mouse, mus musculus molossinus. m. musculus musculus and m. musculus molossinus are two different subspecies of mus and thus only distantly related. the virus grew only on cells foreign to the host, was xenotropic, and readily rescued the murine sarcoma (musv) genome from a normal rat kidney cell line transformed nonproductively by the harvey strain of musv. the virus banded at a density of 1.16 g/ml and contained an rna-dependent dna polyme ... | 1975 | 52716 |
| nucleic acid homology of murine xenotropic type c viruses. | two major subclasses of xenotropic (x-tropic) murine type c viruses can be distinguished by nucleic acid hybridization. the most frequently encountered subclass (mulv-x-alpha) includes isolates from balb/c, c57bl/6j, c58/j, akr/j, cba/j, and dba/2j inbred strains and from the asian feral mouse subspecies mus musculus molossinus. the other subclass (mulv-x-beta) consists of viruses isolated from the nih swiss and nzb/binj strains. thus, significant polymorphism exists among the endogenous type c ... | 1975 | 167191 |
| genetic resistance in japanese wild mice (mus musculus molossinus) to an nb-tropic friend murine leukemia virus. | wild mice (sk, hz-vl, hz-iv om, mol.a, fu, te, and sn) trapped in various areas of japan were crossed with mice of inbred strains (c57bl/6, c57l, balb/c, and c57bl/10), and their progeny were infected with nb-tropic friend nurine leukemia virus. ten days after infection, the spleens were weighed, examined for macroscopic focal lesions, and assayed for infectious virus by the xc test. genetic analysis indicated that 4 of 8 mice tested had a dominant gene that suppresses the virus replication; the ... | 1978 | 280714 |
| frequency distribution of histocompatibility-2 antigenic specificities in the japanese wild mouse genetically remote from the european subspecies. | fifty-eight japanese wild mice, mus musculus molossinus, collected from twenty-eight localities were surveyed for twelve h-2 antigens using the haemagglutination method. significantly higher frequencies of h-2.3 and h-2.5 specifities and relatively lower frequencies of the other public specificities were observed. this was confirmed by examining four specificities, h-2.3, 5, 13 and 23, in 370 mice. quantitative absorption of the alloantisera by erythrocytes and spleen lymphocytes of molossinus m ... | 1979 | 489997 |
| an acid phosphatase locus expressed in mouse kidney (apk) and its genetic location on chromosome 10. | a genetic locus controlling the electrophoretic mobility of an acid phosphatase in mouse kidney is described. this locus, called acid phosphatase-kidney (apk), is not expressed in erythrocytes, liver, spleen, heart, lung, brain, skeletal muscle, stomach, or testes. the product of apk hydrolyzes the substrate naphthol as-mx phosphoric acid but is not active on alpha-naphthylphosphate or 4-methylumbelliferylphosphate. it is not inactivated by 50 c for 1 hr, nor is its electrophoretic mobility alte ... | 1978 | 678292 |
| genetic localization of hao-1, blind-sterile (bs), and emv-13 on mouse chromosome 2. | the blind-sterile (bs) mutation in the mouse was localized on chromosome 2 between hao-1 and emv-13. n2 progeny from a backcross between congenic female 129.akr-bs emv-13 mice and (129.akr-bs/bs x mus musculus molossinus) f1 male mice were typed by analysis of isozyme variants for hao-1, visible inspection for bs, and restriction fragment length polymorphism for emv-13 and emv-15. comparison between markers on mouse chromosome 2 and corresponding markers on human chromosomes suggest that the hum ... | 1992 | 1310954 |
| [establishment of a congenic strain with complement regulatory protein of factor h allotype derived from mus. musculus molossinus]. | factor h is a plasma glycoprotein with m. w of 160 kda which serves as one of the regulatory proteins for c 3 convertases. we have previously reported three serologically defined mouse factor h allotypes by surveying many laboratory and wild mice. in the present work, we established a congenic strain with factor h allotype, h. 2. on balb/c (h. 1 allotype) background and named this strain balb-h.2. alloantiserum against each allotype has been easily prepared using two congenic strains by immuniza ... | 1992 | 1531462 |
| acquisition of two endogenous ecotropic murine leukemia viruses in distinct asian wild mouse populations. | wild mouse dnas were analyzed for two types of endogenous ecotropic murine leukemia viruses (mulvs), akv and fv-4r-associated mulv. endogenous akv viruses were found only in northern chinese mice, korean mice, and japanese (mus musculus molossinus) mice. the fv-4r gene, which is a truncated endogenous mulv with ecotropic interference properties, was carried by southeast asian (m. m. castaneus) mice, korean mice, and m. m. molossinus. sequences related to fv-4r mulv env were found only in m. m. c ... | 1991 | 1672163 |
| a tail length modifier gene discovered in the japanese wild mice (mus musculus molossinus). | the presence of the t haplotypes in strains derived from the japanese wild mice (mus musculus molossinus) was investigated. crosses between the t/+ heterozygous short tailed mice and five normal tailed molossinus strains (mol-anj, moa, mol-nem, mom and mns) produced no tailless mice, indicating that these strains possess no t haplotype. in contrast, tailless mice were produced by a cross between the t/+ heterozygotes and a mol-nis strain. mating experiments showed that the tailless character was ... | 1991 | 1859671 |
| dominant expression of a distinctive v14+ t-cell antigen receptor alpha chain in mice. | a distinctive variable region 14-positive (v14+) alpha chain (v alpha 14+) of the t-cell antigen receptor is predominantly expressed in multiple mouse subspecies. the v alpha 14 family has two members, v alpha 14.1 and v alpha 14.2, which differ by only three amino acids at positions 50-52. based on the ecori restriction fragment length polymorphism of the gene encoding v alpha 14, mice can be divided into three groups: type i with an 11.2-kilobase (kb) fragment, type ii with a 2.0-kb fragment, ... | 1991 | 1881891 |
| recombinational hotspot specific to female meiosis in the mouse major histocompatibility complex. | the wm7 haplotype of the major histocompatibility complex (mhc), derived from the japanese wild mouse mus musculus molossinus, enhances recombination specific to female meiosis in the k/a beta interval of the mhc. we have mapped crossover points of fifteen independent recombinants from genetic crosses of the wm7 and laboratory haplotypes. most of them were confined to a short segment of approximately 1 kilobase (kb) of dna between the a beta 3 and a beta 2 genes, indicating the presence of a fem ... | 1990 | 1968049 |
| sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16. | a region of substantial genetic homology exists between human chromosome 21 (hsa21) and mouse chromosome 16 (mmu16). analysis of 520 backcross animals has been used to establish gene order in the homologous segment. d21s16h and mx are shown to represent the known proximal and distal limits of homology between the chromosomes, while gap43, whose human homolog is on hsa3, is the next proximal marker on mmu16 that has been mapped in the human genome. recombination frequencies (rfs) in four interval ... | 1990 | 1981993 |
