| the in vitro and in vivo antimalarial activity of some mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol, 2-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol, and 4'-chloro-5-(7''-trifluoromethylquinolin-4''-ylamino)biphenyl -2-ols. | a series of di-mannich base derivatives (4 and 5) from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and 2-(7'-trifluoromethylquinolin-4'-ylamino)phenol, respectively, and mono-mannich base derivatives (6) from 4'-chloro-5-(7''-trifluoromethylquinolin-4''- ylamino)biphenyl-2-ol were assayed for activity against the chloroquine-sensitive (fcq-27) isolate of cultured plasmodium falciparum using the inhibition of uptake of radiolabelled hypoxanthine. all seven di-mannich base derivativ ... | 1992 | 1463352 |
| the biology of rodent malaria with particular reference to plasmodium vinckei vinckei rodhain 1952. | | 1971 | 4398609 |
| an approach to development of specific t-lymphocyte lines by use of preprocessed antigens in plasmodium vinckei vinckei murine malaria. | the development of parasite-specific t-cell lines represents one approach to the potential identification of relevant immunogens in erythrocytic malarial infection. however, the use of parasitized-erythrocyte lysates as antigens inhibits the proliferation of t cells. to circumvent this problem, we preincubated antigen-presenting cells (apcs) from spleens of malaria-naive, balb/c mice with a plasmodium vinckei vinckei (hereafter referred to as p. vinckei)-parasitized erythrocyte lysate. apcs were ... | 1993 | 8478085 |
| plasmodium vinckei vinckei and p. yoelii nigeriensis: pattern of gametocyte production and development. | the morphological evolution and the periodicity of the gametocytes of two rodent malaria species were studied in the white mouse. experiments with plasmodium vinckei vinckei, a highly synchronous species, showed that the production of the sexual stages was periodic and was set by the specific rhythm of the asexual stages, i.e. the time of inoculation and the duration of the cycle in the blood. the duration of gametocytogenesis from merozoite to stage 0 was approximately 30 hours, and from stage ... | 1995 | 8532362 |
| oxidative stress and protective mechanisms in erythrocytes in relation to plasmodium vinckei load. | the protection of mouse erythrocytes (rbc) parasitized with plasmodium vinckei vinckei against activated oxygen species was examined in relation to the intraerythrocytic parasite load. rbc from highly infected animals were separated by density gradient centrifugation into six bands with increasing parasite content and with parasitemias ranging from 17% to 100%. increase in parasite load was accompanied by a decrease in the activities of the enzymes superoxide dismutase (ec 1.15.1.1), catalase (e ... | 1985 | 3855565 |
| murine malaria decreases hemopoietic stem cells. | the causes of anemia and immunosuppression, major outcomes of malaria, are not well established. this study was undertaken to investigate whether erythropoietin (ep) production is adequate and whether the hemopoietic stem cells (cfu-s) were affected during the course of infection. groups of female balb/c mice infected with plasmodium vinckei vinckei, plasmodium berghei, or plasmodium chabaudi adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. plasma samples were coll ... | 1987 | 3801660 |
| antimalarial activity of a riboflavin analog against plasmodium vinckei in vivo and plasmodium falciparum in vitro. | the riboflavin analog 10-(4'-chlorophenyl)-3-methylflavin was found to have significant activity against plasmodium vinckei vinckei when administered orally and parenterally; it was active against p. falciparum in culture. it inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. when administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against p. falciparum in vitro. | 1987 | 3688306 |
| increased production of arachidonate metabolites by peritoneal cells of mice infected with plasmodium vinckei vinckei. | peritoneal cells from mice infected with plasmodium vinckei vinckei generate about four times more prostaglandin f and 6-keto prostaglandin f1 alpha, five times the prostaglandin e and ten times the thromboxane b2 than do peritoneal cells from normal mice. these results were not due to differences in the ratios of cell subpopulations from each group. as well as providing additional evidence that macrophage activation occurs in malaria, the increased production of these prostanoids could help exp ... | 1986 | 3579736 |
| interdependence of cd4+ t cells and malarial spleen in immunity to plasmodium vinckei vinckei. relevance to vaccine development. | we studied immunity to the blood stage of the rodent malaria, plasmodium vinckei vinckei, which is uniformly lethal to mice. balb/c mice develop solid immunity after two infections and drug cure. the following experiments define the basis of this immunity. transfer of pooled serum from such immune mice renders very limited protection to balb/c mice and no protection to athymic nu/nu mice. moreover, b cell-deficient c3h/hen mice develop immunity to p. vinckei reinfection in the same manner as imm ... | 1989 | 2570802 |
