| spontaneous cardiomyopathy resembling acute rheumatic heart disease in an owl monkey. | a wild-caught male aotus vociferans died spontaneously during quarantine. histologic examination of the heart showed several small myocardial arteries replaced with fibrinoid necrosis and adjacent inflammation that included lymphocytes and large histiocytic cells. less often, similar inflammatory foci were observed in the myocardium interstitium. the lesions observed in the heart of the owl monkey resembled aschoff bodies. | 1992 | 1307758 |
| infection of aotus vociferans monkeys with different strains of plasmodium falciparum. | twenty-one splenectomized aotus vociferans monkeys were infected with the different strains/clones of plasmodium falciparum. maximum parasitemia ranged from 1,302 to 1,460,000 parasites per mm3. only the santa lucia strain was shown to produce gametocytes for extended periods. gametocytes produced during the primary episode of parasitemia were highly infective to anopheles freeborni mosquitoes. gametocytes produced during recrudescence were not infective to mosquitoes feeding directly on the ani ... | 1991 | 1865263 |
| renal pathology in owl monkeys in plasmodium falciparum vaccine trials. | renal specimens of 16 owl monkeys (aotus vociferans) were studied by light microscopy and immunohistochemistry during a vaccine trial with recombinant proteins of the ring-infected erythrocyte surface antigen (resa) of plasmodium falciparum. deposition of igg, c3, and p. falciparum antigens in the mesangium was demonstrated by the peroxidase anti-peroxidase (pap) method. a relationship between the severity of parasitemia at the time of death and the presence of nephropathy was not apparent. | 1990 | 2202223 |
| mortality causes of owl monkeys (aotus nancymae and aotus vociferans) in captivity. | to determine the main causes of death in "owl monkeys" (aotus nancymae and a. vociferans) in captivity, 115 necropsies were performed. according to the macroscopic findings and clinical data, results are as follow: acute lobular pneumonia (25.2%), chronic nephropathy (10.4%), acute catarrhal enteritis (8.7%), acute hemorrhagic enteritis (7%), acute toxic hepatitis (5.2%), trauma (5.2%), and others. | 1990 | 2338706 |
| differences in mineral metabolism among nonhuman primates receiving diets with only vitamin d3 or only vitamin d2. | we tested for differences in aspects of mineral metabolism during the administration of diets with only vitamin d3 or only vitamin d2 in four nonhuman anthropoid primate species [two catarrhini, macaca fascicularis (crab-eating macaque) and macaca mulatta (rhesus macaque), and two platyrrhini, saimiri sciureus (squirrel monkey) and aotus vociferans (night monkey)]. all four species maintained approximately 2- to 3-fold higher serum 25-hydroxyvitamin d (25ohd) level while receiving vitamin d3 tha ... | 1989 | 2555385 |
| infection of aotus vociferans (karyotype v) monkeys with different strains of plasmodium vivax. | twenty splenectomized aotus vociferans (karyotype v) monkeys were infected with strains of plasmodium vivax from new guinea, north korea, indonesia, el salvador, and honduras. peak parasite densities ranged from 4,840 to 75,500 per mm3. gametocytes infective to different species of mosquitoes were produced with all strains of p. vivax studied. two transmissions of the chesson strain of p. vivax were made by the intravenous inoculation of dissected sporozoites from an. dirus mosquitoes. prepatent ... | 1987 | 2885404 |
| immunization trials with the ring-infected erythrocyte surface antigen of plasmodium falciparum in owl monkeys (aotus vociferans). | a protocol was developed for the testing of blood stage vaccines against plasmodium falciparum using peruvian aotus vociferans and the indochina i/cdc strain of the parasite. three different fused polypeptide vaccines containing elements of the ring-infected erythrocyte surface antigen molecule combined with freund's complete and freund's incomplete adjuvants were tested to determine their ability to protect against overwhelming infection following challenge with this highly virulent strain of p ... | 1988 | 3281493 |
| studies on a newly isolated strain of plasmodium brasilianum in aotus and saimiri monkeys and different anophelines. | a strain of plasmodium brasilianum was isolated from an aotus vociferans monkey from peru. the parasite readily infected aotus monkeys from bolivia and columbia and saimiri sciureus monkeys from peru and bolivia. highest level mosquito infections were obtained by feeding on the saimiri monkeys. the most susceptible mosquito was anopheles freeborni, followed by anopheles dirus, anopheles stephensi, anopheles gambiae, anopheles culicifacies, anopheles maculatus and anopheles albimanus. anopheles q ... | 1985 | 4093810 |