| characterization and strain distribution pattern of the murine ah receptor specified by the ahd and ahb-3 alleles. | two allelic forms of the ah receptor have been previously identified by covalent labeling of the hepatic cytosol fractions of inbred strains of mice with the photoaffinity ligand 2-azido-3-[125i] iodo-7,8-dibromodibenzo-p-dioxin and resolution of the labeled protein by denaturing gel electrophoresis: 1) a mr 95,000 protein encoded by the ahb-1 allele carried by the c57 and c58 family of mice, and 2) a mr 104,000 protein encoded by the ahb-2 allele present in other common inbred strains that are ... | 1990 | 2169579 |
| homogenous junctional sequence of the v14+ t-cell antigen receptor alpha chain expanded in unprimed mice. | nucleotide sequences of vj (variable-joining) junctional regions of v14+ alpha-chain t-cell receptor genes show that most v alpha 14+ t cells use one alpha chain (v alpha 14j alpha 281 with a one-nucleotide n region, which is frequently used in keyhole limpet hemocyanin-specific suppressor t-cell hybridomas) in unprimed mice. moreover, the frequency of this alpha-chain expression was greater than 1.5% of the total alpha chains found in laboratory strains, including b10 congenic mice. this is abo ... | 1990 | 2371269 |
| antigenic polymorphism of a serum protein migrating electrophoretically in the alpha region detected by using a strain derived from the japanese wild mouse (mus musculus molossinus). | antigenic specificities of a serum protein from the mouse mol-a strain (a strain derived from the japanese wild mouse, mus musculus molossinus) was studied by gel precipitation with alloantisera produced by reciprocal alloimmunization between mol-a and balb/c mice. alloantigens which migrate immunoelectrophoretically in the alpha region of serum proteins have also been identified. the evidence indicated that this antigenic specificity is controlled by a codominant autosomal locus designated aph- ... | 1986 | 2426195 |
| a gene locus controlling a serum protein migrating electrophoretically in the beta region of mice and detected by using a strain derived from the japanese wild mouse (mus musculus molossinus). | antigenic specificities of serum proteins from the mol-anj strain of mice (a strain derived from japanese wild mice, mus musculus molossinus) were studied by gel precipitation with alloantisera produced by reciprocal alloimmunization between mol-anj and balb/c mice. an alloantigen which migrates immunoelectrophoretically in the beta region of serum proteins has been identified. evidence indicates that this antigenic specificity is controlled by a co-dominant autosomal gene locus designated by th ... | 1987 | 2443579 |
| genetic polymorphism of serum protein aph-2 found in the japanese wild mouse (mus musculus molossinus). | | 1988 | 2447015 |
| relationship between mouse ly-2 and the mus musculus molossinus-specific ly-35 alloantigenic determinants. | | 1988 | 2459057 |
| serological survey of complement factor h in common laboratory and wild mice: a new third allotype. | antigenic specificities of complement factor h from mice were studied serologically. in addition to previously reported allotypes, referred to as h.1 and h.2, a new allotype of complement factor h, h.3, was identified in the bfm/2ms strain derived from european wild mice. using three different alloantisera raised against the various mouse factor h allotype, a serological survey of the common laboratory strains and wild-derived strains of mus musculus and its relatives, mus spretus, mus spretoide ... | 1989 | 2522412 |
| new evidence for trans-species evolution of the h-2 class i polymorphism. | a serological survey using alloantisera specific for the h-2 class i antigens in japanese wild mice. mus musculus molossinus, revealed a high frequency of the h-2kf antigen. this antigen has also been found in european wild mice, m. m. domesticus and m. m. musculus. in this survey, the h-2kf antigen was characterized through the use of ten newly isolated monoclonal antibodies raised against cells of a japanese wild mouse, and by southern blot analysis using an h-2k locus-specific probe which hyb ... | 1989 | 2569445 |
| blocking of cytotoxic t-cell function of molf/ei mice by anti-ly 35.1 monoclonal antibody. | ly 35.1 antigen is an alloantigen expressed only on t cells of mus musculus molossinus-derived inbred strains. previous findings indicated that the genetic locus coding for ly 35 antigen was closely linked to ly 2/3 on chromosome 6 and that epitopes detected by ly 2.1 and ly 35.1 monoclonal antibodies (mab) were closely associated, as shown by binding inhibition assay. in this study, we examined the blocking effects of anti-ly 2.1 and anti-ly 35.1 mab on cytotoxic t-cell function of molf/ei mice ... | 1989 | 2592017 |
| lactate dehydrogenase isozymes in xenotropic virus producing mice. | lactate dehydrogenase (ldh; e.c. 1.1.1.27) isozymes were compared in three inbred strains of mice, and two strains of wild mice, as well as the f1 hybrids and other genetic crosses involving two of the inbred strains. the strains examined were nzb/b1nj, 129/j and c57bl/6j, mus musculus molossinus and m. musculus castaneus. genetic crosses were made between the xenotropic virus-producing nzb and the non-virus producing 129/j mice. tissue specificity of ldh in these strains was studied using homog ... | 1989 | 2598686 |
| mouse zygotes injected with mitochondria develop normally but the exogenous mitochondria are not detectable in the progeny. | a microinjection procedure to introduce "paternal" mitochondria from a source other than spermatozoa into fertilized mouse eggs is described. when a mitochondrial suspension isolated from the testes or liver of mus molossinus mice was microinjected into fertilized eggs of cd1 mice, the microinjected zygotes survived, developed normally, and offspring were produced. mus molossinus mitochondrial dna can be distinguished from cd1 mitochondrial dna by southern blot analyses using restriction enzymes ... | 1989 | 2627366 |
| in vivo mammalian mutagenesis: in transition to dna molecules. | approaches are presented for the detection of mutations in the mitochondrial and nuclear dna of somatic and germinal cells in vivo in mammals. the difficulties in evaluating mitochondrial mutagenesis are stressed, and simulation experiments using oogonial transfer techniques with mitochondria from two closely subspecies, mus musculus and mus molossinus, are suggested. arguments are presented for using transgenic animals in the study of mutagenesis in the nuclear genome instead of native dna. pre ... | 1989 | 2659337 |
