| regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human t lymphocytes by piperlactam s isolated from piper kadsura. | effects of piperlactam s (c(17)h(13)no(4); mol. wt. 295) isolated from piper kadsura on phytohemagglutinin (pha) stimulated cell proliferation were studied in primary culture of human t cells. the results showed that piperlactam s suppressed t cell proliferation at about 0 to 12 h after stimulation with pha. synthesis of total cellular proteins and rna in activated cell cultures was also suppressed. the inhibitory action of piperlactam s was not through direct cytotoxicity. cell cycle analysis i ... | 2000 | 11040054 |
| chinese vegetative materia medica in a venereological treatise by jean astruc from 1740. | historical medical sources can be still queried for forgotten cures and remedies. traditional chinese medicine has dealt with lues venerea (syphilis) since the five dynasties period (10th century). chinese indigenous materia medica and remedies recorded, studied or imported by the europeans can reveal known or quite unknown medicinal plants. the studied jean astruc's work is a published ethnopharmacological survey carried out in beijing in the 1730s and it deserves a modern interpretation. | 2016 | 27132716 |
| anti-inflammatory activity of chinese medicinal vine plants. | anti-inflammatory activities of ethanol extracts from nine vine plants used in traditional chinese medicine to treat inflammatory conditions were evaluated against a panel of key enzymes relating to inflammation. the enzymes included cyclooxygenase-1 (cox-1), cyclooxygenase-2 (cox-2), phospholipase a(2) (pla(2)), 5-lipoxygenase (5-lo) and 12-lipoxygenase (12-lo). the vine plants studied were: the stem of spatholobus suberectus dunn, the stem of trachelospermum jasminoides lem., the root from tri ... | 2003 | 12576203 |
| antioxidant activity of piperlactam s: prevention of copper-induced ldl peroxidation and amelioration of free radical-induced oxidative stress of endothelial cells. | the protective effects of piperlactam s, an alkaloid isolated from piper kadsura (choisy) ohwi, on lipid peroxidation and free radical-mediated cell injuries were investigated. piperlactam s (1 to 20 microm) concentration-dependently prevented the copper-catalyzed oxidative modification of human low-density lipoproteins (ldl) measured through (i) the lag period, (ii) the slope of the propagation phase, (iii) the total amount of conjugated dienes formed, and (iv) the electrophoretic mobility of l ... | 2003 | 12567271 |
| constituents of chinese piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro. | the n-hexane extracts of 19 piper species, predominantly from china, were screened for their 5-lipoxygenase (5-lox) and cyclooxygenase-1 (cox-1) inhibitory potential. many of them showed considerable inhibitory activity against at least one of these two key enzymes of the arachidonic acid metabolism, especially against cox-1. the best results in inhibiting the formation of leukotrienes were obtained with the extract of piper kadsura. in the terms of prostaglandin synthesis inhibition, the extrac ... | 2001 | 11297843 |
| [studies on paf antagonistic bicyclo(3,2,1) octanoid neolignans from piper kadsura]. | as a continuation of our previous report dealing with the structures of novel neolignans from piper kadsura (choisy) ohwi, two other new bicyclo(3,2,1) octanoid neolignans, named kadsurenin k and kadsurenin l, were isolated. on the basis of spectral analysis and chemical derivatization, their structures were established as 7r,8r,3'r,5'r-delta 8'-3,5'-dimethoxy-4-hydroxy-2',3',4',5'-tetrahydro-2', 4'-oxo-7.3',8.5'-neolignan and 7r, 8r, 3's, 4'r, 5'r-delta 8'-3,4,5'- trimethoxy-4'-acetoxy-2',3',4' ... | 1993 | 8368081 |
| [effect of an extract from the cauline of piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. | arterial hypotension and high-permeability pulmonary edema were induced by intravenous injection of platelet activating factor (paf) or endotoxin in rats. pre-treatment with extract from the cauline of piper kadsura attenuated endotoxin-induced hypotension and lung injury, which may result from the paf antagonistic effect of piper kadsura. | 1989 | 2619897 |
| the chemical constituents of piper kadsura and their cytotoxic and anti-neuroinflammtaory activities. | the n-hexane and chcl₃ soluble fractions of the meoh extract of the aerial parts of piper kadsura were found to potently inhibit nitric oxide (no) production in lps-activated bv-2 cells, a microglial cell line. from the active fractions, a new stereoisomer of guaiane sesquiterpene, 1α,5β-guai-4(15)-ene-6β,10β-diol, kadsuguain a (1) and a new cyclohexadienone, kadsuketanone a (2), together with twelve known compounds (3-14) were isolated. the structures of these compounds were elucidated by exten ... | 2011 | 20687793 |
| pharmacokinetics of kadsurenone and its interaction with cyclosporin a in rats using a combined hplc and microdialysis system. | kadsurenone is a neolignan with specific antagonistic activity of platelet-activating factor, and is derived from the stems of piper kadsura. to investigate the mechanism of hepatobiliary excretion of kadsurenone and its association with p-glycoprotein (p-gp), and to explore whether the hepatobiliary excretion of kadsurenone was associated with p-gp, a microdialysis system coupled with hplc was developed to measure free-form kadsurenone in rat blood and bile. this study design was parallel in th ... | 2009 | 19111511 |
| anti-inflammatory neolignans from piper kadsura. | two new neolignans, piperkadsin a (1) and piperkadsin b (2), as well as 11 known neolignans, three known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of piper kadsura. the anti-inflammatory activities of these compounds were evaluated. compounds 1, 2, futoquinol (3), piperlactam s (4), and n-p-coumaroyl tyramine (5) showed potent inhibition of pma-induced ros production in human polymorphonuclear neutrophils with ic(50) values 4.3 +/-1. ... | 2006 | 16724856 |