| isolation and structure elucidation of parnafungins c and d, isoxazolidinone-containing antifungal natural products. | parnafungins, natural products containing an isoxazolidinone ring, have been isolated from fusarium larvarum and have been shown to be potent inhibitors of the fungal polyadenosine polymerase. the extraction and analysis of fermentation broths of taxonomically related organisms identified as closely related fusarium spp. produce not only parnafungin a and b, but also significant quantities of two related components. these members of the paranfungin family of natural products have been isolated a ... | 2009 | 19147347 |
| diversity, molecular phylogeny, and bioactive potential of fungal endophytes associated with the himalayan blue pine (pinus wallichiana). | in this study, we investigated the diversity of fungal endophytes associated with pinus wallichiana from the western himalayas, with emphasis on comparison of endophytic communities harbored by the stem and needle tissues of the host and their antimicrobial potential. a total number of 130 isolates, comprising of 38 different genera, were recovered from 210 fragments of the plant. among the isolated fungi, only a single isolate, tritirachium oryzae, belonged to the phylum basidiomycota whereas t ... | 2014 | 24563192 |
| discovery of the parnafungins, antifungal metabolites that inhibit mrna polyadenylation, from the fusarium larvarum complex and other hypocrealean fungi. | evaluation of fungal fermentation extracts with whole cell candida albicans activity resulted in the identification of a novel class of isoxazolidinone-containing metabolites named parnafungins. chemical-genetic profiling with the c. albicans fitness test identified the biochemical target as inhibition of polyadenosine polymerase, a component of the mrna cleavage and polyadenylation complex. parnafungins were discovered from fermentation extracts of fungi resembling f. larvarum isolated from pla ... | 2009 | 19623926 |
| isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mrna polyadenylation. | the candida albicans fitness test, a whole-cell screening platform, was used to profile crude fermentation extracts for novel antifungal natural products with interesting mechanisms of action. an extract with intrinsic antifungal activity from the fungus fusarium larvarum displayed a fitness test profile that strongly implicated mrna processing as the molecular target responsible for inhibition of fungal growth. isolation of the active components from this sample identified a novel class of isox ... | 2008 | 18461935 |