| effect of y chromosome and h-2 complex derived from japanese wild mouse on sperm morphology. | segregation of sperm abnormality level and h-2 haplotypes was investigated in f2 hybrid males obtained from reciprocal crosses involving two b10.congenic strains carrying h-2 and the y chromosome of japanese wild mice: b10.mol-ohm (h-2wm4, 23.1% of sperm abnormalities) and b10.mol-okb (h-2wm8, 11.1% of sperm abnormalities). in both types of crosses mean levels of abnormal spermatozoa were significantly higher for males typed as h-2wm4/h-2wm4 than for heterozygous h-2wm4/h-2wm8 or homozygous h-2w ... | 1989 | 2714641 |
| screening for mouse retinal degenerations. ii. molossinus molc and mold strains. | using screening techniques of indirect ophthalmoscopy, electroretinography, and histology, we found inbred strains of mus musculus molossinus to have a variable onset of retinal degeneration, which may present with early loss of outer segments and photoreceptor nuclei. the early affected mice have constricted vessels, optic atrophy, and markedly abnormal electroretinograms. an intermediate form of retinal degeneration was identified with slight arterial narrowing on ophthalmoscopy and electroret ... | 1989 | 2776629 |
| hybrid origin of japanese mice "mus musculus molossinus": evidence from restriction analysis of mitochondrial dna. | the japanese mouse, mus musculus molossinus, has long been considered an independent subspecies of the house mouse. a survey of restriction-site haplotypes of mitochondrial dna (mtdna) showed that japanese mice have two main maternal lineages. the most common haplotype is closely related to the mtdna of the european subspecies m. m. musculus. the other common haplotype and two minor ones are closely related to each other and to the mtdna of an asiatic subspecies, m. m. castaneus. two other rare ... | 1988 | 2833677 |
| the oxygen affinity of mammalian hemoglobins in the absence of 2,3-diphosphoglycerate in relation to body weight. | we studied the oxygenation of mammalian hemoglobins: mouse (mus musculus molossinus), rabbit (oryctolagus cuniculus domesticus), japanese monkey (macaca fuscata), man (homo sapiens), sheep (ovis aries), llama (lama glama), pig (sus scrofa domesticus), cow (bos taurus domesticus) and horse (equus caballus), in the absence of 2,3-diphosphoglycerate (dpg) and compared their oxygen affinity in relation to the body weight. the negative correlation between body weight and the oxygen affinity of the wh ... | 1985 | 2866879 |
| immunoglobulin vh region genes of the mouse are organized in overlapping clusters. | restriction fragment length polymorphism has been compared between the igh loci of c57bl/6 and molf/ei (mus musculus molossinus) mice utilizing probes which detect the c gamma 2b gene and genes from nine vh-gene families. distinct restriction site patterns were found for the ch genes and for vh families pc7183, q52 and x24. vh families v31 and j558 showed identical patterns. mixed patterns of identical and distinct bands were detected in vh families s107, j606, v3660 and vgam3.8. this indicates ... | 1987 | 2888660 |
| genetic mapping and analysis of somatostatin expression in snell dwarf mice. | mice homozygous for the gene dwarf (dw) have elevated levels of somatostatin (ss) in extra-hypothalamic brain regions. by in situ hybridization, increased levels of ss mrna were observed in regions shown previously to contain higher levels of the ss peptide. thus, the rate of transcription and/or the stability of ss mrna are affected by the dw mutation. since both dw and the gene encoding ss, smst, are located on mouse chromosome 16, two backcrosses segregating dw and smst were used to determine ... | 1988 | 2906811 |
| diverse wild mouse origins of xenotropic, mink cell focus-forming, and two types of ecotropic proviral genes. | we analyzed wild mouse dnas for the number and type of proviral genes related to the env sequences of various murine leukemia viruses (mulvs). only mus species closely related to laboratory mice carried these retroviral sequences, and the different subclasses of viral env genes tended to be restricted to specific taxonomic groups. only mus musculus molossinus carried proviral genes which cross-reacted with the inbred mouse ecotropic mulv env gene. the ecotropic viral env sequence associated with ... | 1987 | 3041030 |
| ly-36: a new mouse lymphocyte alloantigen defined by a mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to ly-2/3 region on chromosome 6. | | 1988 | 3378837 |
| variation among mouse ribosomal rna genes within and between chromosomes. | we compared nucleotide sequences of the transcription-initiation region of five mouse ribosomal dna (rdna) clones. two clones were isolated from japanese wild mice, mus musculus molossinus, and the other three from balb/c mice originating in m. m. domesticus. two balb/c clones that are derived from the same chromosome are very similar, suggesting the occurrence of intrachromosomal homogenization of rdna repeats. however, the other clone of balb/c was approximately as different from the former tw ... | 1987 | 3444415 |
| amplified ribosomal spacer sequence: structure and evolutionary origin. | a novel class of repeated sequences consisting of tandem arrays of ribosomal spacer sequence has been discovered in a mouse genome. comparison to normal ribosomal dna reveals that one repeat unit consists of two separate parts of spacer sequence. this amplified spacer sequence has a pseudogene-like structure but is distinct from the previously reported pseudogenes and orphons in regions lacking coding sequences. so far the amplified spacer sequence has been found only in the balb/c mouse genome ... | 1987 | 3473237 |
| sexual preference of meiotic recombination within the h-2 complex. | the recombination frequency between the h-2k and h-2d marker loci in male mice was measured using heterozygotes that carry the h-2wm7 haplotype derived from the japanese wild mouse and common h-2 haplotypes derived from inbred mice. previous mating experiments in which backcross progeny of heterozygous females were screened demonstrated that the h-2wm7 displays marked enhancement of recombination within the h-2 complex. in contrast to recombination in female mice, no enhancement of recombination ... | 1987 | 3570376 |
| altered turnover of hypoxanthine phosphoribosyltransferase in erythroid cells of mice expressing hprt a and hprt b alleles. | we have previously shown that mice expressing hprt a allele(s) have erythrocyte hypoxanthine phosphoribosyltransferase (hprt) levels that are approximately 25-fold (mus musculus castaneus) and 70-fold (mus spretus) higher than in mice that express the hprt b allele (mus musculus domesticus; c57bi/6j; c3h/heha), and that these differences in erythrocyte hprt levels are due to differences in the turnover rates of the hprt a and b proteins as reticulocytes mature to erythrocytes. we show here that: ... | 1987 | 3609725 |
| a hybrid origin of japanese mice "mus musculus molossinus". | | 1986 | 3731855 |
| characterization of newly isolated monoclonal antibodies against mhc of a japanese wild mouse. | we have already developed nine b10.mol congenic strains carrying h-2 haplotypes derived from japanese wild mice, mus musculus molossinus, with the c57bl/10 genetic background. to obtain monoclonal antibodies against the h-2 antigen of the japanese wild mouse, we carried out cell fusion using spleen cells from the animal immunized with one of the b10.mol strains, b10.mol-sgr (h-2wm7). as a result, 19 hybridomas producing monoclonal antibodies were produced. analysis with the intra-h-2 recombinant ... | 1986 | 3793153 |