| comparison of blood and urine analytes between two karyotypes of owl monkey, aotus nancymae and aotus vociferans. | serum and urine analytes were compared between two karyotypes of owl monkey, aotus nancymae and a. vociferans, to determine if normative clinical pathology data obtained from one karyotype were applicable to the other. statistically significant differences (p < or = 0.05) were noted in serum calcium, serum phosphorus, serum sodium, serum potassium, serum urea nitrogen, urine calcium, calcium clearance, and fractional clearance of calcium between the two karyotypes. the results suggest that a. vo ... | 1993 | 8138987 |
| trypanosomes and microfilariae in feral owl and squirrel monkeys maintained in research colonies. | a group of 358 owl and squirrel monkeys imported from colombia, peru, and bolivia for the u.s. agency for international development malaria vaccine development program was examined for trypanosomes and microfilariae. trypanosoma rangeli, isolated by hemoculture from aotus nancymai, saimiri b. boliviensis, and s. b. peruviensis, accounted for 76.6% of all trypanosome infections. trypanosoma cruzi was isolated from 25 of 194 s. b. boliviensis, including two mixed infections with t. rangeli. identi ... | 1993 | 8357088 |
| hematologic values of the wild-caught karyotype v owl monkey (aotus vociferans). | blood samples from 35 wild-caught owl monkeys (aotus vociferans, karyotype v) were analyzed to estimate reference intervals of hematologic variables for the species. findings indicated that distributions were abnormal for leukocytes, neutrophils, eosinophils, basophils, and monocytes. statistically significant sex differences, too small to be of clinical importance, were found in values for mean cell hemoglobin concentration, leukocytes, and basophils. reference intervals for the hematologic var ... | 1995 | 8569160 |
| the santa lucia strain of plasmodium falciparum as a model for vaccine studies. ii. development of aotus vociferans as a model for testing transmission-blocking vaccines. | the santa lucia strain of plasmodium falciparum and the aotus vociferans monkey were studied as models for the testing of transmission-blocking vaccines. virulence developed early in the passage history. despite the use of only small quantities of chlorguanide and/or quinine to control infection coupled with the use of small inocula and delays in splenectomy, mosquito infection was markedly reduced from that seen during primary passage to this species of aotus. it appears that the model may be m ... | 1996 | 8615451 |
| attempts to transmit the n-3 strain of plasmodium fieldi to aotus monkeys. | aotus lemurinus griseimembra monkeys inoculated with parasitized erythrocytes of the n-3 strain of plasmodiumfieldi had transient low-density parasitemia. exoerythrocytic stages of this strain of parasite were demonstrated in sections of liver from aotus vociferans monkeys taken 8 days after the intravenous inoculation of sporozoites dissected from the salivary glands of anopheles dirus mosquitoes; no blood-stage infections were observed. | 1998 | 9488369 |
| systemic yeast infection in owl monkeys (aotus vociferans): ante-mortem screening and diagnosis by examination of bone marrow aspirates. | | 1998 | 10090050 |
| vaccine efficacy of recombinant plasmodium falciparum merozoite surface protein 1 in malaria-naive, -exposed, and/or -rechallenged aotus vociferans monkeys. | protection against a lethal challenge infection of plasmodium falciparum was elicited in malaria-naive aotus vociferans monkeys by vaccination with the c terminus 19-kda protein of the major merozoite surface protein (msp-1(19)) fused to tetanus toxoid universal t-cell epitopes p30 and p2. three of four monkeys were protected against a 10(4)-parasite challenge. four monkeys were challenged with 10(5) parasites; one self-cured the infection, two were protected against high parasitemia (<2%) but w ... | 2000 | 10678955 |
| adaptation of a chloroquine-resistant strain of plasmodium vivax from indonesia to new world monkeys. | the spread of chloroquine-resistant plasmodium vivax from papua new guinea and indonesia poses a serious health threat to areas of southeast asia where this species of malaria parasite is endemic. a strain of p. vivax from indonesia was adapted to develop in splenectomized aotus lemurinus griseimembra, aotus vociferans, aotus nancymai, and saimiri boliviensis monkeys. transmission to splenectomized saimiri monkeys was obtained via sporozoites. chemotherapeutic studies indicated that the strain w ... | 2000 | 11220765 |
| partial characterization of the cd45 phosphatase cdna in the owl monkey (aotus vociferans). | cd45 is a protein tyrosine phosphatase implicated in t and b cell activation, differentiation, and development. it dephosphorylates specific tyrosine residues on its substrates, principally on the src-family of protein tyrosine kinases, thus regulating t cell or b cell activation during the immune response. in this study, we present the partial cd45 nucleotide and deduced amino-acid sequences for the owl monkey (aotus vociferens). there is 97% identity in the nucleotide sequence and 96% in the a ... | 2002 | 11977121 |