| bleomycin-detectable iron in plasma from plasmodium vinckei vinckei-infected mice. | plasma from mice heavily parasitized by plasmodium vinckei vinckei was found to contain micromolar levels of iron as detected by the 'bleomycin assay' (slightly modified) of gutteridge et al. [(1981) biochem. j. 199, 263-265]. uninfected mouse plasma contained little or no bleomycin-detectable iron. plasma ultrafiltrate from infected mice contained no bleomycin-detectable iron, indicating that such iron was associated with the protein/macromolecule fraction. we speculate that this iron could cat ... | 1986 | 2417884 |
| antimalarial action of flavin analogues seems not be due to inhibition of glutathione reductase of host erythrocytes. | a series of 10-(4'-chlorophenyl)-3-substituted flavins (1a-f) were examined with respect to their antimalarial properties. they were tested against plasmodium falciparum in vitro and plasmodium vinckei vinckei in vivo. the proposition that they might act through glutathione reductase (gr) (ec 1.6.4.2) inhibition has been studied. inhibition of p. falciparum in vitro by these compounds shows only slight variation between analogues; in contrast, inhibition of human erythrocyte gr by members of the ... | 1990 | 2182031 |
| [involvement of cellular immunity in pathology. neuromalaria]. | murin cerebral malaria (mcm) with plasmodium berghei anka and the cba/ca mice is the result of an immunopathological process. an overproduction of tnf is implicated in its pathogenesis. recent datas concerning tnf production during the course of plasmodium vinckei vinckei infection, and analysis of relationships between mcm and experimental allergic encephalomyelitis (eae) raise the hypothesis of the involvement of an auto-immune process in the murin disease. the role of cellular immunity in hum ... | 1992 | 1327351 |
| phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. | phagocyte-derived reactive oxygen species have been implicated in the clearance of malaria infections. we investigated the progression of five different strains of murine malaria in gp91(phox-/-) mice, which lack a functional nadph oxidase and thus the ability to produce phagocyte-derived reactive oxygen species. we found that the absence of functional nadph oxidase in the gene knockout mice had no effect on the parasitemia or total parasite burden in mice infected with either resolving (plasmod ... | 2005 | 16041008 |
| provitamin b5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite. | pantothenic acid, a precursor of the crucial enzyme cofactor coenzyme a, is one of a relatively few nutrients for which the intraerythrocytic parasite has an absolute and acute requirement from the external medium. in some organisms the provitamin pantothenol can serve as a source of pantothenic acid; however, this was not the case for the human malaria parasite plasmodium falciparum. instead, pantothenol inhibited the in vitro growth of p. falciparum via a mechanism that involves competition wi ... | 2005 | 15673744 |
| increased choline transport in erythrocytes from mice infected with the malaria parasite plasmodium vinckei vinckei. | parasitized erythrocytes from mice infected with the murine malaria parasite plasmodium vinckei vinckei showed a marked increase in the rate of influx of choline compared with erythrocytes from uninfected mice. in contrast, uninfected erythrocytes from p. vinckei-infected animals transported choline at the same rate as those from uninfected mice. the increased influx of choline into parasitized cells was via two discrete routes. one was a saturable pathway with a km similar to that of the cholin ... | 1998 | 9729457 |
| plasmodium vinckei vinckei, p. v. lentum and p. yoelii yoelii: chronobiology of the asexual cycle in the blood. | the biological rhythms of plasmodium vinckei vinckei, p. v. lentum and p. yoelii yoelii i.e. synchronicity, duration of the erythrocytic cycle, timing of the schizogony and of the penetration of merozoites into red blood cells, were studied in the swiss white mouse. two different methods of synchronisation were used: the freezing-thawing of parasitized blood and the inoculation of a single parasitic stage, separated from the other stages by centrifugation through a percoll-glucose gradient. the ... | 1994 | 9140490 |
| cellular mechanisms in the immune response to malaria in plasmodium vinckei-infected mice. | infection of mice with the malaria parasite plasmodium vinckei vinckei is 100% lethal. however, after two infections followed by drug cure, balb/c mice develop a solid immunity which is antibody independent but mediated by cd4+ t cells. to elucidate the mechanisms of this immunity, spleen cells from immune mice were challenged in vitro with lysates of p. vinckei-infected or uninfected erythrocytes. the parasite antigen induced proliferation of t cells from immune mice but not from nonimmune mice ... | 1995 | 7558309 |