| ultrastructural characterization of novel intracisternal virus-like particles associated with a spontaneous subcutaneous tumor from a japanese wild mouse, mus musculus molossinus (mon/nm). | | 1985 | 3837811 |
| nucleic acid homology of murine type-c viral genes. | the nucleic acid sequence homology between various murine, endogenous type-c viruses (three host range classes of balb/c virus, the at-124 virus, and the ccl 52 virus) and two laboratory strains of murine leukemia virus (rauscher and kirsten) was determined by dna:rna hybridization. the viral sequences exhibit varying degrees of partial homology. dna:dna hybridizations were performed between [(3)h]dna probes prepared from n- and x-tropic balb/c endogenous viruses and cellular dnas from balb/c, n ... | 1974 | 4372403 |
| relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various mus species. | mouse (mus musculus musculus) satellite dna is able to reassociate with repeated dna sequences of mus caroli and mus cervicolor, but low thermal stability of the products indicates significant differences between satellite and related dnas of these two mus species. there appear to be several satellite-related populations in m. caroli dna, each of which forms hybrids of low thermal stability with repeated sequences of m. cervicolor dna. dnas from the subspecies mus musculus molossinus and mus mus ... | 1973 | 4519644 |
| strains originated from the wild japanese mouse (mus musculus molossinus). | | 1973 | 4807742 |
| close similarity between endogenous ecotropic virus of mus musculus molossinus and akr virus. | by using seven different restriction endonucleases, the cleavage patterns of the unintegrated provioral dna from an ecotropic murine leukemia virus isolated from mus musculus molossinus were found to be identical to those of akr virus. an akr [3h]dna probe can be completely saturated with m. musculus molossinus and m. musculus castaneus dnas, although the arrangement of viral sequences in m. musculus molossinus dna differed from that of akr virus. these studies indicate that an akr-type ecotropi ... | 1980 | 6253673 |
| endogenous type c retroviral sequences of mice are organized in a small number of virus-like classes and have been acquired recently. | we studied endogenous type c virus-related sequences of mice by annealing moloney murine leukemia virus dna to agarose gel blot transfers of uninfected mouse cell dna which had been cleaved with restriction enzymes. we found that many of the endogenous murine leukemia virus-related sequences in mice consist of two organizational classes that are integrated into many different loci. both of these classes resemble standard murine leukemia virus proviral dna in both size and sequence organization. ... | 1981 | 6270388 |
| evidence for the horizontal acquisition of murine akr virogenes by recent horizontal infection of the germ line. | several recent reports (8, 10, 11, 13) have established the biological and molecular genetic similarity between the endogenous akv virus of strain akr, and an n-ecotropic endogenous virus found in the genome of feral japanese mice, mus musculus molossinus. the similarities are so striking as to suggest a common origin of these viruses, which are present in some, but not all, inbred mouse strains. the virogenes of akr mice may have been acquired by either: (a) common descent of akr (and other akv ... | 1982 | 6278048 |
| japanese wild mouse, mus musculus molossinus, has duplicated immunoglobulin gamma 2a genes. | | 1982 | 6283372 |
| a unique sequence related to the ecotropic murine leukemia virus is associated with the fv-4 resistance gene. | several strains of laboratory and wild-derived mice from japan carry the dominant allele at the fv-4 locus (fv-4r) that is responsible for resistance to infection by exogenous ecotropic murine leukemia virus. we have used blot hybridization with a probe specific for the ecotropic viral envelope to show that a unique envelope-reactive sequence is present in the japanese mouse mus musculus molossinus and in four independently derived partially congeneic strains carrying fv-4r. analysis of 31 backc ... | 1984 | 6322171 |
| laboratory and wild-derived mice with multiple loci for production of xenotropic murine leukemia virus. | mendelian segregation analysis was used to define genetic loci for the induction of infectious xenotropic murine leukemia virus in several laboratory and wild-derived mice. ma/my mice contain two loci for xenotropic virus inducibility, one of which, bxv -1, is the only induction locus carried by five other inbred strains. the second, novel ma/my locus, designated mxv -1, is unlinked to bxv -1 and shows a lower efficiency of virus induction. the nzb mouse carries two induction loci; both are dist ... | 1984 | 6328046 |
| duplicated immunoglobulin gamma 2a genes in wild mice. | the japanese wild mouse, mus musculus molossinus, has duplicated immunoglobulin gamma 2a genes, whereas most of the laboratory-strain mice have single gamma 2a genes. this duplication provides a unique system in which molecular mechanisms of the evolutionary rearrangement of the immunoglobulin gene can be studied. for this purpose it is important to elucidate the organization of the immunoglobulin genes surrounding the duplicated gamma 2a genes. it is also interesting to assess the distribution ... | 1984 | 6336561 |
| cytoplasmic inheritance of a cell surface antigen in the mouse. | mta is a cell surface antigen of the mouse and serves as a target for specific t killer lymphocytes. using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including mus molossinus, mus castaneus and mus spretus. five strains of rats, non-inbred nmri mice, most substrains of nzb mice and the closely related strain nzo are negative for mta. in reciprocal f1 crosses between ... | 1983 | 6341170 |
| trichinella spiralis: genetics of worm expulsion in inbred and f1 mice infected with different worm doses. | the nematode trichinella spiralis is rejected from the intestine at a time that is characteristic for each inbred strain of mouse. previous work (r. g. bell et al. 1982a) had empirically identified strong, intermediate, and weak phenotypes (nfr, c3h/he, and c57b1/10 mice, respectively) in mice infected with 400 muscle larvae. it is shown that this classification applies to another eight inbred strains: swr, dba/2, dba/1, lp, bub/bn--all intermediate, and nzb/bin, c57l, a, and mus molossinus--all ... | 1984 | 6542023 |
| aryl hydrocarbon hydroxylase induction by benzo[a]anthracene: regulatory gene localized to the distal portion of mouse chromosome 17. | aryl hydrocarbon (benzo[a]pyrene) hydroxylase inducibility by benzo[a]anthracene was studied in 29 somatic cell hybrid clones, developed by fusing mouse spleen or peritoneal cells from four different inbred strains with hypoxanthine phosphoribosyltransferase-deficient chinese hamster e36 cells. karyotype analysis plus 25 markers assigned to 16 autosomes and the x chromosome were examined. in 28 of the 29 clones, the presence or absence of inducibility is associated with the presence or absence, ... | 1984 | 6547399 |