| vaccination of monkeys with recombinant plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria. | a major challenge facing malaria vaccine development programs is identifying efficacious combinations of antigens. to date, merozoite surface protein 1 (msp1) is regarded as the leading asexual vaccine candidate. apical membrane antigen 1 (ama1) has been identified as another leading candidate for an asexual malaria vaccine, but without any direct in vivo evidence that a recombinant form of plasmodium falciparum ama1 would have efficacy. we evaluated the efficacy of a form of p. falciparum ama1, ... | 2002 | 12438375 |
| comparative analysis of cd45 proteins in primate context: owl monkeys vs humans. | transmembrane protein tyrosine phosphatase (ptpase) cd45 has been implicated in activating, differentiating and the development of different immune system cells. it regulates t-or b-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. aotus nancymaae, aotus nigriceps, and aotus vociferans cd45 nucleotide and deduced amino acid sequences are presented here, where we found 90-92% identity with the human counterpart in the nucleot ... | 2004 | 15245371 |
| reference strand conformational analysis (rsca) is a valuable tool in identifying mhc-drb sequences in three species of aotus monkeys. | the aotus monkey has been of great value in the pre-clinical study of malaria vaccine candidates. several components of this primate's immune system have been studied and they display great similarity to their human counterparts. cloning and sequencing studies have revealed extensive sequence polymorphisms in aotus mhc-drb with very high similarities to several human allelic lineages, grouping at least nine distinct mhc-drb lineages. as the efficacy of peptide vaccines in this animal model may b ... | 2006 | 16733718 |
| owl monkey mhc-drb exon 2 reveals high similarity with several hla-drb lineages. | one hundred and ten novel mhc-drb gene exon 2 nucleotide sequences were sequenced in 96 monkeys from three owl monkey species (67 from aotus nancymaae, 30 from aotus nigriceps and 13 from aotus vociferans). owl monkeys, like humans, have high mhc-drb allele polymorphism, revealing a striking similarity with several human allele lineages in the peptide binding region and presenting major convergence with drb lineages from several catarrhini (humans, apes and old world monkeys) rather than with ot ... | 2006 | 16791623 |
| studies on sporozoite-induced and chronic infections with plasmodium fragile in macaca mulatta and new world monkeys. | plasmodium fragile continues to be investigated because of its biologic similarities to the human malaria parasite, plasmodium falciparum. two strains of p. fragile are available for study; one strain is able to infect mosquitoes, whereas the other strain is transmissible only by blood inoculation. the sri lanka strain of p. fragile was transmitted to macaca mulatta, macaca fascicularis, aotus lemurinus griseimembra, aotus nancymaae, aotus vociferans, and saimiri boliviensis monkeys via sporozoi ... | 2006 | 17152944 |
| adaptation of a multi-drug resistant strain of plasmodium falciparum from peru to aotus lemurinus griseimembra, a. nancymaae, and a. vociferans monkeys. | a strain of plasmodium falciparum from peru was adapted to splenectomized aotus nancymaae and aotus vociferans monkeys. the peru 134/cdc strain of p. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this peruvian strain of p. falciparum. | 2007 | 17690397 |
| relationship of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and proteinuria to cardiomyopathy in the owl monkey (aotus vociferans). | the purpose of this study was to determine serum reference values for creatine kinase (ck), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) in captive-born and wild-caught owl monkeys to assess their usefulness for diagnosing myocardial disease. | 2008 | 18269526 |
| multisystemic eosinophilia resembling hypereosinophilic syndrome in a colony-bred owl monkey (aotus vociferans). | in animals, multisystemic eosinophilic disease is a rare condition characterized by eosinophilic and lymphoplasmacytic infiltrates in various organs. this disorder resembles the human disease known as hypereosinophilic syndrome, a condition defined by prolonged peripheral eosinophilia in the absence of recognizable etiology and associated with end-organ damage. in this report we describe a research-naïve, colony-born, juvenile female owl monkey (aotus vociferans) who presented clinically with se ... | 2009 | 19476722 |
| a new world primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1. | human immunodeficiency virus type 1 (hiv-1) does not replicate in primary cells of new world primates. to better understand this restriction, we expressed owl monkey (aotus nancymaae) cd4 and cxcr4 in the owl monkey kidney cell line, omk. an hiv-1 variant modified to evade the owl monkey restriction factor trim-cyp replicated efficiently in these cells but could not replicate in primary a. nancymaae cd4-positive t cells. to understand this difference, we examined apobec3g and tetherin orthologs ... | 2009 | 19553332 |
