| the discovery of australifungin, a novel inhibitor of sphinganine n-acyltransferase from sporormiella australis. producing organism, fermentation, isolation, and biological activity. | potent antifungal activity was detected in fermentation extracts of sporormiella australis and two related components were isolated from solid fermentations using silica gel and high speed countercurrent chromatography. the most active antifungal component, australifungin, contained a unique combination of alpha-diketone and beta-ketoaldehyde functional groups. australifungin exhibited broad spectrum antifungal activity against human pathogenic fungi with mics against candida spp., cryptococcus ... | 1995 | 7797434 |
| biodegradation of fluoranthene by soil fungi. | a selection of 39 strains of micromycetes known as good degraders of polychlorinated aromatic compounds, mostly isolated from soil and belonging to various taxonomic groups, have been investigated for fluoranthene degradation. toxicity assays, first evaluated on solid medium mea, have not shown any toxicity of fluoranthene (1-100 mg.l-1) towards fungi. whereas, consumption assays on a solid synthetic medium showed a toxicity at 100 mg.l-1. the degradation of fluoranthene (10 mg.l-1) was then inv ... | 1999 | 10230046 |
| fungal degradation of fluorene. | a selection of 30 strains of micromycetes known as good degraders of polychlorinated aromatic compounds, mostly isolated from soil and belonging to various taxonomic groups, have been investigated to degrade fluorene. toxicity assays, first evaluated on solid media, have shown high growth inhibition at concentrations above 0.001 g l-1 only towards 23% of strains. degradation of fluorene (0.005 g l-1) was then investigated in liquid synthetic medium for 2 days and evaluated by hplc. among the 30 ... | 2000 | 10665449 |