| h-2-linked murine factor b phenotypes. | a hemolytic assay has been developed which is specific for factor b (b) activity in murine edta-plasma. three discrete levels of b activity were observed among b10-congenic strains. mice with standard h-2 haplotypes, b, d, k, r, f, q, s, and u, all exhibited the same mean level of activity. however, plasma from h-2v (b10.sm) mice contained only 0.25 of that level, and those with standard haplotype h-2ja (b10.wb) or wild haplotype h-2wr7 (b10.wr) exhibited 2.5 times the h-2b (b10) basal level of ... | 1983 | 6550027 |
| a new allele at the mup-1 locus controlling an electrophoretic variant of major urinary proteins in mice. | the present study showed that the presence or absence of a new component of major urinary proteins (mups), which is found in moa mice, an inbred strain of mus musculus molossinus (japanese wild mice), is controlled by a single codominant gene locus. the linkage analysis shows that the locus is on chromosome 4, where the mup-1 locus is assigned; its alleles, mup-1a, and mup-1b determine two phenotypic forms of mups in laboratory mice (m. m. domesticus). recombination values between the locus and ... | 1984 | 6707444 |
| intracisternal a-particle genes in mus musculus: a conserved family of retrovirus-like elements. | the structural organization of intracisternal a-particle genes has been studied, using isolates from a mouse gene library in lambda phage charon 4a. the predominant gene form among the isolates was 7.3 kilobases (kb) in length. r-loops between the 7-kb (35s) a-particle genomic ribonucleic acid and several of these genes were colinear, with no visible evidence of intervening deoxyribonucleic acid sequences. one recombinant was found with an a-particle gene that contained a 1.7-kb deletion. using ... | 1981 | 6821514 |
| modes of inheritance of x-y dissociation in inter-subspecies hybrids between balb/c mice and mus musculus molossinus. | genetic analysis of the high frequency of x-y chromosome dissociation found in primary spermatocytes of f1 hybrids between japanese wild mice (mus musculus molossinus) and inbred laboratory mice (balb/c) was attempted. the frequency of x-y dissociation (x//y) in both balb/c and m. m. molossinus was lower than 30% (low x//y), while the value was more than 70% (high x//y) in their f1 hybrids. two types of progeny (high x//y and low x//y) appeared in the backcross between balb/c and high x//y males ... | 1983 | 6861526 |
| fv-4: gene controlling resistance to nb-tropic friend murine leukemia virus. distribution in wild mice, introduction into genetic background of balb/c mice, and mapping of chromosomes. | a gene controlling resistance to nb-tropic friend murine leukemia virus (f-mulv) was studied in wild mice. mice of various subspecies were crossed with inbred balb/c mice, and their f1 hybrids were tested for resistance to f-mulv. some mice of mus musculus molossinus (japan), m. musculus castaneus (taiwan and the philippines), and m. musculus urbanus (sri lanka) appeared to have a dominant resistance gene. a partially congenic strain, balb/c-fv-4wr (c4w), was established by the introduction of t ... | 1981 | 6946250 |
| biochemical markers of three strains derived from japanese wild mouse (mus musculus molossinus). | twenty-eight biochemical markers were examined in three strains (mol-a, mol-n and mol-t) derived from the the japanese wild mouse, mus musculus molossinus, as well as five laboratory strains, mus musculus musculus. the mol strains showed specific alleles at as many as 12 loci. these findings emphasize that the mol strains have significance in future genetic and developmental studies. | 1982 | 6954949 |
| the primary structure of genetic variants of mouse hemoglobin. | the primary structures of the alpha globins from ce/j, dba/2j, and a stock of potter's mice were determined to identify the amino acid substitutions associated with the unique isoelectric focusing patterns of these hemoglobins. in addition, the primary structures of the alpha globins from mol iii and peru mice were studied in search of amino acid substitutions that may not be detected by isoelectric focusing. ce/j hemoglobin contains a unique kind of alpha globin called chain 5. it differs from ... | 1982 | 7092800 |
| high frequency fo x-y chromosome dissociation in primary spermatocytes of f1 hybrids between japanese wild mice (mus musculus molossinus) and inbred laboratory mice. | in the hybrids between japanese wild mice (mus musculus molossinus) and inbred laboratory mice (balb/c and b10.br, which were probably derived from m. m. domesticus), the x and y chromosomes dissociated precociously at the first meiotic metaphase in some 70% of spermatocytes; that percentage was only 8.9% in inbred laboratory mice and 21.1% in wild mice. x-y dissociation began at least at early diakinesis and continued during metaphase i (mi). some autosomes of the hybrid (10.1%) and balb/c (10. ... | 1981 | 7226897 |
| a novel partial t haplotype with a brachyury-independent effect on tail phenotype. | the btm (brachyury-interacting tail length modifier) mutation was discovered in strain mol-nis derived from japanese wild mice (mus musculus molossinus) as an autosomal recessive mutation. homozygotes for this mutation show a short tail phenotype and, moreover, this mutation causes the tailless character by interacting with the t (brachyury) gene on chromosome (chr) 17. our linkage tests and rflp analyses suggest that btm is located within the t complex on chr 17 and represents a new partial t h ... | 1995 | 7647460 |
| radiation-induced lymphomas in msm, (balb/chea x msm) f1 and (balb/chea x sts/a) f1 hybrid mice. | m.mol-msm (msm) mice derived from mus musculus molossinus progenitors showed extreme resistance to the induction of lymphomas following whole-body x-irradiation with four doses of 1.7 gy. (balb/chea x msm) f1 mice between a high lymphoma strain, balb/chea and the msm showed a high incidence of radiation-induced lymphomas which was quite similar to that in balb/chea mice, but the latent period was prolonged in the hybrids. susceptibility in incidence was dominant over resistance in these crosses. ... | 1995 | 7705478 |
| the gene bfsp1 for the lens fiber cell beaded-filament structural protein cp94 maps to mouse chromosome 2. | bfsp1 is a mouse gene encoding the lens beaded-filament structural protein cp94. by use of rat cp94 cdna as a probe, southern hybridization of mouse dnas prepared from the interspecific backcross progeny between mus molossinus-mit and c57bl/6j strains was carried out. the results indicated that bfsp1 maps at position 58 (+/- 6) on chromosome 2, in the vicinity of the blind-sterile (bs) locus. | 1994 | 7806233 |