| infection of mosquitoes with plasmodium falciparum by feeding on humans and on aotus monkeys. | of 1,004 positive lots of mosquitoes fed on 229 humans infected with plasmodium falciparum, 46.2% had 1-10 oocysts/(+)gut, 21.2% had 10-30 oocysts/(+)gut, 22.2% had 30-100 oocysts/(+)gut, and 10.4% had > 100 oocysts/(+) gut. the highest levels of infection occurred between 6 and 15 days after the peak in the asexual parasite count. of 2,281 lots of anopheles freeborni mosquitoes fed on splenectomized aotus monkeys infected with the santa lucia strain of p. falciparum, 1,191 were infected (52.2%) ... | 2009 | 19706927 |
| mosquito infection studies with aotus monkeys and humans infected with the chesson strain of plasmodiun vivax. | oocyst counts were compared between mosquitoes that fed on humans versus mosquitoes that fed on aotus monkeys, both of which were infected with the chesson strain of plasmodium vivax. oocyst counts obtained from mosquitoes fed on humans were almost 10-fold higher in number. mosquitoes were more likely to be infected and with a higher rate of infection when they fed on monkeys before the peak in the asexual parasite count. mosquitoes that fed on humans were more likely to be more heavily infected ... | 0 | 22403307 |
| identification of owl monkey cd4 receptors broadly compatible with early-stage hiv-1 isolates. | most hiv-1 variants isolated from early-stage human infections do not use nonhuman primate versions of the cd4 receptor for cellular entry, or they do so poorly. we and others have previously shown that cd4 has experienced strong natural selection over the course of primate speciation, but it is unclear whether this selection has influenced the functional characteristics of cd4 as an hiv-1 receptor. surprisingly, we find that selection on cd4 has been most intense in the new world monkeys, anima ... | 2015 | 26063421 |
| characterising a microsatellite for drb typing in aotus vociferans and aotus nancymaae (platyrrhini). | non-human primates belonging to the aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. the immune system of this animal model must be characterised to assess whether the results obtained here can be extrapolated to humans. class i and ii major histocompatibility complex (mhc) proteins are amongst the most important molecules involved in response to pathogens; in spite of this, the techniques availa ... | 2014 | 24820773 |
| identification and diversity of killer cell ig-like receptors in aotus vociferans, a new world monkey. | previous bac clone analysis of the platyrrhini owl monkey kirs have shown an unusual genetic structure in some loci. therefore, cdnas encoding kir molecules from eleven aotus vociferans monkeys were characterized here; ten putative kir loci were found, some of which encoded atypical proteins such as kir4dl and transcripts predicted to encode a d0+d1 configuration (aotvokir2dl1*01v1) which appear to be unique in the aotus genus. furthermore, alternative splicing was found as a likely mechanism fo ... | 2013 | 24223188 |
| owl monkey ccr5 reveals synergism between cd4 and ccr5 in hiv-1 entry. | studying hiv-1 replication in the presence of functionally related proteins from different species has helped define host determinants of hiv-1 infection. humans and owl monkeys, but not macaques, encode a cd4 receptor that permits entry of transmissible hiv-1 variants due to a single residue difference. however, little is known about whether divergent ccr5 receptor proteins act as determinants of host-range. here we show that both owl monkey (aotus vociferans) cd4 and ccr5 receptors are functio ... | 2017 | 28972927 |
| comparison of three reversible injectable chemical restraint protocols in spix´s owl monkeys (aotus vociferans) using ketamine, xylazine and midazolam. | there is scarce information detailing clinical and physiological effects of reversible injectable protocols of chemical restraint on neotropical primates. | 2020 | 32048309 |
| population densities and geographic distribution of night monkeys (aotus nancymai and aotus vociferans) (cebidae: primates) in northeastern peru. | population densities of two species of night (or owl) monkeys (aotus nancymai and aotus vociferans) were estimated using transect census methods. densities of aotus nancymai were approximately 46.3 individuals/km2 in lowland forests and 24.2 individuals/km2 in highland forests. for aotus vociferans densities were 33.0 individuals/km2 in lowland forests and 7.9 individuals/km2 in highland forests. a. vociferans occurs north of the río amazonas-marañon and a. nancymai south of it, except for the n ... | 1988 | 31968914 |
| characteristics and use of sleeping sites in aotus (cebidae: primates) in the amazon lowlands of peru. | in the amazon lowlands of peru, aotus nancymai and a. vociferans were observed to use four different types of sleeping sites: (1) holes in the trunks and branches of dry or senescent trees; (2) concavities in polyaxial branching nodes of trees protected by dense entanglements of creepers, climbing plants, vines, and masses of diverse epiphytes; (3) complex sites among masses of epiphytes, climbers, and vines; and (4) simple sites among thickets and dense foliage. each type is described. there wa ... | 1986 | 31979438 |