| homology of p53 intronic sequences between four laboratory mouse strains and japanese wild mouse (mus musculus molossinus mishima). | strain variation in the mouse p53 gene sequences was investigated in various regions of the gene in 14 inbred strains of laboratory mice and one japanese wild mouse strain (mus musculus molossinus mishima, m. mol-msm). nucleotides within p53 introns 1 and 7, found to be identical in 10 of the laboratory strains (129/j, a/j, akr/j, balb/cj, c3h/hej, c57bl/6j, cba/j, ce/j, nzb, and swr/j), were substituted for other nucleotide sequences in common with m. mol-msm and the four other strains (dba/1j, ... | 1994 | 7828835 |
| positive selection of invariant v alpha 14+ t cells by non-major histocompatibility complex-encoded class i-like molecules expressed on bone marrow-derived cells. | v alpha 14+ t cells are a unique subset expressing an invariant t-cell antigen receptor alpha chain encoded by v alpha 14 and j alpha 281 gene fragments with a 1-nt n region. most invariant v alpha 14+ t cells develop in extrathymic organs, independent of thymus, and expand at a high frequency in various mouse strains regardless of major histocompatibility complex (mhc) haplotype. in this paper, we show that the positive selection of invariant v alpha 14+ t cells requires a beta 2-microglobulin- ... | 1995 | 7862661 |
| structure, function, and evolution of mouse tl genes, nonclassical class i genes of the major histocompatibility complex. | in contrast to well-studied "classical" class i genes of the major histocompatibility complex (mhc), the biology of nonclassical class i genes remains largely unexamined. the mouse tl genes constitute one of the best defined systems among nonclassical class i genes in the t region of the mhc. to elucidate the function and the evolution of tl genes and their relationship to classical class i genes, seven tl dna sequences, including one from a japanese wild mouse, were examined and compared with t ... | 1994 | 8022824 |
| comparison of cdnas encoding the gibbon ape leukaemia virus receptor from susceptible and non-susceptible murine cells. | the gibbon ape leukaemia virus (galv) family of type c retroviruses consists of five closely related viral isolates, galv sf, galv seato, galv br, galv h and simian sarcoma-associated virus. the cdna encoding the human receptor for galv seato had previously been isolated. we now demonstrate that all of the above galvs can use the human form of the galv receptor to infect cells. all murine cells analysed to date have been found to be resistant to infection by galvs owing to the absence of a funct ... | 1994 | 8046392 |
| mapping of the mod-1 locus on mouse chromosome 9. | a new method for typing the mod-1 locus on mouse chromosome (chr) 9 was developed, based on restriction fragment length polymorphism (rflp) within a polymerase chain reaction (pcr)-amplified fragment. the new method led us to revise the strain distribution pattern (sdp) of mod-1 in the bxd (c57bl/6j x dba/2j) and akxd (akr/j x dba/2j) recombinant inbred (ri) strains. the new sdp eliminates several previously reported examples of double recombination events between mod-1 and the closest flanking ... | 1993 | 8100460 |
| hotspots of meiotic recombination in the mouse major histocompatibility complex. | meiotic recombination is not random in the proximal region of the mouse major histocompatibility complex (mhc). it is clustered at four restricted positions, so-called hotspots. some of the mhc haplotypes derived from asian wild mice enhance recombination at the hotspots in genetic crosses with standard mhc haplotypes of laboratory mouse strains. in particular, the wm7 haplotype derived from japanese wild mouse indicated an approximately 2% recombination frequency within a 1.2 kb fragment of dna ... | 1993 | 8224858 |
| a b2 repeat insertion generates alternate structures of the mouse muscle gamma-phosphorylase kinase gene. | a variety of cdna and genomic clones for the gamma-subunit of mouse muscle phosphorylase kinase (phk-gamma m) have been isolated and characterized. the murine gene for phk-gamma m (phkg) exhibits multiple transcription start sites that are identical in skeletal muscle, cardiac muscle, and brain. the gene is composed of 10 exons and includes a 4.9-kb intron located in the 5' untranslated region. two mrna species of 1.75 and 2.55 kb are produced from phkg in icr and c57bl/10 mice; these transcript ... | 1993 | 8486349 |
| [inbreeding process and establishment of new inbred lines derived from the japanese house mouse, mus musculus molossinus]. | inbreeding of 8 groups in molossinus mouse began in (miura female x urawa male) f1 (mu) from the stock captured in the kanto district of japan and were accomplished by each primiparous littermates. the animals were kept under a clean conventional condition at 23.5 +/- 2.5 degrees c and 50 +/- 5% in relative humidity. pellet feed, crf-1, and tap water were provided ad libitum. the respective number of inbreeding generations of mua, muf and mug now exceeds f21, f20 and f22, respectively. inbreedin ... | 1993 | 8519292 |
| [changes in body weight, food and water intake, organ indices and tissue component parts with growth in the established inbred lines derived from the japanese house mouse, mus musculus molossinus]. | changes in body weight, food and water intake, organ indices and tissue component parts with growth in the inbred lines of the molossinus mouse were examined. the characteristic for the mouse is to be very small in body weight; the body weights linearly increased from neonatal period to 1 month and also increased with age, but became constant after 7 months (19.9 +/- 1.6 g) for male and 9 months (19.3 +/- 0.7 g) for female. maximum body weight was 21.5 g for the male and 20.1 g for the female. f ... | 1993 | 8519293 |
| functional comparison of the mus musculus molossinus and mus musculus domesticus sry genes. | the sry gene functions as a genetic switch initiating testicular development of the indifferent mammalian gonad. the mus musculus molossinus sry open reading frame (orf) encodes a 395-amino acid transcription factor (msry) that specifically binds and bends dna through its n-terminal hmg domain and activates transcription through its long c-terminal (residues 144-366) glutamine/histidine-rich activation domain. the m. m. domesticus sry orf encodes a highly homologous, truncated protein (dsry) of ... | 1995 | 8614401 |
| genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9. | the murine polycystic kidney disease gene, pcy, is an autosomal recessive trait located on chromosome 9. to determine the genetic locus of pcy, 222 intraspecific backcross mice were obtained by mating c57bl/6fg-pcy and mus molossinus. restriction fragment length polymorphism analysis of 70 of the 222 backcross progeny showed that pcy, dilute coat color (d), and cholecystokinin (cck) were located in the order d--pcy--cck from the centromere. simple sequence repeat length polymorphism analysis of ... | 1995 | 8825940 |
| rim2 (recombination-induced mutation 2) is a new allele of pearl and a mouse model of human hermansky-pudlak syndrome (hps): genetic and physical mapping. | a mouse mutation, rim2, is one of a series of spontaneous mutations that arose from the intra-mhc recombinants between japanese wild mouse-derived wm7 and laboratory mhc haplotypes. this mutation is single recessive and characterized by diluted coat color and hypo-pigmentation of the eyes. we mapped the rim2 gene close to an old coat color mutation, pearl (pe), on chromosome (chr) 13 by the high-density linkage analysis. the pearl mutant is known to have abnormalities similar to hermansky-pudlak ... | 1998 | 9434937 |
| a new inbred strain jf1 established from japanese fancy mouse carrying the classic piebald allele. | a new inbred strain jf1 (japanese fancy mouse 1) was established from a strain of fancy mouse. morphological and genetical analysis indicated that the mouse originated from the japanese wild mouse, mus musculus molossinus. jf1 has characteristic coat color, black spots on the white coat, with black eyes. the mutation appeared to be linked to an old mutation piebald (s). characterization of the causative gene for piebald, endothelin receptor type b (ednrb), demonstrated that the allele in jf1 is ... | 1998 | 9434939 |
| mapping of genetic modulators of natural resistance to infection with salmonella typhimurium in wild-derived mice. | despite antibiotic therapy and vaccination programs, microbial diseases continue to be the leading cause of morbidity and mortality worldwide. the genetic basis of the host response to infection is complex, and its understanding has been facilitated through the study of mouse models of human infectious diseases. genetic variation in resistance of mice to infection with salmonella typhimurium has been recognized for over 50 years and shown to be a multifactorial trait. we have studied the genetic ... | 1998 | 9479490 |
| prenatal and postnatal maternal effects on body weight in cross-fostering experiment on two subspecies of mice. | a cross-fostering experiment was conducted on two quite distinct subspecies of mice, domesticated laboratory mouse of cf#1 (mus musculus domesticus) and yonakuni wild mouse (yk, mus musculus molossinus yonakuni), to estimate the prenatal and postnatal maternal effects on body weight of offspring. mating was done between subspecies, two or three females being mated to a male at nine-ten weeks of age. two dams of different subspecies that littered at the same day were used as a group of foster dam ... | 1998 | 9606419 |
| loss of imprinting of the insulin-like growth factor ii gene in mouse hepatocellular carcinoma cell lines. | we investigated expression of insulin-like growth factor ii (igf2) in primary cultured hepatocytes, liver epithelial (le) cell lines derived from normal hepatocytes, and hepatocellular carcinoma (hcc) cell lines from crosses between c3h/hej (c3h) and mus musculus molossinus mice (msm). igf2 mrna was detected by reverse transcriptase-polymerase chain reaction in primary cultured hepatocytes from 5 d after the start of cultivation and in all 12 le and 16 hcc cell lines. analysis of the untranslate ... | 1998 | 9869454 |
| spontaneously hyperlipidemic (shl) mice: japanese wild mice with apolipoprotein e deficiency. | during inbreeding of japanese wild mice (mus musculus molossinus), we established a strain of mice with severe cutaneous xanthomatous lesions. since those mice showed high plasma cholesterol values, we named them spontaneously hyperlipidemic (shl) mice; total cholesterol values of these mice (even when fed on conventional low-fat diet) are unusually high throughout the life span. the xanthomatous lesions appear in palms and distal extremities of forelimbs as early as 4 weeks after birth, and con ... | 1999 | 10087291 |
| postnatal blood cell counts of japanese house mice (mus musculus molossinus): maintenance of low numbers of white blood cells. | | 1998 | 10090071 |
| tawny: a novel light coat color mutation found in a wild population of mus musculus molossinus, a new allele at the melanocortin 1 receptor (mc1r) locus. | we found a new coat color mutant in a population of japanese wild mice (mus musculus molossinus) and called the trait tawny. the tawny mutant is characterized by a light yellowish brown coat color. the tawny hair has a so-called agouti pattern, but the yellow band is greatly lengthened. there are no differences between the tawny and wildtype hairs in size and the number of melanosomes. genetic analyses revealed that the tawny trait is an autosomal recessive and its gene is located in the distal ... | 1999 | 10374067 |
| diallel cross analysis of body weight in subspecies of mice. | a complete 4 x 4 diallel cross of cf#1 (c), c57bl/6ncrj (b) c3h/hencrj (h) and yonakuni wild mice (y, mus musculus molossinus yonakuni) has been conducted to estimate the effects of sex, degree of heterosis, general combining ability (gca), specific combining ability (sca), maternal ability, and reciprocal cross on body weight at 1 (wk1), 3 (wk3), 6 (wk6) and 10 (wk10) weeks of age. a least squares analysis was performed on 828 mice and all sources of variation showed significant effects (p < 0. ... | 1999 | 10591008 |
| a genetic linkage map of the msm japanese wild mouse strain with restriction landmark genomic scanning (rlgs). | a high-resolution genetic map of the mus musculus molossinus (msm) japanese wild mouse strain was constructed with restriction landmark genomic scanning (rlgs) and compared with that of the laboratory strain c3h. msm is phylogenetically 1 million years apart from common laboratory mouse strains and is distinctly resistant to chemical carcinogenesis. since it exhibits frequent genetic polymorphisms with laboratory mice but can still be easily crossed with laboratory strains, hybrids between msm a ... | 2000 | 10790533 |
| establishment and characterization of the mskr inbred strain originated from japanese wild mice (mus musculus molossinus). | a new inbred strain, mskr, originated from japanese wild mice was established in april, 1998. the mskr mice were 60% of the c57bl/6n inbred mice in the 60-day body weight. tail length/head-body length and hind-foot length/head-body length of the mskr mice were significantly smaller than those of the c57bl/6n mice (0.896 vs 1.061, 0.189 vs 0.204), but ear length/head-body length of the mskr mice was significantly larger than that of the c57bl/6n mice (0.143 vs 0.137). the age of the first parturi ... | 2000 | 10823731 |
| a major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in nc/nga mice is located on chromosome 9. | nc/nga (nc) is a newly discovered model mouse for human atopic dermatitis, nc mice showing specific symptoms such as dermatitis and overproduction of ige. to detect the loci responsible for the onset of dermatitis in the mice, backcross (n2) progeny between (ncxmsm/ms)f1 and nc were generated, where msm/ms is an inbred strain from japanese wild mice, mus musculus molossinus. linkage disequilibrium between dermatitis and various chromosome-specific microsatellite markers was then examined in the ... | 2001 | 11261926 |
| two interactive genes responsible for a new inherited cataract (rct) in the mouse. | we discovered a mutant mouse, rct (rinshoken cataract), with a new congenital cataract in strain sjl/j. the opacity of the lens associated with microphthalmia could be observed visually at 3 to 3.5 months of age. marked degeneration of the lens, including loss of the fine structure of the lens fibers and swelling of epithelial cells with vacuoles of various sizes in the cortex, but no other defects except photoreceptor degeneration in the retina, was detected. histological change in the lens was ... | 2001 | 11309658 |
| low levels of sry transcripts cannot be the sole cause of b6-y(tir) sex reversal. | sry, a single-copy gene on the y-chromosome, triggers the fetal gonad to begin testis differentiation in mammals. on the other hand, mutation or absence of sry results in ovary differentiation and the female phenotype. however, cases of xy sex reversal in the presence of wild-type sry exist in mice and man. one such example is the b6-y(tir) mouse, whose autosomes and x-chromosome are from the c57bl/6j mouse (an inbred strain of mus musculus molossinus), whereas the y-chromosome is from a mus mus ... | 2001 | 11353512 |
| host immune response to salmonella enterica serovar typhimurium infection in mice derived from wild strains. | studies of mouse models of endotoxemia and sepsis with gram-negative bacteria have shown that the host response is genetically controlled. mice infected with the gram-negative bacterium salmonella enterica serovar typhimurium exhibit marked genetic differences in disease manifestation, and the wild-derived strain mus musculus molossinus molf/ei is extremely susceptible to s. enterica serovar typhimurium. the kinetics of bacterial proliferation within the liver and the spleen and histological exa ... | 2002 | 11895964 |
| respiratory mechanics in mice: strain and sex specific differences. | to assess the contribution of genetic background to respiratory mechanics, we developed a ventilator unit to measure lung function parameters in the mouse. we studied two commonly used inbred mice strains originating from mus musculus domesticus (c57bl/6 and c3heb/fej) and a third strain derived from mus musculus molossinus [japanese fancy mouse 1 (jf1)]. the ventilator allows for accurate performance of the different breathing manoeuvres required for measuring in- and expiratory reserve capacit ... | 2002 | 11942924 |
| helicobacter muricola sp. nov., a novel helicobacter species isolated from the ceca and feces of korean wild mouse (mus musculus molossinus). | a slowly growing microaerophilic helicobacter strain was isolated from the ceca and fecal pellets of korean wild mice (mus musculus molossinus). this bacterial strain possessed a pair of nonsheathed bipolar flagella, was positive for urease, catalase and oxidase, and reduced nitrate to nitrite. it proved susceptible to nalidixic acid and resistant to cephalodine, and did not hydrolyze hippurate. on the basis of phenotypic characteristics and 16s rrna gene sequence analysis, the isolate represent ... | 2002 | 12007652 |
| comparison of glycoprotein hormone alpha-subunits of laboratory animals. | the common alpha-subunit of glycoprotein hormones (cgalpha) is a core protein shared by follicle-stimulating hormone (fsh), luteinizing hormone (lh), and thyroid-stimulating hormone (tsh). in order to obtain a molecular basis for an efficient superovulation technique applicable to a wide range of animal species and to discuss the phylogenetic aspect based on molecules related to the reproductive system, we determined cdna sequences of cgalpha in seven laboratory animals: the guinea pig, mongolia ... | 2002 | 12112597 |
| female mice of ddk strain are fully fertile in the intersubspecific crosses with mus musculus molossinus and m. m. castaneus. | the female mice of ddk strain are almost infertile when mated with males from other strains. this phenomenon is caused by the early death of f1 embryos owing to the incompatibility system attributed to the ovum mutant (om) locus on chromosome (chr) 11 and known as ddk syndrome. in the present study, ddk females were found to be fully fertile in the intersubspecific matings with the males of two wild mouse-derived strains, mom (originated from japanese wild mice, mus musculus molossinus) and cas ... | 2002 | 12140682 |
| hereditary keratoconus-like keratopathy in japanese wild mice mapped to mouse chromosome 13. | human keratoconus is a common corneal disease with non-inflammatory corneal ectasia, and a subset of this disease is heritable. in an effort to establish animal models for this disease, we discovered japanese keratoconus (jkc) mice among mishima molosinus (msm) mice, an inbred strain of japanese wild mice (mus musculus molossinus). typical phenotypic corneas of jkc mice are, like human keratoconus, conical in shape, although the corneas were often associated with a red punctum at the tip. in con ... | 2002 | 12514747 |
| physical performance and soleus muscle fiber composition in wild-derived and laboratory inbred mouse strains. | we compared four inbred mouse strains in their physical performance, measured as a maximal treadmill running time, characteristics of soleus muscle, anatomic character, and growth. the strains used were mus musculus domesticus [c57bl/6 (b6) and balb/c], mus musculus molossinus (msm/ms), and mus spretus. maximal running time was significantly different among these four mouse strains. running time until exhaustion was highest in msm/ms and lowest in m. spretus. maximal times for the laboratory mou ... | 2003 | 12851421 |
| studies on the parasites of the japanese house mouse, mus molossinus. i. helminth parasites in the mouse living in different environments. | | 1962 | 13952267 |
| studies on the parasites of the japanese house mouse, mus molossinus. ii. intestinal protozoa in the mouse living in two different environments and seasons. | | 1963 | 14043118 |
| genetic mapping of the absence of third molars in el mice to chromosome 3. | we noted the absence of all 4 third molars (m3) in epilepsy-like disorder (el) mice, an animal model for the study of epilepsy. this study was conducted to identify the major candidate chromosome and to detect the region that included the candidate gene causing the absence of m3 in el mice. linkage analysis was performed on genetic crosses of el mice and msm (mus musculus molossinus) strain mice, which had a normal complement of teeth. genome-wide screening by individual genotyping of f(2) inter ... | 2003 | 14514757 |
| polymorphisms of mouse apolipoprotein a-ii: seven alleles found among 41 inbred strains of mice. | in mice, apolipoprotein a-ii (apoa-ii) associates to form amyloid fibrils in an age-associated manner. we determined the complete nucleotide sequences of the apoa-ii gene (apoa2) cdna in 41 inbred strains of mice including mus musculus domesticus (laboratory mouse), mus musculus castaneus, mus musculus molossinus, mus musculus musculus and mus spretus. among these strains we identified 7 alleles (apoa2a1, apoa2a2, apoa2b, apoa2c, apoa2d, apoa2e and apoa2f). polymorphisms of nucleotides at 15 pos ... | 2003 | 14986479 |